公开(公告)号：US09340486B2

公开(公告)日：2016-05-17

申请号：US13854491

申请日：2013-04-01

Applicant: ANGUS Chemical Company

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr.

IPC: B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C201/06 ,  B01J10/00

CPC classification number: C07C201/06 ,  B01J10/00 ,  B01J19/00 ,  C07C201/08 ,  C07C201/16 ,  C07C205/02

Abstract: Disclosed are a process and an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. Energy and capital costs may be reduced by recycling a majority of the aqueous phase back to the reactor.

公开(公告)号：US20160083332A1

公开(公告)日：2016-03-24

申请号：US14785763

申请日：2014-04-24

Applicant: Covestro Deutschland AG

Inventor： Antoni Mairata ,  Thomas Knauf

IPC: C07C201/08 ,  C07C201/16

CPC classification number: C07C201/08 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention relates to a continuously operated adiabatic process for the preparation of nitrobenzene by nitration of benzene with nitric acid and sulfuric acid, in which the dilute sulfuric acid obtained after the nitration has taken place and the crude nitrobenzene has been separated off from the aqueous phase is concentrated for the purpose of re-use in the nitration, and after its concentration, at least one minute before it comes into contact with fresh nitric acid again an oxidizing agent is added such that a concentration of the oxidizing agent of from 10 ppm to 5,000 ppm, based on the total weight of the concentrated sulfuric acid to be recycled into the nitration, is established.

Abstract translation: 本发明涉及用硝酸和硫酸硝化苯来制备硝基苯的连续操作的绝热方法，其中在硝化发生后获得的稀硫酸和粗硝基苯已从水溶液中分离出来 浓缩的浓度是为了在硝化中重复使用，并且在其浓缩之后，再次与新鲜硝酸接触至少一分钟，加入氧化剂使得氧化剂的浓度为10ppm 至5,000ppm，基于要再循环到硝化中的浓硫酸的总重量。

公开(公告)号：US09050581B2

公开(公告)日：2015-06-09

申请号：US12808073

申请日：2008-12-16

Applicant: Ludivine Bouvier ,  Stéphane Kieger ,  Catherine Laroche ,  Philibert Leflaive ,  Tom Frising

Inventor： Ludivine Bouvier ,  Stéphane Kieger ,  Catherine Laroche ,  Philibert Leflaive ,  Tom Frising

IPC: B01J20/18 ,  B01J29/80 ,  C07C7/13 ,  C07C17/389 ,  B01J20/28 ,  C07C29/76 ,  C07C37/82 ,  C07C201/16

CPC classification number: B01J20/18 ,  B01J20/183 ,  B01J20/186 ,  B01J20/28004 ,  B01J20/2803 ,  C07C7/13 ,  C07C17/389 ,  C07C29/76 ,  C07C37/82 ,  C07C201/16 ,  Y02P20/52 ,  C07C15/08 ,  C07C25/08 ,  C07C31/18 ,  C07C39/07 ,  C07C205/06

Abstract: The present invention relates to aggregate zeolitic adsorbents based on zeolite X and zeolite LSX.These adsorbents are particularly suitable for separating C8 aromatic isomers and in particular xylenes, separating sugars, separating polyhydric alcohols, separating isomers of substituted toluenes, separating cresols, separating dichlorobenzenes.

Abstract translation: 本发明涉及基于沸石X和沸石LSX的聚合沸石吸附剂。 这些吸附剂特别适用于分离C8芳族异构体，特别是二甲苯，分离糖，分离多元醇，分离取代甲苯的异构体，分离甲酚，分离二氯苯。

公开(公告)号：US20130041189A1

公开(公告)日：2013-02-14

申请号：US13569806

申请日：2012-08-08

Applicant: Petra DECKERT ,  Leo Denissen ,  Bart Van De Voorde ,  Julia Leschinski ,  Stefan Robert Deibel ,  Matthias Fankhänel ,  Samuel Neto

Inventor： Petra DECKERT ,  Leo Denissen ,  Bart Van De Voorde ,  Julia Leschinski ,  Stefan Robert Deibel ,  Matthias Fankhänel ,  Samuel Neto

IPC: C07C201/16

CPC classification number: C07C201/16 ,  C07C205/06

Abstract: The invention relates to a process for purifying crude aromatic nitro compounds which originate from the nitration of aromatic compounds, comprising the single or multiple performance of the following wash stage (a):(a) contacting the crude aromatic nitro compound (N-in) with an aqueous phase (W-res) and then separating the phases to obtain an organic phase (N-res) and an aqueous phase (W-res),wherein at least one demulsifier (D) is present in one or more of the wash stages (a).

