公开(公告)号：US08980846B2

公开(公告)日：2015-03-17

申请号：US13885986

申请日：2011-11-17

Applicant: Kyung Seop Ahn ,  Ha Young Jang ,  Sei Ryang Oh ,  Hyeong Kyu Lee ,  Ok-Kyoung Kwon ,  Semi Kim ,  Jung Hee Kim ,  Doo-Young Kim

Inventor： Kyung Seop Ahn ,  Ha Young Jang ,  Sei Ryang Oh ,  Hyeong Kyu Lee ,  Ok-Kyoung Kwon ,  Semi Kim ,  Jung Hee Kim ,  Doo-Young Kim

IPC: A61K31/70 ,  A61K31/34 ,  A61K31/7048 ,  A61K31/343 ,  A61K36/185 ,  A23L1/30

CPC classification number: A61K31/7048 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/343 ,  A61K36/185 ,  A23V2200/314 ,  A23V2250/21 ,  A23V2250/2116

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating asthma, the composition containing styraxlignolide A or an aglycone thereof as an active ingredient. More particularly, styraxlignolide A compound is one separated from stems and barks of Styrax japonica, and styraxlignolide A or homoegonol, which is an aglycone of styraxlignolide A and which has improved safety, has the effect of attenuating weight loss and airway hyperresponsiveness, inhibiting the generation of reactive oxygen species in airway, inhibiting generation of IgE, TGF-β1, and IL-17 in the serum and bronchoalveolar lavage fluid, inhibiting endobronchial inflammatory cell infiltration, and inhibiting the formation of a mucous plug and subepithelial fibrosis in an asthma-induced mouse model. Therefore, styraxlignolide or homoegonol can be effectively used as the active ingredient of a pharmaceutical composition for preventing or treating bronchial asthma in which airway remodeling has progressed.

Abstract translation: 本发明涉及一种用于预防或治疗哮喘的药物组合物，该组合物含有作为活性成分的苯达洛尔苷A或其糖苷配基。 更特别的是，辛伐利精A化合物是从Styrax japonica的茎和吠声中分离出来的化合物，作为styraxlignolide A的糖苷配基的辛伐利汀A或homoegonol，具有改善的安全性，具有减轻体重减轻和气道高反应性的作用， 的气道中的活性氧，抑制血清和支气管肺泡灌洗液中IgE，TGF-β1和IL-17的产生，抑制支气管炎性细胞浸润，抑制哮喘中粘膜和上皮下纤维化的形成 诱导的鼠标模型。 因此，可以有效地使用辛伐利汀或同型异黄酮作为预防或治疗气道重塑进行的支气管哮喘的药物组合物的活性成分。

公开(公告)号：US20140228427A1

公开(公告)日：2014-08-14

申请号：US14122789

申请日：2012-05-24

Applicant: Sei Ryang Oh ,  Kyung Seop Ahn ,  Hyeong Kyu Lee ,  Ha Young Jang ,  Ok-Kyoung Kwon ,  Jung Hee Kim ,  Ji Won Park ,  Doo-Young Kim

Inventor： Sei Ryang Oh ,  Kyung Seop Ahn ,  Hyeong Kyu Lee ,  Ha Young Jang ,  Ok-Kyoung Kwon ,  Jung Hee Kim ,  Ji Won Park ,  Doo-Young Kim

IPC: A61K31/352

CPC classification number: A61K31/352

Abstract: The present invention relates to a pharmaceutical composition for the prevention or treatment of asthma comprising Wogonin as an active ingredient. The Wogonin of the present invention is excellent not only in relieving airway hypersensitivity that causes asthma in vivo, in inhibiting reactive oxygen species generation in the airway, and in inhibiting the infiltration of inflammatory cells in the bronchus, but also in inhibiting the generation of IgE in serum and bronchoalveolar lavage fluid, and in inhibiting the expressions of Th2 cytokines in the lung. Therefore, the Wogonin of the present invention can be effectively used as a composition for the prevention, treatment, or improvement of asthma.

Abstract translation: 本发明涉及一种用于预防或治疗哮喘的药物组合物，其包含沃可素作为活性成分。 本发明的Wogonin不仅能缓解气道在体内引起哮喘，抑制气道中的活性氧产生，抑制炎症细胞在支气管中的浸润，而且抑制IgE的产生， 在血清和支气管肺泡灌洗液中，并抑制肺中Th2细胞因子的表达。 因此，本发明的沃可素可以有效地用作预防，治疗或改善哮喘的组合物。

公开(公告)号：US08455541B2

公开(公告)日：2013-06-04

申请号：US13427352

申请日：2012-03-22

Applicant: Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Sang Ku Lee ,  Joong Ku Lee ,  Ok Kyoung Kwon ,  Doo Young Kim ,  Hyouk Joung ,  Gui Hua Quan ,  Mi Jin Kim ,  Bo Young Park

