公开(公告)号：US5354920A

公开(公告)日：1994-10-11

申请号：US103697

申请日：1993-08-10

Applicant: Brian G. Cox ,  Daniel Levin

Inventor： Brian G. Cox ,  Daniel Levin

IPC: C07C45/67 ,  C07C45/68 ,  C07C47/565 ,  C07C45/00

CPC classification number: C07C45/68 ,  C07C47/565

Abstract: A method for the preparation of a 2-hydroxyarylaldehyde which comprises reacting an aryloxymagnesium halide derived from a phenol having at least one free ortho position relative to the phenolic hydroxy group with formaldehyde or a formaldehyde-liberating compound under substantially anhydrous conditions in the presence of a polar organic solvent other than hexamethylphosphoramide or 1,3-dimethyl-3,4,5,6-2(1H)-pyrimidone.

Abstract translation: 一种制备2-羟基芳基醛的方法，其包括将衍生自具有至少一个游离邻位酚的苯酚的芳氧基卤化镁与甲酚或释放甲醛的化合物在基本上无水的条件下，在 除六甲基磷酰胺或1,3-二甲基-3,4,5,6-2（1H） - 嘧啶酮以外的极性有机溶剂。

公开(公告)号：US10399920B2

公开(公告)日：2019-09-03

申请号：US15609228

申请日：2017-05-31

Applicant: Daniel Dickman ,  Daniel Levin

Inventor： Daniel Dickman ,  Daniel Levin

IPC: C07C39/23

Abstract: Crystalline Cannabidiol of a novel form, including (R,R)-(−)-crystalline Cannabidiol, as well as methods of making such novel form of Cannabidiol, pharmaceutical formulations comprising such novel form of Cannabidiol, and methods of treating diseases with such novel form of Cannabidiol.

公开(公告)号：US09187097B2

公开(公告)日：2015-11-17

申请号：US13527165

申请日：2012-06-19

Applicant: Daniel Levin ,  Johan Roennberg

Inventor： Daniel Levin ,  Johan Roennberg

IPC: B60Q1/00 ,  B60W30/18 ,  B60W50/00 ,  B60W50/14 ,  B60W30/14

CPC classification number: B60W30/18145 ,  B60W30/146 ,  B60W50/0097 ,  B60W50/14 ,  B60W2050/143 ,  B60W2520/105 ,  B60W2520/125 ,  B60W2540/30 ,  B60W2550/12 ,  B60W2550/142 ,  B60W2550/146 ,  B60W2550/148 ,  B60W2550/402 ,  B60W2720/10 ,  B60W2720/103 ,  Y02T10/84

Abstract: A system and method for determining a speed profile for a vehicle travelling along a road in which a curve speed estimation unit receives inputs indicating a position of the vehicle relative to a curve ahead of the vehicle, and inputs related to vehicle velocity, curve geometry, road surface conditions, vehicle-specific data; and driver preferences. The curve sped estimation unit use at least some of the above-listed inputs to determine a speed profile for the curve by generating an acceleration limit map which depends on a relationship between a maximum possible longitudinal acceleration and a maximum possible lateral acceleration.

Abstract translation: 一种用于确定沿着道路行驶的车辆的速度曲线的系统和方法，其中曲线速度估计单元接收指示车辆相对于车辆前方的曲线的位置的输入，以及与车速，曲线几何形状相关的输入， 路面状况，车辆专用数据; 和司机偏好。 曲线加速估计单元使用至少一些上述输入来通过产生取决于最大可能纵向加速度和最大可能横向加速度之间的关系的加速度限制图来确定曲线的速度曲线。

公开(公告)号：US09117358B2

公开(公告)日：2015-08-25

申请号：US13558780

申请日：2012-07-26

Applicant: Daniel Levin ,  Lena Westervall ,  Susanna Leandersson ,  Peter Kronberg

Inventor： Daniel Levin ,  Lena Westervall ,  Susanna Leandersson ,  Peter Kronberg

