公开(公告)号：US20050275214A1

公开(公告)日：2005-12-15

申请号：US10866922

申请日：2004-06-14

Applicant: Joshua Pokempner ,  Jonathan Wright ,  Kellie Hebert-Folin

Inventor： Joshua Pokempner ,  Jonathan Wright ,  Kellie Hebert-Folin

IPC: B42D15/00

CPC classification number: B44F3/00 ,  B44F1/10 ,  C09D11/50

Abstract: Color-changing inks are used in conjunction with printed material, with defined fields to create unique designs and/or works of art. In the preferred embodiment, pre-printed pages or books are used with fields of invisible inks that are activated with different pens to produce a unique final product. In alternative embodiments, stickers, paints, flocking, foil stamping, thermography, embossing and rubber stamps may be used. In specific embodiments, depictions of cartoon characters or other humans or animals are intermingled with more geometric fields, often with instructions or text explaining to a user what actions should be taken for a desired effect or outcome. Patterns of “invisible inks” having desired properties are pre-printed onto materials according to the invention, such that, through the use of different activator pens, different colors are produced in the various fields, thereby rendering a unique product in each case.

Abstract translation: 变色油墨与印刷材料结合使用，具有定义的领域，以创建独特的设计和/或艺术作品。 在优选实施例中，预打印的页面或书籍与不可见墨水的领域一起使用，其中不同的笔激活以产生独特的最终产品。 在替代实施例中，可以使用贴纸，油漆，植绒，箔压印，热成像，压花和橡胶印章。 在具体实施例中，卡通人物或其他人或动物的描绘与更多的几何场混合，通常具有向用户解释为了期望的效果或结果应采取什么动作的指令或文本。 具有所需性质的“不可见墨水”的图案被预先印刷到根据本发明的材料上，使得通过使用不同的活化笔，在各种领域中产生不同的颜色，从而在每种情况下形成独特的产品。

公开(公告)号：US5409931A

公开(公告)日：1995-04-25

申请号：US192238

申请日：1994-02-04

Applicant: Bradley W. Caprathe ,  Dennis M. Downing ,  Juan C. Jaen ,  Stephen J. Johnson ,  William J. Smith, III ,  Lawrence D. Wise ,  Jonathan Wright ,  David J. Wustrow

Inventor： Bradley W. Caprathe ,  Dennis M. Downing ,  Juan C. Jaen ,  Stephen J. Johnson ,  William J. Smith, III ,  Lawrence D. Wise ,  Jonathan Wright ,  David J. Wustrow

IPC: A61K31/36 ,  A61K31/357 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P43/00 ,  C07D20060101 ,  C07D211/70 ,  C07D211/82 ,  C07D213/38 ,  C07D213/74 ,  C07D239/26 ,  C07D239/42 ,  C07D295/02 ,  C07D295/03 ,  C07D295/04 ,  C07D317/58 ,  C07D401/08 ,  C07D405/08 ,  C07D409/04 ,  C07D409/08 ,  C07D417/08 ,  A61K31/50 ,  C07D401/00 ,  C07D403/00

CPC classification number: C07D213/74 ,  C07D211/70 ,  C07D295/03 ,  C07D401/08 ,  C07D405/08 ,  C07D409/04 ,  C07D409/08

Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

Abstract translation: 描述了1,3-取代的环烯烃和环烷烃，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。

公开(公告)号：US20090074701A1

公开(公告)日：2009-03-19

申请号：US11855450

申请日：2007-09-14

Applicant: Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

Inventor： Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

IPC: A61K8/58 ,  A61Q5/10

CPC classification number: A61Q5/065 ,  A61K8/891 ,  A61K8/898 ,  A61K2800/594

Abstract: The invention relates to methods of artificially coloring hair including applying to hair a composition containing at least one silicone film forming resin, at least one polysilicone polymer, and at least one hair colorant.

Abstract translation: 本发明涉及人发毛发的方法，包括向毛发施用含有至少一种硅氧烷成膜树脂，至少一种聚硅氧烷聚合物和至少一种毛发着色剂的组合物。

公开(公告)号：US20070060598A1

公开(公告)日：2007-03-15

申请号：US11411413

申请日：2006-04-26

Applicant: Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

Inventor： Ronald Albers ,  Leticia Ayala ,  Steven Clareen ,  Maria Delgado Mederos ,  Robert Hilgraf ,  Sayee Hegde ,  Kevin Hughes ,  Adam Kois ,  Veronique Plantevin-Krenitsky ,  Meg McCarrick ,  Lisa Nadolny ,  Moorthy Palanki ,  Kiran Sahasrabudhe ,  John Sapienza ,  Yoshitaka Satoh ,  Marianne Sloss ,  Elise Sudbeck ,  Jonathan Wright

IPC: A61K31/52 ,  C07D473/14

CPC classification number: A61K31/52 ,  C07D473/32

Abstract: Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound and methods for treating or preventing cancer, a cardiovascular disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, ischemia-reperfusion injury, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension or a condition treatable or preventable by inhibition of the JNK pathway comprising administering an effective amount of an Aminopurine Compound to a patient in need thereof.

