公开(公告)号：US20080286238A1

公开(公告)日：2008-11-20

申请号：US12091504

申请日：2006-10-26

Applicant: Chul Woo Kim ,  Wan Seok Yang ,  Min Kyoung Kim

Inventor： Chul Woo Kim ,  Wan Seok Yang ,  Min Kyoung Kim

IPC: A61K35/76 ,  C12N7/00 ,  A61P31/00

CPC classification number: C12N15/86 ,  A61K39/092 ,  A61K2039/5256 ,  C12N2710/10343 ,  C12N2800/30

Abstract: A recombinant adenovirus expressing a streptolysin O (SLO) protein comprising a SLO gene; a promoter operably linked to the SLO gene; a polyadenylation signal sequence; and an adenovirus genome lacking E1 gene effectively kills a cancer cell by expressing a pore-forming toxin, SLO protein, and, therefore, is useful for the suicide cancer gene therapy.

Abstract translation: 表达包含SLO基因的链球菌溶血素O（SLO）蛋白质的重组腺病毒; 可操作地连接到SLO基因的启动子; 多聚腺苷酸化信号序列; 缺乏E1基因的腺病毒基因通过表达成孔毒素SLO蛋白有效地杀死癌细胞，因此可用于自杀癌症基因治疗。

公开(公告)号：US09007039B2

公开(公告)日：2015-04-14

申请号：US13495382

申请日：2012-06-13

Applicant: Chul Woo Kim ,  Jung Moon Kim

Inventor： Chul Woo Kim ,  Jung Moon Kim

IPC: G05F1/577 ,  H02M3/158 ,  H02M1/00

CPC classification number: H02M3/158 ,  H02M2001/009

Abstract: Provided is a single inductor multiple output (SIMO) direct current-to-direct current (DC/DC) converter that may perform DC/DC conversion by transferring, to output nodes, input current that is input and thereby stored in a single inductor. An output selection unit of the SIMO DC/DC converter may select, from output nodes, a first output node to be supplied with current from a driving unit, and provide output voltage of the first output node and reference voltage of the first output node to a hysteresis comparison unit. The hysteresis comparison unit may control on-time and/or inductor peak current by determining whether the output voltage of the first output node is higher than the reference voltage of the first output node by at least a first threshold, and whether the output voltage of the first output voltage is lower than the reference voltage of the first output voltage by at least a second threshold.

Abstract translation: 提供了单电感器多输出（SIMO）直流 - 直流（DC / DC）转换器，其可以通过向输出节点传送输入的输入电流并由此存储在单个电感器中来执行DC / DC转换。 SIMO DC / DC转换器的输出选择单元可以从输出节点选择要从驱动单元提供电流的第一输出节点，并且将第一输出节点的输出电压和第一输出节点的参考电压提供给 滞后比较单元。 滞后比较单元可以通过确定第一输出节点的输出电压是否高于第一输出节点的参考电压至少第一阈值来控制导通时间和/或电感峰值电流，以及是否输出电压 第一输出电压低于第一输出电压的参考电压至少第二阈值。

公开(公告)号：US20130135038A1

公开(公告)日：2013-05-30

申请号：US13611298

申请日：2012-09-12

Applicant: Ki Han KIM ,  Hyun Woo LEE ,  Dae Han KWON ,  Chul Woo KIM ,  Soo Bin LIM

Inventor： Ki Han KIM ,  Hyun Woo LEE ,  Dae Han KWON ,  Chul Woo KIM ,  Soo Bin LIM

IPC: G05F1/10

CPC classification number: H03K19/094 ,  H03K19/0013 ,  H03K19/09482

Abstract: A semiconductor apparatus includes a power supply changing unit. The power supply changing unit is configured to receive an enable signal and power supply voltage, generate first voltage or second voltage according to the enable signal, change a voltage level of the second voltage according to a level signal, and supply the first voltage or the second voltage as a driving voltage of an internal circuit, wherein the internal circuit receives a first input signal to output a second input signal.

