公开(公告)号：US09132128B2

公开(公告)日：2015-09-15

申请号：US14474928

申请日：2014-09-02

Applicant: Cephalon, Inc.

Inventor： Shawn P. Allwein ,  Laurent Courvoisier ,  Martin J. Jacobs ,  Gregory R. Ott

IPC: A61K31/506 ,  C07D403/04 ,  C07D403/12

CPC classification number: A61K31/506 ,  C07D403/04 ,  C07D403/12

Abstract: The present invention provides a compound of formula (I) or a salt form thereof. The compound of formula (I) has ALK and FAK inhibitory activity, and may be used to treat proliferative disorders.

Abstract translation: 本发明提供式（I）化合物或其盐形式。 式（I）化合物具有ALK和FAK抑制活性，可用于治疗增殖性疾病。

公开(公告)号：US20150051258A1

公开(公告)日：2015-02-19

申请号：US14531023

申请日：2014-11-03

Applicant: Cephalon, Inc.

Inventor： Martin Ian Cooper ,  Laurent D. Courvoisier ,  Mark Eddleston ,  Robert E. McKean

IPC: C07D235/16 ,  A61K31/4184

CPC classification number: A61K31/4184 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/19 ,  A61K47/26 ,  C07D235/16

Abstract: Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.

Abstract translation: 描述了新型固体形式的盐酸苯达莫司汀，以及它们的制备和使用方法。

公开(公告)号：US20140088042A1

公开(公告)日：2014-03-27

申请号：US13949346

申请日：2013-07-24

Applicant: Cephalon, Inc.

Inventor： Raffaella Bernardini ,  Alberto Bernareggi ,  Paolo G. Cassara ,  Sankar Chatterjee ,  Germano D'Arasmo ,  Sergio De Munari ,  Edmondo Ferretti ,  Mohamed Iqbal ,  Ernesto Menta ,  Patricia A. Messina McLaughlin ,  Ambrogio Oliva

IPC: A61K31/69 ,  A61K45/06 ,  C07F5/02

CPC classification number: A61K31/69 ,  A61K45/06 ,  C07F5/025

Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.

Abstract translation: 本发明提供了可通过抑制蛋白酶体活性来调节细胞凋亡的硼酸化合物，硼酸酯及其组合物。 化合物和组合物可以用于诱导凋亡和直接与蛋白酶体活性间接相关的疾病如癌症和其它疾病的方法中。

公开(公告)号：US20130144068A1

公开(公告)日：2013-06-06

申请号：US13737213

申请日：2013-01-09

Applicant: Cephalon, Inc..

Inventor： Rachel Y. LaBell ,  Piyush R. Patel

IPC: A61L2/00

CPC classification number: A61L2/0023 ,  A61K31/4184 ,  A61L2/0035 ,  A61L2/007

Abstract: The present application is directed to methods of sterilizing bendamustine and its pharmaceutically acceptable salt forms. Preferred sterilization methods include dry heat sterilization, gamma irradiation, and e beam radiation. Sterile pharmaceutical compositions are also described.

Abstract translation: 本申请涉及灭菌苯达莫司汀及其药学上可接受的盐形式的方法。 优选的灭菌方法包括干热灭菌，γ照射和电子束辐射。 还描述了无菌药物组合物。

公开(公告)号：US20040229943A1

公开(公告)日：2004-11-18

申请号：US10845836

申请日：2004-05-14

Applicant: Cephalon Inc

Inventor： Rodney J. Hughes ,  Jeffry L. Vaught

IPC: A61K031/343 ,  A61K031/165

CPC classification number: A61K45/06 ,  A61K31/165 ,  A61K31/166 ,  A61K31/343 ,  A61K2300/00

Abstract: Compositions and methods for the treatment of disorders through the administration of modafinil with M-drugs.

Abstract translation: 通过用M药物施用莫达非尼治疗疾病的组合物和方法。

公开(公告)号：US20030216419A1

公开(公告)日：2003-11-20

申请号：US10422164

申请日：2003-04-24

Applicant: Cephalon, Inc.

Inventor： Robert L. Hudkins

IPC: A61K031/4745 ,  A61K031/407 ,  C07D487/14

CPC classification number: C07D471/14 ,  C07D487/04 ,  C07D491/14 ,  C07D495/14

Abstract: The present invention is directed to novel fused pyrrolocarbazoles and isoindolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.

