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11.发明授权公开(公告)号：US10213384B2
公开(公告)日：2019-02-26
申请号：US15883134
申请日：2018-01-30
发明人： Dov Tamarkin , David Schuz , Tal Berman , Yohan Hazot
IPC分类号： A61K9/12 , A61Q19/00 , A61K47/38 , A61K47/26 , A61K8/04 , A61K47/14 , A61K9/00 , A61K8/46 , A61K47/20
摘要： The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
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公开(公告)号：US09795564B2
公开(公告)日：2017-10-24
申请号：US13967546
申请日：2013-08-15
发明人： Dov Tamarkin , David Schuz , Yohan Hazot , Elana Gazal
CPC分类号： A61K9/12 , A61K8/046 , A61K9/0014 , A61K9/122 , A61K31/20 , A61K31/355 , A61K31/522 , A61K31/59 , A61K31/65 , A61K31/7056 , A61K45/06 , A61K47/06 , A61K47/14 , A61K47/24 , A61K47/34 , A61K47/44 , Y10S514/871 , Y10S514/945
摘要： A waterless foamable carrier and pharmaceutical composition which is suitable for external and internal administration is disclosed. The composition is single phase and includes at least one liquid oil; and a glyceride. Pharmaceutical compositions comprising active agents, methods for their preparation, propellants suitable for use with the carriers and uses thereof are further described.
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公开(公告)号：US20170216334A1
公开(公告)日：2017-08-03
申请号：US15401743
申请日：2017-01-09
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
IPC分类号： A61K31/7056 , A61K47/10 , A61K31/58 , A61K31/327 , A61K31/573 , A61K31/196 , A61K9/12 , A61K47/38
CPC分类号： A61K31/7056 , A01N25/16 , A61K9/0014 , A61K9/122 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K47/10 , A61K47/38
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
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公开(公告)号：US09463919B2
公开(公告)日：2016-10-11
申请号：US14634208
申请日：2015-02-27
发明人： Meir Eini , Tami Winitz , David Schuz
IPC分类号： B65D83/00 , B65D83/68 , B65D83/54 , B65D83/52 , B01F3/04 , B01F5/06 , B01F13/00 , B01F15/00 , B65D83/16 , B65D83/14 , B65D83/20 , B65D83/40 , B65D83/48 , B05B7/08
CPC分类号： B01F15/0087 , B01F3/04446 , B01F5/0606 , B01F5/0607 , B01F13/0022 , B05B7/08 , B65D83/14 , B65D83/16 , B65D83/201 , B65D83/202 , B65D83/205 , B65D83/206 , B65D83/207 , B65D83/40 , B65D83/48 , B65D83/525 , B65D83/54 , B65D83/546 , B65D83/68 , B65D83/682
摘要： A apparatus for delivering a predetermined quantity of content from a pressurized container includes a dispensing assembly which sits on the container and connects with an upper portion of a valve stem of the valve assembly, wherein the dispensing assembly includes a) an actuator cap having a discharge passage, which is open or obstructed and wherein the actuator cap acts as a metering chamber in combination with b) an adaptor which fits inside the cap and also snuggly engages the valve stem. The cap fits snuggly over the adjuster to define a metering chamber which depending on its position can close off the metered chamber or open it to the dispensing conduit\nozzle. When the cap is depressed it pushes down on the adjuster which depresses the valve. The chamber fills, but nothing is released until the upstroke.
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15.发明申请SURFACTANT-FREE WATER-FREE FOAMABLE COMPOSITIONS, BREAKABLE FOAMS AND GELS AND THEIR USES 审中-公开无表面活性剂的无水可泡沫组合物，可破碎的水泥和凝胶及其用途公开(公告)号：US20150196570A1
公开(公告)日：2015-07-16
申请号：US14577659
申请日：2014-12-19
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K31/65
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.
摘要翻译： 一种基本上无表面活性剂的组合物，其包含疏水性溶剂和/或凡士林，石蜡和/或脂肪醇，脂肪酸和/或蜡和/或乳木果油，具有和不具有推进剂。 一种基本上无表面活性剂的组合物，还包含四环素抗生素或维生素D衍生物，或一种或多种其它活性剂。 使用基本上无表面活性剂的组合物的治疗方法。
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公开(公告)号：US20150157586A1
公开(公告)日：2015-06-11
申请号：US14528038
申请日：2014-10-30
发明人： Dov Tamarkin , Doron Friedman , Meir Eini
IPC分类号： A61K31/196 , A61K31/17 , A61Q19/08 , A61K8/42 , A61K8/365 , A61K9/00 , A61K31/167 , A61K31/19
CPC分类号： A61K9/122 , A01N25/16 , A61K8/046 , A61K8/06 , A61K8/062 , A61K8/31 , A61K8/365 , A61K8/42 , A61K9/0014 , A61K9/107 , A61K9/12 , A61K9/124 , A61K31/167 , A61K31/17 , A61K31/19 , A61K31/196 , A61K31/496 , A61K31/497 , A61K45/00 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/24 , A61K47/36 , A61K47/38 , A61K47/44 , A61K2800/75 , A61Q17/02 , A61Q19/00 , A61Q19/08 , A61Q19/10 , Y10S514/945 , A01N53/00
摘要： The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.