Inventor： Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Sang Ku Lee ,  Joong Ku Lee ,  Ok Kyoung Kwon ,  Doo Young Kim ,  Hyouk Joung ,  Gui Hua Quan ,  Mi Jin Kim ,  Bo Young Park

IPC: A61K31/35

CPC classification number: A61K31/7048 ,  A61K9/2059 ,  A61K9/4866

Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其中分离出的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。

公开(公告)号：US08168235B2

公开(公告)日：2012-05-01

申请号：US11916216

申请日：2006-05-30

Applicant: Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Sang Ku Lee ,  Joong Ku Lee ,  Ok Kyoung Kwon ,  Doo Young Kim ,  Hyouk Joung ,  Gui Hua Quan ,  Mi Jin Kim ,  Bo Young Park

Inventor： Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Sang Ku Lee ,  Joong Ku Lee ,  Ok Kyoung Kwon ,  Doo Young Kim ,  Hyouk Joung ,  Gui Hua Quan ,  Mi Jin Kim ,  Bo Young Park

IPC: A61K36/00

CPC classification number: A61K36/185 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/35 ,  A61K31/352 ,  A61K36/68 ,  A61K36/80 ,  C07H17/04 ,  A23V2250/21 ,  A23V2200/324 ,  A23V2200/304

Abstract: The present invention relates to a composition comprising an extract of Pseudolysimachion genus plant, and the catalpol derivatives isolated therefrom having anti-inflammatory, antiallergic and anti-asthmatic activity. The extract of Pseudolysimachion genus plant and the catalpol derivatives isolated therefrom shows potent suppressing effect on elevated IgE, IL-4 and IL-13 levels and eosinophilia in the plasma and BALF, and mucus overproduction in the lung tissues in an OVA-induced asthmatic mouse model. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Abstract translation: 本发明涉及包含假单胞菌属植物提取物和从其分离的具有抗炎，抗过敏和抗哮喘活性的梓醇衍生物的组合物。 假单胞菌属植物的提取物和从其中分离的梓醇衍生物显示出对OVA诱导的哮喘小鼠肺组织中升高的IgE，IL-4和IL-13水平以及血浆和BALF中的嗜酸性粒细胞增多和粘液过度产生的有效抑制作用 模型。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。

公开(公告)号：US07763286B2

公开(公告)日：2010-07-27

申请号：US11989053

申请日：2006-07-18

Applicant: Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Joong Ku Lee ,  Sang Ku Lee ,  Jung Hee Kim ,  Doo Young Kim ,  Gui Hua Quan ,  Ok Kyoung Kwon ,  Eun Ah Kim ,  Soon Ja Choi ,  Guang Hai Shen ,  Mi Jin Kim ,  Bo Young Park ,  Byung Sun Min ,  Gyoon Hee Han ,  Hea Young Park ,  Gun Cheol Kim ,  Joo Heon Kim ,  So Young Kim

Inventor： Hyeong Kyu Lee ,  Sei Ryang Oh ,  Kyung Seop Ahn ,  Joong Ku Lee ,  Sang Ku Lee ,  Jung Hee Kim ,  Doo Young Kim ,  Gui Hua Quan ,  Ok Kyoung Kwon ,  Eun Ah Kim ,  Soon Ja Choi ,  Guang Hai Shen ,  Mi Jin Kim ,  Bo Young Park ,  Byung Sun Min ,  Gyoon Hee Han ,  Hea Young Park ,  Gun Cheol Kim ,  Joo Heon Kim ,  So Young Kim

IPC: A61K36/00 ,  A61K47/00

CPC classification number: C07J53/00 ,  A23L33/105 ,  A61K36/185 ,  Y10S514/826

Abstract: The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine (IL-4, IL-5 and IL-13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.

Abstract translation: 本发明涉及一种组合物，其中含有天竺葵提取物和从其中分离得到的具有抗炎，抗过敏和抗哮喘活性的天竺葵酸。 Tiarella polyphylla的提取物和从其中分离的tiarellic酸显示对LTC4释放体外试验的抑制作用和对IgE水平和细胞因子（IL-4，IL-5和IL-13）产生，气道高反应性的抑制作用 ，和OVA诱导的哮喘小鼠白细胞浸润。 因此，它可以用作用于治疗和预防炎性，过敏性和哮喘性疾病的治疗剂或功能性保健食品。

公开(公告)号：US20100068315A1

公开(公告)日：2010-03-18

申请号：US12623341

申请日：2009-11-20

Applicant: Jong Won LEE ,  Ki-Chul HWANG ,  Hyung Soo HAN ,  Sun Ha LIM ,  Hyeong-Kyu LEE ,  Sang Hyuk LEE ,  Kyu Won KIM ,  Hyung Oh JUN ,  Hyun Jeong KIM ,  In-Seon LEE ,  Chae Ha YANG