Abstract translation: 一种半导体装置，包括电源改变单元。 电源改变单元被配置为接收使能信号和电源电压，根据使能信号产生第一电压或第二电压，根据电平信号改变第二电压的电压电平，并且提供第一电压或 第二电压作为内部电路的驱动电压，其中内部电路接收第一输入信号以输出第二输入信号。

公开(公告)号：US08435748B2

公开(公告)日：2013-05-07

申请号：US12993198

申请日：2009-03-13

Applicant: Chul Woo Kim ,  Pil Je Park ,  Yong-Sung Shin ,  Kil Hyon Lee ,  Ho Sang Shin ,  Byoung-Kwon Kim

Inventor： Chul Woo Kim ,  Pil Je Park ,  Yong-Sung Shin ,  Kil Hyon Lee ,  Ho Sang Shin ,  Byoung-Kwon Kim

IPC: G01N33/53

CPC classification number: G01N33/57438 ,  C07K16/36 ,  G01N33/57415 ,  G01N33/57446 ,  G01N33/57488 ,  G01N2333/974

Abstract: The present invention relates to a method for diagnosis and screening of cancer by measuring the expression of des-R prothrombin activation peptide fragment F2 (des-R F2) in serum, more precisely, des-R-prothrombin activation peptide fragment F2 which is the protein marker down-regulated specifically in liver cancer, breast cancer, and stomach cancer, and a method for diagnosis and screening of liver cancer, breast cancer, and stomach cancer by quantifying the protein marker. The protein marker of the present invention can be effectively used for diagnosis and screening of liver cancer, breast cancer and stomach cancer by comparing the expression of the said protein marker in a normal subject with that of a liver cancer, breast cancer, or stomach cancer patients.

Abstract translation: 本发明涉及一种通过测定血清中des-R凝血酶原活化肽片段F2（des-R F2）的表达，更确切地说，des-R-凝血酶原活化肽片段F2的表达来诊断和筛选癌症的方法， 特异性下调肝癌，乳腺癌和胃癌的蛋白质标记，以及通过量化蛋白质标记物来诊断和筛选肝癌，乳腺癌和胃癌的方法。 通过比较正常对象中所述蛋白质标记物与肝癌，乳腺癌或胃癌的蛋白质标记物的表达，本发明的蛋白质标记物可以有效地用于肝癌，乳腺癌和胃癌的诊断和筛选 耐心。

公开(公告)号：US08339561B2

公开(公告)日：2012-12-25

申请号：US12353317

申请日：2009-01-14

Applicant: Ji-Hwan Hwang ,  Dong-Han Kim ,  Chul-Woo Kim ,  Chung-Ye Chung ,  Kwang-Jin Bae

Inventor： Ji-Hwan Hwang ,  Dong-Han Kim ,  Chul-Woo Kim ,  Chung-Ye Chung ,  Kwang-Jin Bae

IPC: G02F1/1345

CPC classification number: H05K1/0277 ,  H01L23/49838 ,  H01L23/4985 ,  H01L24/50 ,  H01L2924/14 ,  H01L2924/181 ,  H05K1/111 ,  H05K1/189 ,  H05K2201/097 ,  H05K2201/09709 ,  H05K2201/10128 ,  H05K2201/10674 ,  Y02P70/611 ,  H01L2924/00

Abstract: A wiring substrate includes a base film, a plurality of first wirings and a plurality of second wirings. The base film has a chip-mounting region configured for mounting a semiconductor chip thereon. The first wirings extend in a first direction from inside the chip-mounting region to outside the chip-mounting region, and include first connection end portions extending in a second direction different from the first direction. The first connection end portions may be formed inside the chip-mounting region and configured to electrically connect to the semiconductor chip. The second wirings extend in the first direction from inside the chip-mounting region to outside the chip-mounting region, and include second connection end portions extending in the opposite direction to the second direction in which the first connection end portions extend, and the second connection end portions may be formed inside the chip-mounting region and configured to electrically connect to the semiconductor chip.

Abstract translation: 布线基板包括基膜，多个第一布线和多个第二布线。 基膜具有芯片安装区域，用于在其上安装半导体芯片。 第一布线沿芯片安装区域内的第一方向延伸到芯片安装区域的外部，并且包括沿与第一方向不同的第二方向延伸的第一连接端部。 第一连接端部可以形成在芯片安装区域的内部并且被配置为电连接到半导体芯片。 所述第二配线从所述芯片安装区域的内部朝向所述芯片安装区域的外侧沿所述第一方向延伸，并且包括沿与所述第一连接端部延伸的所述第二方向相反的方向延伸的第二连接端部， 连接端部可以形成在芯片安装区域内部，并且被配置为电连接到半导体芯片。

公开(公告)号：US08319537B2

公开(公告)日：2012-11-27

申请号：US13034002

申请日：2011-02-24

Applicant: Chul Woo Kim ,  Se Wook Hwang ,  Min Young Song

Inventor： Chul Woo Kim ,  Se Wook Hwang ,  Min Young Song

IPC: H03K3/017

CPC classification number: H03C3/0916 ,  H03C3/0975 ,  H03L7/097

Abstract: There is provided a modulation profile generator and spread spectrum clock generator including the modulation profile generator. The modulation profile generator includes an input signal generator that generates an input signal; a function calculator that outputs a function calculation result in the form of a square root graph by using the input signal as an input of a function; and a profile generator that generates a non-linear modulation profile based on the function calculation result. As a result, it is possible to effectively reduce electromagnetic interference.

