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    METHOD AND SYSTEM OF MANUFACTURING A LOAD-BEARING STRUCTURE AND A LOAD-BEARING STRUCTURE MANUFACTURED THEREOF
    171.
    发明申请
    METHOD AND SYSTEM OF MANUFACTURING A LOAD-BEARING STRUCTURE AND A LOAD-BEARING STRUCTURE MANUFACTURED THEREOF 审中-公开

    公开(公告)号：US20200086624A1

    公开(公告)日：2020-03-19

    申请号：US16472860

    申请日：2017-12-21

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Stephen DAYNES ,  Stefanie FEIH ,  Jun WEI

    IPC: B33Y10/00 ,  G06F17/50 ,  B32B5/14 ,  B33Y50/02

    Abstract: A method of manufacturing a load-bearing structure. The method may include establishing overall dimensions and expected loading conditions of the load-bearing structure; determining a material density distribution within a solid model for the load-bearing structure based on the overall dimensions and the expected loading conditions for a predetermined objective end constraint; generating stress field data for the determined material density distribution based on the expected loading conditions; transforming the solid model into a spatially-graded mesh model having a plurality of three-dimensional cells based on orthogonal isostatic lines populated along principal stress directions of the stress field data; and fabricating the load-bearing structure with truss members aligned according to the spatially-graded mesh model. A system for manufacturing a load-bearing structure and a load-bearing structure manufactured thereof.

    A METHOD FOR REGULATING THE FUNCTION OF A HEART CELL, RELATED NUCLEOTIDES AND COMPOUNDS
    172.
    发明申请
    A METHOD FOR REGULATING THE FUNCTION OF A HEART CELL, RELATED NUCLEOTIDES AND COMPOUNDS 审中-公开

    公开(公告)号：US20200080081A1

    公开(公告)日：2020-03-12

    申请号：US16469603

    申请日：2017-12-14

    Applicant: Agency for Science, Technology and Research

    Inventor： Kelvin Zhenwei SEE ,  Roger Sik Yin FOO

    IPC: C12N15/113 ,  C12Q1/6881 ,  C12N15/115 ,  A01K67/027 ,  A61P9/00

    Abstract: The invention relates to inhibitors of Sghrt and/or Gas5 lincRNAs, in particular to polynucleotides complementary to coding and non-coding sequences of said lincRNAs, and methods of producing said inhibitors. Also disclosed are the use of the afore agents to proliferate, regenerate or dedifferentiate a heart cell; methods for preventing and treating cardiac disease using the afore agents; and a prognostic or diagnostic assay to assess the regenerative or proliferative capacity of heart tissue before, after or during a cardiac treatment regimen, comprising determining the presence or amount of Sghrt and/or Gas5 lincRNAs. The present disclosure also relates to a method for screening for a therapeutic agent that can be used to treat or prevent a heart disorder, comprising analysing the functional expression and/or expression level of Sghrt and/or Gas5 lincRNAs in the presence and in the absence of the therapeutic agent.

    A COMPUTER SYSTEM FOR ACQUIRING A CONTROL COMMAND
    175.
    发明申请
    A COMPUTER SYSTEM FOR ACQUIRING A CONTROL COMMAND 审中-公开

    公开(公告)号：US20200057499A1

    公开(公告)日：2020-02-20

    申请号：US16498872

    申请日：2018-03-29

    Applicant: Agency for Science, Technology And Research

    Inventor： Zhuo Zhang ,  Cuntai Guan ,  Chuanchu Wang

    IPC: G06F3/01 ,  A61B5/0484 ,  G05B15/02

    Abstract: A computer system for acquiring a control command. The system includes one or more processors in communication with non-transitory data storage media having instructions stored thereon that, when executed by the one or more processors, configure the one or more processors to perform particular steps. The steps include: receiving, at an electroencephalogram (EEG) receiver, baseline EEG data; and acquiring, using a normalisation module, one or more normalisation factors from the baseline EEG data. The steps further include: receiving, at the EEG receiver, stimulated EEG data sensed by one or more EEG sensors; and correlating the stimulated EEG data across the one or more EEG sensors, using a correlation module, to generate one or more correlation coefficients corresponding to one or more stimulation frequencies, each of the one or more stimulation frequencies corresponding to a respective candidate control command.

    ELLIPSOMETRY SYSTEM FOR MEASURING MOLECULAR BINDING, ADSORPTION AND DESORPTION
    178.
    发明申请
    ELLIPSOMETRY SYSTEM FOR MEASURING MOLECULAR BINDING, ADSORPTION AND DESORPTION 审中-公开

    公开(公告)号：US20200018690A1

    公开(公告)日：2020-01-16

    申请号：US16583198

    申请日：2019-09-25

    Applicant: Agency for Science, Technology and Research

    Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

    IPC: G01N21/21 ,  G01N21/05

    Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.

    FAN-OUT WAFER-LEVEL PACKAGING METHOD AND THE PACKAGE PRODUCED THEREOF
    179.
    发明申请
    FAN-OUT WAFER-LEVEL PACKAGING METHOD AND THE PACKAGE PRODUCED THEREOF 审中-公开

    公开(公告)号：US20190393051A1

    公开(公告)日：2019-12-26

    申请号：US16300538

    申请日：2017-04-27

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Masaya KAWANO ,  Ka Fai Chang

    IPC: H01L21/56 ,  H01L23/31 ,  H01L23/00 ,  H01L23/60

    Abstract: A fan-out wafer-level packaging method and the package produced thereof are provided in the present application. The method comprises steps including: providing a silicon substrate layer having a first thickness; forming one or more active/passive devices comprising at least sources and drains and one or more diffusion layers adjoining the sources and drains, wherein forming the one or more active/passive devices comprises forming the sources and the drains in a front-end-of-line (FEOL) layer on a first side of the silicon substrate layer while forming the one or more diffusion layers at locations in the silicon substrate layer adjoining the sources and the drains; forming a redistribution layer (RDL) over the FEOL layer by copper damascene formation of multiple metallization layers for connecting the one or more active/passive devices to the one or more IC dies when the one or more IC dies are mounted on a side of the RDL opposite the FEOL layer; thinning the silicon substrate layer to a second thickness to form a thinned silicon substrate, the thinned silicon substrate comprising at least the one or more diffusion layers; and patterning the thinned silicon substrate to form one or more silicon regions, each of the one or more silicon regions comprising the one or more diffusion layers.

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