公开(公告)号：US20210179536A1

公开(公告)日：2021-06-17

申请号：US16830037

申请日：2020-03-25

Applicant: Sichuan University

Inventor： Fener CHEN ,  Lin DONG ,  Yingqi XIA ,  Pei TANG ,  Youcai XIAO

IPC: C07C201/12 ,  B01J31/18

Abstract: Disclosed is a method of synthesizing a (1R,2R)-nitroalcohol compound of formula (I), as shown in the following reaction scheme, including: subjecting a compound of formula (II) and a compound of formula (III) to a condensation reaction in an organic solvent in the presence of a copper complex generated in situ from a chiral (1S,2R)-amino alcohol ligand and a cupric salt to produce the (1R,2R)-nitroalcohol compound of formula (I), where R1 and R2 are defined in the same manner as that in the specification. The method involves mild reaction conditions, excellent diastereoselectivity and high chemical yield, and thus it is suitable for industrial applications.

公开(公告)号：US11008358B2

公开(公告)日：2021-05-18

申请号：US16724654

申请日：2019-12-23

Applicant: President and Fellows of Harvard College

Inventor： Andrew G. Myers ,  Ziyang Zhang

IPC: C07H15/12 ,  C07H17/02 ,  C07H11/02 ,  C07H15/18 ,  C07C201/12 ,  C07C201/14 ,  C07H1/00

Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US10702858B2

公开(公告)日：2020-07-07

申请号：US16214793

申请日：2018-12-10

Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.

Inventor： Bo Xu ,  Zhichao Lu ,  Gerald B. Hammond

IPC: B01J27/055 ,  C07D277/56 ,  C07C67/287 ,  C07C303/30 ,  C07D209/50 ,  C07C303/34 ,  C07C201/12 ,  C07C213/08 ,  C07C253/30 ,  C07C45/63 ,  C07D215/227 ,  C07D307/68 ,  C07D333/38 ,  C07D207/34 ,  C01D5/00 ,  C07C17/087 ,  C07C67/307 ,  C07C51/363 ,  C07B39/00 ,  C07C29/62 ,  B01J31/00

Abstract: Some embodiments of the invention include inventive catalysts (e.g., compounds of Formula (I) or (Ia)). Other embodiments include compositions comprising the inventive catalysts. Some embodiments include methods of using the inventive catalysts (e.g., in hydrofluorination of an organic compound). Further embodiments include methods for making the inventive catalysts. Additional embodiments of the invention are also discussed herein.

公开(公告)号：US10544182B2

公开(公告)日：2020-01-28

申请号：US15558910

申请日：2016-03-25

Applicant: President and Fellows of Harvard College

Inventor： Andrew G. Myers ,  Ziyang Zhang

IPC: C07H15/12 ,  C07H17/02 ,  C07H11/02 ,  C07H15/18 ,  C07H1/00 ,  C07C201/12 ,  C07C201/14

Abstract: The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.

公开(公告)号：US10539872B2

公开(公告)日：2020-01-21

申请号：US15323043

申请日：2015-07-14

Applicant: TOKYO OHKA KOGYO CO., LTD.

Inventor： Yoshinori Tadokoro ,  Dai Shiota

IPC: G03F7/031 ,  G03F7/004 ,  C07C251/66 ,  C07C45/46 ,  G02B5/22 ,  G02F1/1335 ,  C07C201/12 ,  C07C249/10 ,  C07D333/22 ,  G03F7/00 ,  C07C333/26

Abstract: A photosensitive composition having excellent sensitivity, an insulating film formed using the composition, a color filter formed using the composition, a display device provided with the insulating film or color filter, and a compound suitable for incorporation as a photopolymerization initiator into the composition. This photosensitive composition includes a photopolymerizable compound and a photopolymerization initiator. The photopolymerization initiator contains a compound represented by formula (1) below in which R1 is a hydrogen atom, a nitro group, or a monovalent organic group; R2 and R3 are each an optionally substituted linear alkyl group, an optionally substituted cyclic organic group, or a hydrogen atom, and R2 and R3 may be bonded to one another to form a ring; R4 is a monovalent organic group; R5 is a hydrogen atom, an optionally substituted C1-11 alkyl group, or an optionally substituted aryl group; n is an integer from 0 to 4; and m is 0 or 1.

