公开(公告)号：US20140377182A1

公开(公告)日：2014-12-25

申请号：US14293075

申请日：2014-06-02

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Karl L. SKORECKI ,  Maty TZUKERMAN

IPC: G01N33/50 ,  A61K49/00 ,  G01N33/574

CPC classification number: G01N33/5011 ,  A61K49/0008 ,  C12N5/0606 ,  C12N5/0693 ,  C12N2501/115 ,  C12N2502/02 ,  G01N33/57492 ,  G01N2500/10

Abstract: Methods are provided for producing novel multicellular compositions comprising cancer cells together with pluripotent human stem cells, which are capable of proliferating and differentiating into various normal cell lines and tissue structures. These novel multicellular compositions are useful for investigating the properties of cancer cells in a normal human tissue microenvironment, and for studying interventions that will modulate these properties including devising, testing and screening therapeutic drugs.

Abstract translation: 提供了用于生产新型多细胞组合物的方法，其包含癌细胞以及能够增殖和分化成各种正常细胞系和组织结构的多能人干细胞。 这些新颖的多细胞组合物可用于研究正常人组织微环境中癌细胞的性质，并用于研究将调节这些性质的干预，包括设计，测试和筛选治疗药物。

公开(公告)号：US08895054B2

公开(公告)日：2014-11-25

申请号：US12411855

申请日：2009-03-26

Applicant: Yechezkel Barenholz ,  Dorit Nitzan ,  Izhak Etsion ,  Avi Schroeder ,  Grigory Halperin ,  Sarit Sivan

Inventor： Yechezkel Barenholz ,  Dorit Nitzan ,  Izhak Etsion ,  Avi Schroeder ,  Grigory Halperin ,  Sarit Sivan

IPC: A61K9/127 ,  A61K9/00 ,  A61K31/685 ,  A61L27/50

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/1271 ,  A61K31/685 ,  A61L27/50 ,  A61L2430/24

Abstract: The present invention concerns methods of joint lubrication and/or prevention of cartilage wear making use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C15 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20° C. to about 39° C. for lubrication of joints.

Abstract translation: 本发明涉及联合润滑和/或预防软骨磨损的方法，其使用具有至少一种磷脂（PL）的脂质体的脂质体，所述磷脂由具有两个相同或不同的C12-脂肪酸的甘油磷脂（GPL）组成， C16烃链和具有C12-C18烃链的鞘脂（SPL），所述一种或多种膜具有其中发生固体有序（SO）至液体无序（LD）相变的相变温度，相转变温度在 温度为约20℃至约39℃，用于润滑接头。

公开(公告)号：US08865222B2

公开(公告)日：2014-10-21

申请号：US12867204

申请日：2009-02-11

Applicant: Dganit Danino ,  Yoav D. Livney ,  Ory Ramon ,  Irina Portnoy ,  Uri Cogan

Inventor： Dganit Danino ,  Yoav D. Livney ,  Ory Ramon ,  Irina Portnoy ,  Uri Cogan

IPC: A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A23L1/305 ,  A23J1/22 ,  A23B4/03 ,  A61K31/665 ,  A61K31/415 ,  A61K9/00 ,  A61K9/107 ,  A61K31/573

CPC classification number: A61K9/00 ,  A23C9/1307 ,  A23C9/1322 ,  A23L2/52 ,  A23L33/10 ,  A23L33/155 ,  A23L33/19 ,  A23V2002/00 ,  A61K9/1075 ,  A61K31/415 ,  A61K31/573 ,  A23V2200/25 ,  A23V2250/54246 ,  A23V2200/254 ,  A23V2200/224 ,  A23V2250/71

Abstract: The invention relates to a composition for the enrichment of food and/or beverage and to a method of preparing such composition. The composition comprises additive loaded beta-casein micelles which are of a diameter of about 100 nm or less. These nano-sized beta-casein assemblies are formed at pH values which are preferably one or more pH units above or below the pI of the protein (pI=5.3). More preferably the beta-casein nano-assemblies are formed at a pH range between about 6.0 and about 8, or between about 2.0 and about 4.2. The invention provides vehicles for delivery of additives via transparent beverages and other foods and drinks and/or acidic foods and drinks and/or non fat foods and drinks.