IPC: A61B1/04 ,  G08B21/06 ,  A61B5/00 ,  A61B5/18 ,  B60W40/08

CPC classification number: G08B21/06 ,  A61B5/18 ,  A61B5/7221 ,  B60W40/08 ,  B60W2040/0827 ,  G06F19/00

Abstract: The present invention generally relates to a method for improving the reliability of a portion of physiological data from an image sensor monitoring an operator positioned in an operator compartment of a vehicle. An embodiment of the method includes receiving, from the image sensor, physiological data including information relating to at least one of eye, face, head, arms and body motion of the operator, identifying an indication of at least an eyelid closure, eye movement or head movement of the operator based on the physiological data; comparing at least one of the physiological data and a lighting condition within the operator compartment with a set of rules for a current operator status; and classifying the type of eyelid closure, eye movement and/or head movement by correlating the identified eyelid closure, eye movement and/or head movement and a result of the comparison.

Abstract translation: 本发明一般涉及一种用于提高来自监视位于车辆操作室中的操作员的图像传感器的一部分生理数据的可靠性的方法。 该方法的实施例包括从图像传感器接收生理数据，其包括与操作者的眼睛，脸部，头部，手臂和身体运动中的至少一个有关的信息，识别至少一个眼睑闭合，眼睛运动或 基于生理数据的操作员的头部运动; 将所述操作员室内的生理数据和照明条件中的至少一个与用于当前操作者状态的一组规则进行比较; 并通过将所识别的眼睑关闭，眼睛运动和/或头部移动与比较的结果相关联来分类眼睑闭合的类型，眼睛运动和/或头部运动。

公开(公告)号：US08410304B2

公开(公告)日：2013-04-02

申请号：US12905767

申请日：2010-10-15

Applicant: James Luchi ,  Daniel Levin

Inventor： James Luchi ,  Daniel Levin

IPC: C07C69/66

CPC classification number: C07C51/09 ,  C07C51/412 ,  C07C59/01

Abstract: Disclosed herein are processes for preparing aqueous γ-hydroxybutyrate having a pH of about 8 or less (upon reaching equilibrium). The disclosed processes include both continuous processes and batch processes wherein the ratio of reactants is controlled to provide the product at the desired pH.

Abstract translation: 本文公开了具有约8或更低（达到平衡）pH值的γ-羟基丁酸水溶液的方法。 所公开的方法包括连续方法和分批方法，其中控制反应物的比例以将产物提供在所需pH。

公开(公告)号：US20110082292A1

公开(公告)日：2011-04-07

申请号：US12968651

申请日：2010-12-15

Applicant: George S. DRUMMOND ,  Robert CAROSELLI ,  Keith A. COOKE ,  Daniel LEVIN ,  David G. ROE ,  Christopher P. BOUCHER

Inventor： George S. DRUMMOND ,  Robert CAROSELLI ,  Keith A. COOKE ,  Daniel LEVIN ,  David G. ROE ,  Christopher P. BOUCHER

IPC: C07D487/22

CPC classification number: C07F7/2284 ,  A61K9/0019 ,  A61K31/555 ,  C07D487/22 ,  C07F7/003

Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.

Abstract translation: 公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

公开(公告)号：US20110034727A1

公开(公告)日：2011-02-10

申请号：US12905767

申请日：2010-10-15

Applicant: James Luchi ,  Daniel Levin

Inventor： James Luchi ,  Daniel Levin

IPC: C07C51/12

CPC classification number: C07C51/09 ,  C07C51/412 ,  C07C59/01

Abstract: Disclosed herein are processes for preparing aqueous γ-hydroxybutyrate having a pH of about 8 or less (upon reaching equilibrium). The disclosed processes include both continuous processes and batch processes wherein the ratio of reactants is controlled to provide the product at the desired pH.

