公开(公告)号：US20240137129A1

公开(公告)日：2024-04-25

申请号：US18261999

申请日：2022-01-25

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Nikolaos Bamiedakis ,  David George Cunningham ,  Richard Vincent Penty

IPC: H04B10/58

CPC classification number: H04B10/58

Abstract: Techniques for driving a directly modulated laser whilst correcting non-linearities an optical output waveform, based on generating a modulating current waveform that approximates an ideal modulating current that produces a linear optical output waveform. The techniques enable useful, practical approximations to the ideal modulating current to be determined.

公开(公告)号：US20240132554A1

公开(公告)日：2024-04-25

申请号：US18274839

申请日：2022-01-27

Applicant: Cambridge Enterprise Limited

Inventor： Sudhakaran PRABAKARAN

IPC: C07K14/445 ,  C12N15/113

CPC classification number: C07K14/445 ,  C12N15/113 ,  C07K2317/622 ,  C12N2310/14 ,  C12N2740/15043 ,  C12N2750/14143

Abstract: The present application features methods of diagnosing treating malaria by targeting novel open reading frames in Plasmodium falciparum. The novel open reading frames (nORFs) associated with malaria are expressed in a mosquito and in a human

公开(公告)号：US20240122991A1

公开(公告)日：2024-04-18

申请号：US18546746

申请日：2022-02-17

Applicant: Cambridge Enterprise Limited

Inventor： Fotios Sampaziotis ,  Ludovic Vallier ,  Kourosh Saeb-Parsy ,  Andrew Butler ,  Christopher Watson ,  Teik Choon See

IPC: A61K35/407 ,  A61K35/413 ,  A61P1/16

CPC classification number: A61K35/407 ,  A61K35/413 ,  A61P1/16

Abstract: This invention relates to in vitro and in vivo methods for engrafting liver cells, such as cholangiocytes, into a liver comprising administering the liver cells to the biliary tree of the liver. The liver cells may be in the form of aggregates and may be administered in the direction of decreasing biliary duct diameter. This may be useful for example for the treatment of an individual with a diseased or damaged liver.

公开(公告)号：US20240093180A1

公开(公告)日：2024-03-21

申请号：US17999619

申请日：2021-05-27

Applicant: Cambridge Enterprise Limited

Inventor： Rebecca FITZGERALD ,  Karol NOWICKI-OSUCH ,  Juliane PERNER

IPC: C12N15/10

CPC classification number: C12N15/1065

Abstract: The invention relates to a method of preparing a nucleic acid library from a sample comprising high molecular weight DNA (HMW DNA), preferably genomic DNA, comprising the steps (i) contacting said DNA with a first restriction enzyme and a second restriction enzyme; (ii) contacting said DNA with a pair of oligonucleotide adapters according to any of claims 1 to 12; (iii) contacting said DNA with at least one DNA ligase; and (iv) incubating to allow digestion of the DNA by said first restriction enzyme and second restriction enzyme, annealing of said oligonucleotide adapters to the digested DNA, and ligation of the annealed oligonucleotide adapters to the digested DNA by said at least one DNA ligase. The invention also relates to oligonucleotide adapters, a kit, and uses of same.

公开(公告)号：US20240055076A1

公开(公告)日：2024-02-15

申请号：US18266387

申请日：2021-12-09

Applicant: Cambridge Enterprise Limited ,  International Centre for Genetic Engineering and Biotechnology

Inventor： Sudhakaran PRABAKARAN

IPC: G16B35/00 ,  G16B20/20 ,  C12N15/10

CPC classification number: G16B35/00 ,  G16B20/20 ,  C12N15/1089

Abstract: The present application features methods of treating a disease associated with a genetic variant. The genetic variant is also present within a novel open reading frame (nORF) associated with the gene in which the variant encodes either the gain or loss of a stop codon.

公开(公告)号：US20230416938A1

公开(公告)日：2023-12-28

申请号：US18367328

申请日：2023-09-12

Applicant: Cambridge Enterprise Limited

Inventor： Davor Copic ,  Michael Franciscus De Volder ,  Jan Johan Rongé

IPC: C25D15/00 ,  C25D1/16 ,  C25D13/02 ,  F28D15/04 ,  H01M4/66 ,  C25D7/00 ,  B82Y30/00

CPC classification number: C25D15/00 ,  C25D1/16 ,  C25D13/02 ,  F28D15/046 ,  H01M4/666 ,  C25D7/00 ,  B82Y30/00

Abstract: A composite layer of carbon nanotubes and metal such as copper is formed by electrodeposition. The layer has a thickness of at least 10 μm. The carbon nanotubes are distributed through the layer and are present in the layer at a volume fraction of at least 0.001 vol % and at most 65 vol %. The volume fraction is based on the total volume of the metal and carbon nanotubes and not including any pore volume. The carbon nanotubes are substantially uniformly plated with the metal. The composite layer has a density ratio satisfying Player Pmetal ≤0.35 where player is the bulk density of the composite layer of thickness of at least 10 μm, including any voids that are present in the composite layer and pmetal is the volumetric mass density material property of the metal. The composite layer is of use in evaporation-condensation apparatus, as an active material layer in an electrochemical device or in an electroforming process.

