Patent search ap:"MATTHIAS GERLACH" Page 2

11.

发明申请
SULFONYLGUANIDINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF 失效
Title translation: 磺酰胺类化合物及其药物用途

公开(公告)号：US20080085900A1

公开(公告)日：2008-04-10

申请号：US11742946

申请日：2007-05-01

Applicant: MATTHIAS GERLACH , Heinz Uragg , Michael Haurand , Claudia Puetz , Corinna Sundermann , Boris Chizh

Inventor： MATTHIAS GERLACH , Heinz Uragg , Michael Haurand , Claudia Puetz , Corinna Sundermann , Boris Chizh

IPC: A61K31/18 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4402 , A61K31/4458 , A61K31/495 , A61K31/505 , A61K31/5375 , A61P25/00 , C07C311/18 , C07D207/16 , C07D213/58 , C07D213/72 , C07D231/38 , C07D239/26 , C07D295/12 , C07D295/28 , C07D307/52 , C07D333/22

CPC classification number: C07D213/40 , C07C311/49 , C07C311/64 , C07C2601/14 , C07D213/75 , C07D213/77 , C07D231/40 , C07D239/26 , C07D295/215 , C07D295/32 , C07D307/52 , C07D333/20 , C07D401/12 , C07D409/12 , C07D521/00

Abstract: Sulfonylguanidine compounds corresponding to the tautomeric formulas I and Ia, a method for producing them, pharmaceutical compositions containing them, and methods of using them to prepare medicaments and for treating various medical conditions. The sulfonylguanidine compounds have an affinity for the gabapentin binding site and can be used to treat conditions such as pain, epilepsy, migraine and others.

Abstract translation: 对应于互变异构体式I和Ia的磺酰胍化合物，其制备方法，含有它们的药物组合物及其用于制备药物和用于治疗各种医疗条件的方法。磺酰胍类化合物对加巴喷丁结合位点具有亲和力，可用于治疗疼痛，癫痫，偏头痛等疾病。

12.

发明授权
Substituted 1 and 2-naphthol Mannich bases 失效
Title translation: 取代的1和2-萘酚曼尼希碱

公开(公告)号：US07202242B2

公开(公告)日：2007-04-10

申请号：US10757581

申请日：2004-01-15

Applicant: Matthias Gerlach , Corinna Maul

Inventor： Matthias Gerlach , Corinna Maul

IPC: A61K31/535 , C07D265/30

CPC classification number: C07D295/096 , C07C215/50 , C07C217/58 , C07C219/28 , C07C225/16 , C07C229/38 , C07C237/48 , C07C243/38 , C07C311/37 , C07D295/135 , C07D295/155

Abstract: The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of medicaments.

Abstract translation: 本发明涉及取代的1和2萘酚曼尼希碱，其制备方法，含有所述化合物的药物和所述化合物在制备药物中的用途。

13.

发明授权
Substituted 5,6,6a, 11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds as NMDA-antagonists 失效
Title translation: 取代5,6,6a，11b-四氢-7-氧杂-5-氮杂 - 苯并[c]芴-6-羧酸化合物作为NMDA-拮抗剂

公开(公告)号：US07199130B2

公开(公告)日：2007-04-03

申请号：US10770126

申请日：2004-02-03

Applicant: Matthias Gerlach , Michael Przewosny , Werner Guenter Englberger , Elke Reissmueller , Petra Bloms-Funke , Corinna Maul , Utz-Peter Jagusch

Inventor： Matthias Gerlach , Michael Przewosny , Werner Guenter Englberger , Elke Reissmueller , Petra Bloms-Funke , Corinna Maul , Utz-Peter Jagusch

IPC: A61K31/4741 , C07D491/06

CPC classification number: C07D491/04

Abstract: Substituted 5,6,6a,11b-tetrahydro-7-oxa-5-aza-benzo[c]fluorene-6-carboxylic acid compounds, and processes for the production thereof, pharmaceutical compositions containing these compounds and the use thereof in treatment methods and for the production of pharmaceutical preparations for specific indications, in particular for the treatment of pain.

Abstract translation: 取代的5,6,6a，11b-四氢-7-氧杂-5-氮杂 - 苯并[c]芴-6-羧酸化合物及其制备方法，含有这些化合物的药物组合物及其在治疗方法中的用途并用于制备具体适应症的药物制剂，特别是用于治疗疼痛。

14.

发明授权
Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines 失效

公开(公告)号：US07153873B2

公开(公告)日：2006-12-26

申请号：US11447141

申请日：2006-06-06

Applicant: Matthias Gerlach , Corinna Sundermann

Inventor： Matthias Gerlach , Corinna Sundermann

IPC: C07D487/04 , C07D417/04 , A61K31/4188 , C07D513/04

CPC classification number: C07D471/04 , C07D487/04 , C07D513/04

Abstract: Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceutical compositions comprising the same and methods using the pharmaceutical compositions for the treatment or prophylaxis of pain, drug or alcohol abuse, diarrhoea, gastritis, ulcers, urinary incontinence, depression, narcolepsy, overweight, asthma, glaucoma, tinnitus, itching, hyperkinetic syndrome, epilepsy, or schizophrenia, for inducing anesthesia, and for anxiolysis.

15.