Abstract translation: 本发明涉及一种用于纯化源自芳族化合物硝化的粗芳族硝基化合物的方法，其包括以下洗涤阶段（a）的单次或多次性能：（a）使粗芳族硝基化合物（N-in） （W-res），然后分离相以获得有机相（N-res）和水相（W-res），其中至少一个破乳剂（D）存在于一个或多个 洗涤阶段（a）。

公开(公告)号：US20090221747A1

公开(公告)日：2009-09-03

申请号：US10848557

申请日：2004-05-17

Applicant: Nese Orbey ,  B. Michael Cushman ,  Marina Temchenko

Inventor： Nese Orbey ,  B. Michael Cushman ,  Marina Temchenko

IPC: C08B15/06 ,  C08B15/10 ,  C07C249/14 ,  C07C201/16

CPC classification number: C06B21/0091 ,  F42B33/06 ,  Y10S149/124

Abstract: Methods for the separation of targeted components from gun propellant formulations. In particular, the methods separate targeted components in a usable/useful form. Preferred methods are directed to the separation of nitrocellulose, nitroguanidine and/or nitroglycerine from a formulation containing one or more of these components.

Abstract translation: 从喷枪推进剂制剂中分离目标组分的方法。 特别地，这些方法以可用/有用的形式分离目标成分。 优选的方法是从含有一种或多种这些组分的制剂中分离硝化纤维素，硝基胍和/或硝酸甘油。

公开(公告)号：US6077963A

公开(公告)日：2000-06-20

申请号：US213887

申请日：1998-12-17

Applicant: James R. Gage ,  Robert C. Kelly ,  Bradley D. Hewitt

Inventor： James R. Gage ,  Robert C. Kelly ,  Bradley D. Hewitt

IPC: C07C205/43 ,  A61K31/366 ,  A61P31/18 ,  C07C45/30 ,  C07C47/277 ,  C07C59/48 ,  C07C201/16 ,  C07C205/56 ,  C07D309/32 ,  C07D405/04 ,  C07D405/12 ,  C07D309/30

CPC classification number: C07D405/04 ,  C07C205/56 ,  C07C45/30 ,  C07C47/277 ,  C07C59/48 ,  C07D309/32 ,  C07D405/12

Abstract: Disclosed is a novel process and novel intermediates to prepare [R-(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenylethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromethyl)-2-pyridinesulfonamide (XIX) ##STR1## which is a protease inhibitor useful in treating humans infected with the HIV virus.

Abstract translation: 公开了一种制备[R-（R *，R *）] -N- [3- [1- [5,6-二氢-4-羟基-2-氧代-6-（2- 苯基乙基）-6-丙基-2H-吡喃-3-基]丙基]苯基] -5-（三氟甲基）-2-吡啶磺酰胺（XIX），其是可用于治疗感染HIV病毒的人的蛋白酶抑制剂。

公开(公告)号：US06042723A

公开(公告)日：2000-03-28

申请号：US131241

申请日：1998-08-07

Applicant: Raphael Duval ,  Hubert Leveque

Inventor： Raphael Duval ,  Hubert Leveque

IPC: B01D15/08 ,  B01J20/26 ,  B01J20/32 ,  B01J31/02 ,  B01J31/06 ,  C07B57/00 ,  C07C201/16 ,  C08B37/16

CPC classification number: C08B37/0012 ,  B01D15/3833 ,  B01J20/26 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/328 ,  B01J31/065 ,  C07B57/00 ,  B01J31/1616

Abstract: Mono- and di-derivatives of cyclodextrins are completely defined, also a method for their synthesis and purification, functionalised cyclodextrins obtained from these derivatives, and the synthesis of supports comprising these cyclodextrin derivatives. Use of the supports for the preparation of separation of enantiomers, for asymmetric synthesis, for catalysis, for the preparation or separation of geometrical isomers or positional isomers, or for the preparation or separation of organic molecules with a hydrophobic nature is also described.

