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公开(公告)号：US20200332737A1
公开(公告)日：2020-10-22
申请号：US16387677
申请日：2019-04-18
摘要： A low speed pre-ignition detection, mitigation, and driver notification system and method utilize a controller to analyze a knock signal from a knock sensor to detect LSPI knock of the engine and in response to detecting the LSPI knock, enrich a fuel/air ratio of the engine and limit a torque output of the engine to a level that is less than a maximum torque output of the engine, and when enriching the fuel/air ratio of the engine and limiting the torque output of the engine does not mitigate the LSPI knock, output at least one message for a driver of the vehicle instructing the driver to take remedial action to mitigate the LSPI knock.
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公开(公告)号：US20110244473A1
公开(公告)日：2011-10-06
申请号：US12308542
申请日：2007-06-20
申请人： Cary D. Austin , David A. Lawrence , Avi Ashkenazi
发明人： Cary D. Austin , David A. Lawrence , Avi Ashkenazi
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： G01N33/574 , G01N2510/00
摘要： The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.
摘要翻译： 本发明提供了用于观察凋亡过程中产生的蛋白质片段的方法和材料，以便在哺乳动物细胞中观察该过程。 本发明的实施方案可用于例如观察细胞凋亡以检查哺乳动物癌细胞对凋亡诱导剂的敏感性。
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公开(公告)号：US07258983B2
公开(公告)日：2007-08-21
申请号：US10895545
申请日：2004-07-21
申请人： David Botstein , Audrey Goddard , David A. Lawrence , Diane Pennica , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Audrey Goddard , David A. Lawrence , Diane Pennica , Margaret Ann Roy , William I. Wood
CPC分类号： C12Q1/6886 , A01K2217/05 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/52 , C07K16/18 , C07K16/24 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12Q2600/136 , G01N33/57484 , G01N2333/52 , G01N2500/00
摘要： The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.
摘要翻译： 本发明涉及用于诊断和治疗哺乳动物（包括人）中的肿瘤细胞生长和增殖的复合和方法。 本发明基于在肿瘤细胞基因组中扩增的心肌营养因子-1基因的鉴定。 预期这种基因扩增与基因产物的过表达有关，并有助于肿瘤发生。 因此，被扩增的基因编码的心肌营养因子-1多肽被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。
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公开(公告)号：US5985658A
公开(公告)日：1999-11-16
申请号：US970363
申请日：1997-11-14
CPC分类号： G01N33/5005
摘要： The invention provides a method for separating target cells from a plurality of cells which is based on a reversible high affinity interaction between two molecules. The method comprises: forming a target cell/cell binding reagent/first molecule/second molecule/solid support complex, wherein the cell binding reagent is specific for target cells present within a plurality of cells and wherein the first molecule reversibly binds to the second molecule; removing non-target cells of the plurality of cells not attached to the solid support; and reversing the first molecule binding to the second molecule, thereby releasing the target cells as separate cells from the plurality of cells.
摘要翻译： 本发明提供了一种基于两个分子之间的可逆高亲和力相互作用的从多个细胞中分离靶细胞的方法。 该方法包括：形成靶细胞/细胞结合试剂/第一分子/第二分子/固体支持复合物，其中所述细胞结合试剂对存在于多个细胞内的靶细胞是特异性的，并且其中所述第一分子可逆地结合到所述第二分子 ; 去除未连接到固体支持物上的多个细胞的非靶细胞; 并且使与第二分子结合的第一分子反转，从而从多个细胞释放作为分离的细胞的靶细胞。
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公开(公告)号：US4859613A
公开(公告)日：1989-08-22
申请号：US929937
申请日：1986-11-12
申请人： David A. Lawrence
发明人： David A. Lawrence
IPC分类号： G01N33/574 , G01N33/68 , G01N33/74
CPC分类号： G01N33/68 , G01N33/574 , G01N33/743 , Y10S435/948 , Y10S530/806 , Y10S530/808 , Y10S530/809 , Y10S530/868
摘要： Monoclonal antibodies specifically immunologically reactive to thiol-modified glutathione and hybridoma cell lines producing such monoclonal antibodies. A method of producing antibodies specifically immunologically reactive with reduced glutathione by immunizing an animal using a thiol-modified glutathione, for example, a glutathione-N-ethylmaleimide-keyhole limpet hemocyanin conjugate. A method of utilizing the antibodies produced to quantitate the amount of reduced glutathione in a biological sample, to monitor glutathione-associated conditions, to monitor the formation of normal metabolic intermediates and to monitor the detoxification of foreign compounds.