Abstract translation: 提供了包括调制曲线生成器的调制曲线生成器和扩频时钟发生器。 调制曲线生成器包括产生输入信号的输入信号发生器; 函数计算器，通过使用输入信号作为函数的输入，输出以平方根图形式的函数计算结果; 以及基于函数计算结果生成非线性调制曲线的简档生成器。 结果，可以有效地减少电磁干扰。

公开(公告)号：US20120001658A1

公开(公告)日：2012-01-05

申请号：US13034002

申请日：2011-02-24

Applicant: Chul Woo Kim ,  Se Wook Hwang ,  Min Young Song

Inventor： Chul Woo Kim ,  Se Wook Hwang ,  Min Young Song

IPC: H03D3/00 ,  G06G7/12 ,  G06F1/04

CPC classification number: H03C3/0916 ,  H03C3/0975 ,  H03L7/097

Abstract: There is provided a modulation profile generator and spread spectrum clock generator including the modulation profile generator. The modulation profile generator includes an input signal generator that generates an input signal; a function calculator that outputs a function calculation result in the form of a square root graph by using the input signal as an input of a function; and a profile generator that generates a non-linear modulation profile based on the function calculation result. As a result, it is possible to effectively reduce electromagnetic interference.

Abstract translation: 提供了包括调制曲线生成器的调制曲线生成器和扩频时钟发生器。 调制曲线生成器包括产生输入信号的输入信号发生器; 功能计算器，通过使用输入信号作为功能的输入，输出以平方根图形式的函数计算结果; 以及基于函数计算结果生成非线性调制曲线的简档生成器。 结果，可以有效地减少电磁干扰。

公开(公告)号：US20110247871A1

公开(公告)日：2011-10-13

申请号：US13032100

申请日：2011-02-22

Applicant: Soo-Jeoung Park ,  Chul-Woo Kim ,  Kyoung-Sei Choi ,  Kwang-Jin Bae

Inventor： Soo-Jeoung Park ,  Chul-Woo Kim ,  Kyoung-Sei Choi ,  Kwang-Jin Bae

IPC: H05K1/11

CPC classification number: H05K3/46 ,  H05K3/4602 ,  H05K3/462 ,  H05K2201/096 ,  Y10T29/49155

Abstract: A multi-layer printed circuit board (PCB) and a method for fabricating the same are provided. The multi-layer printed circuit board may include a first film and a first insulation layer. The first film may include a first via therein and the first film may further include a first conductive pattern on an upper surface thereof and the first conductive layer may be electrically connected to the first via. The first insulation layer may be on the upper surface of the first film and the first insulation layer may include a second via therein and a second conductive pattern on an upper surface thereof and the second conductive pattern may be electrically connected to the second via. The second via may be electrically connected to the first conductive pattern.

Abstract translation: 提供了一种多层印刷电路板（PCB）及其制造方法。 多层印刷电路板可以包括第一膜和第一绝缘层。 第一膜可以包括其中的第一通孔，并且第一膜还可以包括在其上表面上的第一导电图案，并且第一导电层可以电连接到第一通孔。 第一绝缘层可以在第一膜的上表面上，并且第一绝缘层可以包括其中的第二通孔和在其上表面上的第二导电图案，并且第二导电图案可以电连接到第二通孔。 第二通孔可以电连接到第一导电图案。

公开(公告)号：US20110086404A1

公开(公告)日：2011-04-14

申请号：US12993198

申请日：2009-03-13

Applicant: Chul Woo Kim ,  Pil Je Park ,  Yong-Sung Shin ,  Kil Hyon Lee ,  Ho Sang Shin ,  Byoung-Kwon Kin

Inventor： Chul Woo Kim ,  Pil Je Park ,  Yong-Sung Shin ,  Kil Hyon Lee ,  Ho Sang Shin ,  Byoung-Kwon Kin

IPC: C12N9/96 ,  C07K16/18 ,  C07K17/00 ,  C40B40/10 ,  G01N1/00 ,  B01D59/44 ,  G01N33/559 ,  G01N27/447

CPC classification number: G01N33/57438 ,  C07K16/36 ,  G01N33/57415 ,  G01N33/57446 ,  G01N33/57488 ,  G01N2333/974

