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    Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components
    11.
    发明申请
    Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components 有权
    多层次流速率区域或等离子体分离与血细胞和其他静态组分的全息光学捕获

    公开(公告)号：US20050061962A1

    公开(公告)日：2005-03-24

    申请号：US10867328

    申请日：2004-06-13

    申请人： Daniel Mueth ,  Amy Anderson ,  Jessica Shireman

    发明人： Daniel Mueth ,  Amy Anderson ,  Jessica Shireman

    IPC分类号： A61M1/36 ,  A61M1/38 ,  G01N33/483 ,  G21K1/00 ,  B01D61/00

    CPC分类号： A61M1/3693 ,  A61M1/36 ,  A61M1/3678 ,  A61M1/38 ,  A61M2206/11 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T436/25375

    摘要： The invention provides a method and apparatus for separating blood into components, may be expanded to include other types of cellular components, and can be combined with holographic optical manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    摘要翻译： 本发明提供了一种用于将血液分离成组分的方法和装置，其可以扩展成包括其它类型的细胞组分，并且可以与全息光学操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

    Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components
    14.
    发明授权
    Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components 有权
    多层次流速率区域或等离子体分离与血细胞和其他静态组分的全息光学捕获

    公开(公告)号：US07704395B2

    公开(公告)日：2010-04-27

    申请号：US11594094

    申请日：2006-11-08

    申请人： Daniel Mueth ,  Amy Anderson ,  Jessica Shireman

    发明人： Daniel Mueth ,  Amy Anderson ,  Jessica Shireman

    IPC分类号： B01D36/02 ,  B01D21/00

    CPC分类号： A61M1/3693 ,  A61M1/36 ,  A61M1/3678 ,  A61M1/38 ,  A61M2206/11 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0652 ,  B03C1/28 ,  B03C5/005 ,  B03C2201/02 ,  B03C2201/18 ,  G01N30/0005 ,  G03H1/08 ,  G03H1/2294 ,  G03H2001/0077 ,  G03H2001/085 ,  Y10T436/25375

    摘要： The invention provides a method and apparatus for separating blood into components, may be expanded to include other types of cellular components, and can be combined with holographic optical manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

    摘要翻译： 本发明提供了一种用于将血液分离成组分的方法和装置，其可以扩展成包括其它类型的细胞组分，并且可以与全息光学操作或其他形式的光学镊子组合。 示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。 然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。 全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

    Apparatus for optically-based sorting within liquid core waveguides
    15.
    发明授权
    Apparatus for optically-based sorting within liquid core waveguides 失效
    液芯波导内光学分选装置

    公开(公告)号：US07574076B2

    公开(公告)日：2009-08-11

    申请号：US11399569

    申请日：2006-04-07

    申请人： Daniel Mueth ,  Evan Tanner ,  Joseph Plewa ,  Osman Akcakir

    发明人： Daniel Mueth ,  Evan Tanner ,  Joseph Plewa ,  Osman Akcakir

    IPC分类号： G02B6/12 ,  G02B6/032 ,  G02B6/10

    CPC分类号： G01N21/05 ,  G01N21/0303 ,  G01N2015/149 ,  G01N2021/0346 ,  G02B6/032

    摘要： The present invention is related to an apparatus for the sorting of particles in a fluid medium flowing within a liquid-core waveguide, by combining customized light intensity patterns formed inside the waveguide, and diluting the suspension of particles (i.e., cells, blood, nanoparticles, etc.) flowing within the fluid medium of the waveguide. With this customized light intensity pattern, which controls the optical forces introduced by the light confined within the waveguide, and the control of the hydrodynamic forces introduced by the liquid flow (or multiple channel liquid flows), the sorting of particles can be achieved.

    摘要翻译： 本发明涉及一种用于通过组合形成在波导内的定制的光强度图案和稀释颗粒（即细胞，血液，纳米颗粒）的悬浮液来分选在液体芯波导内流动的流体介质中的颗粒的装置 等）在波导的流体介质内流动。 通过这种定制的光强度图案，其控制由限制在波导内的光引入的光学力，以及由液体流（或多通道液体流）引入的流体动力的控制，可以实现颗粒的分选。

    Automated extraction and purification of samples using optical tweezers
    17.
    发明申请
    Automated extraction and purification of samples using optical tweezers 失效
    使用光学镊子自动提取和纯化样品

    公开(公告)号：US20060134603A1

    公开(公告)日：2006-06-22

    申请号：US11298565

    申请日：2005-12-12

    申请人： Joseph Plewa ,  Evan Tanner ,  Daniel Mueth ,  Crystal Duke ,  Kevin Ehrenreich

    发明人： Joseph Plewa ,  Evan Tanner ,  Daniel Mueth ,  Crystal Duke ,  Kevin Ehrenreich

    IPC分类号： C12Q1/00

    CPC分类号： G02B21/32 ,  B01L3/502761 ,  G01N1/34 ,  G01N15/1463 ,  G01N2001/007 ,  G01N2015/1454 ,  G01N2015/149 ,  G02B5/32 ,  Y10T436/25375

    摘要： An apparatus and method for purifying a forensic sample using an automated extraction and purification system includes optical tweezers; an input channel through which the sample is introduced; a chamber which receives the sample from the input channel; a collection channel through which selected particles of the sample are removed; and an output through which unselected particles of the sample are removed. At least one buffer input channel is provided. The input channel may allow sedimentation of the sample into the chamber by gravity. In another arrangement, the system includes an optical trapping system; a first channel through which the sample is introduced; a second channel through which buffer is introduced; wherein the optical tweezers are used to move selected particles of the sample from the first channel to the second channel. The selected particles may be sperm. The optical tweezers preferably utilize holographic optical trapping.

    摘要翻译： 使用自动提取和净化系统来净化法医样品的装置和方法包括光学镊子; 导入样品的输入通道; 从输入通道接收样品的室; 取出样品的所选粒子的收集通道; 以及去除样品的未选择的颗粒的输出。 提供至少一个缓冲器输入通道。 输入通道可以允许样品通过重力沉降到室中。 在另一种布置中，该系统包括光学捕获系统; 引入样品的第一通道; 引入缓冲液的第二通道; 其中所述光学镊子用于将所述样品的选定颗粒从所述第一通道移动到所述第二通道。 所选择的颗粒可能是精子。 光学镊子优选利用全息光学捕获。