公开(公告)号：US5585109A

公开(公告)日：1996-12-17

申请号：US518956

申请日：1995-08-24

Applicant: James A. Hayward ,  Mindy S. Goldstein ,  Miriam Brown ,  Joseph D. Ceccoli

Inventor： James A. Hayward ,  Mindy S. Goldstein ,  Miriam Brown ,  Joseph D. Ceccoli

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/11 ,  A61K8/14 ,  A61K8/33 ,  A61K8/368 ,  A61K8/44 ,  A61K8/55 ,  A61K8/58 ,  A61K9/127 ,  A61K31/60 ,  A61P17/00 ,  A61Q19/00 ,  B01J13/06

CPC classification number: A61K8/368 ,  A61K8/14 ,  A61Q19/00 ,  A61K2800/75

Abstract: A cosmetic composition and salicylic acid delivery system includes membrane lipid bylayers formed as liposomes and un-neutralized salicylic acid localized within the lipidic bylayers of the liposomes. Other cosmetic ingredients may be located either within the membrane compartment or in either the external or internal aqueous compartments relative the liposomal bylayers. The composition also includes an organic, water-soluble membrane-impermeant base and water.

Abstract translation: 化妆品组合物和水杨酸递送系统包括作为脂质体形成的膜脂质层和位于脂质体的脂质层内的未中和的水杨酸。 其他化妆品成分可以位于膜隔室内，也可以位于相对于脂质体层的外部或内部水性隔室中。 该组合物还包括有机的水溶性膜 - 不渗透基质和水。

公开(公告)号：US4675310A

公开(公告)日：1987-06-23

申请号：US803404

申请日：1985-11-21

Applicant: Dennis Chapman ,  James A. Hayward

Inventor： Dennis Chapman ,  James A. Hayward

IPC: A61K38/00 ,  A61K9/00 ,  A61K9/127 ,  A61K38/42 ,  A61K37/14 ,  A61K31/685

CPC classification number: A61K38/42 ,  A61K9/1273

Abstract: The invention herein involves the use of ligands and phospholipid liposomes as a carrier for the transport of various gases.

Abstract translation: PCT No.PCT / GB85 / 00114 Sec。 371日期：1985年11月21日 102（e）1985年11月21日PCT PCT。 出版物WO85 / 04326 1985年10月10日。本发明涉及使用配体和磷脂脂质体作为运输各种气体的载体。

公开(公告)号：US5935572A

公开(公告)日：1999-08-10

申请号：US781643

申请日：1997-01-10

Applicant: James A. Hayward ,  David C. Watkins

Inventor： James A. Hayward ,  David C. Watkins

IPC: A61K38/48 ,  A61K38/54 ,  A61P33/14 ,  A61K38/47 ,  C12N11/02

CPC classification number: A61K38/47 ,  A01N63/00 ,  A61K38/4873 ,  C12Y302/01014 ,  C12Y302/01017 ,  C12Y304/22002 ,  A61K9/127

Abstract: A composition containing a protease and glycosidase is provided for removing nits in the treatment of lice infestation. The protease and glycosidase are separated from each other to prevent the protease from hydrolyzing the glycosidase Separation is accomplished by encapsulating either the protease or glycosidase in a lipidic bilayer vesicle while leaving the other outside the vesicle. The protease and glycosidase destroy complex carbohydrate and protein in nit shells, nit embryos and substances secreted by adult lice. In a method of treatment, an infestation site such as hair is treated with a pediculoside and then with the composition containing a protease and glycosidase, and nits are removed such as by washing.

Abstract translation: 提供了含有蛋白酶和糖苷酶的组合物，用于在治疗虱子感染中除去尼丝。 将蛋白酶和糖苷酶彼此分离，以防止蛋白酶水解糖苷酶。通过将蛋白酶或糖苷酶包封在脂质双层囊泡中，同时将另一个留在囊泡外部来实现分离。 蛋白酶和糖苷酶破坏了硝基壳中的复合碳水化合物和蛋白质，硝基胚胎和成年虱子分泌的物质。 在一种治疗方法中，用梭菌素处理诸如头发的侵染部位，然后用含有蛋白酶和糖苷酶的组合物进行处理，并通过洗涤来除去尼丝。

