公开(公告)号：US09089554B2

公开(公告)日：2015-07-28

申请号：US14000587

申请日：2012-02-21

申请人： Kyu-Won Kim ,  Jong-Ho Cha

发明人： Kyu-Won Kim ,  Jong-Ho Cha

IPC分类号： A01N37/18 ,  A61K38/00 ,  A61K39/395 ,  C12N15/113

CPC分类号： A61K39/3955 ,  C12N15/113 ,  C12N2310/14

摘要： The invention includes a pharmaceutical composition comprising an expression or activity regulator of AKAP12 (A-kinase anchoring protein 12) as the active ingredient. The compositions of the invention are useful for treating central nervous system diseases. The invention further includes a method of treating central nervous system diseases using a pharmaceutical composition of the invention. The central nervous system diseases contemplated within the invention include post-traumatic stress syndrome, stroke, and spinal injury.

摘要翻译： 本发明包括含有作为活性成分的AKAP12（A激酶锚定蛋白12）的表达或活性调节剂的药物组合物。 本发明的组合物可用于治疗中枢神经系统疾病。 本发明还包括使用本发明的药物组合物治疗中枢神经系统疾病的方法。 本发明中考虑的中枢神经系统疾病包括创伤后应激综合征，中风和脊髓损伤。

公开(公告)号：US08395701B2

公开(公告)日：2013-03-12

申请号：US12782299

申请日：2010-05-18

申请人： Jungwon Kim ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

发明人： Jungwon Kim ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

IPC分类号： H04N7/01 ,  H04N11/00

CPC分类号： H04N21/44008 ,  G09G2320/103 ,  G09G2340/0435 ,  H04N21/4126 ,  H04N21/41407 ,  H04N21/440281

摘要： Provided is an operating voltage scaling method for a portable terminal. The method includes, if reproduction of a moving image is requested, acquiring DYNamicity (DYN) of the reproduction-requested moving image, determining whether frame skipping is possible for the moving image according to the acquired DYN of the moving image, and if it is determined that frame skipping is possible for the moving image, supplying a low operating voltage to a controller of the mobile terminal to control the mobile terminal to operate with a low-speed clock, and reproducing the moving image while skipping a frame.

摘要翻译： 提供了一种用于便携式终端的操作电压缩放方法。 该方法包括：如果请求了运动图像的再现，则获取再现请求的运动图像的DYNamicity（DYN），根据获取的运动图像的DYN确定运动图像的跳帧是否可能，并且如果是 确定对于运动图像可能跳帧，向移动终端的控制器提供低工作电压以控制移动终端以低速时钟操作，并且在跳过帧时再现运动图像。

公开(公告)号：US20110162092A1

公开(公告)日：2011-06-30

申请号：US12997653

申请日：2009-06-12

申请人： Kyu-Won Kim ,  Hyouk-Bum Kwon

发明人： Kyu-Won Kim ,  Hyouk-Bum Kwon

IPC分类号： A61K38/45 ,  C12N9/12 ,  G01N33/00 ,  A61P7/04

CPC分类号： A61K38/1709

摘要： The present invention relates to a composition comprised of AKAP12 (A-Kinase anchoring protein 12) and to uses of AKAP12 mutant zebrafish as an animal model. More particularly, the following characteristics are noted in the present AKAP12 mRNA knockdown zebrafish: crooked or shortened tail, inability to move normally, non-uniform micro-vasculature in the brain, and change in heart shape with non-uniform and weak heartbeats. It also has various circulatory and genetic defects, such as hemorrhage from the ventricles of the heart, brain, and retina. All of these defects can be cured with AKAP12 injection. Therefore, AKAP12 can be used as an active component for a composition to prevent and heal circulatory and genetic defects that are caused by AKAP12 deficiency, and as a hemorrhage inhibitor. Further, the AKAP12 deficient mutant zebrafish can be useful as an animal model for verification of effectiveness of treatment for genetic defects in the circulatory system.

