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公开(公告)号：US08586324B2
公开(公告)日：2013-11-19
申请号：US13209982
申请日：2011-08-15
Applicant: Michael D. Leach , Jennifer E. Woodell-May , Hillary Overholser , Joel C. Higgins , Jason Chavarria , Ned M. Hamman
Inventor： Michael D. Leach , Jennifer E. Woodell-May , Hillary Overholser , Joel C. Higgins , Jason Chavarria , Ned M. Hamman
IPC: C12Q1/56
CPC classification number: B01F15/026 , A61K35/16 , B01F1/0027 , B01F3/04446 , B01F13/0023 , B01F13/0052 , B01F15/00512 , B01F15/0227 , B01F15/0237 , B01F15/0266
Abstract: A method for preparing and isolating clotting serum. The method includes adding reagent and a clotting serum source to a reaction chamber of a clotting serum production device that includes an activator. The reagent, clotting serum source and activator are mixed by shaking the serum production device to bring the contents to a foam. The serum production device is placed in either a vacuum or at room temperature for a period of time, and the clotting serum is extracted from the reaction chamber.
Abstract translation: 制备和分离凝血液的方法。 该方法包括将试剂和凝血血清来源加入到包含活化剂的凝血血清生产装置的反应室中。 通过摇动血清生产装置将试剂，凝血血清来源和活化剂混合，使内容物发泡。 将血清产生装置置于真空或室温下一段时间，并从反应室中提取凝血液。
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12.发明授权公开(公告)号：US08523805B2
公开(公告)日：2013-09-03
申请号：US12260541
申请日：2008-10-29
Applicant: Jason Chavarria
Inventor： Jason Chavarria
IPC: A61M37/00
CPC classification number: A61B17/00491 , A61B2017/00495
Abstract: A system for expressing two materials onto a selected site is disclosed. The system can include a syringe that is operable to maintain two separated materials substantially separate until a selected time. The system can further include a tip portion operable to direct the two materials, either mixed or unmixed, to a selected site. The materials can include tissue sealants, growth factors, or other appropriate materials to be directed to a selected site.
Abstract translation: 公开了一种将两种材料表现在所选择的部位上的系统。 该系统可以包括可操作以将两个分离的材料基本上分离直到选定的时间的注射器。 该系统还可以包括可操作以将两种混合或不混合的材料引导到选定部位的尖端部分。 这些材料可以包括组织密封剂，生长因子或要被引导到选定部位的其它合适的材料。
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公开(公告)号：US08420029B2
公开(公告)日：2013-04-16
申请号：US13476587
申请日：2012-05-21
Applicant: Jason Chavarria
Inventor： Jason Chavarria
CPC classification number: B65B69/00 , B01L3/5021 , B01L3/508 , B01L9/06 , B01L2200/025 , B01L2200/141 , B01L2300/041 , B01L2300/0832 , B01L2400/0409 , Y10T436/2525 , Y10T436/25375
Abstract: A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed.
Abstract translation: 用于在无菌场和非无菌场之间运输生物材料容器并且基本上保持生物材料容器的无菌性的运输系统包括可移除地容纳生物材料容器的壳体组件。 该系统还包括由壳体组件限定的端口，并且该端口从壳体组件的外部提供到生物材料容器的连通。 壳体组件包括覆盖生物材料容器的第一部分的第一构件，使得生物材料容器的第二部分从第一构件延伸。 壳体组件还包括覆盖生物材料容器的第二部分的第二构件。 第二构件可移除地联接到第一构件以暴露生物材料容器的第二部分。 还公开了将离心机中的运输系统关键的键控构件。
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公开(公告)号：US20130045523A1
公开(公告)日：2013-02-21
申请号：US13209982
申请日：2011-08-15
Applicant: Michael D. Leach , Jennifer E. Woodell-May , Hillary Overholser , Joel C. Higgins , Jason Chavarria , Ned M. Hamman
Inventor： Michael D. Leach , Jennifer E. Woodell-May , Hillary Overholser , Joel C. Higgins , Jason Chavarria , Ned M. Hamman
CPC classification number: B01F15/026 , A61K35/16 , B01F1/0027 , B01F3/04446 , B01F13/0023 , B01F13/0052 , B01F15/00512 , B01F15/0227 , B01F15/0237 , B01F15/0266
Abstract: A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device.
