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    Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it
    14.
    发明授权
    Cobalt-polypyridyl complex for treatment of cancer, a pharmaceutical composition and a kit comprising it 有权

    公开(公告)号：US09895338B1

    公开(公告)日：2018-02-20

    申请号：US15242883

    申请日：2016-08-22

    Applicant: Macau University of Science and Technology

    Inventor： Kam Wai Wong ,  Man Chung Wong

    IPC: A61K31/28 ,  A61K31/555 ,  A61K45/06

    CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

    Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

    MAC design for wireless hot-spot networks
    18.
    发明授权
    MAC design for wireless hot-spot networks 有权

    公开(公告)号：US09743309B2

    公开(公告)日：2017-08-22

    申请号：US14945306

    申请日：2015-11-18

    Applicant: Macau University of Science and Technology

    Inventor： Li Feng

    IPC: H04W28/02 ,  H04W74/08 ,  H04L12/54 ,  H04L1/18 ,  H04L12/911

    CPC classification number: H04W28/021 ,  H04L1/1854 ,  H04L47/70 ,  H04W74/08 ,  H04W74/0816

    Abstract: In widely deployed wireless “hot-spot” networks, nodes frequently join or leave, inelastic/elastic and saturated/non-satuarted flows coexist. In such dynamic and diverse environments, it is challenging to maximize the channel utilization while providing satisfactory user experiences. In this invention, one proposes a novel contention-on-demand (CoD) MAC scheme to address this problem. The CoD scheme consists of a fixed-CW algorithm, a dynamic-CW algorithm, and an admission control unit. The fixed-CW algorithm allows elastic flows to access limited system bandwidth; the dynamic-CW algorithm enables inelastic flows to contend for channel on demand and quickly adapt to network change; and the admission control unit rejects overloaded traffic for providing good user experiences. One then performs an asymptotic analysis to develop a simple but efficient admission control rule. Finally, extensive simulations verify that the scheme is very effective and the theoretical result is very accurate.

    Location management utilizing initial position for mobile networks
    20.
    发明授权
    Location management utilizing initial position for mobile networks 有权
    利用移动网络初始位置进行位置管理

    公开(公告)号：US09232351B1

    公开(公告)日：2016-01-05

    申请号：US14658227

    申请日：2015-03-15

    Applicant: Macau University of Science and Technology

    Inventor： Qinglin Zhao

    IPC: H04W24/00 ,  H04W4/02 ,  H04W64/00 ,  H04W68/00

    CPC classification number: H04W4/02 ,  H04W4/021 ,  H04W60/04 ,  H04W64/003 ,  H04W68/005

    Abstract: The present invention provides a method for updating a mobile terminal (MT) for a mobile communication network when the MT crosses a boundary of a first location-update (LA) area. The method comprises determining a second LA to be assigned to the MT for replacing the first LA. The second LA is characterized by a LA center and a LA size, both determined by optimizing them in a sense that a mean total location-management cost is minimized without restricting the LA center to be fixed at the initial position. The initial position is defined as the location where the MT performs a latest location update at the first LA before crossing the boundary. This invention also provides schemes of partitioning the second LA into sub-paging areas for use in paging the MT when a call arrives at the network, so as to minimize the paging cost while satisfying delay requirements.

    Abstract translation: 本发明提供一种当MT越过第一位置更新（LA）区域的边界时，为移动通信网络更新移动终端（MT）的方法。 该方法包括确定要分配给MT以用于替换第一LA的第二LA。 第二个LA的特征在于LA中心和LA大小，两者都通过优化它们来确定，即在平均总位置管理成本最小化的意义上，而不将LA中心限制在初始位置。 初始位置被定义为MT在穿过边界之前在第一LA处执行最新位置更新的位置。 本发明还提供了当呼叫到达网络时将第二LA划分为子寻呼区域以用于寻呼MT的方案，以便在满足延迟要求的同时最小化寻呼成本。

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