公开(公告)号：US20230416815A1

公开(公告)日：2023-12-28

申请号：US18025664

申请日：2021-09-14

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： Manuel NAPPI ,  Alexandre HOFER ,  Shankar BALASUBRAMANIAN ,  Matthew J. GAUNT

IPC: C12Q1/6874 ,  C12Q1/6818 ,  C07D213/61 ,  C07D213/81 ,  C07D213/75

CPC classification number: C12Q1/6874 ,  C12Q1/6818 ,  C12Q1/6806 ,  C07D213/81 ,  C07D213/75 ,  C07D213/61

Abstract: The invention provides a method for labeling a nucleic acid comprising N6-methyl adenine. The method comprises forming an alpha-amino radical on the N6-methyl group of N6mAde, and capturing the alpha-amino radical with a radical acceptor comprising a nitrosopyridyl group. The presence of N6mAde in a nucleic acid may then be established by detection of the labeled nucleic acid, or the labeled nucleic acid may be extracted or further modified using the label. Also provided is a method for mapping the position of N6mAde within a target nucleic acid, and probe molecules and kits for use in the method.

公开(公告)号：US11752176B2

公开(公告)日：2023-09-12

申请号：US16493888

申请日：2018-03-15

Applicant: UNIVERSITY OF WASHINGTON ,  CAMBRIDGE ENTERPRISE LIMITED

Inventor： Charles E. Murry ,  Sanjay Sinha ,  Johannes Bargehr

IPC: A61K35/34 ,  A61K35/545 ,  A61K31/4409 ,  A61K38/13 ,  A61K38/30 ,  A61P9/10 ,  A61P9/04 ,  C12N5/00

CPC classification number: A61K35/34 ,  A61K31/4409 ,  A61K35/545 ,  A61K38/13 ,  A61K38/30 ,  A61P9/04 ,  A61P9/10

Abstract: Provided herein are methods and compositions comprising cardiomyocytes and epicardial cells for the treatment of cardiac disease.

公开(公告)号：US20230204620A1

公开(公告)日：2023-06-29

申请号：US17926794

申请日：2021-05-18

Applicant: Cambridge Enterprise Limited

Inventor： Ashwin SESHIA ,  Chun ZHAO

IPC: G01P15/097 ,  G01P1/00

CPC classification number: G01P15/097 ,  G01P1/00

Abstract: An accelerometer comprising: a frame; one or more proof masses suspended from the frame by one or more flexures and movable relative to the frame along a sensing axis; a first resonant element fixed between an anchor on the frame and the one or more proof masses, and extending from the anchor to the one or more proof masses along the sensing axis; a second resonant element fixed between the anchor and the one or more proof masses and extending from the anchor to the one or more proof masses along the sensing axis in a opposite direction to the first resonant element.

公开(公告)号：US20230158732A1

公开(公告)日：2023-05-25

申请号：US17917165

申请日：2021-04-06

Applicant: CAMBRIDGE ENTERPRISE LIMITED

Inventor： David Michael ROPER ,  Serena Michelle BEST ,  Kyung-Ah KWON ,  Ruth Elizabeth CAMERON

IPC: B29C64/118 ,  B29C64/321 ,  B29C64/40 ,  B33Y10/00 ,  B33Y80/00

CPC classification number: B29C64/118 ,  B29C64/40 ,  B29C64/321 ,  B33Y10/00 ,  B33Y80/00 ,  B29K2995/0032 ,  B29K2995/0041 ,  B29L2031/753

Abstract: Various methods of additive layer manufacturing, and objects obtainable by such manufacturing, are disclosed. In particular, there is provided a method of additive layer manufacturing comprising depositing a layer of a material on a surface, and controlling the deposition to vary a material property of the material within the layer. There is also provided a method of additive layer manufacturing comprising depositing at least one layer of material on a sacrificial layer, the layer of material having a thickness of 400 microns or less, wherein the sacrificial layer is located on a base surface.