Abstract translation: 本发明涉及一种用于富集食物和/或饮料的组合物及其制备方法。 该组合物包含直径约100nm或更小的添加剂负载的β-酪蛋白胶束。 这些纳米尺寸β-酪蛋白集合体的pH值优选为高于或低于蛋白质pI的一个或多个pH单位（pI = 5.3）。 更优选地，β-酪蛋白纳米组件在约6.0至约8或约2.0至约4.2之间的pH范围内形成。 本发明提供了用于通过透明饮料和其它食品和饮料和/或酸性食品和饮料和/或非脂肪食物和饮料递送添加剂的车辆。

公开(公告)号：US20140254723A1

公开(公告)日：2014-09-11

申请号：US14203593

申请日：2014-03-11

Applicant: Technion Research and Development Foundation LTD.

Inventor： Moshe Nazarathy ,  Igor Tselniker ,  Alex Tolmachev

IPC: H04L27/38

CPC classification number: H04L27/3872 ,  H04B10/61 ,  H04B10/611 ,  H04B10/6165 ,  H04B10/677 ,  H04L27/2071 ,  H04L27/227 ,  H04L27/38 ,  H04L27/3818 ,  H04L2027/0055 ,  H04L2027/0067 ,  H04L2203/00

Abstract: A method for calculating a reconstructed phase that includes: Calculating a current phase signal and current amplitude signal that represent a phase and amplitude of a current input symbol, respectively. Generating, in response to the current phase signal and an estimate of a phase of a last input symbol that preceded the current input symbol, multiple partial references, some of which are responsive to (i) phase signals representative of phases of a plurality of input symbols that preceded the current input symbol, and (ii) estimates of the phase of the plurality of input symbols. Calculating unwrapped partial references. Estimating a constant carrier frequency offset (CFO) phase rotation in response to the unwrapped partial references. Calculating a reconstructed phase of the current input symbol in response to, at least, the estimate of the constant CFO phase rotation and to the unwrapped partial references.

Abstract translation: 一种用于计算重构相位的方法，包括：分别计算表示当前输入符号的相位和幅度的当前相位信号和电流幅度信号。 响应于当前相位信号和对当前输入符号之前的最后输入符号的相位的估计，产生多个部分参考，其中一些部分参考响应于（i）代表多个输入的相位的相位信号 在当前输入符号之前的符号，以及（ii）多个输入符号的相位的估计。 计算未打包的部分引用。 响应于展开的部分参考，估计恒定的载波频率偏移（CFO）相位旋转。 至少响应于常数CFO相位旋转和未展开的部分参考的估计，计算当前输入符号的重构相位。

公开(公告)号：US20140244912A1

公开(公告)日：2014-08-28

申请号：US14191471

申请日：2014-02-27

Applicant: Technion Research and Development Foundation LTD.

Inventor： Yitzhak Birk ,  Amit Berman

IPC: G06F12/02

CPC classification number: G06F12/0246 ,  G06F2212/7205 ,  G06F2212/7207

Abstract: A method for writing data to a memory module, the method may include determining to write a representation of a data unit to a retired group of memory cells; searching for a selected retired group of memory cells that can store a representation of the data unit without being erased; and writing the representation of the data unit to the selected retired group of memory cells.

Abstract translation: 一种将数据写入存储器模块的方法，所述方法可以包括确定将数据单元的表示写入退出的存储器单元组; 搜索可以存储数据单元的表示而不被擦除的所选退出的存储器单元组; 以及将数据单元的表示写入所选择的退出的存储单元组。

公开(公告)号：US08791064B2

公开(公告)日：2014-07-29

申请号：US12989384

申请日：2009-04-26

Applicant: Yoav D. Livney

Inventor： Yoav D. Livney

IPC: C07K14/00 ,  A61K9/16 ,  A61K38/00

CPC classification number: A61K9/0095 ,  A23L2/52 ,  A23L29/206 ,  A23L33/105 ,  A23L33/12 ,  A23L33/15 ,  A23L33/155 ,  A23L33/19 ,  A23V2002/00 ,  A61K9/5161 ,  A61K9/5169 ,  A23V2250/54244 ,  A23V2250/51 ,  A23V2250/1868 ,  A23V2250/71

Abstract: The present invention provides colloidally stable dispersions of nanoparticles comprising beta-lactoglobulin and a polysaccharide which are transparent when diluted in aqueous media. In particular these colloidally stable dispersions of nanoparticles are useful as delivery vehicles of hydrophobic nutraceuticals and fat-soluble vitamins, for enrichment of food products, especially of transparent beverages and other non-fat or low fat foods and drinks. The present invention further provides methods for the preparation of said colloidally stable dispersions.