公开(公告)号：US5437867A

公开(公告)日：1995-08-01

申请号：US33819

申请日：1993-03-19

Applicant: Thomas J. Vichroski ,  Regina A. Costa ,  James A. Hayward

Inventor： Thomas J. Vichroski ,  Regina A. Costa ,  James A. Hayward

IPC: A61K8/33 ,  A61K8/81 ,  A61K9/10 ,  A61K9/107 ,  A61Q19/00

CPC classification number: A61K8/33 ,  A61K8/8147 ,  A61Q19/00 ,  A61K2800/262 ,  A61Q13/00 ,  Y10S514/937 ,  Y10S514/944

Abstract: A cosmetic composition includes (a) ether alcohols conforming to the general formula C.sub.(n) H.sub.(2n+2) O.sub.(n/2), where n is an integer which ranges 4 to 12; (b) a homopolymer of acrylic acid cross-linked with an allyl ether of pentaerythritol or an allyl ether of sucrose, or copolymers of acrylic acid or acrylate derivative/acrylonitrile copolymers, or polyacrylic acid; (c) a fragrance oil or oils, or cosmetically acceptable oils or oily-type materials; and (d) water.

Abstract translation: 化妆品组合物包括（a）符合通式C（n）H（2n + 2）O（n / 2）的醚醇，其中n为4-12的整数; （b）与季戊四醇或蔗糖烯丙基醚的烯丙基醚交联的丙烯酸均聚物，或丙烯酸或丙烯酸酯衍生物/丙烯腈共聚物或聚丙烯酸的共聚物; （c）香料油或油，或化妆品可接受的油或油性物质; 和（d）水。

公开(公告)号：US4999348A

公开(公告)日：1991-03-12

申请号：US131458

申请日：1987-12-11

Applicant: Gheorghe Cioca ,  James A. Hayward ,  Manuel L. Tan ,  Morris Herstein ,  Walter P. Smith

Inventor： Gheorghe Cioca ,  James A. Hayward ,  Manuel L. Tan ,  Morris Herstein ,  Walter P. Smith

IPC: A61K8/02 ,  A61K8/67 ,  A61K9/127 ,  A61K31/07 ,  A61K31/23 ,  A61K31/355 ,  A61Q19/00

CPC classification number: A61Q19/00 ,  A61K31/07 ,  A61K31/23 ,  A61K31/355 ,  A61K8/0295 ,  A61K8/671 ,  A61K8/678 ,  A61K9/1274 ,  A61Q19/08

Abstract: Cosmetic and pharmaceutical compositions and methods comprising delivery systems for the controlled release and enhanced penetration of biologically active materials (e.g., Vitamin A) to the skin. The delivery systems comprise cholesteric liquid crystals wherein the active material is retained within the lamellar molecular structure (i.e., between the molecular sheets) of the cholesteric liquid crystal.

Abstract translation: 化妆品和药物组合物和方法包括用于控制释放和增强生物活性物质（例如维生素A）渗透到皮肤中的递送系统。 递送系统包括胆甾型液晶，其中活性材料保留在胆甾醇型液晶的层状分子结构内（即分子片之间）。

公开(公告)号：US20090075261A1

公开(公告)日：2009-03-19

申请号：US11954055

申请日：2007-12-11

Applicant: JAMES A. HAYWARD ,  MING-HWA LIANG ,  STEPHANE SHU-KIN-SO

Inventor： JAMES A. HAYWARD ,  MING-HWA LIANG ,  STEPHANE SHU-KIN-SO

IPC: C12Q1/68 ,  G01N21/00 ,  C09K11/84

CPC classification number: C12Q1/6816 ,  C08K5/09 ,  C09D7/63 ,  C09D11/03 ,  Y10T436/14 ,  Y10T436/143333 ,  Y10T442/2508 ,  C12Q2563/185

Abstract: A method for authenticating and verifying a pharmaceutical item to be genuine is described. The method for authenticating a tablet comprises applying a particular nucleic acid material associated with a particular sequence of nucleic acid bases to a tablet or capsule. The method also comprises collecting a sample of the tablet and verifying the tablet is genuine by detecting the particular nucleic acid material.

