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151.发明公开公开(公告)号：US20240008360A1
公开(公告)日：2024-01-04
申请号：US18276084
申请日：2022-03-15
发明人： Nam Jin LEE , GWANG IL DONG , Won Jang JEONG , Dong Jun KIM
IPC分类号： H10K85/60 , C07D498/06
CPC分类号： H10K85/636 , C07D498/06 , H10K85/633 , H10K50/11
摘要： The present specification relates to a heterocyclic compound represented by Chemical Formula 1, an organic light emitting device comprising the same, a method for manufacturing the same, and a composition for an organic material layer.
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公开(公告)号：US11833156B2
公开(公告)日：2023-12-05
申请号：US16649597
申请日：2018-09-20
申请人： JUBILANT EPIPAD LLC
发明人： Gurulingappa Hallur , Athisayamani Jeyaraj Duraiswamy , Buchi Reddy Purra , N. V. S. K. Rao , Sridharan Rajagopal
IPC分类号： C07D498/06 , C07D498/16 , A61K31/5365 , A61P1/00 , A61P11/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P35/00 , A61K31/5383 , A61K31/4985 , A61K31/553 , A61K45/06 , C07D487/06
CPC分类号： A61K31/5383 , A61K31/4985 , A61K31/553 , A61K45/06 , C07D487/06 , C07D498/06
摘要： Heterocyclic compounds of Formula (I), (II), and (III) are described herein along with their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof. The compounds described herein, their polymorphs, stereoisomers, prodrugs, solvates, co-crystals, intermediates, pharmaceutically acceptable salts, and metabolites thereof are PAD4 inhibitors and may be useful in the treatment of various disorders, for example rheumatoid arthritis, vasculitis, systemic lupus erythematosis, cutaneous lupus erythematosis, ulcerative colitis, cancer, cystic fibrosis, asthma, multiple sclerosis and psoriasis.
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公开(公告)号：US20230357169A1
公开(公告)日：2023-11-09
申请号：US18351664
申请日：2023-07-13
发明人： Lei WEN , Huaijun CHEN , Junyou PAN
IPC分类号： C07D498/06 , C07D251/22 , C07D513/06 , H10K85/60 , C07D239/26 , C07D213/53 , H10K85/30 , H10K85/40
CPC分类号： C07D251/22 , C07D213/53 , C07D239/26 , C07D498/06 , C07D513/06 , H10K85/342 , H10K85/346 , H10K85/40 , H10K85/615 , H10K85/622 , H10K85/631 , H10K85/654 , H10K85/6572 , H10K85/6574 , H10K85/6576 , H10K85/658 , C07B2200/05 , H10K2101/10
摘要： Provided are organic compounds including a structure of formula (I). Also provided are mixtures containing the organic compounds. Further provided are organic electronic devices containing the organic compounds or mixtures.
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公开(公告)号：US11751473B2
公开(公告)日：2023-09-05
申请号：US16069123
申请日：2017-07-05
申请人： LG CHEM, LTD.
发明人： Minseung Chun , Sang Young Jeon , Tae Yoon Park , Seongmi Cho
IPC分类号： H10K85/60 , C07D487/04 , C07D209/86 , C07D487/14 , C07D471/06 , C07D403/10 , C07D403/14 , C07D405/14 , C07D403/12 , C09K11/06 , C07C211/61 , C07D307/91 , C07D471/10 , C07D487/16 , C07D498/06 , H10K50/11 , H10K101/10 , H10K101/30 , H10K101/00
CPC分类号： H10K85/6572 , C07C211/61 , C07D209/86 , C07D307/91 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D471/06 , C07D471/10 , C07D487/04 , C07D487/14 , C07D487/16 , C07D498/06 , C09K11/06 , H10K85/615 , H10K85/622 , H10K85/626 , H10K85/633 , H10K85/636 , H10K85/654 , H10K85/657 , C07C2603/18 , C07C2603/42 , C07C2603/97 , C09K2211/1018 , H10K50/11 , H10K85/624 , H10K85/6574 , H10K2101/10 , H10K2101/30 , H10K2101/90
摘要： The present specification relates to an organic light emitting device including: an anode; a cathode disposed to face the anode; and a light emitting layer disposed between the anode and the cathode, in which the light emitting layer includes: a host including a P-type host and an N-type host, which produce an exciplex; and a phosphorescent dopant, and the host including the P-type host and the N-type host, which produce an exciplex, emits a photoluminescence light with a longer wavelength than a wavelength of each of the P-type host and the N-type host.
