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公开(公告)号：US20130005782A1
公开(公告)日：2013-01-03
申请号：US13583068
申请日：2011-03-23
Applicant: Alexandre Chigaev , Larry A. Sklar
Inventor： Alexandre Chigaev , Larry A. Sklar
IPC: G01N33/566 , G01N33/577 , G01N21/64 , A61K31/197 , C07C233/63 , A61K31/42 , C07D261/18 , A61K31/36 , C07D317/68 , A61P25/00 , A61P21/04 , A61P27/02 , A61P7/00 , A61P7/06 , A61P9/00 , A61P19/02 , A61P29/00 , A61P17/00 , A61P19/04 , A61P19/00 , A61P1/00 , A61P1/16 , A61P1/04 , A61P3/10 , A61P5/00 , A61P17/06 , A61P11/06 , A61P11/00 , A61P37/00 , A61P9/10 , A61P13/12 , A61P37/06 , A61P17/12 , A61P35/00 , A61P35/04 , C40B30/04
CPC classification number: G01N33/5041 , A61K31/195 , A61K31/197 , A61K31/357 , A61K31/36 , A61K31/42 , G01N33/5055 , G01N33/68 , G01N2333/70546 , G01N2333/7055 , G01N2500/04 , G01N2500/10
Abstract: This invention relates generally to integrin ligand discovery and to a method of integrin ligand discovery base upon induction of ligand-induced epitopes. Such ligands have the potential to be active agent as anti-inflammatory, anti-angiogenesis and/or anti-thrombotic agents and for the treatment of integrin mediated diseases and/or conditions.
Abstract translation: 本发明一般涉及整合素配体发现和基于诱导配体诱导表位的整联蛋白配体发现的方法。 这样的配体具有作为抗炎，抗血管生成和/或抗血栓形成剂的活性剂的潜力，并且用于治疗整联蛋白介导的疾病和/或病症。
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公开(公告)号：US20110312536A1
公开(公告)日：2011-12-22
申请号：US13136807
申请日：2011-08-11
Applicant: Larry A. Sklar , Bruce S. Edwards , Frederick W. Kuckuck
Inventor： Larry A. Sklar , Bruce S. Edwards , Frederick W. Kuckuck
CPC classification number: G01N15/1436 , B01L3/5085 , G01N15/1404 , G01N15/1459 , G01N21/6428 , G01N21/6486 , G01N35/0099 , G01N35/085 , G01N35/1095 , G01N2015/0065 , G01N2015/1006 , G01N2015/1402 , G01N2015/1413 , G01N2015/1477 , G01N2015/149 , G01N2021/6439 , G01N2201/06113 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。
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公开(公告)号：US07842244B2
公开(公告)日：2010-11-30
申请号：US12151252
申请日：2008-05-05
Applicant: Larry A. Sklar , Bruce S. Edwards , Frederick W. Kuckuck
Inventor： Larry A. Sklar , Bruce S. Edwards , Frederick W. Kuckuck
CPC classification number: G01N15/1436 , B01L3/5085 , G01N15/1404 , G01N15/1459 , G01N21/6428 , G01N21/6486 , G01N35/0099 , G01N35/085 , G01N35/1095 , G01N2015/0065 , G01N2015/1006 , G01N2015/1402 , G01N2015/1413 , G01N2015/1477 , G01N2015/149 , G01N2021/6439 , G01N2201/06113 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。
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14.发明申请Rapid Mixing Device for Subsecond Analysis of Cell Surface Kinetics in Flow Cytometry 审中-公开快速混合装置，用于流式细胞术中细胞表面动力学的二次分析公开(公告)号：US20100129848A1
公开(公告)日：2010-05-27
申请号：US12375931
申请日：2007-08-28
Applicant: James Bogert , Richard Posner , Larry A. Sklar
Inventor： James Bogert , Richard Posner , Larry A. Sklar
CPC classification number: G01N15/1404 , G01N1/38 , G01N2015/1409
Abstract: The present invention provides improved flow cytometry tubes containing ports to allow rapid addition and mixing of reagents with sample during flow cytometry. The present invention further provides rapid mixing cytometry devices and method for their use in rapid reagent mixing during flow cytometry.