摘要翻译： 本发明涉及由AKAP12（A-激酶锚定蛋白12）组成的组合物和AKAP12突变斑马鱼作为动物模型的用途。 更具体地，在本发明的AKAP12mRNA敲低斑马鱼中注意到以下特征：弯曲或缩短的尾巴，不能正常移动，脑中不均匀的微血管系统，以及心脏形状与心脏不均匀和微弱的变化。 它还具有各种循环和遗传缺陷，例如来自心脏，脑和视网膜心室的出血。 所有这些缺陷都可以用AKAP12注射固化。 因此，AKAP12可用作组合物的活性成分，用于预防和治疗由AKAP12缺乏引起的循环和遗传缺陷，以及作为出血抑制剂。 此外，AKAP12缺陷突变体斑马鱼可用作验证循环系统遗传缺陷治疗有效性的动物模型。

公开(公告)号：US20100295990A1

公开(公告)日：2010-11-25

申请号：US12782299

申请日：2010-05-18

申请人： Jungwon KIM ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

发明人： Jungwon KIM ,  Jaejin Lee ,  Kyu-Won Kim ,  Sung-Kwan Heo

IPC分类号： H04N7/01

CPC分类号： H04N21/44008 ,  G09G2320/103 ,  G09G2340/0435 ,  H04N21/4126 ,  H04N21/41407 ,  H04N21/440281

摘要： Provided is an operating voltage scaling method for a portable terminal. The method includes, if reproduction of a moving image is requested, acquiring DYNamicity (DYN) of the reproduction-requested moving image, determining whether frame skipping is possible for the moving image according to the acquired DYN of the moving image, and if it is determined that frame skipping is possible for the moving image, supplying a low operating voltage to a controller of the mobile terminal to control the mobile terminal to operate with a low-speed clock, and reproducing the moving image while skipping a frame.

摘要翻译： 提供了一种用于便携式终端的操作电压缩放方法。 该方法包括：如果请求了运动图像的再现，则获取再现请求的运动图像的DYNamicity（DYN），根据获取的运动图像的DYN确定运动图像的跳帧是否可能，并且如果是 确定对于运动图像可能跳帧，向移动终端的控制器提供低工作电压以控制移动终端以低速时钟操作，并且在跳过帧时再现运动图像。

公开(公告)号：US20100068315A1

公开(公告)日：2010-03-18

申请号：US12623341

申请日：2009-11-20

申请人： Jong Won LEE ,  Ki-Chul HWANG ,  Hyung Soo HAN ,  Sun Ha LIM ,  Hyeong-Kyu LEE ,  Sang Hyuk LEE ,  Kyu Won KIM ,  Hyung Oh JUN ,  Hyun Jeong KIM ,  In-Seon LEE ,  Chae Ha YANG

发明人： Jong Won LEE ,  Ki-Chul HWANG ,  Hyung Soo HAN ,  Sun Ha LIM ,  Hyeong-Kyu LEE ,  Sang Hyuk LEE ,  Kyu Won KIM ,  Hyung Oh JUN ,  Hyun Jeong KIM ,  In-Seon LEE ,  Chae Ha YANG

IPC分类号： A61K36/899 ,  A61P25/28

CPC分类号： A61K36/899 ,  A23L33/105 ,  A23V2002/00 ,  A23V2200/322 ,  A23V2250/21

摘要： The present invention relates to a composition comprising extracts of Gramineae plant that improves cell viability under hypoxic conditions by inhibiting apoptosis. Thus, the extract of Triticum aestivum L., one of the Gramineae plant, of the present invention, in particular, prevents damage of brain, heart and kidney in animal models of ischemic diseases, and it also improves memory in an animal model of Alzheimer's disease. Therefore, a composition comprising extracts of Gramineae can be used as therapeutic agents or health care foods for preventing and treating ischemic diseases and degenerative brain diseases.

摘要翻译： 本发明涉及包含通过抑制细胞凋亡在缺氧条件下改善细胞活力的禾本科植物提取物的组合物。 因此，特别地，本发明的禾本科植物之一的小麦Triticum aestivum L.的提取物防止脑，心脏和肾脏在缺血性疾病的动物模型中的损伤，并且还改善了阿尔茨海默病动物模型中的记忆 疾病。 因此，包含禾本科植物提取物的组合物可用作预防和治疗缺血性疾病和退行性脑疾病的治疗剂或保健食品。

公开(公告)号：US07652370B2

公开(公告)日：2010-01-26

申请号：US10899177

申请日：2004-07-27

申请人： Dae Sik Lee ,  Hae Sik Yang ,  Yong Taik Lim ,  Kwang Hyo Chung ,  Sung Jin Kim ,  Se Ho Park ,  Kyu Won Kim ,  Yun Tae Kim

发明人： Dae Sik Lee ,  Hae Sik Yang ,  Yong Taik Lim ,  Kwang Hyo Chung ,  Sung Jin Kim ,  Se Ho Park ,  Kyu Won Kim ,  Yun Tae Kim

