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    Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof
    11.
    发明授权
    Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof 有权
    双环杂环，含有所述化合物的药物，其用途及其生产方法

    公开(公告)号：US07998949B2

    公开(公告)日：2011-08-16

    申请号：US12525742

    申请日：2008-01-30

    申请人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz ,  Markus Ostermeier

    发明人： Frank Himmelsbach ,  Birgit Jung ,  Ralf Lotz ,  Markus Ostermeier

    IPC分类号： A61K31/517

    CPC分类号： C07D239/94 ,  C07D401/12

    摘要： The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb and Rc are defined as in claim 1, their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids and bases, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式的双环杂环，其中Ra，Rb和Rc如权利要求1所定义，其互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸和碱的生理上可接受的盐，其中 具有有价值的药理学特性，特别是对由酪氨酸激酶介导的信号转导的抑制作用，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生（BPH））肺和气道疾病的用途 ，及其制备。

    STEREOSELECTIVE SYNTHESIS OF BICYCLIC HETEROCYCLES
    15.
    发明申请
    STEREOSELECTIVE SYNTHESIS OF BICYCLIC HETEROCYCLES 审中-公开
    双相杂环化合物的选择性合成

    公开(公告)号：US20140135495A1

    公开(公告)日：2014-05-15

    申请号：US14154441

    申请日：2014-01-14

    申请人： Markus OSTERMEIER ,  Juergen DAEUBLER ,  Guenther HUCHLER ,  Stephan KLING ,  Marco SANTAGOSTINO

    发明人： Markus OSTERMEIER ,  Juergen DAEUBLER ,  Guenther HUCHLER ,  Stephan KLING ,  Marco SANTAGOSTINO

    IPC分类号： C07D403/12 ,  C07D241/38

    CPC分类号： C07D403/12 ,  C07D239/70 ,  C07D241/38 ,  Y02P20/55

    摘要： The present invention relates to a process for the stereoselective preparation of compounds of formulae (1A) and (1B) and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids and bases, which have valuable pharmacological properties, particularly an inhibitory effect on signal transduction mediated by tyrosine kinases, the use thereof for the treatment of diseases, particularly tumoral diseases as well as benign prostatic hyperplasia (BPH), diseases of the lungs and airways.

    摘要翻译： 本发明涉及立体选择性制备式（1A）和（1B）化合物及其盐，特别是其与无机或有机酸和碱的生理上可接受的盐，其具有有价值的药理学性质，特别是抑制性 对由酪氨酸激酶介导的信号转导的作用，其用于治疗疾病，特别是肿瘤疾病以及良性前列腺增生（BPH），肺和气道疾病的用途。

    BICYCLIC HETEROCYCLES, DRUGS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION THEREOF
    19.
    发明申请
    BICYCLIC HETEROCYCLES, DRUGS CONTAINING SAID COMPOUNDS, USE THEREOF, AND METHOD FOR PRODUCTION THEREOF 有权
    双相异构体，含有化合物的药物，其用途及其生产方法

    公开(公告)号：US20100022505A1

    公开(公告)日：2010-01-28

    申请号：US12525742

    申请日：2008-01-30

    申请人： Frank Himmelsbach ,  Birgil Jung ,  Ralf Lotz ,  Markus Ostermeier

    发明人： Frank Himmelsbach ,  Birgil Jung ,  Ralf Lotz ,  Markus Ostermeier

    IPC分类号： A61K31/497 ,  C07D239/72 ,  A61K31/517 ,  A61P35/04 ,  C07D403/12

    CPC分类号： C07D239/94 ,  C07D401/12

    摘要： The present invention relates to bicyclic heterocycles of general formula wherein Ra, Rb and Rc are defined as in claim 1, their tautomers, their stereoisomers, their mixtures and their salts, in particular their physiologically acceptable salts with inorganic or organic acids and bases, which have valuable pharmacological properties, in particular an inhibitory action on the signal transduction mediated by tyrosine kinases, their use for the treatment of illnesses, in particular of tumoral diseases and of benign prostatic hyperplasia (BPH), of diseases of the lung and of the airways, and the preparation thereof.

    摘要翻译： 本发明涉及通式的双环杂环，其中Ra，Rb和Rc如权利要求1所定义，其互变异构体，其立体异构体，其混合物及其盐，特别是其与无机或有机酸和碱的生理上可接受的盐，其中 具有有价值的药理学特性，特别是对由酪氨酸激酶介导的信号转导的抑制作用，其用于治疗疾病，特别是肿瘤疾病和良性前列腺增生（BPH））肺和气道疾病的用途 ，及其制备。