公开(公告)号：US08207154B2

公开(公告)日：2012-06-26

申请号：US11628719

申请日：2005-06-07

Applicant: Avigdor Scherz ,  Alexander Brandis ,  Yoram Salomon ,  Doron Eren ,  Avraham Cohen

Inventor： Avigdor Scherz ,  Alexander Brandis ,  Yoram Salomon ,  Doron Eren ,  Avraham Cohen

IPC: A01N55/02 ,  C07B47/00

CPC classification number: A61K31/409 ,  A61K41/0071 ,  Y02A50/406

Abstract: The invention provides cationic tetracyclic and pentacyclic bacteriochlorophyll derivatives (Bchls) containing at least one positively charged group and/or at least one basic group that is converted to a positively charged group under physiological conditions, preferably Bchls having an onium group derived from a N-containing aliphatic or heterocyclic radical such as ammonium, guanidinium, imidazolium, pyridinium, and the like or a phosphonium, arsonium, oxonium, sulfonium, selenonium, telluronium, stibonium, or bismuthonium group, or a basic group that is converted to such onium groups under physiological conditions, said groups being bound to one or more of the positions 17 , 13 and 3 of the Bchl molecule by ester or amide bond. The Bchls are useful for photodynamic therapy and diagnosis.

Abstract translation: 本发明提供了含有至少一个带正电基团和/或至少一个碱性基团的阳离子四环和五环类细菌叶绿素衍生物（Bchls），其在生理条件下转化为带正电荷的基团，优选具有衍生自N- 含有脂族或杂环基团如铵，胍，咪唑鎓，吡啶鎓等，或鏻，ium，氧鎓，锍，硒鎓，碲鎓，锑或铋鎓基团，或转化为这种鎓基团的碱性基团 生理条件，所述基团通过酯或酰胺键与Bchl分子的一个或多个位置17 3，13 3和3 2结合。 Bchls可用于光动力疗法和诊断。

公开(公告)号：US20120144504A1

公开(公告)日：2012-06-07

申请号：US12090478

申请日：2006-10-16

Applicant: David Wallach ,  Andrei Kovalenko ,  Tae-Bong Kang ,  Jin Chul Kim

Inventor： David Wallach ,  Andrei Kovalenko ,  Tae-Bong Kang ,  Jin Chul Kim

IPC: A61K31/713 ,  C07K14/435 ,  C07H21/02 ,  A61K38/48 ,  A61K31/711 ,  A61K38/17 ,  A61P17/00 ,  A61P17/06 ,  C12N9/50 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/573 ,  A01K67/027 ,  C40B30/00 ,  A61K49/00 ,  C12N15/57

CPC classification number: C12N15/1137 ,  A61K38/1761 ,  A61K38/177 ,  A61K38/4873 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y304/22061 ,  G01N33/573 ,  G01N2333/96466

Abstract: The invention relates to the treatment or prevention of an inflammatory skin disease, disorder or condition, by modulating a protein that is normally regulated by caspase-8 in the skin or by increasing caspase-8 activity or level in the skin. Another aspect of the invention relates to methods for diagnosing an inflammatory skin disease, disorder or condition or a predisposition to develop said disease disorder or condition in an individual. Further aspects of the invention relate to methods for identifying target proteins involved in the course or pathology of an inflammatory skin disease, disorder or condition and to methods of screening a candidate compound for treating said disease, disorder or condition. In particular, the invention relates to inflammatory skin diseases such as atopic dermatitis and psoriasis.

Abstract translation: 本发明涉及治疗或预防炎性皮肤疾病，病症或病症，通过调节通常由皮肤中的胱天蛋白酶-8调节的蛋白质或通过增加皮肤中的半胱天冬酶-8活性或水平。 本发明的另一方面涉及用于诊断炎症性皮肤疾病，病症或病症或倾向于在个体中发展所述疾病病症或病症的方法。 本发明的其它方面涉及用于鉴定涉及炎性皮肤病，病症或病症的病程或病理学的靶蛋白的方法以及筛选候选化合物以治疗所述疾病，病症或病症的方法。 特别地，本发明涉及炎性皮肤疾病如特应性皮炎和牛皮癣。

公开(公告)号：US20120086850A1

公开(公告)日：2012-04-12

申请号：US13138894

申请日：2010-04-20

Applicant: Michal Irani ,  Daniel Glasner ,  Oded Shahar ,  Shai Bagon

Inventor： Michal Irani ,  Daniel Glasner ,  Oded Shahar ,  Shai Bagon

IPC: H04N7/01 ,  G06K9/00 ,  G06K9/32

CPC classification number: G06T3/4053 ,  G06T3/40 ,  G09G2340/0407

Abstract: A method implementable on a computing device includes exploiting data redundancy to combine high frequency information from at least two different scales of an input signal to generate a super resolution version of said input signal. An alternative method includes exploiting recurrence of data from an input signal in at least two different scales of at least one reference signal to extract and to combine high frequency information from a plurality of scales of said at least one reference signal to generate a super resolution version of said input signal. An alternative method includes generating a super resolution version of a single input video sequence in at least the temporal dimension by exploiting data recurrence within the input video sequence or with respect to an external database of example video sequences. A signal may be an image, a video sequence, an audio signal, etc.