IPC分类号： H01L29/06

CPC分类号： B01J19/0093 ,  B01J2219/00495 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/00833 ,  B01J2219/00853 ,  B01J2219/00858 ,  B01J2219/00873 ,  B01J2219/00961 ,  B01L3/502707 ,  B01L3/50851 ,  B01L2200/12 ,  B01L2200/147 ,  B01L2300/0819 ,  B01L2300/12 ,  B01L2300/1827 ,  B33Y80/00 ,  C40B60/14 ,  G01N27/128

摘要： Provided are a plastic microfabricated structure, and a microfabricated thermal device, a microfabricated reactor, a microfabricated reactor array and a micro array using the same, which may be applied to a bio chip, and the present invention may fabricate the plastic microfabricated structure for providing a heating region by means of insulating plastic, which has a thin thickness, flatness enough to allow a photolithography process to be performed, thermal isolation in its some or total area, and a small thermal mass, and on top of the heating region of the plastic microfabricated structure, a heater, a temperature sensor for sensing a temperature, an electrode, and an electrode pad are formed to thereby fabricate the microfabricated heating device, whereby element may be readily fabricated at a low cost, and the heating region is formed of a plastic thin layer, so that uniform temperature control is possible even with a low power, and various samples may be thermally treated at a fast speed to obtain their reaction and analysis.

摘要翻译： 本发明提供一种塑料微制造结构，微制造热装置，微制造反应器，微制造反应器阵列和使用其的微阵列，其可以应用于生物芯片，并且本发明可以制造塑料微制造结构以提供 通过绝缘塑料的加热区域，其具有薄的厚度，足够的平坦度，以允许执行光刻工艺，其一些或总面积的热隔离和小的热质量，以及在 形成塑料微加工结构，加热器，用于感测温度的温度传感器，电极和电极焊盘，从而制造微制造加热装置，从而可以以低成本容易地制造元件，并且加热区域由 塑料薄层，使得即使在低功率下也能进行均匀的温度控制，并且各种样品可以在fa处进行热处理 速度获得反应和分析。

公开(公告)号：US20080176534A1

公开(公告)日：2008-07-24

申请号：US12017753

申请日：2008-01-22

申请人： Kyu-Won KIM

发明人： Kyu-Won KIM

IPC分类号： H04Q7/22

CPC分类号： H04M1/72547 ,  H04L12/1859 ,  H04L51/38 ,  H04W68/00

摘要： Provided is a system for providing a silent advertisement that includes a multimedia message server for generating a multimedia message containing at least one piece of silent advertisement data and transmitting the multimedia message to an arbitrary mobile terminal, and the mobile terminal for receiving the multimedia message, detecting and storing the silent advertisement data contained in the multimedia message without notifying a user, and if a current operational state of the mobile terminal corresponds to a pre-set silent advertisement output condition, outputting the silent advertisement data. Accordingly, provided is a method, apparatus, and system for silently transmitting advertisement data to a mobile terminal of a user even if the user does not request to receive advertisements in advance, which are used by a communication provider to modify advertisement data stored in advance in the mobile terminal of the user in response to a request of a sponsor.

摘要翻译： 提供了一种用于提供静音广告的系统，其包括：多媒体消息服务器，用于生成包含至少一个静音广告数据的多媒体消息，并将多媒体消息发送到任意的移动终端;以及移动终端，用于接收多媒体消息， 检测和存储多媒体消息中包含的静音广告数据，而不通知用户，并且如果移动终端的当前操作状态对应于预置的无声广告输出条件，则输出静音广告数据。 因此，提供了即使用户没有请求预先接收广告来通知用户的广告数据静默地发送的方法，装置和系统，由通信提供商使用来修改预先存储的广告数据 在用户的移动终端中响应于赞助者的请求。

公开(公告)号：US07183056B2

公开(公告)日：2007-02-27

申请号：US10697295

申请日：2003-10-31

申请人： Se Ho Park ,  Hae Sik Yang ,  Dae Sik Lee ,  Yong Beom Shin ,  Kyu Won Kim ,  Tae Hwan Yoon ,  Sung Jin Kim ,  Yun Tae Kim

发明人： Se Ho Park ,  Hae Sik Yang ,  Dae Sik Lee ,  Yong Beom Shin ,  Kyu Won Kim ,  Tae Hwan Yoon ,  Sung Jin Kim ,  Yun Tae Kim

IPC分类号： C12Q1/68

CPC分类号： C12Q1/686 ,  C12Q2537/143 ,  C12Q2527/113 ,  C12Q2527/101

摘要： The present invention is directed to an improved multiplex PCR method for obtaining at least two PCR products from one PCR solution. In the multiplex PCR method for having at least two DNA amplified products from a sample positioned in a PCR equipment, the object of the present invention is to provide a novel multiplex PCR method characterized in that a primer annealing temperature and an extension time be changed per cycle with constant periods. When a multiplex PCR is performed in accordance with the present invention, limitations in determining PCR conditions due to a various sizes of PCR products or dimers caused by primers can be eliminated, and time and efforts required for determining the PCR conditions to various samples can also be reduced. Further, not only refined DNAs like cDNA, genomic DNA, vector, etc, but blood can be directly used as a multiplex PCR sample, and PCR amplification reaction can be performed even with a sample having the smallest amounts.

