公开(公告)号：US06270805B1

公开(公告)日：2001-08-07

申请号：US09187319

申请日：1998-11-06

Applicant: Chih-Ming Chen ,  Xiu Xiu Cheng

Inventor： Chih-Ming Chen ,  Xiu Xiu Cheng

IPC: A61K916

CPC classification number: A61K9/5078 ,  A61K9/5026 ,  A61K9/5084 ,  A61K31/554 ,  Y10S514/97

Abstract: A once-a-day controlled release formulation of a water soluble drug is described which includes: (a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of a water soluble drug and a binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and (b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of a water soluble drug and a binder and a second layer which comprises a polymeric membrane and a alkaline earth metal stearate which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to said water soluble drug; and (c) a unit dose containment system.

Abstract translation: 描述了一种每日一次的水溶性药物的控释制剂，其包括：（a）20至50重量％的肠溶性聚合物膜包衣的丸剂，其包含聚合物膜包衣的核心，其包含生物惰性核心，其包被 其具有基本上由水溶性药物和粘合剂组成的第一层; 以及第二层，其包括包含pH依赖性聚合物材料的膜; 和（b）50％至80％重量的延迟脉冲聚合物膜包衣的丸粒，其包含聚合物膜包衣芯，其包含生物学惰性芯，其涂覆有基本上由水溶性药物和粘合剂组成的第一层，以及 第二层，其包含聚合物膜和碱土金属硬脂酸盐，其将在胃肠道的变化的pH条件下基本上保持其完整性，但对所述水溶性药物是可渗透的; 和（c）单位剂量遏制系统。

公开(公告)号：US06227462B1

公开(公告)日：2001-05-08

申请号：US09589738

申请日：2000-06-09

Applicant: Chih-Ming Chen

Inventor： Chih-Ming Chen

IPC: B05B110

CPC classification number: B60S1/52 ,  B60S1/487

Abstract: A wide angle, atomizing-type of cleaning device for windshield of car is disclosed. The cleaning solution storage tank is heated by the energy of the engine of the car and by means of a liquid pump and an air pump, together with nozzles, the cleaning solution is atomized to clean the windshield by rapidly dissolving of the oil mist and moisture. The wiper faces little resistance from the surface of the windshield as the entire surface is provided with the atomized cleaning solution from the tank.

Abstract translation: 公开了一种用于汽车挡风玻璃的广角雾化型清洁装置。 清洗溶液储罐由汽车发动机的能量通过液体泵和空气泵与喷嘴一起被加热，清洁溶液被雾化以通过快速溶解油雾和湿气来清洁挡风玻璃 。 当整个表面设置有来自罐的雾化的清洁溶液时，刮水器从挡风玻璃的表面几乎没有阻力。

公开(公告)号：US06184123B2

公开(公告)日：2001-02-06

申请号：US09365982

申请日：1999-08-02

Applicant: Chun-Hu Ge ,  Liang Szuma ,  Chih-Ming Chen

Inventor： Chun-Hu Ge ,  Liang Szuma ,  Chih-Ming Chen

IPC: H01L214763

CPC classification number: H01L21/02321 ,  H01L21/02126 ,  H01L21/022 ,  H01L21/02282 ,  H01L21/3122 ,  H01L21/3144 ,  H01L21/316 ,  H01L21/76825 ,  H01L21/76829

Abstract: A method of forming an integrated circuit device using ion implantation to improve the adhesion of plasma nitride to spin-on-glass is achieved. Semiconductor device structures are provided in and on a substrate where conductive connections are planned between the device structures and planned conductive traces overlying a planned interlevel dielectric layer. An insulating oxide layer is deposited overlying the device structures. A spin-on-glass layer is coated overlying the insulating oxide layer. The spin-on-glass layer is dried. The spin-on-glass layer is ion implanted to form an amorphous, silicon rich, adhesion layer at the top surface of the spin-on-glass layer. The spin-on-glass layer is cured. A first plasma-enhanced silicon nitride layer deposited overlying the adhesion layer of the spin-on-glass and completing the interlevel dielectric layer. Via openings are etched through to the top surfaces of the semiconductor device. A conductive layer is deposited to fill the via openings and is etched to form the conductive traces. A second plasma-enhanced silicon nitride layer is deposited to complete the integrated circuit.