Abstract translation: 本发明提供改进的流式细胞仪管，其包含端口，以允许在流式细胞术期间快速添加和混合试剂与样品。 本发明还提供了快速混合细胞计量装置及其在流式细胞术中快速试剂混合中的应用。
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15.发明授权Multiplex analysis for high throughput discrimination of GPCR agonists and antagonists 有权GPCR激动剂和拮抗剂高通量鉴别的多重分析公开(公告)号：US07232659B1
公开(公告)日：2007-06-19
申请号：US10771853
申请日：2004-02-04
Applicant: Larry A. Sklar , Eric R. Prossnitz , Peter Simons , Anna Waller , Daniel Cimino , Sean Biggs
Inventor： Larry A. Sklar , Eric R. Prossnitz , Peter Simons , Anna Waller , Daniel Cimino , Sean Biggs
IPC: G01N33/53 , G01N33/566 , G01N27/00 , G01N21/76 , C07N1/00
CPC classification number: G01N33/74 , G01N33/537 , Y10T436/13
Abstract: The present invention relates generally to molecular assemblies, more particularly to an assay for the detection of G-protein coupled receptor (GPCR) molecular assemblies and bead-based detection of ligand-GPCR complexes and to methods for identifying compounds as agonists, partial agonists or antagonists of the binding of G-protein coupled receptors to G-protein and for use of these compounds in the treatment of conditions or disease states in a mammalian subject or patient, including humans, where G-protein coupled receptor binding to G-protein is implicated.
Abstract translation: 本发明一般涉及分子组装，更具体地涉及用于检测G蛋白偶联受体（GPCR）分子组装和基于珠子的配体-GPCR复合物的检测方法，以及鉴定化合物作为激动剂，部分激动剂或 G蛋白偶联受体与G蛋白结合的拮抗剂，以及这些化合物用于治疗哺乳动物受试者或患者（包括人）中的条件或疾病状态的用途，其中G蛋白偶联受体结合G蛋白是 牵连
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Patent Agency Ranking
16.发明授权Modular assembly for reagentless affinity separation and detection of analyte 有权用于无试剂亲和力分离和分析物检测的模块化装配公开(公告)号：US06660532B1
公开(公告)日：2003-12-09
申请号：US09402682
申请日：1999-12-16
Applicant: Gabriel P. Lopez , Larry A. Sklar , Philip Hampton , Leonard Tender , Kimberly Opperman , Emmanuel Rabinovich , Ravinder K. Jain , Juchao Yan
Inventor： Gabriel P. Lopez , Larry A. Sklar , Philip Hampton , Leonard Tender , Kimberly Opperman , Emmanuel Rabinovich , Ravinder K. Jain , Juchao Yan
IPC: G01N3353
CPC classification number: B82Y30/00 , G01N33/54373 , G01N33/553 , G01N33/582 , Y10S435/808 , Y10S436/805 , Y10S436/806
Abstract: The invention provides a reagentless assay kit for analyte in a sample comprising a modular affinity assembly including at least one sensor unit comprising a ligand having binding affinity for the analyte (affinity module) operatively associated with a reporter probe (reporter module) responsive to changes in the sensor unit induced by analyte/receptor complex formation by transduction of a characteristic detectable signal. Assays employing the modular assembly are also provided.
Abstract translation: 本发明提供了一种用于样品中分析物的无试剂测定试剂盒，其包括模块化亲和力组件，其包括至少一个传感器单元，所述至少一个传感器单元包含与分析物（亲和性模块）具有结合亲合力的配体， 通过转导特征可检测信号由分析物/受体复合物形成引起的传感器单元。 还提供了使用模块化组件的测定。
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公开(公告)号：US20140187442A1
公开(公告)日：2014-07-03
申请号：US14134754
申请日：2013-12-19
Applicant: Larry A. Sklar , Bruce Edwards , Frederick Kuckuck
Inventor： Larry A. Sklar , Bruce Edwards , Frederick Kuckuck
IPC: G01N21/64
CPC classification number: G01N15/1436 , B01L3/5085 , G01N15/1404 , G01N15/1459 , G01N21/6428 , G01N21/6486 , G01N35/0099 , G01N35/085 , G01N35/1095 , G01N2015/0065 , G01N2015/1006 , G01N2015/1402 , G01N2015/1413 , G01N2015/1477 , G01N2015/149 , G01N2021/6439 , G01N2201/06113 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流动流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。
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公开(公告)号：US20130150336A1
公开(公告)日：2013-06-13
申请号：US13636785
申请日：2011-03-24
Applicant: WIlliam C. Burhans , Catherine E. Prudom , Christopher P. Allen , Oleg Ursu , Anna Waller , Larry A. Sklar
Inventor： WIlliam C. Burhans , Catherine E. Prudom , Christopher P. Allen , Oleg Ursu , Anna Waller , Larry A. Sklar
CPC classification number: A61K31/58 , A61K31/498 , A61K31/56 , C12Q1/025 , G01N2500/10 , G01N2800/7009
Abstract: Provided are methods and compositions for reducing superoxide anions such that a prophylactic or therapeutic effect against conditions associated with excess oxidative stress achieved. The compositions and methods provide for reducing inflammation and for enhancing lifespan of eukaryotic organisms. A screen for identifying compounds that can be used in these methods is also provided.
