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    Fungal cell wall degrading enzyme
    14.
    发明授权
    Fungal cell wall degrading enzyme 有权
    真菌细胞壁降解酶

    公开(公告)号：US07635470B2

    公开(公告)日：2009-12-22

    申请号：US10586026

    申请日：2006-02-16

    申请人： Wenping Wu ,  Kirk Matthew Schnorr

    发明人： Wenping Wu ,  Kirk Matthew Schnorr

    IPC分类号： A61K38/46 ,  C12Q1/34 ,  C12N9/14

    CPC分类号： C12N9/2462 ,  A23K20/147 ,  A23K20/189 ,  A61K8/64 ,  A61K38/00 ,  A61Q11/00 ,  C11D3/386 ,  C11D3/38636

    摘要： A novel fungal enzyme having lysozyme activity has been isolated. The invention further relates to a fungal polypeptide having lysozyme activity and belonging to the GH25 family, wherein the enzyme is selected from the group consisting of (a) a polypeptide comprising an amino acid sequence, which has at least 80% identity with amino acids 1 to 233 of SEQ ID NO:2; (b) a polypeptide comprising an amino acid sequence, which has at least 80% identity with the polypeptide encoded by the lysozyme encoding part of the nucleotide sequence inserted into a plasmid present in strain DSM 16084; (c) a polypeptide which is encoded by a nucleotide sequence which hybridizes under high stringency conditions with a polynucleotide probe consisting of the complementary strand of nucleotides 84 to 782 of SEQ ID NO:1; or (d) a fragment of (a), (b) or (c) that has lysozyme activity.

    摘要翻译： 已经分离出具有溶菌酶活性的新型真菌酶。 本发明还涉及具有溶菌酶活性并属于GH25家族的真菌多肽，其中所述酶选自（a）包含氨基酸序列的多肽，所述氨基酸序列与氨基酸1具有至少80％的同一性 至233的SEQ ID NO：2; （b）包含氨基酸序列的多肽，所述氨基酸序列与插入到菌株DSM 16084中存在的质粒中的编码核苷酸序列的部分的溶菌酶编码的多肽具有至少80％的同一性; （c）由在高严格条件下与SEQ ID NO：1的核苷酸84至782的互补链组成的多核苷酸探针的核苷酸序列编码的多肽; 或（d）具有溶菌酶活性的（a），（b）或（c）的片段。