Abstract translation: 本文提供具有以下结构的氨基嘌呤化合物：其中R 1，R 2和R 3如本文所定义，包含有效量的组合物 的氨基嘌呤化合物和治疗或预防癌症，心血管疾病，肾脏疾病，自身免疫病症，炎性病症，黄斑变性，缺血再灌注损伤，疼痛和相关综合征，疾病相关性消耗，石棉相关的方法 条件，肺动脉高压或通过抑制JNK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的氨基嘌呤化合物。

公开(公告)号：US5314896A

公开(公告)日：1994-05-24

申请号：US957277

申请日：1992-10-15

Applicant: Bradley W. Caprathe ,  Dennis M. Downing ,  Juan C. Jaen ,  Stephen J. Johnson ,  William J. Smith, III ,  Lawrence D. Wise ,  Jonathan Wright ,  David J. Wustrow

Inventor： Bradley W. Caprathe ,  Dennis M. Downing ,  Juan C. Jaen ,  Stephen J. Johnson ,  William J. Smith, III ,  Lawrence D. Wise ,  Jonathan Wright ,  David J. Wustrow

IPC: A61K31/36 ,  A61K31/357 ,  A61K31/425 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/495 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P43/00 ,  C07D20060101 ,  C07D211/70 ,  C07D211/82 ,  C07D213/38 ,  C07D213/74 ,  C07D239/26 ,  C07D239/42 ,  C07D295/02 ,  C07D295/03 ,  C07D295/04 ,  C07D317/58 ,  C07D401/08 ,  C07D405/08 ,  C07D409/04 ,  C07D409/08 ,  C07D417/08

CPC classification number: C07D213/74 ,  C07D211/70 ,  C07D295/03 ,  C07D401/08 ,  C07D405/08 ,  C07D409/04 ,  C07D409/08

Abstract: 1,3-Substituted cycloalkenes and cycloalkanes are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as dopaminergic, antipsychotic, and antihypertensive agents as well as for treating hyperprolactinaemia-related conditions and central nervous system disorders.

Abstract translation: 描述了1,3-取代的环烯烃和环烷烃，以及其制备方法及其药物组合物，其可用作中枢神经系统试剂，并且特别可用作多巴胺能抗精神病药和抗高血压药以及用于治疗高泌乳素血症 相关病症和中枢神经系统疾病。

公开(公告)号：US20100233114A1

公开(公告)日：2010-09-16

申请号：US12699941

申请日：2010-02-04

Applicant: Michael S. DeGeorge ,  Jonathan Wright ,  Jeremy Puco

Inventor： Michael S. DeGeorge ,  Jonathan Wright ,  Jeremy Puco

IPC: A61K8/84 ,  A61K8/898 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12

CPC classification number: A61Q5/12 ,  A61K8/585 ,  A61K8/898 ,  A61K2800/594 ,  A61Q5/00 ,  A61Q5/02

Abstract: The invention relates to compositions containing at least one silicone film forming resin and at least one polysilicone polymer, as well as to methods of applying such compositions to keratin materials.

Abstract translation: 本发明涉及含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物，以及将这些组合物应用于角蛋白材料的方法。

公开(公告)号：US06448270B1

公开(公告)日：2002-09-10

申请号：US09592883

申请日：2000-06-13

Applicant: Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F.W. Keana

Inventor： Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F.W. Keana

IPC: A61K31445

CPC classification number: C07D401/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D405/06

Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using the 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as cerebral ischemia, central nervous system trauma, hypoglycemia, neurodegenerative disorders, anxiety, migraine headaches, convulsions, aminoglycoside antibiotics-induced hearing loss, chronic pain, psychosis, glaucoma, CMV retinitis, opioid tolerance or withdrawal, urinary incontinence and neurodegenerative disorders such as lathyrism, Alzheimers' Disease, Parkinsonism, and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.

