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公开(公告)号：US09487495B2
公开(公告)日：2016-11-08
申请号：US14369982
申请日：2013-01-07
Applicant: ABIDE THERAPEUTICS, INC. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M. Lum , Benjamin F. Cravatt
IPC: C07D295/205 , C07D317/46 , C07D317/58 , C07D401/06 , C07D403/06 , C07D407/06 , C07D413/06 , A61K31/495 , A61K31/496 , C07D295/26 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D213/55 , C07D401/04 , C07C271/10 , C07D207/09
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds having the structure: wherein L3, R7, Rd and p are defined herein, which are modulators of MAGL and/or ABHD6. Further provided is the use of these compounds as medicinal agents, processes for their preparation, and pharmaceutical compositions that include the disclosed compounds. The disclosure also provides a method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
Abstract translation: 本公开提供了可以是MAGL和/或ABHD6的调节剂的化合物和组合物及其作为药物的用途，其制备方法和包含公开的化合物作为至少一种活性剂的药物组合物。 本公开还提供了治疗有需要的患者的方法，其中患者患有诸如疼痛，实体瘤癌症和/或肥胖的适应症，其包括施用所公开的化合物或组合物。
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公开(公告)号：US20210363105A1
公开(公告)日：2021-11-25
申请号：US17338182
申请日：2021-06-03
Applicant: Celgene Corporation , Abide Therapeutics, Inc.
Inventor： Lianfeng Huang , Nancy Tsou , Nicole Suzanne White , Jun Xu , Qun Zhang
IPC: C07D211/94 , A61P35/00
Abstract: Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.
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公开(公告)号：US11129827B2
公开(公告)日：2021-09-28
申请号：US16431632
申请日：2019-06-04
Applicant: Abide Therapeutics, Inc.
Inventor： Cheryl A. Grice , Justin S. Cisar , Katharine K. Duncan , Yu Feng , John J. M. Wiener , Olivia D. Weber
IPC: A61K31/496 , A61K31/506 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US11053199B2
公开(公告)日：2021-07-06
申请号：US16569578
申请日：2019-09-12
Applicant: Celgene Corporation , Abide Therapeutics, Inc.
Inventor： Lianfeng Huang , Nancy Tsou , Nicole Suzanne White , Jun Xu , Qun Zhang
IPC: C07D211/94 , A61P35/00
Abstract: Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.
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公开(公告)号：US20200095201A1
公开(公告)日：2020-03-26
申请号：US16569578
申请日：2019-09-12
Applicant: Celgene Corporation , Abide Therapeutics, Inc.
Inventor： Lianfeng Huang , Nancy Tsou , Nicole Suzanne White , Jun Xu , Qun Zhang
IPC: C07D211/94 , A61P35/00
Abstract: Provided herein are crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate. Pharmaceutical compositions comprising crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20180327416A1
公开(公告)日：2018-11-15
申请号：US15777201
申请日：2016-11-18
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. GRICE , Todd K. JONES , Katharine K. DUNCAN , Justin S. CISAR , Jeffrey E. MERIT , Olivia D. WEBER
IPC: C07D487/10 , C07D487/04 , C07D471/10 , C07D519/00 , C07D403/06 , C07D491/08 , C07D231/40 , C07D231/38 , C07D403/12 , C07D417/12 , C07D401/12 , C07D413/12
CPC classification number: C07D487/10 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/10 , C07D487/04 , C07D491/08 , C07D498/08 , C07D519/00
Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.
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公开(公告)号：US20180256566A1
公开(公告)日：2018-09-13
申请号：US15919113
申请日：2018-03-12
Applicant: ABIDE THERAPEUTICS, INC.
Inventor： Cheryl A. GRICE , Justin S. CISAR , Katharine K. DUNCAN , Yu FENG , John J.M. WIENER , Olivia D. WEBER
IPC: A61K31/496 , A61K31/506 , A61P25/04
CPC classification number: A61K31/496 , A61K31/506 , A61K2121/00 , A61P25/04
Abstract: Provided herein are compounds and pharmaceutical compositions comprising said compounds useful as modulators of MAGL and/or FAAH. The subject compounds and compositions are useful for the treatment of pain and neurological disorders.
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公开(公告)号：US09957242B2
公开(公告)日：2018-05-01
申请号：US15272313
申请日：2016-09-21
Applicant: Abide Therapeutics, Inc. , THE SCRIPPS RESEARCH INSTITUTE
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Micah J. Niphakis , Jae Won Chang , Kenneth M Lum , Benjamin F. Cravatt
IPC: C07D213/55 , C07D231/12 , C07D261/08 , A61K31/496 , C07D295/205 , C07D405/14 , C07D215/42 , C07D213/40 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D295/26 , C07D307/79 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
CPC classification number: C07D295/205 , C07C271/10 , C07C271/12 , C07D205/04 , C07D207/09 , C07D207/14 , C07D213/38 , C07D213/40 , C07D213/55 , C07D215/42 , C07D215/46 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D261/08 , C07D263/32 , C07D271/06 , C07D295/26 , C07D307/79 , C07D317/46 , C07D317/58 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/14 , C07D407/06 , C07D413/06 , C07D413/10 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/107
Abstract: This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from indications such as pain, solid tumor cancer and/or obesity comprising administering a disclosed compound or composition.
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公开(公告)号：US20170334874A1
公开(公告)日：2017-11-23
申请号：US15672165
申请日：2017-08-08
Applicant: Abide Therapeutics, Inc.
Inventor： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Olivia D. WEBER , Dong-Hui WANG
IPC: C07D295/205 , C07D207/08 , C07D471/10 , C07D417/04 , C07D403/04 , C07D401/04 , C07D295/26 , C07D265/30 , C07D211/62 , C07D211/58 , C07D211/38 , C07D211/14 , C07D207/16 , C07D207/14 , C07D207/12 , C07D487/04 , C07D498/08
CPC classification number: C07D295/205 , C07D207/08 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/38 , C07D211/58 , C07D211/62 , C07D265/30 , C07D295/26 , C07D401/04 , C07D403/04 , C07D417/04 , C07D471/10 , C07D487/04 , C07D498/08
Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
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公开(公告)号：US20150080364A1
公开(公告)日：2015-03-19
申请号：US14383076
申请日：2013-03-15
Applicant: Abide Therapeutics, Inc. , The Scripps Research Insititute
Inventor： Justin S. Cisar , Cheryl A. Grice , Todd K. Jones , Dong-Hui Wang , Olivia Weber , Benjamin F. Cravatt , Micah J. Niphakis , Armand Cognetta , Jae Won Chang
IPC: C07D207/46 , C07D401/12 , C07D487/04 , C07D491/107 , C07D471/04 , C07D405/14 , C07D413/12
CPC classification number: C07D207/46 , C07D209/48 , C07D233/80 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D471/10 , C07D487/04 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。
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