Abstract translation: 实现了使用离子注入形成集成电路器件以提高等离子体氮化物与旋涂玻璃的粘附性的方法。 半导体器件结构设置在衬底中和衬底上，其中在器件结构之间规划导电连接并且覆盖在计划的层间电介质层上的预定的导电迹线。 绝缘氧化物层沉积在器件结构上。 覆盖绝缘氧化物层的旋涂玻璃层。 将旋涂玻璃层干燥。 旋涂玻璃层被离子注入以在旋涂玻璃层的顶表面上形成无定形，富硅的粘附层。 旋涂玻璃层固化。 第一等离子体增强的氮化硅层沉积在覆膜上，并且完成了层间电介质层。 通孔开口蚀刻到半导体器件的顶表面。 沉积导电层以填充通孔开口并被蚀刻以形成导电迹线。 沉积第二等离子体增强氮化硅层以完成集成电路。

公开(公告)号：US06169008A

公开(公告)日：2001-01-02

申请号：US09166680

申请日：1998-10-05

Applicant: Wen-Ying Wen ,  Chih-Ming Chen

Inventor： Wen-Ying Wen ,  Chih-Ming Chen

IPC: H01L2120

CPC classification number: H01L28/10 ,  H01L27/08

Abstract: A high Q inductor and its forming method is disclosed. In this forming method, a semiconductor substrate is first provided with a trench formed thereon. The trench is defined by dry etching and formed to a depth of 3˜5 &mgr;m. A material having a higher resistivity than that of the semiconductor is then provided to fill the trench. The material can be formed by first depositing an epitaxy layer with a lower dopant concentration than that of the semiconductor substrate by several orders of magnitude on the semiconductor substrate, then etching back the epitaxy layer to expose the surface of the semiconductor substrate. Thereafter, a dielectric layer is formed on the semiconductor substrate and the trench, and an inductor winding is formed on the dielectric layer above the trench to form the high Q inductor.

Abstract translation: 公开了一种高Q电感器及其形成方法。 在这种形成方法中，半导体衬底首先设置有形成在其上的沟槽。 沟槽通过干蚀刻定义，形成深度为3〜5μm。 然后提供具有比半导体更高的电阻率的材料以填充沟槽。 可以通过首先在半导体衬底上沉积比半导体衬底的掺杂剂浓度低几个数量级的外延层，然后蚀刻外延层以暴露半导体衬底的表面来形成材料。 此后，在半导体衬底和沟槽上形成电介质层，并且在沟槽上方的电介质层上形成电感器绕组以形成高Q电感。

公开(公告)号：US6104518A

公开(公告)日：2000-08-15

申请号：US432829

申请日：1999-11-02

Applicant: Chih-Ming Chen

Inventor： Chih-Ming Chen

IPC: G02B26/10 ,  G02B26/08

CPC classification number: G02B26/101

Abstract: A scanner includes a bottom cover, a top cover, at least one elastic member, at least one rod, an optical module and at least one spacer. The elastic member is disposed on the bottom cover. The rod is supported by the elastic member. The optical module is movably supported by the rod. The spacer is disposed between the top cover and the rod so that the optical module moves parallel to the top cover.

Abstract translation: 扫描器包括底盖，顶盖，至少一个弹性构件，至少一个杆，光学模块和至少一个间隔件。 弹性构件设置在底盖上。 杆由弹性构件支撑。 光学模块由杆可移动地支撑。 间隔件设置在顶盖和杆之间，使得光学模块平行于顶盖移动。

公开(公告)号：US6099859A

公开(公告)日：2000-08-08

申请号：US45330

申请日：1998-03-20

Applicant: Xiu Xiu Cheng ,  Chih-Ming Chen ,  Steve Jan ,  Joseph Chou

Inventor： Xiu Xiu Cheng ,  Chih-Ming Chen ,  Steve Jan ,  Joseph Chou

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/52 ,  A61K31/155 ,  A61P3/10

CPC classification number: A61K9/2866 ,  A61K31/155 ,  A61K9/0004 ,  A61K9/2072 ,  A61K9/282 ,  A61K9/2886

Abstract: A controlled release antihyperglycemic tablet that does not contain an expanding polymer and comprising a core containing the antihyperglycemic drug, a semipermeable membrane coating the core and at least one passageway in the membrane.

公开(公告)号：US6096340A

公开(公告)日：2000-08-01

申请号：US970489

申请日：1997-11-14

Applicant: Chih-Ming Chen ,  Joseph C. H. Chou ,  Timothy Weng

Inventor： Chih-Ming Chen ,  Joseph C. H. Chou ,  Timothy Weng

IPC: A61K9/28 ,  A61K9/30 ,  A61K9/32 ,  A61K9/34 ,  A61K9/36 ,  A61K9/50 ,  A61K31/4439 ,  A61K47/02 ,  A61K47/38 ,  A61P1/00 ,  A61P1/04

CPC classification number: A61K9/5078

Abstract: A pharmaceutical composition of omeprazole for oral administration is described which consists essentially of:(a) a pellet comprising an inert core component, a therapeutically effective amount of omeprazole, a surface active agent, a filler, a pharmaceutically acceptable alkaline agent and a binder; and(b) a single layer of coating on said pellet which comprises a layer of an enteric coating agent.