Abstract translation: 可在计算设备上实现的方法包括利用数据冗余来组合来自输入信号的至少两个不同尺度的高频信息以产生所述输入信号的超分辨率版本。 一种替代方法包括利用来自至少两个不同尺度的至少一个参考信号的来自输入信号的数据的再现以提取和组合来自所述至少一个参考信号的多个尺度的高频信息以产生超分辨率版本 的所述输入信号。 一种替代方法包括通过利用输入视频序列内的数据重复或相对于示例视频序列的外部数据库，至少在时间维度上生成单个输入视频序列的超分辨率版本。 信号可以是图像，视频序列，音频信号等

公开(公告)号：US08138323B2

公开(公告)日：2012-03-20

申请号：US10319536

申请日：2002-12-16

Applicant: David Wallach ,  Hartmut Engelmann ,  Dan Aderka ,  Daniela Novick ,  Menachem Rubinstein

Inventor： David Wallach ,  Hartmut Engelmann ,  Dan Aderka ,  Daniela Novick ,  Menachem Rubinstein

IPC: C12N15/28 ,  C12N15/79 ,  C12N15/74 ,  C12N5/10 ,  C12N1/21

CPC classification number: C07K16/2866 ,  A61K38/00 ,  C07K14/7151

Abstract: An isolated DNA molecule has the sequence of encoding a fragment of encoding Tumor Necrosis Factor (TNF) Binding Protein II. It has a length sufficient to serve as an immunogen for raising antibodies against a polypeptide that is a fragment of TNF Binding Protein II. The DNA may be used to produce replicable expression vehicles and prokaryotic or eukaryotic expression host cells. Such host cells may be used to produce polypeptides encoded by such DNA molecules.

Abstract translation: 分离的DNA分子具有编码肿瘤坏死因子（TNF）结合蛋白II的片段的序列。 其长度足以用作用于产生针对作为TNF结合蛋白II的片段的多肽的抗体的免疫原。 DNA可用于产生可复制的表达载体和原核或真核表达宿主细胞。 这样的宿主细胞可用于产生由这样的DNA分子编码的多肽。

公开(公告)号：US20120052469A1

公开(公告)日：2012-03-01

申请号：US13265891

申请日：2010-04-22

Applicant: Noam Sobel ,  Aharon Weissbrod ,  Lee Sela ,  Anton Plotkin

Inventor： Noam Sobel ,  Aharon Weissbrod ,  Lee Sela ,  Anton Plotkin

IPC: G09B23/28

CPC classification number: G06F3/011 ,  A61B5/087 ,  A61B5/097 ,  G16H10/60 ,  G16H10/65

Abstract: A method of receiving input from a user, comprising measuring a nasal air parameter and generating an instruction for one or both of a device and controller based on said measurement.

Abstract translation: 一种从用户接收输入的方法，包括基于所述测量来测量鼻气参数并产生对设备和控制器中的一者或两者的指令。

公开(公告)号：US20120003236A1

公开(公告)日：2012-01-05

申请号：US13175978

申请日：2011-07-05

Applicant: Irit SAGI ,  Tamar Danon

Inventor： Irit SAGI ,  Tamar Danon

IPC: A61K39/395 ,  G01N33/53 ,  G01N33/573 ,  A61P35/00 ,  C07K16/40 ,  C07K16/18

CPC classification number: C07K16/40 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/44

Abstract: A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain of the metalloprotein, thereby producing the metalloprotein inhibitor.

Abstract translation: 一种生产金属蛋白抑制剂的方法，该方法包括产生针对包含金属离子结合的螯合剂的组合的抗体，其中选择具有与金属蛋白的功能结构域相似的结构和电子性质的组合物，从而产生金属蛋白抑制剂。

公开(公告)号：US20110301093A1

公开(公告)日：2011-12-08

申请号：US13152270

申请日：2011-06-03

Applicant: Adi Kimchi ,  Einat Zalckvar

Inventor： Adi Kimchi ,  Einat Zalckvar

IPC: A61K38/17 ,  C40B30/00 ,  C12Q1/68 ,  C07K14/47 ,  C07H21/00 ,  A61P35/00 ,  C12N7/01 ,  C12N5/10 ,  C12N1/00 ,  G01N33/577 ,  C12N15/85 ,  G01N33/574 ,  C12N15/63

CPC classification number: G01N33/6872 ,  C07K16/44 ,  G01N2440/14 ,  G01N2500/02

Abstract: The present invention relates to antibodies specific for human Beclin-1 protein phosphorylated at position Thr 119 and uses thereof. In particular, these antibodies are useful in diagnosing diseases associated with impaired autophagy including cancer and neurodegenerative diseases. The invention further relates to human Beclin-1 mutated at position 119 with a phospho-mimicking residue and uses thereof for treating cancer and neurodegenerative diseases.