Abstract translation: 一种凝血清洗生产装置，包括主室，入口壳体和出口。 主室由第一端壁，与第一端壁相对的第二端壁和在第一端壁和第二端壁之间延伸的侧壁限定。 入口壳体从第一端壁延伸。 入口壳体包括第一入口端口，第二入口端口和在第一入口端口和第二管道之间延伸的第一管道。 第二导管在第二入口和主室之间延伸。 入口壳体构造成提供从第一入口到第二入口的单向流体流，并且提供从第二入口到主室的单向流体流。 出口与主室流体连通并提供与凝血血清生产装置的外部的流体连通。
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公开(公告)号：US20110251041A1
公开(公告)日：2011-10-13
申请号：US12758127
申请日：2010-04-12
Applicant: Jason Chavarria , Michael D. Leach
Inventor： Jason Chavarria , Michael D. Leach
CPC classification number: A61M1/3693 , A61M1/3695 , B01D17/0217 , B01D21/262 , B01D21/307 , B01D2221/10 , B01L3/5021
Abstract: A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side.
Abstract translation: 一种用于将多组分材料分离成至少两个级分的分离系统。 分离系统包括具有第一端，与第一端相对的第二端以及在第一端和第二端之间延伸以限定具有内部容积的分离室的侧壁的分离装置。 所述系统还包括可在打开位置和关闭位置之间移动的阀，所述阀安装在所述分离室内的固定位置处，该位置比所述第一端更靠近所述第二端并与所述第二端分隔开 所述阀可操作以将所述阀的第一侧上具有第一密度的所述多组分材料的第一部分与所述阀的与所述第一侧相对的第二侧上具有第二密度的第二部分隔离。
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Patent Agency Ranking
公开(公告)号：US20090221075A1
公开(公告)日：2009-09-03
申请号：US12395085
申请日：2009-02-27
Applicant: Randel Dorian , Michael D. Leach , Richard W. Storrs , Jason Chavarria
Inventor： Randel Dorian , Michael D. Leach , Richard W. Storrs , Jason Chavarria
CPC classification number: C12M47/04 , B01L3/5021 , B01L3/50825 , B01L3/5635 , B01L2200/026 , B01L2300/046 , C12M47/02 , G01N1/286 , G01N1/4077
Abstract: Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
Abstract translation: 公开了从生物组织如组织样品分离，富集和/或纯化细胞群的系统。 例如，可以获取并破坏脂肪组织样品。 然后可以分离和纯化破碎的组织样品。 分离的组分可以包括多能，多能或其他细胞群体。
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公开(公告)号：US08790519B2
公开(公告)日：2014-07-29
申请号：US12485619
申请日：2009-06-16
Applicant: Michael D. Leach , Jason Chavarria
Inventor： Michael D. Leach , Jason Chavarria
CPC classification number: B04B11/06 , B01D21/0012 , B04B3/00 , B04B5/0442
Abstract: A method of extracting or removing a liquid phase from a whole sample using a centrifugal force is disclosed. Centrifugal forces are used to apply pressure to a whole sample and drive a liquid phase through a passage region that can be perforated and/or porous and maintain a drier portion within a separate container. The whole sample can be drier, which includes a remaining sample where excess or a selected amount of liquid is removed. Direct access to the separate container or area can then be made to provide for an efficient withdrawal of the drier material from the separation container.
