公开(公告)号：US20060089381A1

公开(公告)日：2006-04-27

申请号：US11254864

申请日：2005-10-21

Applicant: Atsushi Onishi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Kozo Tachibana

IPC: C07D215/14 ,  A61K31/47 ,  C08B37/00

CPC classification number: C07D215/14 ,  C07B2200/07

Abstract: A method of producing Ethyl (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-yl]-3,5-dihydroxy-6-heptenoate by means of liquid chromatography using a packing material comprising a carrier and, carried thereon, a polysaccharide derivative, wherein a part or all of the hydrogen atoms of hydroxyl and amino groups of the polysaccharide derivative are substituted with one or more substituents, such as a carbamoyl group wherein one hydrogen atom is substituted with an aromatic group having a specific alkyl group. The method allows the production of the above (3R,5S,6E) isomer with enhanced productivity to a conventional method.

Abstract translation: 通过液相色谱法使用（3R，5S，6E）-7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯 包含载体的载体和载体上的多糖衍生物，其中多糖衍生物的羟基和氨基的一部分或全部氢原子被一个或多个取代基取代，例如氨基甲酰基，其中一个氢原子是 被具有特定烷基的芳基取代。 该方法允许以常规方法以高生产率生产上述（3R，5S，6E）异构体。

公开(公告)号：US06946557B2

公开(公告)日：2005-09-20

申请号：US10398915

申请日：2001-10-12

Applicant: Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

Inventor： Atsushi Onishi ,  Koichi Murazumi ,  Kozo Tachibana

IPC: A61K31/47 ,  B01D15/08 ,  B01D15/18 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J20/29 ,  B01J20/32 ,  C07B57/00 ,  C07D215/04 ,  C07D215/14

CPC classification number: B01J20/328 ,  B01D15/185 ,  B01D15/3833 ,  B01J20/262 ,  B01J20/265 ,  B01J20/286 ,  B01J20/29 ,  B01J20/3204 ,  B01J20/3272 ,  B01J2220/54 ,  C07B2200/07 ,  C07D215/14

Abstract: The objective of this invention is to provide a process for producing an optically active isomer of ethyl 7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6-heptenoate by optically resolving an optical isomer mixture of the compound at a high productivity. The process is characterized by employing a filler comprising a carrier and a specific amount of cellulose tris (4-chlorophenyl carbamate) supported the carrier and carrying out chromatographic separation under the condition that the capacity factors have specific values.

Abstract translation: 本发明的目的是提供通过光学制备7- [2-环丙基-4-（4-氟苯基）喹啉-3-基] -3,5-二羟基-6-庚烯酸乙酯的旋光异构体的方法 以高生产率分解化合物的旋光异构体混合物。 该方法的特征在于使用包含载体和特定量的纤维素三（4-氯苯基氨基甲酸酯）的填料负载载体并在容量因子具有特定值的条件下进行色谱分离。

公开(公告)号：US5514818A

公开(公告)日：1996-05-07

申请号：US386865

申请日：1995-02-10

Applicant: Kozo Tachibana

Inventor： Kozo Tachibana

IPC: B01J20/281 ,  B01J20/24 ,  B01J20/291 ,  C07B57/00 ,  C07D301/00 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07D303/12 ,  C07D303/14 ,  C07D303/16 ,  C07D303/22 ,  C07D303/48 ,  G01N30/02 ,  G01N30/88

CPC classification number: C07D303/22 ,  C07D301/00 ,  C07D301/32 ,  C07D303/04 ,  C07D303/08 ,  C07D303/12 ,  C07D303/16 ,  C07D303/48

Abstract: A method of resolving a mixture of stereoisomers of an aliphatic epoxide containing two or less oxygen atoms is provided. The method comprises utilizing a polysaccharide or a derivative thereof as a resolving agent.

Abstract translation: 提供了一种拆分含有两个或更少氧原子的脂族环氧化物的立体异构体的混合物的方法。 该方法包括使用多糖或其衍生物作为拆分剂。

公开(公告)号：US5412114A

公开(公告)日：1995-05-02

申请号：US15408

申请日：1993-02-09

Applicant: Seiji Shinkai ,  Tsutomu Matsuda ,  Takashi Arimura ,  Hirosuke Kawabata ,  Kozo Tachibana

Inventor： Seiji Shinkai ,  Tsutomu Matsuda ,  Takashi Arimura ,  Hirosuke Kawabata ,  Kozo Tachibana

IPC: C07B57/00 ,  C07C2/86 ,  C07C13/70 ,  C07C41/01 ,  C07C43/20 ,  C07C43/21 ,  C07D213/30 ,  C07D313/00

CPC classification number: C07D213/30 ,  C07C43/21 ,  C07C2103/92

Abstract: The present invention relates to an improvement in the process for preparing a calixarene derivative in which the rotation of its benzene units are hindered and which comprises replacing all or a part of the hydrogen atoms of the hydroxyl groups of a calixarene derivative represented by the general formula: ##STR1## and is characterized by conducting the reaction in the presence of an alkaline earth metal. According to the present invention, an asymmetric calixarene derivative having a "cone" conformation can be selectively prepared by virtue of the template effect of the metal.

