摘要:
The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen, lower acyl, lower alkoxycarbonyl or the like; R3 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl or the like; R4 is cyano, lower alkoxycarbonyl, carboxy or the like, which exhibit potent COMT inhibitory activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
摘要翻译:本发明提供由通式(I)表示的化合物或其药学上可接受的盐,其中R 1和R 2各自为氢,低级酰基,低级烷氧基羰基等; R 3是低级烷基,卤素 - 低级烷基,环烷基,杂环烷基,任选取代的芳基,任选取代的杂芳基等; R4是氰基,低级烷氧基羰基,羧基等,其表现出强烈的COMT抑制活性。 本发明还提供含有所述化合物的药物组合物及其用途。
摘要:
A mobile station (14) transmits a signal after connection is established, by using the same number of subcarriers as the number of subcarriers equal to or smaller than a predetermined number used for transmitting a connection request signal (TCCH). A base station (12) detects the number of subcarriers used for transmitting the connection request signal (TCCH) (S106), and controls in accordance with the detected number of subcarriers the passband width of a bandpass filter having a passband with a variable width accommodating the predetected number of subcarriers, for separating a signal of the mobile station (14) falling within the passband from a received signal (S108).
摘要:
The invention relates to a container for electric energy storage device excellent in the manufacturing efficiency and easy for surface mounting to an external electric circuit board, and a battery and electric double layer capacitor at high performance using the same. A container for electric energy storage device includes a frame (1), a first sealing member (2) bonded to the frame (1) so as to close a first opening of the frame (1), and a second sealing member bonded to the frame (1) so as to close a second opening of the frame (1) and having a connection end portion disposed side by side with the first sealing member (2). The container for electric energy storage device can be manufactured through a simple manufacturing process and can be surface-mounted easily.
摘要:
A device and method for determining whether a malfunction is present in a drive circuit, which drives an electric device that generates counter-electromotive force, when all gates in the switching elements of the drive circuit are blocked. After the gates are blocked, the temperature of the switching elements is monitored and the presence of a malfunction is determined based on the detected temperature of the switching elements. A malfunction is determined to be present when the detected temperature equals or exceeds a predetermined temperature; the change in the detected temperature equals or exceeds a predetermined value; or the rate of change in the detected temperature equals or exceeds than a predetermined rate. Thus, it can be appropriately determined whether the gates in the drive circuit are appropriately blocked and minimize the influence of any malfunctions on other elements outside of the drive circuit.
摘要:
The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.
摘要:
In order to satisfy the requirements for satisfactory levels of melting•burn-off characteristics in response to heat application, high temperature burn-off characteristics and ease of residual ash removal that a resin model should assure as an alternative to a wax model, the burn-off resin model according to the present invention, which can be used in the lost wax process, is manufactured by forming a liquid resin compound containing 1 to 30 wt. % of a plasticizer (D) and 1 to 20 wt. % of a wax component (E) blended into a double fluid reactive setting liquid urethane resin (C) constituted of a multifunctional polyol component (A) and a multifunctional polyisocyanate component (B) and then by setting the liquid resin compound within a working life of 5 minutes or less.
摘要:
The use of the undefined low-order four bits of an 8-bit watermark is defined and, when contents are reproduced, a predetermined operation is performed according to the information stored in the low-order four bits. That is, a watermark is added to an original image to create an image with the watermark inserted. When the contents are reproduced, the watermark is detected in the image and, based on the information stored in the low-order four bits of the detected watermark, a predetermined operation, for example, access to a web site on the Internet, is performed.
摘要:
A copper alloy for electronic machinery and tools, containing Ni 2.0 to 4.5 mass %, and Si 0.3 to 1.0 mass %, with the balance being Cu and unavoidable impurities, which satisfies the following expression: I{311}×A/(I{311}+I{220}+I{200})
摘要翻译:含有Ni 2.0〜4.5质量%的Ni的电子机械用工具用铜合金,Si为0.3〜1.0质量%,余量为Cu和不可避免的杂质,满足以下表达式:&lt;线内配方说明=“ 在线公式“end =”lead“?> I {311} xA /(I {311} + I {220} + I {200})<1.5 <?in-line-formula description = “end =”tail“?>其中I {311}表示在片材表面的{311}平面的X射线衍射强度; I {220}表示在片材表面的{220}平面的X射线衍射强度; I {200}表示来自板表面的{200}平面的X射线衍射强度; A(mum)表示晶粒尺寸,具有良好的弯曲性。
摘要:
A copper alloy, which contains: a precipitate X composed of Ni and Si; and a precipitate Y that comprises Ni or Si or neither Ni nor Si, wherein the precipitate X has a grain size of 0.001 to 0.1 μm, and the precipitate Y has a grain size of 0.01 to 1 μm.
摘要:
A digital camera having an acoustic member includes a first cover, a water-proof sheet and a second cover. The second cover is spaced from the water-proof sheet. The first cover has a first sound hole opposed to the acoustic member. The water-proof sheet is disposed such as to covers the first sound hole. The second cover has a second sound hole. The second sound hole is deviated in position toward an outer periphery of the first sound hole so that the second sound hole is not located on an extension of an axis of the first sound hole.