Abstract translation: 提供了用于减少超氧化物阴离子的方法和组合物，使得针对与过量氧化应激相关的病症达到预防或治疗效果。 组合物和方法提供减少炎症并增加真核生物的寿命。 还提供了用于鉴定可用于这些方法中的化合物的筛选。
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公开(公告)号：US08268571B2
公开(公告)日：2012-09-18
申请号：US13136807
申请日：2011-08-11
Applicant: Larry A Sklar , Bruce Edwards , Frederick Kuckuck
Inventor： Larry A Sklar , Bruce Edwards , Frederick Kuckuck
IPC: G01N33/53 , G01N33/567 , G01N35/08
CPC classification number: G01N15/1436 , B01L3/5085 , G01N15/1404 , G01N15/1459 , G01N21/6428 , G01N21/6486 , G01N35/0099 , G01N35/085 , G01N35/1095 , G01N2015/0065 , G01N2015/1006 , G01N2015/1402 , G01N2015/1413 , G01N2015/1477 , G01N2015/149 , G01N2021/6439 , G01N2201/06113 , Y10T436/117497 , Y10T436/118339 , Y10T436/119163 , Y10T436/2575
Abstract: The present invention, provides a flow cytometry apparatus for the detection of particles from a plurality of samples comprising: means for moving a plurality of samples comprising particles from a plurality of respective source wells into a fluid flow stream; means for introducing a separation gas between each of the plurality of samples in the fluid flow stream; and means for selectively analyzing each of the plurality of samples for the particles. The present invention also provides a flow cytometry method employing such an apparatus.
Abstract translation: 本发明提供了一种用于检测多个样品中的颗粒的流式细胞仪装置，包括：用于将包含多个相应源阱的颗粒的多个样品移动到流体流中的装置; 用于在所述流体流动流中的所述多个样品中的每一个之间引入分离气体的装置; 以及用于选择性地分析用于颗粒的多个样品中的每一个的装置。 本发明还提供了使用这种装置的流式细胞术方法。
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20.发明申请Compounds and methods for the selective inhibition of ABCB1, ABCC1 and ABCG2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors 审中-公开用于选择性抑制ABCB1，ABCC1和ABCG2转运蛋白的化合物和方法以及治疗癌症，特别是耐药性癌症和高通量流式细胞术检测选择性抑制剂公开(公告)号：US20090208493A1
公开(公告)日：2009-08-20
申请号：US12315132
申请日：2008-11-28
Applicant: Richard S. Larson , Larry A. Sklar , Bruce S. Edwards , Irena D. Ivnitski-Steele , Tudor I. Oprea , Debbie M. Lovato , Hadya M. Khawaja , Stuart S. Winter , Susan M. Young
Inventor： Richard S. Larson , Larry A. Sklar , Bruce S. Edwards , Irena D. Ivnitski-Steele , Tudor I. Oprea , Debbie M. Lovato , Hadya M. Khawaja , Stuart S. Winter , Susan M. Young
CPC classification number: A61K31/12 , A61K31/415 , A61K45/06 , A61K2300/00
Abstract: Compounds disclosed which inhibit ABCB1 transporter protein are useful for treating diseases in which ABCB1 transporter protein mediates the disease state, including numerous cancers, including hematopoietic cancers, including various leukemias, especially T-lineage acute lymphoblastic leukemia, as well as cancerous tumors, especially forms which exhibit multiple drug resistance. Pharmaceutical compositions which comprise an inhibitor of ABCB1 transporter protein and at least one additional anticancer agent, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient are another aspect of the present invention. A flow cytometry based, high-throughput screening (HST) assay that quantifies ABCB1 efflux is also disclosed. Methods of identifying inhibitors of ABCB1, ABCG2 and ABCC1 transporter proteins are also disclosed.
Abstract translation: 公开的抑制ABCB1转运蛋白的化合物可用于治疗其中ABCB1转运蛋白介导疾病状态的疾病，包括许多癌症，包括造血癌，包括各种白血病，特别是T-lineage急性成淋巴细胞白血病，以及癌性肿瘤，特别是形式 其表现出多种耐药性。 包含ABCB1转运蛋白抑制剂和至少一种另外的抗癌剂的药物组合物，任选与药学上可接受的载体，添加剂或赋形剂组合是本发明的另一方面。 还公开了量化ABCB1流出的基于流式细胞术的高通量筛选（HST）测定。 还公开了鉴定ABCB1，ABCG2和ABCC1转运蛋白抑制剂的方法。
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