Abstract translation: 描述了用于认证和验证正品的药物的方法。 用于鉴定片剂的方法包括将与特定的核酸碱基序列相关联的特定核酸材料施用于片剂或胶囊。 该方法还包括收集片剂样品并通过检测特定的核酸材料来验证片剂是真实的。

公开(公告)号：US07175834B2

公开(公告)日：2007-02-13

申请号：US11114668

申请日：2005-04-26

Applicant: Duncan T. Aust ,  James M. Wilmott ,  James A. Hayward

Inventor： Duncan T. Aust ,  James M. Wilmott ,  James A. Hayward

IPC: A61Q17/04 ,  A61Q17/00 ,  A61Q19/00 ,  A61K8/00 ,  A61K8/04

CPC classification number: A61K8/044 ,  A61K8/73 ,  A61K2800/413 ,  A61Q17/04 ,  B82Y5/00

Abstract: The present invention relates to a sunscreen formulation which exhibits superior ultraviolet protection and water resistance than prior art sunscreen compositions. The sunscreen formulation comprises (a) a dispersion comprising a sunscreen active agent and (b) a base composition comprising a rheological modifying agent and water. The sunscreen formulation is substantially free of surfactants. According to a preferred embodiment, the sunscreen active agent is ethylhexylmethoxycinnamate, butylmethoxydibenzoylmethane, or a combination thereof. The sunscreen formulation preferably comprises a phosphorylated starch derivative as a rheological modifying agent. Another embodiment of the present invention is a method of protecting skin or hair from ultraviolet radiation by applying an effective amount of the sunscreen formulation of the present invention to the skin or hair.

Abstract translation: 本发明涉及与现有技术的防晒组合物相比表现出优异的紫外线防护性和耐水性的防晒制剂。 防晒制剂包含（a）包含防晒活性剂的分散体和（b）包含流变改性剂和水的基础组合物。 防晒制剂基本上不含表面活性剂。 根据优选的实施方案，防晒活性剂是甲氧基肉桂酸乙基己酯，丁基甲氧基二苯甲酰甲烷或其组合。 防晒制剂优选包含作为流变改性剂的磷酸化淀粉衍生物。 本发明的另一个实施方案是通过将有效量的本发明的防晒制剂施用于皮肤或毛发来保护皮肤或头发免受紫外线辐射的方法。

公开(公告)号：US06417171B1

公开(公告)日：2002-07-09

申请号：US09211931

申请日：1998-12-15

Applicant: James Maioriello ,  Jairo Rene Martinez ,  James A. Hayward

Inventor： James Maioriello ,  Jairo Rene Martinez ,  James A. Hayward

IPC: A01N4304

CPC classification number: C08B37/0072

Abstract: This invention utilizes methods of emulsion chemistry to derivative polymers, as distinguished from the synthetic methods of the prior art, whereby such polymers are derivative in a true solution. The derivative polymers are useful in that they may be readily reacted with small polymers or other molecules to form new polymeric entities. The new polymeric entities may be further derivative during the step of interracial dramatization, or may be provided for reaction to the product in a subsequent step to form the target product.

Abstract translation: 本发明利用乳液化学方法对衍生聚合物，与现有技术的合成方法不同，其中这种聚合物是真正的溶液中的衍生物。 衍生聚合物是有用的，因为它们可以容易地与小聚合物或其它分子反应形成新的聚合物。 新的聚合物可以在异种显色的步骤期间进一步衍生，或者可以在后续步骤中产生与产物的反应以形成目标产物。

公开(公告)号：US6071535A

公开(公告)日：2000-06-06

申请号：US255160

申请日：1999-02-22

Applicant: James A. Hayward ,  David C. Watkins ,  Duncan T. Aust

Inventor： James A. Hayward ,  David C. Watkins ,  Duncan T. Aust

IPC: A61K9/127 ,  A61K7/00 ,  A61K9/133

CPC classification number: A61K9/1272 ,  Y10S514/88 ,  Y10S514/881

Abstract: The present invention provides for liposomes formed with alkylammonium fatty acid salts, and methods for manufacturing same. The liposomes of the invention may deliver entrapped load material or materials at the occurrence of a preset triggering condition. Preferred liposomes of the invention are cationic liposomes. The preferred liposomes of the invention are formed with alkylammonium fatty acid salts, e.g., trialkylammonium fatty acid salts of long chain amides. The liposomes of the invention are used to encapsulate both hydrophobic and hydrophilic load materials. The liposomes formed accordingly are capable of delivering their loads upon the occurrence of a trigger or control condition.

Abstract translation: 本发明提供用烷基铵脂肪酸盐形成的脂质体及其制造方法。 本发明的脂质体可以在预设触发条件发生时传送截留的负载材料或材料。 本发明优选的脂质体是阳离子脂质体。 本发明优选的脂质体由烷基铵脂肪酸盐形成，例如长链酰胺的三烷基铵脂肪酸盐。 本发明的脂质体用于包封疏水和亲水负载材料。 相应形成的脂质体能够在发生触发或控制条件时递送其负载。