摘要翻译： 与硫醇修饰的谷胱甘肽和产生这种单克隆抗体的杂交瘤细胞系特异性免疫反应的单克隆抗体。 通过使用硫醇修饰的谷胱甘肽，例如谷胱甘肽-N-乙基马来酰亚胺 - 钥孔血蓝蛋白缀合物免疫动物，产生与还原型谷胱甘肽特异性免疫反应的抗体的方法。 一种利用产生的抗体来定量生物样品中还原型谷胱甘肽的量，监测谷胱甘肽相关病症，监测正常代谢中间体形成和监测外源化合物解毒的方法。
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公开(公告)号：US20240068882A1
公开(公告)日：2024-02-29
申请号：US17893345
申请日：2022-08-23
申请人： Shu S. Wang , David A. Lawrence , Michael Barkey
发明人： Shu S. Wang , David A. Lawrence , Michael Barkey
CPC分类号： G01K7/16 , B60R16/03 , B60W20/50 , B60W2510/0676 , B60W2510/068 , B60W2510/087 , B60W2520/10 , B60W2555/20
摘要： A system and method of controlling a powertrain to protect a high voltage cable by determining a temperature characteristic for a busbar, determining a temperature characteristic adjacent to a component, and determining a current through the high voltage cable. Thereafter, the method reduces an operating characteristic of the powertrain based on the temperature characteristic for the busbar, the temperature characteristic adjacent to the component, and the current.
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公开(公告)号：US11125202B1
公开(公告)日：2021-09-21
申请号：US16929258
申请日：2020-07-15
摘要： Engine combustion phasing control techniques utilize a trained feedforward artificial neural network (ANN) to model both base and maximum brake torque (MBT) spark timing based on six inputs: intake and exhaust camshaft positions, mass and temperature of an air charge being provided to each cylinder of the engine, engine speed, engine coolant temperature. The selected target spark timing could be adjusted based on a two-dimensional surface having engine speed and air charge mass as inputs. The target spark timing adjustment could be performed only during an initial period when the trained ANN is immature. The ANN could also be trained using dynamometer data for the engine that is artificially weighted for high load regions where accuracy of spark timing is critical.
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公开(公告)号：US20190390595A1
公开(公告)日：2019-12-26
申请号：US16018960
申请日：2018-06-26
摘要： A control system and method for an engine including a turbocharger without a surge valve involve utilizing one or more pressure sensors configured to measure air pressure in an intake system of the engine, the intake system comprising a compressor of the turbocharger and a throttle valve downstream from the compressor, and a controller configured to control the engine to avoid surge at the compressor and eliminate a need for the surge valve by determining a desired position for the throttle valve based on a driver requested engine torque, determining a minimum mass flow through the compressor that avoids surge based on the measured air pressure in the intake system and a predetermined compressor map, and commanding the throttle valve to a target position to maintain at least the minimum compressor mass flow, wherein the target position is greater than the desired position, thereby avoiding surge at the compressor.
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公开(公告)号：US10415457B2
公开(公告)日：2019-09-17
申请号：US15805335
申请日：2017-11-07
申请人： Shuonan Xu , David A Lawrence , Ethan E Bayer
发明人： Shuonan Xu , David A Lawrence , Ethan E Bayer
摘要： Techniques for setting a boost target for a turbocharged engine comprise (i) operating the engine in a scavenging mode such that opening of intake and exhaust valves of cylinders of the engine overlap and (ii) while transitioning the engine in/out of the scavenging mode: determining an engine torque request, creating a torque reserve by setting independent targets for throttle inlet pressure (TIP) and intake manifold absolute pressure (MAP), determining a target TIP based on a target total air charge, engine speed, and a previously-determined target engine volumetric efficiency (VE), controlling a wastegate valve based on the target TIP, determining a target MAP based on the engine torque request, and controlling a throttle valve based on the target MAP. During steady-state scavenging operation, the controller calculates a conventional target TIP based on the engine torque request and controls the wastegate valve based on the conventionally calculated target TIP.
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公开(公告)号：US08198033B2
公开(公告)日：2012-06-12
申请号：US12308542
申请日：2007-06-20
申请人： Cary D. Austin , David A. Lawrence , Avi Ashkenazi
发明人： Cary D. Austin , David A. Lawrence , Avi Ashkenazi
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574 , G01N33/00
CPC分类号： G01N33/574 , G01N2510/00
摘要： The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells. Embodiments of the invention can be used for example to observe apoptosis in order to examine the sensitivity of a mammalian cancer cell to apoptosis inducing agents.
摘要翻译： 本发明提供了用于观察凋亡过程中产生的蛋白质片段的方法和材料，以便在哺乳动物细胞中观察该过程。 本发明的实施方案可用于例如观察细胞凋亡以检查哺乳动物癌细胞对凋亡诱导剂的敏感性。
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