Inventor： Jong Won LEE ,  Ki-Chul HWANG ,  Hyung Soo HAN ,  Sun Ha LIM ,  Hyeong-Kyu LEE ,  Sang Hyuk LEE ,  Kyu Won KIM ,  Hyung Oh JUN ,  Hyun Jeong KIM ,  In-Seon LEE ,  Chae Ha YANG

IPC: A61K36/899 ,  A61P25/28

CPC classification number: A61K36/899 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/21

Abstract: The present invention relates to a composition comprising extracts of Gramineae plant that improves cell viability under hypoxic conditions by inhibiting apoptosis. Thus, the extract of Triticum aestivum L., one of the Gramineae plant, of the present invention, in particular, prevents damage of brain, heart and kidney in animal models of ischemic diseases, and it also improves memory in an animal model of Alzheimer's disease. Therefore, a composition comprising extracts of Gramineae can be used as therapeutic agents or health care foods for preventing and treating ischemic diseases and degenerative brain diseases.

Abstract translation: 本发明涉及包含通过抑制细胞凋亡在缺氧条件下改善细胞活力的禾本科植物提取物的组合物。 因此，特别地，本发明的禾本科植物之一的小麦Triticum aestivum L.的提取物防止脑，心脏和肾脏在缺血性疾病的动物模型中的损伤，并且还改善了阿尔茨海默病动物模型中的记忆 疾病。 因此，包含禾本科植物提取物的组合物可用作预防和治疗缺血性疾病和退行性脑疾病的治疗剂或保健食品。

公开(公告)号：US09375456B2

公开(公告)日：2016-06-28

申请号：US13505727

申请日：2010-11-03

Applicant: Sei-Ryang Oh ,  Jae Wha Kim ,  Hyeong-Kyu Lee ,  Kyung Seop Ahn ,  Doo Young Kim ,  Jung Hee Kim ,  Jae Sung Song ,  Ho-Bum Kang ,  Inpyo Choi

Inventor： Sei-Ryang Oh ,  Jae Wha Kim ,  Hyeong-Kyu Lee ,  Kyung Seop Ahn ,  Doo Young Kim ,  Jung Hee Kim ,  Jae Sung Song ,  Ho-Bum Kang ,  Inpyo Choi

IPC: A61K36/47 ,  A61K36/83

CPC classification number: A61K36/47 ,  A61K36/83

Abstract: The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-γ (IFN-γ) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.

Abstract translation: 本发明涉及含有Aleutites fordii或Daphne kiusiana提取物或其一部分作为活性成分的抗病毒组合物。 详细地说，di of i，，，，，，，can can can can for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for 病毒性疾病，因此可以有效地用于抗病毒组合物。

公开(公告)号：US08722110B2

公开(公告)日：2014-05-13

申请号：US13820474

申请日：2011-08-30

Applicant: Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Sei Ryang Oh ,  Jung Hee Kim ,  Hyeong Kyu Lee ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-Youl Lee ,  Soo Yong Kim ,  Giselle Tomayo-Castillo ,  Katia Rosales-Ovares ,  Rodrigo Gamez-Lobo

Inventor： Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Sei Ryang Oh ,  Jung Hee Kim ,  Hyeong Kyu Lee ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-Youl Lee ,  Soo Yong Kim ,  Giselle Tomayo-Castillo ,  Katia Rosales-Ovares ,  Rodrigo Gamez-Lobo

IPC: A01N65/00

CPC classification number: A61K36/44

Abstract: Disclosed is a pharmaceutical composition for the prophylaxis and therapy of inflammatory diseases, allergic diseases, or asthma, comprising a velvet apple (Diospyros blancoi A. DC.) extract as an active ingredient. Having the inhibitory activity against the nuclear translocation of NF-κB, whose level is rapidly elevated in response to inflammatory stimuli, the velvet apple extract can suppress the production of NO and PGE2, the expression of iNOS and COX-2, and the release of IL-1β and TNF-α, and can significantly down regulate Th2-mediated IL-4 and IL-13 production. In addition, the extract was found to inhibit the activation of eosinophils in bronchoalveolar lavage fluid, and to suppress the secretion of immunoglobulins and chemokines in bronchoalveolar lavage fluid and blood, as measured by in vivo tests on an ovalbumin-induced asthma mouse model. Therefore, the extract can be used in the method for preventing or treating various inflammatory disorders, allergic diseases, or asthma.