Abstract translation: 本发明提供包含β-乳球蛋白和多糖的胶体稳定的分散体，当在水性介质中稀释时，其是透明的。 特别地，这些胶体稳定的纳米颗粒分散体可用作疏水营养药物和脂溶性维生素的输送载体，用于富集食品，特别是透明饮料和其它非脂肪或低脂肪食品和饮料。 本发明还提供了制备所述胶体稳定分散体的方法。

公开(公告)号：US08741581B2

公开(公告)日：2014-06-03

申请号：US13266567

申请日：2010-04-27

Applicant: Arie Admon ,  Eilon Barnea ,  Ilan Beer ,  Tamar Ziv

Inventor： Arie Admon ,  Eilon Barnea ,  Ilan Beer ,  Tamar Ziv

IPC: G01N33/53

CPC classification number: G01N33/57419 ,  A61K39/0011 ,  G01N2800/56

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.

Abstract translation: 本发明涉及用于检测，预后和分期癌症，特别是胃肠道癌症的方法。 本发明的方法包括检测感兴趣的组织中的特异性蛋白质标记，其中检测的水平可以指示癌前或癌组织，或癌症的阶段或预后。 还提供了治疗癌症的方法和癌症检测试剂盒。

公开(公告)号：US20140061650A1

公开(公告)日：2014-03-06

申请号：US14027713

申请日：2013-09-16

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.

Inventor： Nir TESSLER ,  Moti MARGALIT ,  Oded GLOBERMAN ,  Roy SHENHAR

IPC: H01L29/786

CPC classification number: H01L51/0545 ,  B82Y10/00 ,  H01L29/786 ,  H01L51/0021 ,  H01L51/0036 ,  H01L51/004 ,  H01L51/0043 ,  H01L51/0046 ,  H01L51/0516 ,  H01L51/0541 ,  H01L51/0558 ,  H01L51/057 ,  H01L51/102 ,  H01L51/5012

Abstract: An electronic device is presented, such as a thin film transistor. The device comprises a patterned electrically-conductive layer associated with an active element of the electronic device. The electrically-conductive layer has a pattern defining an array of spaced-apart electrically conductive regions. This technique allows for increasing an electric current through the device.

Abstract translation: 提出了一种电子器件，例如薄膜晶体管。 该装置包括与电子装置的有源元件相关联的图案化导电层。 导电层具有限定间隔开的导电区域阵列的图案。 该技术允许增加通过该装置的电流。

公开(公告)号：US08577830B2

公开(公告)日：2013-11-05

申请号：US12953463

申请日：2010-11-24

Applicant: Assaf Klar ,  Raphael Linker

Inventor： Assaf Klar ,  Raphael Linker

IPC: G06F15/00

CPC classification number: G01B11/16 ,  G01M5/0091

Abstract: A non transitory computer readable medium and a method of detecting excavation of an underground tunnel, the method includes: propagating a light pulse through an underground optic fiber; generating detection signals responsive to Brillion scattered light resulting from the propagating of the light pulse through the underground optic fiber; wherein the detection signals represent tension values at multiple locations along the underground optic fiber; and processing the detection signals to detect excavation of the underground tunnel.

Abstract translation: 一种非临时计算机可读介质和一种检测地下隧道挖掘的方法，该方法包括：通过地下光纤传播光脉冲; 产生响应于通过地下光纤传播光脉冲而产生的百万分散光的检测信号; 其中所述检测信号表示沿着所述地下光纤的多个位置处的张力值; 并处理检测信号以检测地下隧道的挖掘。

公开(公告)号：US08552422B2

公开(公告)日：2013-10-08

申请号：US13667821

申请日：2012-11-02

Applicant: Technion Research and Development Foundation LTD.

Inventor： Nir Tessler ,  Moti Margalit ,  Oded Globerman ,  Roy Shenhar

IPC: H01L35/24

CPC classification number: H01L51/0545 ,  B82Y10/00 ,  H01L29/786 ,  H01L51/0021 ,  H01L51/0036 ,  H01L51/004 ,  H01L51/0043 ,  H01L51/0046 ,  H01L51/0516 ,  H01L51/0541 ,  H01L51/0558 ,  H01L51/057 ,  H01L51/102 ,  H01L51/5012

Abstract: An electronic device is presented, such as a thin film transistor. The device comprises a patterned electrically-conductive layer associated with an active element of the electronic device. The electrically-conductive layer has a pattern defining an array of spaced-apart electrically conductive regions. This technique allows for increasing an electric current through the device.