Abstract translation: 本发明涉及制备其苯单元旋转受阻的杯芳烃衍生物的制备方法的改进，其包括用通式（I）表示的杯芳烃衍生物的羟基的全部或一部分代替 ：，其特征在于在碱土金属存在下进行反应。 根据本发明，可以通过金属的模板效应选择性地制备具有“锥形”构型的不对称杯芳烃衍生物。

公开(公告)号：US20110084716A1

公开(公告)日：2011-04-14

申请号：US12996215

申请日：2008-08-18

Applicant: Eiichi Nagao ,  Kentaro Taninouchi ,  Noboru Hosokawa ,  Tsuyoshi Amimoto ,  Kozo Tachibana ,  Hirotaka Muto ,  Junji Tanimura ,  Satoru Toyama

Inventor： Eiichi Nagao ,  Kentaro Taninouchi ,  Noboru Hosokawa ,  Tsuyoshi Amimoto ,  Kozo Tachibana ,  Hirotaka Muto ,  Junji Tanimura ,  Satoru Toyama

IPC: G01R27/08

CPC classification number: H01F27/14 ,  G01N27/92 ,  G01R27/14 ,  H01F27/402 ,  H01F2027/404

Abstract: An object of the invention is to provide a diagnostic method for an oil-filled electrical device that considers a temperature distribution in the oil-filled electrical device and enables accurate diagnosis to be conducted even when the method is applied to diagnosis of an actually operating device, and further provide a method with which such diagnosis of an oil-filled electrical device can be conducted from a component analysis value of an insulating oil in the oil-filled electrical device. The invention is a diagnostic method for an oil-filled electrical device including in an insulating oil a metal part wrapped with insulating paper, and determines that a time when a surface resistivity of a maximum precipitation site where metal sulfide is most precipitated on the insulating paper reaches a preset surface resistivity management value is a time of occurrence of an abnormality.

Abstract translation: 本发明的目的是提供一种充油电气装置的诊断方法，其考虑充油电气装置中的温度分布，并且即使当该方法应用于实际操作装置的诊断时也能够进行准确的诊断 并且还提供了一种通过充油电气装置中的绝缘油的成分分析值来进行充油电气装置的这种诊断的方法。 本发明是一种充油电气装置的诊断方法，其包括绝缘油中的绝缘纸包裹的金属部件，并且确定在绝缘纸上金属硫化物最沉淀的最大析出位置的表面电阻率 达到预设的表面电阻率管理值是发生异常的时间。

公开(公告)号：US20060079708A1

公开(公告)日：2006-04-13

申请号：US11254856

申请日：2005-10-21

Applicant: Keiko Kudo ,  Kozo Tachibana ,  Koichi Murazumi

Inventor： Keiko Kudo ,  Kozo Tachibana ,  Koichi Murazumi

IPC: C07C69/76 ,  C08B37/00

CPC classification number: C07D209/24 ,  B01D15/1821 ,  B01D15/3833 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/328 ,  C07B2200/07 ,  C07D209/12

Abstract: An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid chromatography with a packing material constituted of a carrier and a polysaccharide derivative carried on the carrier. The polysaccharide derivative is a polysaccharide in which the hydrogen atoms constituting the hydroxyl and amino groups are partially or all replaced by one or more kinds of groups selected from among carbamoyl groups monosubstituted with aromatic groups having specific alkyl groups and benzoyl groups having specific alkyl groups. According to the invention, optically active dihydroxyheptenoic acid esters can be separated more distinctly.

Abstract translation: 具有芳族基团的光学活性二羟基庚烯酸酯通过液相色谱与含有载体的载体和载体上的多糖衍生物的包装材料从含有二羟基庚酸的旋光异构体的混合物的溶液中分离出来。 多糖衍生物是其中构成羟基和氨基的氢原子部分或全部被选自由具有特定烷基的芳族基团和具有特定烷基的苯甲酰基单取代的氨基甲酰基中的一种或多种基团取代的多糖。 根据本发明，可以更明确地分离光学活性的二羟基庚烯酸酯。