公开(公告)号：US20040086555A1

公开(公告)日：2004-05-06

申请号：US10607134

申请日：2003-06-27

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Yasunori Takada ,  Koji Tanaka ,  Yasuhiro Ikeura

IPC: A61K009/70

CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/19

Abstract: A plaster comprising a styrene-isoprene-styrene block copolymer 10-40 wt %, a rosin-based resin 5-30 wt %, a plasticizer 20-70 wt %, polyisobutylene 6-40 wt %, an antioxidant 0.1-5 wt %, and felbinac as a medicinally effective component 1.1-10 wt %, wherein the plaster does not contain crotamiton which is a solubilizer for the felbinac, the felbinac is uniformly dispersed in a semi-solubilized state in the plaster, wherein solubilized felbinac and microcrystalline felbinac coexist in the plaster, and a thickness of the plaster is 50-300 nullm.

公开(公告)号：US20040086554A1

公开(公告)日：2004-05-06

申请号：US10607132

申请日：2003-06-27

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Yasunori Takada ,  Koji Tanaka ,  Yasuhiro Ikeura

IPC: A61K009/70

CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/19

Abstract: A plaster comprising a styrene-isoprene-styrene block copolymer 10-40 wt %, a rosin-based resin 5-30 wt %, a plasticizer 20-70 wt %, polyisobutylene 6-40 wt %, an antioxidant 0.1-5 wt %, and felbinac as a medicinally effective component 1.1-10 wt %, wherein the plaster does not contain crotamiton which is a solubilizer for the felbinac, the felbinac is uniformly dispersed in a semi-solubilized state in the plaster, wherein solubilized felbinac and microcrystalline felbinac coexist in the plaster, and a thickness of the plaster is 50-300 nullm.

公开(公告)号：US20030135150A1

公开(公告)日：2003-07-17

申请号：US10315066

申请日：2002-12-10

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Mitsuru Kuribayashi ,  Hiroyuki Maeda ,  Nobuhiro Koga ,  Naruhito Higo

IPC: A61N001/30

CPC classification number: A61N1/0448

Abstract: Herein disclosed is an iontophoresis device suitable for effective use of a drug supported on a drug support. A donor electrode-printed portion (6) and a reference electrode-printed portion (7) are arranged on a backing layer (4). The backing layer is provided with, at the periphery, an adhesive film (3) for fixing a pharmaceutical preparation to an application site. The both electrode-printed portions (6), (7) are electrically connected to a current-generating portion (Ia) through a conductive snap connector (Id). The drug support (14) is removably joined with a conductive layer (11) formed on the electrode on the side of the donor electrode-printed portion (6). The drug support (14) is subjected to a drug diffusion-inhibitory treatment (30).

Abstract translation: 本文公开了适用于有效使用药物载体上的药物的离子渗透装置。 供体电极印刷部分（6）和参考电极印刷部分（7）布置在背衬层（4）上。 背衬层在周边设置有用于将药物制剂固定到施用部位的粘合剂膜（3）。 两个电极印刷部分（6），（7）通过导电卡扣连接器（Id）电连接到电流产生部分（1a）。 药物载体（14）可移除地与形成在施主电极印刷部分（6）侧上的电极上的导电层（11）接合。 对药物载体（14）进行药物扩散抑制处理（30）。

公开(公告)号：US20030097090A1

公开(公告)日：2003-05-22

申请号：US10335641

申请日：2002-12-30

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

IPC: A61M031/00

CPC classification number: A61N1/0424 ,  A61N1/042 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

Abstract: Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.

公开(公告)号：US20250161229A1

公开(公告)日：2025-05-22

申请号：US18839843

申请日：2022-12-22

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Sho SATO ,  Keiichiro TSURUSHIMA ,  Shinji YAMASOTO ,  Tetsuro TATEISHI

IPC: A61K9/70 ,  A61K45/06 ,  A61K47/02 ,  A61K47/38

Abstract: The present invention relates to a poultice including: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer comprises at least one selected from the group consisting of carboxymethyl cellulose and pharmaceutically acceptable salts thereof; a silicic anhydride; a drug; and a water-soluble polymer; and a particle diameter D50 at which a cumulative volume in a particle size distribution of the silicic anhydride becomes 50% is 0.2 to 9.0 μm.

