公开(公告)号：US20130306897A1

公开(公告)日：2013-11-21

申请号：US13955309

申请日：2013-07-31

Applicant: EMD Millipore Corporation

Inventor： Brian Hillier ,  Martin Szyk ,  Aaron Burke ,  Joseph Almasian

IPC: F16K31/44 ,  F16K11/22 ,  F16K31/60

CPC classification number: F16K31/50 ,  F16K1/12 ,  F16K11/22 ,  F16K31/445 ,  F16K31/60 ,  G01N15/0826 ,  Y10T137/0318 ,  Y10T137/7932 ,  Y10T137/794 ,  Y10T137/85938 ,  Y10T137/87885

Abstract: Fluid transfer apparatus including a body having a bore formed through at least a portion of its interior. Contained within the bore is a movable plunger that moves without changing the axial dimensions of the body. A first end of the body contains a face designed to be attached to an upstream component. A second end of the body is connected to a downstream component such as a filter, pipeline, etc. A first end of the plunger, when it is in the closed position, is in alignment with the face of the body, which combined form a steamable surface and a sterile barrier against the environment to the remainder of the interior of the body, the plunger and downstream components. An outer annular collar is rotatable relative to the body and causes the plunger to move axially within the bore from an open to a closed position.

公开(公告)号：US08541224B2

公开(公告)日：2013-09-24

申请号：US13732870

申请日：2013-01-02

Applicant: EMD Millipore Corporation

Inventor： Shawn Bates ,  Kerry Roche Lentine ,  Nada Bsat

IPC: C12N1/20 ,  C12Q1/02 ,  C12Q1/22

CPC classification number: C12N1/20 ,  C12Q1/02 ,  C12Q1/22

Abstract: A method for retention testing sterilizing grade filters comprises: a) providing a stock of Acholeplasma laidlawii; b) growing up the stock of A. laidlawii for about 24 hours or less in a single serum-free growth medium that supports cell growth to a high titer and yields a cellular morphology where the cells are small, deaggregated and spherical, thereby producing a bacterial culture; c) challenging a test filter by filtering the bacterial culture through the test filter at a known challenge level, thereby producing a filtrate downstream of the test filter; and d) detecting concentration of A. laidlawii in the filtrate. Serum-free growth media for cultivating or storing A. laidlawii are also described.

公开(公告)号：US20250092089A1

公开(公告)日：2025-03-20

申请号：US18890289

申请日：2024-09-19

Applicant: North Carolina State University ,  Merck Sharp and Dohme LLC ,  EMD Millipore Corporation ,  Rensselaer Polytechnic Institute

Inventor： Stefano Menegatti ,  Ruben G. Carbonell ,  Jacob P. LeBarre ,  Cristiana Boi ,  Steven Cramer ,  Michael Phillips ,  David Roush

IPC: C07K1/16 ,  B01D15/34 ,  B01D15/36

Abstract: The present disclosure provides methods related to the purification of a biologic. In particular, the present disclosure methods for purifying a biologic using a multifunctional chromatography medium comprising porous beads or particles having a defined pore diameter distribution and one or more ligands conjugated to the surface of the pores capable of removing process-related impurities and product-related impurities from a target biologic.

公开(公告)号：US20240269455A1

公开(公告)日：2024-08-15

申请号：US18411879

申请日：2024-01-12

Applicant: EMD Millipore Corporation

Inventor： Heejin Lee ,  Michael James Susienka ,  John Paul Amara

IPC: A61M39/18 ,  A61M39/14

CPC classification number: A61M39/18 ,  A61M39/14 ,  A61M2205/75

Abstract: A system for sterilizing or bioburden-reducing a filter device includes a breathable microbial barrier, a filter device, and a tubing arrangement. The tubing arrangement may be coupled to at least one opening of the filter device. The tubing arrangement may include an aseptic connector, a sealable component, and a port, all of which are in fluid communication with one another. The sealable component may be disposed in the tubing arrangement between the at least one opening of the filter device and the aseptic connector. The sealable component may be reconfigurable between an open configuration, which facilitates the entry of a sterilization vapor into the tubing arrangement and the filter device when subjected to a sterilization or bioburden reduction process, and a closed configuration, where the tubing arrangement is sealed from a surrounding environment. The breathable microbial barrier may at least partially enclose the port of the tubing arrangement.

公开(公告)号：US12050159B2

公开(公告)日：2024-07-30

申请号：US16644109

申请日：2018-09-27

Applicant: EMD Millipore Corporation

Inventor： Brian Pereira ,  Stephen Proulx

IPC: G01M3/32 ,  B01L3/00

CPC classification number: G01M3/3218 ,  B01L3/505 ,  B01L2300/0861

Abstract: A testing method that includes the steps of evacuating air from a container to a negative atmospheric pressure, the container being a collapsible, flexible container, and comprising at least two opposing flexible walls, wherein a surface of at least one of the walls internal to the container comprises a plurality of channels or recessed features on said at least one wall and monitoring a mass flow or a state of vacuum so as to determine the integrity of the container. The container can be of any size or conformation, with or without attached fittings.