公开(公告)号：US10526262B2

公开(公告)日：2020-01-07

申请号：US14437628

申请日：2012-10-24

Applicant: Gregory Rosocha

Inventor： Gregory Rosocha ,  Robert Batey

IPC: C07C17/23 ,  C07C23/18 ,  C07C25/22 ,  C07C201/12 ,  C07C253/30 ,  C07C2/86 ,  C07D217/04 ,  C07D471/06

Abstract: According to embodiments described in the specification, a chemical process includes the steps of reacting a chemical reaction fluid including a solvent, 1,2-biaryl gem-dibromocyclopropane or 1,2-biphenyl-gem-dibromocyclopropane, and a metal salt including a silver tetrafluoroborate salt at low temperatures to make 1-phenyl-2-bromo indenes in a vessel that is capable of being closed.

公开(公告)号：US10464899B2

公开(公告)日：2019-11-05

申请号：US15511243

申请日：2015-06-12

Applicant: Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

Inventor： Xiaoming Feng ,  Qian Yao ,  Xiaohua Liu ,  Lili Lin ,  Yuheng Zhang

IPC: C07D211/88 ,  C07D231/12 ,  C07D231/16 ,  C07D207/267 ,  C07D405/06 ,  C07D409/06 ,  C07C201/12 ,  C07C205/53

Abstract: A synthesis method of γ-nitropyrazole amide compound through asymmetrical catalyzing technique is provided, a nitroalkane and an α,β-unsaturated pyrazole amide are applied as the raw material, a complex formed by a chiral amine oxide with a rare earth metal compound is served as the catalyst, a 4 Å molecular sieve is served as an additive, the γ-nitropyrazole amide compound can be obtained with a yield more than 99% and enantiomeric excess more than 99% ee. The catalytic system not only has the advantages of simple operation, mild reaction conditions, requiring no acid/base additives, convenient product purification, high yield and enatioselectivity, compliance with green atomic economy, and promising prospects for industrial application, but also allows the obtained γ-nitropyrazole amide compound to undergo some simple chemical conversions to produce some molecules having physiological activities.

公开(公告)号：US10385010B1

公开(公告)日：2019-08-20

申请号：US15970478

申请日：2018-05-03

Applicant: GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

Inventor： Hao Xu ,  Hongze Li ,  Shoujie Shen ,  Chengliang Zhu

IPC: C07C231/10 ,  C07C247/14 ,  C07C201/12 ,  C12P13/00 ,  C07C269/04

Abstract: Disclosed herein are improved methods for the preparation of oseltamivir, and intermediates useful thereto.

公开(公告)号：US10377700B2

公开(公告)日：2019-08-13

申请号：US15912772

申请日：2018-03-06

Applicant: BRACCO IMAGING S.P.A.

Inventor： Elisa Battistini ,  Federica Buonsanti ,  Daniela Imperio ,  Luciano Lattuada ,  Roberta Napolitano

IPC: C07C231/14 ,  C07C231/02 ,  C07F5/04 ,  C07F5/05 ,  C07C201/12 ,  C07C227/04 ,  C07C231/12 ,  C07F5/02 ,  C07C237/46

Abstract: The present invention discloses a process for recovery of a boronic acid of formula R3—B(OH)2, wherein R3 is selected from the group consisting of C1-C6 linear or branched alkyl, C3-C6 cycloalkyl, and C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl, and phenyl, comprising admixing the boronic acid with a water-immiscible organic solvent in a weight ratio between the boronic acid and the water-immiscible organic solvent from 1:10 to 1:20, adding an aqueous solution to a final pH of neutral, and partitioning the boronic acid into an organic water-immiscible phase and recovery of the organic water-immiscible phase.

公开(公告)号：US10364208B2

公开(公告)日：2019-07-30

申请号：US15861020

申请日：2018-01-03

Applicant: The Governors of the University of Alberta

Inventor： Rylan Lundgren ,  Patrick Moon

IPC: C07C67/32 ,  C07C69/614 ,  C07C69/38 ,  C07F5/02 ,  C07C67/343 ,  C07C303/40 ,  C07C201/12 ,  C07C315/04 ,  C07C231/12 ,  C07D295/185 ,  C07D213/55 ,  C07D213/61 ,  C07D213/64 ,  C07D307/91 ,  C07F7/08 ,  C07F9/40

Abstract: Described herein are methods of oxidative coupling of aryl boron reagents with sp3-carbon nucleophiles, and ambient decarboxylative arylation of malonate half-esters via oxidative catalysis.