公开(公告)号：US5916595A

公开(公告)日：1999-06-29

申请号：US989253

申请日：1997-12-12

Applicant: Chih-Ming Chen ,  Joseph Chou ,  David Wong

Inventor： Chih-Ming Chen ,  Joseph Chou ,  David Wong

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K31/22 ,  A61K31/351 ,  A61K31/366 ,  A61P43/00

CPC classification number: A61K31/366 ,  A61K31/22 ,  A61K9/0004 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2886

Abstract: A controlled release dosage formulation is described which is based on a combination of:(a) a compressed tablet core which contains an alkyl ester of a hydroxy substituted naphthalene derivative a pharmaceutically acceptable, water swellable polymer and an osmotic agent; and(b) an outer coating layer which completely covers the osmotic core and comprises a pH sensitive coating agent and a water insoluble polymer.

Abstract translation: 描述了一种控释剂量制剂，其基于以下组合：（a）压缩片芯，其包含羟基取代的萘衍生物的药学上可接受的水溶胀性聚合物和渗透剂的烷基酯; 和（b）完全覆盖渗透芯并包含pH敏感性涂层剂和水不溶性聚合物的外涂层。

公开(公告)号：US5508040A

公开(公告)日：1996-04-16

申请号：US244745

申请日：1994-06-13

Applicant: Chih-Ming Chen

Inventor： Chih-Ming Chen

IPC: A61K9/52 ,  A61K9/22 ,  A61K9/26 ,  A61K9/50 ,  A61K9/56 ,  A61K9/48

CPC classification number: A61K9/5084

Abstract: A unit dosage form of capsule, tablet or the like is composed of a large number of pellets made up of two or more populations of pellets or particles. Each pellet contains a core containing the therapeutic drug and a water soluble osmotic agent. A water-permeable, water-insoluble polymer film encloses each core. Incorporated into the polymer film is a hydrophobic, water insoluble agent which alters the permeability of the polymer film. The film coating of each population of pellets differs from the coating of every other population of pellets in the dosage form in the rate at which water passes through to the core and the rate at which drug diffuses out of the core. The osmotic agent dissolves in the water, causing the pellet to swell and regulating the rate of diffusion of drug into the environment of use. As each population of pellets releases its drug into the environment sequentially, the effect is to provide a series of pulsatile administrations of the drug from a single dosage form.

Abstract translation: PCT No.PCT / US93 / 05922 Sec。 371日期1994年6月13日 102（e）日期1994年6月13日PCT提交1993年6月3日PCT公布。 第WO94 / 28882号PCT公告 日期为1994年12月22日。胶囊，片剂等的单位剂型由大量由两粒或多种粒料或粒子组成的丸粒组成。 每个丸粒含有含有治疗药物和水溶性渗透剂的核心。 水可渗透的水不溶性聚合物膜包围每个核心。 掺入聚合物膜中的是疏水的水不溶性试剂，其改变聚合物膜的渗透性。 每个颗粒群的薄膜包衣与水剂通过核心的速率以及药物扩散出核心的速率不同，剂量形式的每个其他粒料群的涂层不同。 渗透剂溶解在水中，导致颗粒膨胀并调节药物扩散到使用环境中的速度。 随着每个颗粒群体依次将其药物释放到环境中，其效果是从单一剂型提供药物的一系列脉动施用。

公开(公告)号：US5397574A

公开(公告)日：1995-03-14

申请号：US131118

申请日：1993-10-04

Applicant: Chih-Ming Chen

Inventor： Chih-Ming Chen

IPC: A61K9/20 ,  A61K9/26 ,  A61K9/50 ,  A61K9/62 ,  A61K33/14 ,  A61K47/38

CPC classification number: A61K9/2081 ,  A61K33/14 ,  A61K9/5047

Abstract: A pharmaceutical composition for oral administration of potassium salt in a form not irritating to the gastrointestinal mucosa comprises tablets or capsules of micropellets of a potassium salt, such as potassium chloride. The micropellets are coated with a permeable polymer comprising a low viscosity (10 cp.) ethylcellulose in combination with triacetin. This coating provides a strong film resistant to breakage during formation of tablets and filling of capsules. The protective coating of the micropellets prevents the early release of potassium ions, while the tablet or capsule disintegrates and the micropellets are dispersed within the lumen of the gastrointestinal tract. As water passes through the permeable but insoluble coating, potassium ions are gradually eluted into the fluid of the tract over a period of many hours, thereby allowing time for the ions to be absorbed from the tract before high, irritating ion concentrations can form.

Abstract translation: 用于以不刺激胃肠粘膜的形式口服给药钾盐的药物组合物包括钾盐如氯化钾的微丸的片剂或胶囊。 微丸用包含与三醋精组合的低粘度（10cp）乙基纤维素的可渗透聚合物涂覆。 该涂层在片剂形成和胶囊填充期间提供了抗破坏性强的薄膜。 微丸的保护性涂层防止钾离子的早期释放，同时片剂或胶囊崩解并且微丸分散在胃肠道的内腔中。 当水通过可渗透但不溶性的涂层时，钾离子在多个小时的时间段内逐渐被洗脱到管道的流体中，从而在高的刺激性离子浓度形成之前允许离子被吸收的时间。