公开(公告)号：US20240246034A1

公开(公告)日：2024-07-25

申请号：US18624011

申请日：2024-04-01

Applicant: EMD Millipore Corporation

Inventor： Alison Dupont

IPC: B01D63/10 ,  B01D61/18 ,  B01D63/08 ,  B01D65/02 ,  B01D65/08 ,  C12M1/00

CPC classification number: B01D63/103 ,  B01D63/0822 ,  B01D63/10 ,  C12M29/10 ,  B01D61/18 ,  B01D65/02 ,  B01D65/08 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/25 ,  B01D2313/143 ,  B01D2315/10 ,  C12M29/04

Abstract: Filter elements for perfusion systems and methods are provided. A filter element sheet includes a microporous membrane having a mean pore size of at least about 0.65 μm and a feed spacer comprising woven fibers and having an open area of at least about 35%. The filter element sheet can be arranged within a filter element, for example, in a spiral-wound format or in a cassette format. A perfusion system includes at least one filter element and a pump configured to control flow of a liquid feed through the at least one filter element.

公开(公告)号：USD1025288S1

公开(公告)日：2024-04-30

申请号：US29799417

申请日：2021-07-14

Applicant: EMD Millipore Corporation

Designer： James Ormond ,  Gregory Straeffer ,  Bailey Vaillancourt ,  Joseph Michael Almasian

Abstract: FIG. 1 is a first perspective view of the filter assembly bracket of the present invention.
FIG. 2 is a second perspective view of the filter assembly bracket of the present invention.
FIG. 3 is a front view of the filter assembly bracket of the present invention.
FIG. 4 is a rear view of the filter assembly bracket of the present invention.
FIG. 5 is a left-side view of the filter assembly bracket of the present invention.
FIG. 6 is a right-side view of the filter assembly bracket of the present invention.
FIG. 7 is a top view of the filter assembly bracket of the present invention.
FIG. 8 is a bottom view of the filter assembly bracket of the present invention; and,
FIG. 9 is a view of the filter assembly bracket of the present invention illustrating environmental context holding two filter unit assemblies together.
The view labels used herein to denote, front, rear, left-side, right-side, top and bottom views are for convenience only and should not be interpreted as limiting her orientation of the bracket.
The broken lines in the Figures are for illustrative purposes only and form no part of the claimed design.

公开(公告)号：USD1024269S1

公开(公告)日：2024-04-23

申请号：US29799414

申请日：2021-07-14

Applicant: EMD Millipore Corporation

Designer： James Ormond ,  Gregory Straeffer ,  Bailey Vaillancourt ,  Joseph Michael Almasian

Abstract: FIG. 1 is a first perspective view of the filter assembly holder of the present invention.
FIG. 2 is a second perspective view of the filter assembly holder of the present invention.
FIG. 3 is a front view of the filter assembly holder of the present invention.
FIG. 4 is a rear view of the filter assembly holder of the present invention.
FIG. 5 is a left-side view of the filter assembly holder of the present invention.
FIG. 6 is a right-side view of the filter assembly holder of the present invention.
FIG. 7 is a top view of the filter assembly holder of the present invention.
FIG. 8 is a bottom view of the filter assembly holder of the present invention.
FIG. 9 is a first view of the filter assembly holder of the present invention in an environmental context holding two filter unit assemblies together; and,
FIG. 10 is a second view of the filter assembly holder of the present invention illustrating environmental context holding two filter unit assemblies together.
The view labels used herein to denote, front, rear, left-side, right-side, top and bottom views are for convenience only and should not be interpreted as limiting her orientation of the Bracket.
The broken lines in the Figures are for illustrative purposes only and form no part of the claimed design.

公开(公告)号：US20240042398A1

公开(公告)日：2024-02-08

申请号：US18552525

申请日：2022-04-14

Applicant: EMD Millipore Corporation

Inventor： Marisa Maher ,  Stefano Berti Perez ,  Anne Hansen ,  Noah Rhein ,  Amy Mei ,  Sualyneth Galarza ,  John Caulmare ,  Joseph W. Muldoon ,  Amy Wood

IPC: B01F23/231 ,  B01F35/513

CPC classification number: B01F23/231241 ,  B01F23/231151 ,  B01F23/23125 ,  B01F23/231264 ,  B01F35/513 ,  B01F2101/44

Abstract: A multi-layered flexible sparger (100) that has a bottom film layer (102), a middle film layer (106), and a top film layer (110); a first inner mesh (104) disposed between the bottom film layer and the middle film layer; a second inner mesh (114) disposed between the middle film layer and the top film layer; and a port capable of delivering a gas to the multi-layered flexible sparger disposed between the top film layer and the bottom film layer, wherein the middle film layer comprises drill holes and the top film layer comprises drill holes.

公开(公告)号：US11772020B2

公开(公告)日：2023-10-03

申请号：US17819969

申请日：2022-08-16

Applicant: EMD Millipore Corporation

Inventor： Maybelle Woo ,  David Yavorsky ,  John Amara ,  Nripen Singh ,  Kwok-Shun Cheng

IPC: B01D39/16 ,  B01D29/66

CPC classification number: B01D39/1623 ,  B01D29/66 ,  B01D39/163 ,  B01D2239/0407 ,  B01D2239/0654 ,  B01D2239/086

Abstract: A depth filtration device for the clarification of biological fluids including a composite depth filter media having a nonwoven first layer integral with a second layer containing a polyacrylonitrile (PAN) fibers, a filter aid, and a wet-strength resin. The depth filter media exhibits increased binding capacity for soluble impurities such as DNA and host cell proteins from biological/cell culture feedstreams during secondary clarification and low-level impurity clearance of harvested cell culture fluids, such as those used for the manufacture of monoclonal antibodies. The depth filter media additionally exhibits significantly lower flushing requirements, resulting in lower levels of organic, inorganic and bioburden extractables released, high dirt holding capacities and good chemical and/or radiation resistance.