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    PROCESS FOR FERMENTING CO-CONTAINING GASEOUS SUBSTRATES
    11.
    发明申请
    PROCESS FOR FERMENTING CO-CONTAINING GASEOUS SUBSTRATES 审中-公开
    用于发生含有气相基质的方法

    公开(公告)号：US20140308723A1

    公开(公告)日：2014-10-16

    申请号：US14176094

    申请日：2014-02-09

    Applicant: INEOS BIO SA

    Inventor： Peter Simpson BELL ,  Song LIU

    IPC: C12P7/06 ,  C12P3/00

    CPC classification number: C12P7/06 ,  C12P3/00 ,  C12P7/065 ,  Y02E50/17

    Abstract: A process provides high ethanol productivity levels during fermentation of a CO-containing substrate. The process controls CO-substrate feed rates and cell density to avoid culture upset and CO inhibition. The process includes fermenting a CO-containing gaseous substrate to obtain a target cell density and a target CO feed rate, and then periodically reducing and increasing the CO feed rate.

    Abstract translation: 一种方法在含CO底物的发酵过程中提供高的乙醇生产率水平。 该过程控制CO底物进料速率和细胞密度，以避免培养不适和CO抑制。 该方法包括发酵含CO气体底物以获得目标细胞密度和目标CO进料速率，然后周期性地降低和提高CO进料速率。

    PROCESS FOR REDUCING CO2 EMISSIONS AND INCREASING ALCOHOL PRODUCTIVITY IN SYNGAS FERMENTATION
    12.
    发明申请
    PROCESS FOR REDUCING CO2 EMISSIONS AND INCREASING ALCOHOL PRODUCTIVITY IN SYNGAS FERMENTATION 审中-公开
    减少二氧化碳排放和增加酒精发酵中酒精生产力的方法

    公开(公告)号：US20140080195A1

    公开(公告)日：2014-03-20

    申请号：US14017903

    申请日：2013-09-04

    Applicant: INEOS BIO SA

    Inventor： Ryan Senaratne

    IPC: C12P7/08

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process is provided that is effective for reducing CO2 emissions, enhancing STY and/or increasing cell density. The process allows for utilization of syngas from different sources by controlling concentration levels of CO, CO2 and H2 in syngas provided to the fermentation and by controlling relative concentrations of CO, CO2 and H2 in the syngas provided to the fermentation. The process includes providing syngas to a first fermentation zone and fermenting the syngas. If the first fermentation zone off-gas includes about 4 mole % or more CO, then at least a portion of the first fermentor off-gas is provided to one or more subsequent fermentation zones.

    Abstract translation: 提供了一种有效减少二氧化碳排放，增强STY和/或增加细胞密度的方法。 该过程允许通过控制提供给发酵的合成气中的CO，CO 2和H 2的浓度水平以及通过控制提供给发酵的合成气中的CO，CO 2和H 2的相对浓度来利用来自不同来源的合成气。 该方法包括向第一发酵区提供合成气并发酵合成气。 如果第一发酵区废气包括约4摩尔％或更多的CO，则至少一部分第一发酵罐废气被提供给一个或多个后续的发酵区。

    PROCESS TO AVOID INHIBITION OF ACETOGENS BY CO
    13.
    发明申请
    PROCESS TO AVOID INHIBITION OF ACETOGENS BY CO 有权
    防止乙酰胆碱酯酶抑制的方法

    公开(公告)号：US20140080117A1

    公开(公告)日：2014-03-20

    申请号：US14018670

    申请日：2013-09-05

    Applicant: INEOS BIO SA

    Inventor： David Scott Snyder

    IPC: C12Q3/00

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 μM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 μM or less.

    Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12μM或更大的值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续发酵区，其量有效 用于在约0.12μM或更少的任何后续发酵区域中提供CO浓度。

    PROCESS FOR FERMENTATION OF SYNGAS
    16.
    发明申请
    PROCESS FOR FERMENTATION OF SYNGAS 审中-公开
    SYNGAS发酵工艺

    公开(公告)号：US20160090610A1

    公开(公告)日：2016-03-31

    申请号：US14962075

    申请日：2015-12-08

    Applicant: INEOS BIO SA

    Inventor： Peter Simpson Bell ,  Ching-Whan Ko

    IPC: C12P7/06

    Abstract: A process for fermenting syngas is provided which is effective for decreasing an amount of time needed to inoculate a main reactor. The process includes propagating a culture of acetogenic bacteria to provide an incoulum for a main reactor and fermenting syngas in the main reactor.