摘要翻译： 本发明涉及无水化妆品或药物泡沫组合物，其包含水，疏水性溶剂，表面活性剂，胶凝剂，选自脲，羟基酸和治疗性增强剂和推进剂的活性成分。 泡沫还包含具有增强的皮肤渗透性的治疗性质的活性剂和赋形剂。
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公开(公告)号：US08865139B1
公开(公告)日：2014-10-21
申请号：US14327040
申请日：2014-07-09
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K47/02 , A61K47/12 , A61K9/12 , A61K47/10 , A61K45/06 , A61K47/44 , A61K47/24
CPC分类号： A61K47/44 , A61K8/31 , A61K8/342 , A61K8/361 , A61K9/0014 , A61K9/0048 , A61K9/12 , A61K9/122 , A61K9/124 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K45/06 , A61K47/02 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/24 , A61K2800/31 , A61K2800/33 , A61Q17/04 , A61Q19/00 , A61Q19/10
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
摘要翻译： 一种局部治疗疏水性可破坏组合物包括载体，其包含（a）约60％至约99％重量的至少一种疏水性油; （b）至少一种选自脂肪醇，脂肪酸和蜡的粘度调节剂; 和（c）四环素抗生素，其特征在于至少部分四环素抗生素悬浮于组合物中; 组合物的粘度比没有四环素抗生素的载体的粘度高至少约30％; 并且高于没有粘度改性剂的疏水性油和四环素类抗生素的粘度。 四环素在组合物中化学稳定至少六个月; 其中大于约90％的四环素未分解。 该组合物包装成易碎泡沫，在施加剪切力时容易破裂。
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公开(公告)号：US11219631B2
公开(公告)日：2022-01-11
申请号：US16108799
申请日：2018-08-22
发明人： Dov Tamarkin , Enbal Ziv , Yohan Hazot , David Schuz
IPC分类号： A61K31/7056 , A01N25/16 , A61K9/12 , A61K47/10 , A61K47/38 , A61K31/196 , A61K31/327 , A61K31/573 , A61K31/58 , A61K9/00
摘要： A substantially surface active agent-free foamable composition which includes short-chain alcohol, water, polymer, fatty alcohol or fatty acid or a combination of fatty alcohol and fatty acid and propellant. A substantially surface active agent-free foamable composition which includes, water, polymer, fatty alcohol or fatty acid and propellant. A method of treatment using a substantially surface active agent-free foamable compositions.
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19.发明申请公开(公告)号：US20210015927A1
公开(公告)日：2021-01-21
申请号：US16948631
申请日：2020-09-25
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K47/44 , A61K47/06 , A61K9/00 , A61K9/12 , A61K8/31 , A61Q17/04 , A61Q19/00 , A61Q19/10 , A61K31/137 , A61K31/192 , A61K31/4164 , A61K31/57 , A61K31/573 , A61K31/593 , A61K31/65 , A61K8/34 , A61K8/36 , A61K47/10 , A61K47/12 , A61K45/06 , A61K47/02 , A61K47/24
摘要： A substantially surface active agent free composition which includes a hydrophobic solvent, and/or a petrolatum, a paraffin wax and/or a fatty alcohol, a fatty acid and/or a wax and/or shea butter, with and without a propellant. A substantially surface active agent free composition, further comprising, a tetracycline antibiotic, or a vitamin D derivative, or one or more other active agents. A method of treatment using a substantially surface active agent free composition.
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公开(公告)号：US20210000842A1
公开(公告)日：2021-01-07
申请号：US16948352
申请日：2020-09-15
发明人： Meir EINI , Mitchell SHIRVAN , Rita KEYNAN , Tal BERMAN , David SCHUZ , Yohan HAZOT
IPC分类号： A61K31/65 , A61K9/12 , A61K9/06 , A61K47/06 , A61K47/44 , A61K47/24 , A61K47/12 , A61K47/10 , A61K9/00 , A61P17/10 , A61K45/06
摘要： Methods of treatment and dosage regimes using a composition comprising a tetracycline antibiotic in treating or alleviating a disorder including EGFRI associated rash, EGFRI associated rash related symptoms, a tetracycline antibiotic responsive EGFRI associated rash related disorder, skin disorder caused by a bacteria, and a tetracycline antibiotic responsive sebaceous gland disease, P. EGFRI associated rash bacteria associated disorders and other superficial infections, including skin infections are provided.
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