Abstract: The present invention relates to a method for diagnosis and screening of cancer by measuring the expression of des-R prothrombin activation peptide fragment F2 (des-R F2) in serum, more precisely, des-R-prothrombin activation peptide fragment F2 which is the protein marker down-regulated specifically in liver cancer, breast cancer, and stomach cancer, and a method for diagnosis and screening of liver cancer, breast cancer, and stomach cancer by quantifying the protein marker. The protein marker of the present invention can be effectively used for diagnosis and screening of liver cancer, breast cancer and stomach cancer by comparing the expression of the said protein marker in a normal subject with that of a liver cancer, breast cancer, or stomach cancer patients.

Abstract translation: 本发明涉及一种通过测定血清中des-R凝血酶原活化肽片段F2（des-R F2）的表达，更确切地说，des-R-凝血酶原活化肽片段F2的表达来诊断和筛选癌症的方法， 特异性下调肝癌，乳腺癌和胃癌的蛋白质标记，以及通过量化蛋白质标记物来诊断和筛选肝癌，乳腺癌和胃癌的方法。 通过比较正常对象中所述蛋白质标记物与肝癌，乳腺癌或胃癌的蛋白质标记物的表达，本发明的蛋白质标记物可以有效地用于肝癌，乳腺癌和胃癌的诊断和筛选 耐心。

公开(公告)号：US07815753B2

公开(公告)日：2010-10-19

申请号：US11719871

申请日：2005-08-11

Applicant: Seong-Hoon Yi ,  Hong-Xiang Li ,  Myung-Il Heo ,  Jong-Chul Yi ,  Dong-Jin Yu ,  Sang-Hum Kwon ,  Chul-Woo Kim ,  Jong-Won Kim ,  In-Seok Hwang

Inventor： Seong-Hoon Yi ,  Hong-Xiang Li ,  Myung-Il Heo ,  Jong-Chul Yi ,  Dong-Jin Yu ,  Sang-Hum Kwon ,  Chul-Woo Kim ,  Jong-Won Kim ,  In-Seok Hwang

IPC: C22C45/02

CPC classification number: C22C45/02

Abstract: Disclosed is a Fe-based bulk amorphous alloy composition which forms a bulk amorphous substance due to its excellent amorphous formability when it is cooled to a temperature lower than its glass transition temperature from the liquid state at a relatively low cooling rate of 1000 K/s or less, has high warm processability in a low temperature range owing to its supercooled liquid region of 20K or higher and has excellent fluidity in the liquid state and thereby good castability. The Fe-based multi-element bulk amorphous alloy composition is represented by a formula of FeαCβSiγBxPyMa, in which M is at least one element selected from Ti(titanium), Cr(chromium), Mo(molybdenum), Nb(niobium), Zr(Zirconium), Ta(tantalum), W(tungsten) and V(vanadium), α, β, γ, x, y, and a each represent atomic % of iron(Fe), Carbon(C), silicon(Si), boron(B), phosphorus(P) and the selected metal element, in which α is 100-(β+γ+x+y+a) atomic %, β is 6 atomic % or more and 13 atomic % or less, γ is 1 atomic % or more and 5 atomic % or less, x is 4.5 atomic % or more and 9.5 atomic % or less, y is 3 atomic % or more and 10 atomic % or less and a is 0.1 atomic % or more and 6 atomic % or less.

Abstract translation: 公开了一种Fe基块状非晶态合金组合物，由于其以非常低的冷却速度1000K / s从液态冷却到比其玻璃化转变温度低的温度时，由于其非晶形成性优异而形成块状非晶态物质 或更低，由于其过冷液体区域为20K以上，在低温范围内具有高温加工性，并且在液态下具有优异的流动性，从而具有良好的浇铸性。 Fe基多元素块状非晶合金组合物由FeαCbBiSiYBxPyMa的式表示，其中M为选自Ti（钛），Cr（铬），Mo（钼），Nb（铌） ，Zr（锆），Ta（钽），W（钨）和V（钒），α，bgr，γ，x，y和a分别表示铁（Fe），碳（C） （Si），硼（B），磷（P）和选择的金属元素，其中α为100 - （＆bgr。+γ+ x + y + a）原子％，bgr; 为6原子％以上且13原子％以下，γ为1原子％以上且5原子％以下，x为4.5原子％以上且9.5原子％以下，y为3原子％以上10 原子％以下，a为0.1原子％以上且6原子％以下。