公开(公告)号：US08058442B2

公开(公告)日：2011-11-15

申请号：US10534357

申请日：2003-11-07

Applicant: Moussa Youdim ,  Matitiyahu Fridkin ,  Hailin Zheng ,  Abraham Warshawsky ,  Rivka Warshawsky, legal representative

Inventor： Moussa Youdim ,  Matitiyahu Fridkin ,  Hailin Zheng ,  Abraham Warshawsky

IPC: C07D215/38

CPC classification number: C07D295/15 ,  A61K38/00 ,  A61K45/06 ,  A61K47/547 ,  C07D213/69 ,  C07D215/26 ,  C07D295/205 ,  C07K7/06 ,  C07K7/22 ,  C07K7/23 ,  C07K14/57563 ,  C07K14/70 ,  Y02A50/411

Abstract: Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, eg. a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, a inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding ageing, and prevention and/or treatment of skin ageing and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety, the neuroprotective function is imparted to the compound e.g. by a neuroprotective peptide, and a combined antiapoptotic and neuroprotective function by a propargyl group.

Abstract translation: 显示出神经保护和良好转运性质的新型铁螯合剂可用于铁螯合治疗用于治疗与铁过载和氧化应激相关的疾病，病症或病症，例如， 神经变性或脑血管疾病或病症，肿瘤性疾病，血色素沉着病，地中海贫血，心血管疾病，糖尿病，炎症性疾病，蒽环类心脏毒性，病毒感染，原生动物感染，酵母感染，延迟衰老以及预防和/或治疗 的皮肤老化和皮肤防晒防晒和/或紫外线。 铁螯合剂功能由8-羟基喹啉，羟基吡啶酮或异羟肟酸盐部分提供，神经保护功能被赋予化合物例如 通过神经保护肽，以及由炔丙基组合的抗细胞凋亡和神经保护功能。

公开(公告)号：US08029780B2

公开(公告)日：2011-10-04

申请号：US10552331

申请日：2004-04-07

Applicant: Orit Kollet ,  Tsvee Lapidot

Inventor： Orit Kollet ,  Tsvee Lapidot

IPC: C12N5/07 ,  C12N5/071

CPC classification number: A61K38/18 ,  A61K35/28 ,  A61K38/1833 ,  A61K38/204 ,  C12N5/0647 ,  C12N2501/12 ,  C12N2501/125 ,  C12N2501/23 ,  A61K2300/00

Abstract: The present invention relates to stem cells which exhibit increased sensitivity to a chemoattractant and, more particularly, to methods of generating and using them such as in clinical applications involving stem cell transplantation.

Abstract translation: 本发明涉及对化学引诱物显示增加的敏感性的干细胞，更具体地涉及产生和使用它们的方法，例如涉及干细胞移植的临床应用。

公开(公告)号：US20110195083A1

公开(公告)日：2011-08-11

申请号：US13122972

申请日：2009-09-30

Applicant: Jacob Anglister ,  Osnat Rosen ,  Adi Moseri

Inventor： Jacob Anglister ,  Osnat Rosen ,  Adi Moseri

IPC: A61K39/00 ,  C07K14/00 ,  C07H21/00 ,  C12N15/63 ,  A61P37/04 ,  A61P31/18

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K16/1063 ,  C07K2317/76 ,  C12N2740/16122 ,  C12N2740/16134

Abstract: Isolated cyclic polypeptides useful as vaccinations for the treatment/prevention of HIV are disclosed. An exemplary peptide comprises at least 18 consecutive amino acids of a V3 domain of gp120, starting at position 303 and ending at position 322, the positioning being according to a numbering of the V3 domain of gp120 in a HXB2 strain, wherein amino acids at position 303 and 322 are bonded. Vaccines comprising same and methods of treating AIDS using same are also disclosed.

Abstract translation: 公开了用作治疗/预防HIV的疫苗接种的分离的环状多肽。 示例性肽包含gp120的V3结构域的至少18个连续的氨基酸，从位置303开始并结束于位置322，定位是根据HXB2菌株中gp120的V3结构域的编号，其中氨基酸位于 303和322结合。 还公开了包含其的疫苗以及使用它们治疗AIDS的方法。