公开(公告)号：US12297380B2

公开(公告)日：2025-05-13

申请号：US17798412

申请日：2021-02-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro Nakashima ,  Kento Ichinohe ,  Keiichiro Tsurushima ,  Takaaki Yoshinaga

IPC: C09J133/02 ,  C09J7/30 ,  C09J11/06 ,  C09J11/08

Abstract: A method for producing an adhesive layer composition for producing a cooling sheet including a backing layer, an adhesive layer, and a liner layer, the method comprising the step of: mixing a composition to be mixed containing water, an alum, sodium edetate, a polyacrylic acid, and a neutralized polyacrylic acid such that a mixing temperature becomes 5 to 23° C., to obtain an adhesive layer composition, wherein in the composition to be mixed, a content of the water is 69 to 938.24% by mass relative to a total mass of the composition to be mixed, a content of the alum is 0.18 to 0.42% by mass relative to the total mass of the composition to be mixed, a content of the sodium edetate is 0.08 to 0.18% by mass relative to the total mass of the composition to be mixed, and a mass ratio between the content of the alum and the content of the sodium edetate (the content of the alum: the content of the sodium edetate) is 1:1 to 5.25:1.

公开(公告)号：US12290653B2

公开(公告)日：2025-05-06

申请号：US16973553

申请日：2019-07-11

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eisuke Hatanaka ,  Kazuki Kuriyama ,  Naoki Yamamoto

IPC: A61M37/00

Abstract: A method of producing a microneedle sheet according to an embodiment includes: preparing a sheet having a first surface and a second surface; making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge that defines a tip end of the microneedle; and making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge that defines the tip end of the microneedle, thereby forming the tip end of the microneedle.

公开(公告)号：US12151030B2

公开(公告)日：2024-11-26

申请号：US17426796

申请日：2020-01-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takao Kurokawa ,  Hidekazu Kuma ,  Masaki Yukuhiro

IPC: A61K9/70 ,  A61K31/13 ,  A61K31/27 ,  A61K31/381 ,  A61K31/403 ,  A61K31/407 ,  A61K31/4422 ,  A61K31/573

Abstract: The present invention provides a patch comprising an adhesive layer on a backing, wherein the adhesive layer contains a adhesive base, a skin irritant drug or a pharmaceutically acceptable salt thereof, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0009 to 0.08% by mass based on the total mass of the adhesive layer.

公开(公告)号：US20240269446A1

公开(公告)日：2024-08-15

申请号：US17766434

申请日：2020-09-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoki YAMAMOTO ,  Shinpei NISHIMURA

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle sheet according to one embodiment includes: a sheet body having a main surface; and at least one microneedle formed on the sheet body and lying along the main surface. Each of the at least one microneedle has a base positioned on a first side of the sheet body and a tip oriented toward a second side of the sheet body that is opposite to the first side. A first portion of the sheet body is bent from the first side, whereby the microneedle positioned in the first portion is raised from the main surface and the raised microneedle is applied to skin.

公开(公告)号：US20240122870A1

公开(公告)日：2024-04-18

申请号：US18278304

申请日：2022-02-22

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Hiroyuki SATO ,  Hirochika TAKANO

IPC: A61K9/70 ,  A61K31/196 ,  A61K47/12 ,  A61K47/32

CPC classification number: A61K9/7053 ,  A61K31/196 ,  A61K47/12 ,  A61K47/32

Abstract: Disclosed is a transdermal patch for treating osteoarthritis. The transdermal patch comprises a support layer and an adhesive layer laminated on the support layer. The adhesive layer includes an adhesive base, diclofenac sodium, dimethyl sulfoxide, and an organic acid. The organic acid content is 6-8 mass % of the total mass of the adhesive layer. The transdermal patch is applied once daily to an affected part and the dosage of diclofenac sodium per application is 70-150 mg.