Abstract translation: 公开了一种用于预防和治疗炎性疾病，过敏性疾病或哮喘的药物组合物，其包含天鹅绒苹果（Diospyros blancoi A.DC。）提取物作为活性成分。 天鹅绒苹果提取物对NF-κB的核易位具有抑制活性，其水平迅速升高，可抑制NO和PGE2的产生，iNOS和COX-2的表达，以及 释放IL-1和bgr; 和TNF-α，并可显着下调Th2介导的IL-4和IL-13产生。 此外，发现提取物抑制支气管肺泡灌洗液中嗜酸性粒细胞的活化，并且通过卵清蛋白诱导的哮喘小鼠模型的体内试验测量，抑制支气管肺泡灌洗液和血液中免疫球蛋白和趋化因子的分泌。 因此，提取物可用于预防或治疗各种炎性疾病，过敏性疾病或哮喘的方法。

公开(公告)号：US20130323331A1

公开(公告)日：2013-12-05

申请号：US13985533

申请日：2012-02-07

Applicant: Sei Ryang Oh ,  Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Hyeong Kyu Lee ,  Joongku Lee ,  Hyouk Joung ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-youl Lee ,  Sang Woo Lee ,  Hang Jin ,  Wan Yi Li

Inventor： Sei Ryang Oh ,  Kyung Seop Ahn ,  Ok-Kyoung Kwon ,  Hyeong Kyu Lee ,  Joongku Lee ,  Hyouk Joung ,  Mee-Young Lee ,  Hwa-Young Son ,  Kyoung-youl Lee ,  Sang Woo Lee ,  Hang Jin ,  Wan Yi Li

IPC: A61K36/61

CPC classification number: A61K36/61

Abstract: The present invention relates to a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma comprising the extract of Decaspermum fruticosum as an active ingredient. The extract of Decaspermum fruticosum of the present invention inhibited the increase of eosinophils in bronchoalveolar lavage fluid of the ovalbumin-induced asthma animal model, had the activity of inhibiting the secretions of immunoglobulin and chemokine (Eotaxin) in bronchoalveolar lavage fluid and blood, and inhibited the secretions of NO and TNF-α in macrophages. Therefore, the extract of Decaspermum fruticosum of the present invention can be effectively used as an active ingredient of a pharmaceutical composition for the prevention and treatment of inflammatory disease or asthma, and of a health functional food for the prevention and improvement of inflammatory disease or asthma.

Abstract translation: 本发明涉及一种用于预防和治疗炎症性疾病或哮喘的药物组合物，其包含作为活性成分的Dececpermum fruticosum的提取物。 本发明的Decaspermum fruticosum的提取物抑制卵清蛋白诱导的哮喘动物模型的支气管肺泡灌洗液中嗜酸性粒细胞的增加，具有抑制支气管肺泡灌洗液和血液中免疫球蛋白和趋化因子（Eotaxin）分泌的活性，并被抑制 NO和TNF-α在巨噬细胞中的分泌。 因此，本发明的Decaspermum fruticosum的提取物可以有效地用作预防和治疗炎性疾病或哮喘的药物组合物的活性成分，以及用于预防和改善炎性疾病或哮喘的健康功能食品 。

公开(公告)号：US20120308676A1

公开(公告)日：2012-12-06

申请号：US13505727

申请日：2010-11-03

Applicant: Sei-Ryang Oh ,  Jae Wha Kim ,  Hyeong-Kyu Lee ,  Kyung Seop Ahn ,  Doo Young Kim ,  Jung Hee Kim ,  Jae Sung Song ,  Ho-Bum Kang ,  Inpyo Choi

Inventor： Sei-Ryang Oh ,  Jae Wha Kim ,  Hyeong-Kyu Lee ,  Kyung Seop Ahn ,  Doo Young Kim ,  Jung Hee Kim ,  Jae Sung Song ,  Ho-Bum Kang ,  Inpyo Choi

IPC: A61K36/47 ,  A61P31/16 ,  A61K36/83 ,  A61P31/18 ,  A61P31/14 ,  A61P31/20 ,  A61P31/12 ,  A61P31/22

CPC classification number: A61K36/47 ,  A61K36/83

Abstract: The present invention relates to an antiviral composition containing an Aleurites fordii or Daphne kiusiana extract or a fraction thereof as an active ingredient. In detail, extracts of Aleurites fordii or Daphne kiusiana or fractions thereof can induce the secretion of an immune-related cytokine, interferon-γ (IFN-γ) in natural killer (NK) cells, and thus exhibit potent antiviral activity and superior effects for viral diseases, and therefore can be effectively used in an antiviral composition.

Abstract translation: 本发明涉及含有Aleutites fordii或Daphne kiusiana提取物或其一部分作为活性成分的抗病毒组合物。 详细地说，di of i，，，，，，，can can can can for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for for 病毒性疾病，因此可以有效地用于抗病毒组合物。