Abstract translation: 本文公开了具有约8或更低（达到平衡）pH值的γ-羟基丁酸水溶液的方法。 所公开的方法包括连续方法和分批方法，其中控制反应物的比例以将产物提供在所需pH。

公开(公告)号：US20080125585A1

公开(公告)日：2008-05-29

申请号：US11867559

申请日：2007-10-04

Applicant: George S. DRUMMOND ,  Robert Caroselli ,  Keith A. Cooke ,  Daniel Levin ,  David G. Roe ,  Christopher P. Boucher

Inventor： George S. DRUMMOND ,  Robert Caroselli ,  Keith A. Cooke ,  Daniel Levin ,  David G. Roe ,  Christopher P. Boucher

IPC: C07D487/22

CPC classification number: C07F7/2284 ,  A61K9/0019 ,  A61K31/555 ,  C07D487/22 ,  C07F7/003

Abstract: Large scale (bulk) compositions comprising high-purity stannsoporfin are disclosed, as well as methods of synthesizing such compositions.

Abstract translation: 公开了包含高纯度固体锡的大规模（本体）组合物，以及合成这些组合物的方法。

公开(公告)号：US20060234976A1

公开(公告)日：2006-10-19

申请号：US11393374

申请日：2006-03-30

Applicant: Paul Watson ,  James Douglass ,  Bob Suchozak ,  Subramanian Pandiaraju ,  Craig Dixon ,  Daniel Levin

Inventor： Paul Watson ,  James Douglass ,  Bob Suchozak ,  Subramanian Pandiaraju ,  Craig Dixon ,  Daniel Levin

IPC: A61K31/7076 ,  A61K31/7072 ,  C07F9/6512 ,  A61K31/675

CPC classification number: C07F9/6561 ,  C07F9/65616 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20

Abstract: The present invention is directed to a processes for the synthesis of trans isomer of 4,6-disubstituted-tetrahydro-furo, thieno, pyrrolo and cyclopenta-[3,4][1,3]dioxoles (Formula I). The process comprises the steps of: (a) obtaining a compound of Formula II, which is a mixture of cis and trans-diastereomers, and (b) chemically decomposing the compound of Formula II in a solution comprising a solvent and an acid that is a hydrogen donor or an electron pair acceptor, whereby the cis diastereomer is decomposed and the compound of Formula I is obtained. The compounds prepared by the present invention are useful in treating diseases or conditions associated with platelet aggregation and/or platelet activation.

Abstract translation: 本发明涉及合成4,6-二取代 - 四氢 - 呋喃，噻吩并，吡咯并环戊烷并[3,4] [1,3]二氧杂环戊烯（式I）的反式异构体的方法。 该方法包括以下步骤：（a）获得式II化合物，其是顺式和反式 - 非对映异构体的混合物，和（b）在包含溶剂和酸的溶液中化学分解式II化合物， 氢供体或电子对受体，由此使顺式非对映异构体分解并获得式I化合物。 通过本发明制备的化合物可用于治疗与血小板聚集和/或血小板活化相关的疾病或病症。

公开(公告)号：US07074931B2

公开(公告)日：2006-07-11

申请号：US10333669

申请日：2001-07-31

Applicant: Ian Patel ,  Ian Ashworth ,  Daniel Levin

Inventor： Ian Patel ,  Ian Ashworth ,  Daniel Levin

IPC: C07D211/02 ,  C07D215/16

CPC classification number: C07D215/20

Abstract: A process is described for reacting a vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound to form an 1,5-diketone which is converted to a 1,4-dihydropyridine. Asymmetric substituted 1,4-dihydropyridines are synthesized by the process by preparing an asymmetric vinylogous amide by reacting a 1,3-cyclohexanedione with a substantially homo-chiral phenylethylamine. Reaction of the asymmetric vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound forms an asymmetric 1,5-diketone. The 1,5-diketone is converted to an asymmetric substituted 1,4-dihydropyridine.

Abstract translation: 描述了一种方法，用于在硅化合物存在下使乙烯基酰胺与α，β-不饱和酮反应，形成1,5-二酮，将其转化为1,4-二氢吡啶。 不对称取代的1,4-二氢吡啶通过该方法通过使1,3-环己二酮与基本上同质的手性苯基乙胺反应制备不对称维生素酰胺来合成。 在硅化合物存在下，不对称戊烯酰胺与α，β-不饱和酮的反应形成不对称的1,5-二酮。 将1,5-二酮转化为不对称取代的1,4-二氢吡啶。