Abstract translation: 新的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如脑缺血，中枢神经 系统性创伤，低血糖症，神经退行性疾病，焦虑症，偏头痛，惊厥，氨基糖苷类抗生素诱发的听力损失，慢性疼痛，精神病，青光眼，CMV视网膜炎，阿片样物质耐受或戒断，尿失禁和神经退行性疾病，如莱姆里斯，阿尔茨海默病， 描述了帕金森综合征和亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

公开(公告)号：US6130234A

公开(公告)日：2000-10-10

申请号：US91594

申请日：1996-12-20

Applicant: Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F. W. Keana

Inventor： Christopher F. Bigge ,  Jonathan Wright ,  Sui Xiong Cai ,  Eckard Weber ,  Richard Woodward ,  Nancy C. Lan ,  Zhang-Lin Zhou ,  John F. W. Keana

IPC: A61K31/00 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/451 ,  A61K31/4523 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/498 ,  A61K31/505 ,  A61K31/517 ,  A61K31/529 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P43/00 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/48 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D211/70 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/06 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D235/08

CPC classification number: C07D401/06 ,  C07D211/14 ,  C07D211/18 ,  C07D211/42 ,  C07D211/44 ,  C07D211/46 ,  C07D211/52 ,  C07D211/54 ,  C07D211/58 ,  C07D405/06

Abstract: Novel 4-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 4-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartate (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headaches, glaucoma, CMV retinitis, chronic pain, opioid tolerance or withdrawals, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described. Also described are novel methods for preparing 4-substituted piperidine analogs and novel intermediates of the 4-substituted piperidine analogs.

Abstract translation: PCT No.PCT / US96 / 20766 Sec。 371日期：1998年9月16日 102（e）1998年9月16日PCT PCT 1996年12月20日PCT公布。 公开号WO97 / 23214 PCT 日期1997年7月3日新颖的4-取代的哌啶类似物，含有它们的药物组合物和使用4-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如中风 ，脑缺血，中枢神经系统创伤，低血糖症，焦虑症，抽搐，氨基糖苷类抗生素诱发的听力损失，偏头痛，青光眼，CMV视网膜炎，慢性疼痛，阿片样物质耐受或戒断，或神经退行性疾病，如幻影，阿尔茨海默病，帕金森综合征 并描述亨廷顿氏病。 还描述了制备4-取代的哌啶类似物和4-取代的哌啶类似物的新中间体的新方法。

公开(公告)号：US07601179B2

公开(公告)日：2009-10-13

申请号：US11855598

申请日：2007-09-14

Applicant: Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

Inventor： Delphine Allard ,  David W. Cannell ,  Michael S. DeGeorge ,  Jeremy Puco ,  Jonathan Wright

IPC: A61Q5/10

CPC classification number: A61Q5/065 ,  A61K8/891 ,  A61K8/898 ,  A61K2800/594

Abstract: The invention relates to methods of preserving artificial color on keratin materials including applying to artificially colored keratin materials a composition containing at least one silicone film forming resin and at least one polysilicone polymer.

Abstract translation: 本发明涉及在角蛋白材料上保存人造色的方法，包括向人造着色的角蛋白材料施用含有至少一种硅氧烷成膜树脂和至少一种聚硅氧烷聚合物的组合物。

公开(公告)号：US20090157841A1

公开(公告)日：2009-06-18

申请号：US11957134

申请日：2007-12-14

Applicant: Richard Shailer Turner, JR. ,  Pradyumna Siddhartha ,  Ignatius Setiadi ,  Eric Jonathan Wright

Inventor： Richard Shailer Turner, JR. ,  Pradyumna Siddhartha ,  Ignatius Setiadi ,  Eric Jonathan Wright

IPC: G06F15/16

CPC classification number: G06F16/958

Abstract: A media publisher manager generates a plug-in for each of a plurality of providers. Each provider hosts a web space including a media object and implements a plurality of services related to the media object. Executing the plug-in causes at least one of the plurality of services related to the media object to be performed on at least one of plurality of providers. The media publisher manager request is receives from a client. The request includes a function related to a media object and a moniker of the media object. The moniker is generated from a media object identifier and a provider identifier. A plug-in is selected based on the provider identifier of the moniker. Executing the selected plug-in causes a service related to the media object to be preformed on the provider, said service related to the requested function.

Abstract translation: 媒体发行商经理为多个提供商中的每一个生成插件。 每个提供商承载包括媒体对象的网络空间，并且实现与媒体对象相关的多个服务。 执行插件导致在多个提供者中的至少一个提供者上执行与媒体对象相关的多个服务中的至少一个。 媒体发布商经理的请求是从客户端接收。 该请求包括与媒体对象和媒体对象的标记相关的功能。 标记是从媒体对象标识符和提供者标识符生成的。 基于标记的提供商标识符选择插件。 执行所选择的插件导致与媒体对象相关的服务在提供者上执行，所述服务涉及所请求的功能。