    Abstract translation: 提供一种发酵合成气的方法，其有效减少接种主反应器所需的时间。 该方法包括传播乙酰酵母细菌的培养物，以提供主反应器的入口和在主反应器中发酵合成气。

    PROCESS TO CONTROL CO CONCENTRATIONS IN FERMENTATIONS
    18.
    发明申请
    PROCESS TO CONTROL CO CONCENTRATIONS IN FERMENTATIONS 有权
    控制发酵食物浓度的过程

    公开(公告)号：US20150152464A1

    公开(公告)日：2015-06-04

    申请号：US14612528

    申请日：2015-02-03

    Applicant: INEOS BIO SA

    Inventor： David Scott Snyder

    IPC: C12Q1/04

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.

    Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。

    Process to avoid inhibition of acetogens by CO
    19.
    发明授权
    Process to avoid inhibition of acetogens by CO 有权
    CO避免醋酸菌抑制的过程

    公开(公告)号：US08980576B2

    公开(公告)日：2015-03-17

    申请号：US14018670

    申请日：2013-09-05

    Applicant: Ineos Bio SA

    Inventor： David Scott Snyder

    IPC: C12Q1/02 ,  B01D57/00 ,  C12P7/06 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process is provided for fermenting CO-containing gaseous substrates. The process is effective for decreasing lag times and maintaining a culture in steady state by controlling CO concentration and minimizing effects of high or low CO concentrations during fermentation. The process includes providing syngas to a first fermentation zone, fermenting the syngas, and determining a CO concentration in a fermentation medium in the first fermentation zone. If the CO concentration in fermentation medium in the first fermentation zone has a value of about 0.12 μM or greater, then at least a portion of the syngas being provided to the first fermentation zone is provided to one or more subsequent fermentation zones in an amount effective for providing a CO concentration in any subsequent fermentation zone of about 0.12 μM or less.

    Abstract translation: 提供了一种用于发酵含CO气体底物的方法。 该方法通过控制CO浓度和最小化发酵过程中高浓度或低CO浓度的影响，有效减少滞后时间并保持培养状态。 该方法包括向第一发酵区提供合成气，发酵合成气，以及确定第一发酵区中发酵培养基中的CO浓度。 如果第一发酵区的发酵培养基中的CO浓度具有约0.12μM或更大的值，则将提供给第一发酵区的合成气的至少一部分提供给一个或多个后续发酵区，其量有效 用于在约0.12μM或更少的任何后续发酵区域中提供CO浓度。

    PROCESS TO CONTROL CO CONCENTRATIONS IN FERMENTATIONS
    20.
    发明申请
    PROCESS TO CONTROL CO CONCENTRATIONS IN FERMENTATIONS 有权
    控制发酵食物浓度的过程

    公开(公告)号：US20140080116A1

    公开(公告)日：2014-03-20

    申请号：US14018608

    申请日：2013-09-05

    Applicant: INEOS BIO SA

    Inventor： David Scott Snyder

    IPC: C12Q3/00 ,  G01N33/84

    CPC classification number: C12Q1/04 ,  C12P7/065 ,  C12P7/08 ,  C12Q3/00 ,  G01N21/31 ,  G01N33/84 ,  Y02E50/17

    Abstract: A process for controlling concentration of CO in a bioreactor provides a direct and real time measurement of dissolved CO in a fermentation medium. The process for controlling concentrations of CO in a bioreactor includes contacting an aliquot of fermentation medium with at least one CO binding ligand and at least one microbial inactivator.

    Abstract translation: 用于控制生物反应器中CO浓度的方法提供了发酵培养基中溶解的CO的直接和实时测量。 用于控制生物反应器中CO浓度的方法包括将等分试样的发酵培养基与至少一种CO结合配体和至少一种微生物灭活剂接触。

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