摘要翻译： 本发明涉及一种用于从一种PCR溶液获得至少两种PCR产物的改进的多重PCR方法。 本发明的目的是提供一种新的多重PCR方法，其特征在于，引物退火温度和延长时间根据 周期不变的周期。 当根据本发明进行多重PCR时，可以消除由于由引物引起的各种大小的PCR产物或二聚体导致的PCR条件的限制的限制，并且确定各种样品的PCR条件所需的时间和努力也可以 减少 此外，不仅可以将cDNA，基因组DNA，载体等精制DNA与血液直接用作多重PCR样品，即使使用量少的样品也能进行PCR扩增反应。

公开(公告)号：US20110171661A1

公开(公告)日：2011-07-14

申请号：US13057029

申请日：2008-08-26

申请人： Young Hwa Chung ,  Eun Sil Yu ,  Soo Hyung Ryu ,  Kyu Won Kim ,  Jeong A Kim

发明人： Young Hwa Chung ,  Eun Sil Yu ,  Soo Hyung Ryu ,  Kyu Won Kim ,  Jeong A Kim

IPC分类号： G01N33/53

CPC分类号： G01N33/57438 ,  G01N2800/54

摘要： Provided are a method of diagnosing the recurrence or possibility of recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery and a method of screening a drug for preventing the recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery and treating hepatocellular carcinoma. Specifically, the recurrence or possibility of recurrence of hepatocellular carcinoma after hepatocellular carcinoma surgery is diagnosed and a drug for preventing the recurrence of hepatocellular carcinoma after surgery and treating hepatocellular carcinoma is screened, by measuring expression levels of a metastatic tumor antigen 1 or metastasis associated 1 (MTA1) protein in a biological sample taken from a patient in which hepatocellular carcinoma recurs or is likely to recur after hepatocellular carcinoma surgery and comparing the measured expression levels of the MTA1 protein with those of a normal control group.

摘要翻译： 提供一种诊断肝细胞癌手术后肝细胞癌复发或复发可能性的方法，以及筛选肝细胞癌手术治疗肝细胞癌后肝细胞癌复发的药物方法。 具体来说，通过测定转移性肿瘤抗原1或转移相关的表达水平，筛选肝细胞癌手术后肝细胞癌复发或复发的可能性，并筛选用于预防手术后肝细胞癌复发和治疗肝细胞癌的药物 （MTA1）蛋白质，其中肝细胞癌复发或可能在肝细胞癌手术后复发的患者中获取，并比较测量的MTA1蛋白表达水平与正常对照组的表达水平。

公开(公告)号：US20110153855A1

公开(公告)日：2011-06-23

申请号：US12842608

申请日：2010-07-23

申请人： Kyu-won KIM

发明人： Kyu-won KIM

IPC分类号： G06F15/16

CPC分类号： H04L63/1441 ,  H04W12/12 ,  H04W88/02 ,  Y02D70/144

摘要： Provided is a method of defending against a battery exhaustion attack on a wireless communication device. The method includes: determining whether a battery exhaustion attack against a first wireless communication device occurred based on a connection state between the first wireless communication device and at least one second wireless communication device; if it is determined to be a battery exhaustion attack against the first wireless communication device, defending the battery exhaustion attack using a communication module of the first wireless communication device; and if it is determined that the is no a battery exhaustion attack against the first wireless communication device, performing communication between the first wireless communication device and the at least one second wireless communication device according to the connection state.

摘要翻译： 提供了防止无线通信设备上的电池耗尽攻击的方法。 该方法包括：基于第一无线通信设备和至少一个第二无线通信设备之间的连接状态来确定是否发生针对第一无线通信设备的电池耗尽攻击; 如果确定是针对第一无线通信设备的电池耗尽攻击，则使用第一无线通信设备的通信模块来防范电池耗尽攻击; 并且如果确定对第一无线通信设备没有电池耗尽攻击，则根据连接状态在第一无线通信设备和至少一个第二无线通信设备之间执行通信。