Abstract translation: 完全限定了环糊精的单 - 和二 - 衍生物，也是合成和纯化由这些衍生物获得的官能化环糊精的方法，以及包含这些环糊精衍生物的载体的合成。 还描述了用于制备分离对映异构体，用于不对称合成，催化，用于制备或分离几何异构体或位置异构体或用于制备或分离具有疏水性质的有机分子的载体的用途。

公开(公告)号：US5714647A

公开(公告)日：1998-02-03

申请号：US785577

申请日：1997-01-21

Applicant: Heinz Ulrich Blank ,  Helmut Judat ,  Bernd-Michael Konig

Inventor： Heinz Ulrich Blank ,  Helmut Judat ,  Bernd-Michael Konig

IPC: C07C201/08 ,  C07C201/16 ,  C07C205/12 ,  C07C205/00

CPC classification number: C07C201/08

Abstract: Mononitrohalogenobenzenes can be prepared by mixing halogenobenzene, nitric acid, sulphuric acid and water intensively with one another, simultaneously or in succession in their total quantity, and by redispersing them at least twice in the case of continuous preparation, applying a mixing energy of 1-40 watts per liter of the overall reaction mixture, preferably 3-30 W/l, largely suppressing back-mixing in the continuous procedure, and observing adiabatic reaction conditions.

Abstract translation: 一硝基卤代苯可以通过将卤代苯，硝酸，硫酸和水彼此同时或相继地以总量相互重叠混合，并且在连续制备的情况下将它们再分散至少两次来制备， 总体反应混合物为40瓦/升，优选为3-30W / l，在连续方法中大大抑制了反混合，并且观察绝热反应条件。

公开(公告)号：US5679873A

公开(公告)日：1997-10-21

申请号：US510992

申请日：1995-08-03

Applicant: Uwe Klingler ,  Thomas Schieb ,  Gerhard Wiechers ,  Jurgen Zimmermann

Inventor： Uwe Klingler ,  Thomas Schieb ,  Gerhard Wiechers ,  Jurgen Zimmermann

IPC: C07C201/08 ,  C07C201/16 ,  C07C205/06

CPC classification number: C07C201/08

Abstract: Dinitrotoluene is produced in a two-stage process from toluene and nitric acid in the presence of sulfuric acid under adiabatic conditions in the presence of nitrating acids made up of specified components. The reaction product of the first phase is separated into an acid phase and an organic phase containing the mononitrotoluene. Some water is removed from the acid phase, nitric acid is added and the resultant mixture is recycled. The organic phase containing mononitrotoluene is further nitrated to produce the dinitrotoluene. This nitration mixture is also separated into an acid phase and an organic phase. The acid phase is treated to remove some water, nitric acid is added and the resultant acid mixture is recycled. Dinitrotoluene is recovered from the organic phase. This process is advantageous in that dilute nitric acid may be used and the heat of the nitration reaction is utilized.

Abstract translation: 在绝酸条件下，在由特定组分组成的硝酸的存在下，在硫酸存在下，甲苯和硝酸二步法生产二硝基甲苯。 将第一相的反应产物分离成酸相和含有一硝基甲苯的有机相。 从酸相中除去一些水，加入硝酸并将所得混合物回收。 含有单硝基甲苯的有机相进一步硝化以产生二硝基甲苯。 该硝化混合物也分离成酸相和有机相。 处理酸相以除去一些水，加入硝酸并将所得酸混合物再循环。 从有机相回收二硝基甲苯。 该方法的优点在于可以使用稀硝酸并利用硝化反应的热。

公开(公告)号：US5648565A

公开(公告)日：1997-07-15

申请号：US679323

申请日：1996-07-12

Applicant: Bernd-Michael Konig ,  Helmut Judat ,  Heinz Ulrich Blank

Inventor： Bernd-Michael Konig ,  Helmut Judat ,  Heinz Ulrich Blank

IPC: C01B17/88 ,  C07C201/08 ,  C07C201/16 ,  C07C205/06 ,  C07C205/00

CPC classification number: C07C201/08

Abstract: Mononitrotoluenes can be prepared by intensively mixing together toluene, nitric acid, sulphuric acid and water, simultaneously or successively in their total amount, and, in the case of continuous preparation, redispersing the mixture at least twice, for which purpose a mixing energy of 1 to 40 watts per liter of the total reaction mixture, preferably 3 to 30 W/l, is employed per volume of the reactor, and, for the continuous procedure, the back mixing is substantially repressed. Adiabatic reaction conditions are maintained.

Abstract translation: 单硝基甲苯可以通过将甲苯，硝酸，硫酸和水同时或相继浓缩在一起而制备，并且在连续制备的情况下，将混合物再分散至少两次，为此目的的混合能量为1 至40瓦/升的总反应混合物，优选3至30W / l，并​​且对于连续方法，背混合基本上被压制。 保持绝热反应条件。