公开(公告)号：US20020082301A1

公开(公告)日：2002-06-27

申请号：US10029306

申请日：2001-12-20

Applicant: Cephalon, Inc.

Inventor： Matthew S. Miller ,  Thomas E. Scammell

IPC: A61K031/165

CPC classification number: G01N33/5088 ,  A61K31/165 ,  Y10S514/903

Abstract: Modafinil is effective in improving symptoms of attention deficit hyperactivity disorder and symptoms of multiple sclerosis fatigue. The administration of modafinil is also shown to activate the tuberomamillary neurons of the posterior hypothalamus, and thus exhibits activity in an area of the brain associated with normal wakefulness functions.

公开(公告)号：US6286698B2

公开(公告)日：2001-09-11

申请号：US73208000

申请日：2000-12-07

Applicant: CEPHALON INC

Inventor： HAGUE BRIAN ,  SHOEMAKER STEVE

IPC: A61J1/00 ,  A61J1/14 ,  A61J7/00 ,  B65D50/06 ,  B65D50/00

CPC classification number: A61J7/003 ,  A61J1/1437 ,  A61J7/0046 ,  B65D50/061 ,  Y02W30/807

Abstract: An apparatus for the reusable interim storage of partially consumed medicated oral dosage forms and methods for employing such an apparatus in order to use medicated oral dosage forms in the safest possible manner. The apparatus of the present invention in its broadest terms comprises (1) a container sized to hold a medicated oral dosage form, (2) means for allowing a medicated oral dosage form easy access into the container but substantially preventing the medicated oral dosage form from passing out of the container, and (3) a child resistant means for allowing an adult to remove a medicated oral dosage form from within the container despite the one-way access means. The preferred embodiment comprises an opaque container having one opening, a child resistant closure with an aperture there through that extends over said opening, and a plastic slitted membrane covering said aperture. The method of the present invention comprises providing a patient with the apparatus of the present invention, administering to the patient a medicated oral dosage form, and when the patient has received sufficient medication, inserting the partially consumed medicated oral dosage form into the apparatus via the one-way access means.

Abstract translation: 用于可重复使用的部分消耗的药物口服剂型的临时储存的装置和使用这种装置的方法，以便以最安全的方式使用药物口服剂型。 本发明的最广泛的装置包括（1）容纳大量药物口服剂型的容器，（2）允许药物口服剂型容易进入容器但基本上防止药物口服剂型 从容器中流出，以及（3）使用成年人从儿童容器内取出药物口服剂型的儿童抵抗手段，尽管是单向通道。 优选实施例包括具有一个开口的不透明容器，具有穿过所述开口延伸的孔的儿童防护盖，以及覆盖所述孔的塑料切割膜。 本发明的方法包括向患者提供本发明的装置，向患者施用药物口服剂型，并且当患者已经接受足够的药物时，将部分消耗的药物口服剂型通过经由 单向接入方式。

公开(公告)号：US20210361777A1

公开(公告)日：2021-11-25

申请号：US17384350

申请日：2021-07-23

Applicant: CEPHALON, INC.

Inventor： Anthony S. DRAGER ,  Paritosh WATTAMWAR

IPC: A61K47/69 ,  A61K47/54 ,  C07H19/12 ,  C07H15/24 ,  C07H15/26 ,  A61K9/51 ,  A61K9/00 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/704

Abstract: The disclosure provides compounds of Formula (I), wherein X, Y, and Z are defined herein. The disclosure also provides particles comprising one or more compounds described herein, compositions comprising one or more compounds or particles described herein and a pharmaceutically acceptable carrier, and methods of treating a subject in need thereof comprising administering one or more compounds, particles, or compositions described herein to the subject. X—Y—Z  (I)

公开(公告)号：US20210113530A1

公开(公告)日：2021-04-22

申请号：US17015175

申请日：2020-09-09

Applicant: Cephalon, Inc.

Inventor： Anthony S. Drager ,  Rachel Y. LaBell ,  Piyush R. Patel

IPC: A61K31/4184 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/40 ,  A61K9/08

Abstract: Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.