发明授权
Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines 失效

公开(公告)号：US07087607B2

公开(公告)日：2006-08-08

申请号：US10273344

申请日：2002-10-18

Applicant: Matthias Gerlach , Corinna Sundermann

Inventor： Matthias Gerlach , Corinna Sundermann

IPC: C07D487/04 , C07D235/00 , A61K31/4188

CPC classification number: C07D471/04 , C07D487/04 , C07D513/04

Abstract: Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceutical compositions comprising the same and methods using the pharmaceutical compositions for the treatment or prophylaxis of pain, drug or alcohol abuse, diarrhoea, gastritis, ulcers, urinary incontinence, depression, narcolepsy, overweight, asthma, glaucoma, tinnitus, itching, hyperkinetic syndrome, epilepsy, or schizophrenia, for inducing anesthesia, and for anxiolysis.

16.

发明授权
Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring 失效
Title translation: 在6元环上取代的双环咪唑-3-基 - 胺衍生物

公开(公告)号：US06849642B2

公开(公告)日：2005-02-01

申请号：US10117334

申请日：2002-04-08

Applicant: Matthias Gerlach , Corinna Maul

Inventor： Matthias Gerlach , Corinna Maul

IPC: C07D487/00 , A61K31/437 , A61K31/4745 , A61K31/519 , A61P25/04 , A61P43/00 , C07B61/00 , C07D471/04 , C07D487/04 , C07D513/04 , C07F9/6561 , C07D471/00

CPC classification number: C07D471/04 , C07D487/04 , C07D513/04 , C07F9/6561 , C40B40/00

Abstract: Bicyclic imidazo-3-yl-amine derivatives substituted on the 6-membered ring, and pharmaceutical compositions containing these compounds, useful, inter alia, as analgesics.

Abstract translation: 在6元环上取代的双环咪唑-3-基 - 胺衍生物，以及含有这些化合物的药物组合物，尤其用作镇痛药。

17.

发明申请
Acridine derivatives and their use as medicaments 审中-公开
Title translation: 吖啶衍生物及其用作药物

公开(公告)号：US20050009809A1

公开(公告)日：2005-01-13

申请号：US10879280

申请日：2004-06-29

Applicant: Matthias Gerlach , Peter Emig , Klaus Paulini , Michael Czech , Tilman Schuster , Eckhard Gunther

Inventor： Matthias Gerlach , Peter Emig , Klaus Paulini , Michael Czech , Tilman Schuster , Eckhard Gunther

IPC: A61K31/496 , A61K31/551 , C07D219/04 , C07D219/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D493/04 , C07

CPC classification number: C07D219/04 , C07D219/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D493/04

Abstract: The invention relates to novel acridine derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for the treatment of tumors.

Abstract translation: 本发明涉及式1的新型吖啶衍生物，其制备及其用作药物，特别是用于治疗肿瘤。

18.

发明授权
Triazole derivatives with improved receptor activity and bioavailability properties as ghrelin antagonists of growth hormone secretagogue receptors 有权
Title translation: 具有改善的受体活性和生物利用度性质的三唑衍生物作为生长激素促分泌素受体的生长素释放肽拮抗剂

公开(公告)号：US08546435B2

公开(公告)日：2013-10-01

申请号：US13235116

申请日：2011-09-16

Applicant: Babette Aicher , Gilbert Mueller , Klaus Paulini , Lars Blumenstein , Peter Schmidt , Matthias Gerlach , Michael Teifel , Jean Martinez , Jean-Alain Fehrentz , Anne-Laure Blayo

Inventor： Babette Aicher , Gilbert Mueller , Klaus Paulini , Lars Blumenstein , Peter Schmidt , Matthias Gerlach , Michael Teifel , Jean Martinez , Jean-Alain Fehrentz , Anne-Laure Blayo

IPC: A61K31/41 , C07D249/08

CPC classification number: A61K31/4196 , C07D401/14 , C07D403/06 , C07D403/14 , C07D413/14

Abstract: The present invention provides novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin analogue ligands of growth hormone secretagogue receptors according to formula (I) that are useful in the treatment or prophylaxis of physiological and/or pathophysiological conditions in mammals, preferably humans, that are mediated by GHS receptors. The present invention further provides GHS receptor antagonists and agonists that can be used for modulation of these receptors and are useful for treating above conditions, in particular alcohol disorder, drug abuse, growth retardation, cachexia, short-, medium-, and/or long term regulation of energy balance, short-, medium-, and/or long term regulation (stimulation and/or inhibition) of food intake, intake of rewarding food, adipogenesis, adiposity and/or obesity, body weight gain and/or reduction, diabetes, diabetes type I, diabetes type II, tumor cell proliferation, inflammation, inflammatory effects, gastric postoperative ileus, postoperative ileus and/or gastrectomy (ghrelin replacement therapy).

Abstract translation: 本发明提供具有改善的受体活性和生物利用度性质的新型三唑衍生物，其作为根据式（I）的生长激素促分泌素受体的生长激素释放肽类似物配体可用于治疗或预防哺乳动物（优选人）中的生理和/或病理生理状况，这是由GHS受体介导的。本发明还提供了可用于调节这些受体的GHS受体拮抗剂和激动剂，并且可用于治疗上述病症，特别是酒精障碍，药物滥用，生长迟缓，恶病质，短期，中期和/或长期能量平衡，短期，中期和/或长期调节（刺激和/或抑制）食物摄取，有益食物摄取，肥胖和/或肥胖，体重增加和/或减少的长期调节，糖尿病，I型糖尿病，II型糖尿病，肿瘤细胞增殖，炎症，炎症反应，胃后肠梗阻，术后肠梗阻和/或胃切除术（Ghrelin替代疗法）。