Abstract translation: 公开了一种使用离心力从整个样品中提取或除去液相的方法。 离心力用于对整个样品施加压力，并将液相驱动通过可穿孔和/或多孔的通道区域，并将干燥器部分保持在单独的容器内。 整个样品可以是干燥的，其包括剩余的样品，其中去除了过量或选择量的液体。 然后可以直接进入单独的容器或区域以提供干燥剂材料从分离容器的有效抽出。
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公开(公告)号：US08591391B2
公开(公告)日：2013-11-26
申请号：US12758127
申请日：2010-04-12
Applicant: Jason Chavarria , Michael D. Leach
Inventor： Jason Chavarria , Michael D. Leach
IPC: B04B1/04
CPC classification number: A61M1/3693 , A61M1/3695 , B01D17/0217 , B01D21/262 , B01D21/307 , B01D2221/10 , B01L3/5021
Abstract: A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side.
Abstract translation: 一种用于将多组分材料分离成至少两个级分的分离系统。 分离系统包括具有第一端，与第一端相对的第二端以及在第一端和第二端之间延伸以限定具有内部容积的分离室的侧壁的分离装置。 所述系统还包括可在打开位置和关闭位置之间移动的阀，所述阀安装在所述分离室内的固定位置处，该位置比所述第一端更靠近所述第二端并与所述第二端分隔开 所述阀可操作以将所述阀的第一侧上具有第一密度的所述多组分材料的第一部分与所述阀的与所述第一侧相对的第二侧上具有第二密度的第二部分隔离。
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公开(公告)号：US20120228291A1
公开(公告)日：2012-09-13
申请号：US13476587
申请日：2012-05-21
Applicant: Jason Chavarria
Inventor： Jason Chavarria
IPC: B65D21/02
CPC classification number: B65B69/00 , B01L3/5021 , B01L3/508 , B01L9/06 , B01L2200/025 , B01L2200/141 , B01L2300/041 , B01L2300/0832 , B01L2400/0409 , Y10T436/2525 , Y10T436/25375
Abstract: A transportation system for transporting a biological material container between a sterile field and a nonsterile field and substantially maintaining sterility of the biological material container includes a housing assembly that removably houses the biological material container. The system also includes a port defined by the housing assembly, and the port provides communication into the biological material container from outside the housing assembly. The housing assembly includes a first member that covers a first portion of the biological material container such that a second portion of the biological material container extends from the first member. The housing assembly also includes a second member that covers the second portion of the biological material container. The second member is removably coupled to the first member to expose the second portion of the biological material container. A keying member that keys the transportation system in a centrifuge is also disclosed.
Abstract translation: 用于在无菌场和非无菌场之间运输生物材料容器并且基本上保持生物材料容器的无菌性的运输系统包括可移除地容纳生物材料容器的壳体组件。 该系统还包括由壳体组件限定的端口，并且该端口从壳体组件的外部提供到生物材料容器的连通。 壳体组件包括覆盖生物材料容器的第一部分的第一构件，使得生物材料容器的第二部分从第一构件延伸。 壳体组件还包括覆盖生物材料容器的第二部分的第二构件。 第二构件可移除地联接到第一构件以暴露生物材料容器的第二部分。 还公开了将离心机中的运输系统关键的键控构件。
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公开(公告)号：US20110014705A1
公开(公告)日：2011-01-20
申请号：US12504413
申请日：2009-07-16
Applicant: Michael D. Leach , Jason Chavarria
Inventor： Michael D. Leach , Jason Chavarria
CPC classification number: A61M1/029 , A61M1/3693 , A61M2202/0437 , A61M2202/10 , B01D21/262 , B01D21/307 , B01D2221/10
Abstract: According to various embodiments, a system can be provided to separate undifferentiated cells and/or stromal cells from a whole tissue sample. The whole tissue sample can be any appropriate tissue sample obtained directly from a patient. The tissue sample can be obtained during a selected operating procedure for immediate or quick application or re-application to the patient. Accordingly, autologous cells can be obtained intraoperatively for application to a patient substantially soon after obtaining a whole tissue sample.
Abstract translation: 根据各种实施方案，可以提供系统以从整个组织样品中分离未分化的细胞和/或基质细胞。 整个组织样本可以是直接从患者获得的任何合适的组织样本。 可以在选择的操作程序期间获得组织样品，以立即或快速施用或重新施用于患者。 因此，在获得整个组织样本之后，可以在术中基本上很快获得自体细胞以供给患者。
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