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公开(公告)号：US10065970B2
公开(公告)日：2018-09-04
申请号：US15258175
申请日：2016-09-07
申请人： Genentech, Inc.
发明人： Marie-Gabrielle Braun , Keira Garland , Emily Hanan , Hans Purkey , Steven T. Staben , Robert Andrew Heald , Jamie Knight , Calum Macleod , Aijun Lu , Guosheng Wu , Siew Kuen Yeap
IPC分类号： C07D498/04 , A61K31/553 , A61K31/5383 , A61K31/498 , A61K31/4439 , A61K31/428 , A61K31/423 , A61K31/4196 , C07D491/044 , A61K45/06 , C07D519/00
CPC分类号： C07D498/04 , A61K31/4188 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/498 , A61K31/5365 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D491/044 , C07D498/06 , C07D519/00
摘要： Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.
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公开(公告)号：US20180162873A9
公开(公告)日：2018-06-14
申请号：US15258175
申请日：2016-09-07
申请人： Genentech, Inc.
发明人： Marie-Gabrielle Braun , Keira Garland , Emily Hanan , Hans Purkey , Steven T. Staben , Robert Andrew Heald , Jamie Knight , Calum Macleod , Aijun Lu , Guosheng Wu , Siew Kuen Yeap
IPC分类号： C07D498/04 , A61K31/553 , A61K31/5383 , A61K31/498 , A61K31/4439 , A61K31/428 , A61K31/423 , A61K31/4196 , C07D491/044 , A61K45/06 , C07D519/00
CPC分类号： C07D498/04 , A61K31/4188 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/4439 , A61K31/498 , A61K31/5365 , A61K31/5383 , A61K31/553 , A61K45/06 , C07D491/044 , C07D498/06 , C07D519/00
摘要： Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure: or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.
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公开(公告)号：US09969752B2
公开(公告)日：2018-05-15
申请号：US15514536
申请日：2015-09-23
发明人： Jiaqiang Cai , Alejandro Crespo , Xiaoxing Du , Byron Gabriel Dubois , Deodialsingh Guiadeen , Shankaran Kothandaraman , Ping Liu , Rongqiang Liu , Weiguo Quan , Christopher Sinz , Liping Wang
IPC分类号： C07D471/06 , C07D498/06 , C07D513/06 , C07D498/16
CPC分类号： C07D513/06 , C07D471/04 , C07D471/06 , C07D498/04 , C07D498/06 , C07D498/16 , C07D513/04
摘要： The present invention concerns compounds of formula I or pharmaceutically acceptable salts thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
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公开(公告)号：US09902742B2
公开(公告)日：2018-02-27
申请号：US15437605
申请日：2017-02-21
发明人： Donald J. P. Pinto , James R. Corte , Paul J. Gilligan , Tianan Fang , Leon M. Smith, II , Yufeng Wang , Wu Yang , William R. Ewing
IPC分类号： C07D487/08 , C07D519/00 , C07D471/08 , C07D498/08
CPC分类号： C07D519/00 , C07D471/06 , C07D471/08 , C07D487/06 , C07D487/08 , C07D498/06 , C07D498/08
摘要： The present invention provides compounds of Formula (Ia): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20180022753A1
公开(公告)日：2018-01-25
申请号：US15718431
申请日：2017-09-28
发明人： James R. Corte , Tianan Fang , Carl P. Decicco , Donald J.P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
IPC分类号： C07D487/04 , C07D487/14 , C07D471/14 , C07D487/18 , C07D471/18 , C07D498/06 , C07D487/16 , C07D487/06 , C07D498/08 , C07D498/04 , C07D487/08
CPC分类号： C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
摘要： The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20170362180A1
公开(公告)日：2017-12-21
申请号：US15691216
申请日：2017-08-30
发明人： Mamuti ABUDUSAIMI , Fangguo YE , Jiangqin SUN , Hisashi MIYAMOTO , Jay-Fei CHENG , Daisuke OKA
IPC分类号： C07D215/56 , C07D401/04 , C07D498/04 , C07D487/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D413/12 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/04 , C07D401/14 , C07D401/10 , C07D498/06 , C07D519/00
CPC分类号： C07D215/56 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/06 , C07D519/00
摘要： The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile-associated diarrhea.
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