公开(公告)号：US20060073346A1

公开(公告)日：2006-04-06

申请号：US10957993

申请日：2004-10-04

申请人： Michael Super ,  Karl Haider

发明人： Michael Super ,  Karl Haider

IPC分类号： B32B27/40

CPC分类号： C08G18/672 ,  C08G18/7664 ,  Y10T428/31551

摘要： The present invention provides polyester-polyurethane composites made by applying a polyurethane matrix including at least one polyether containing both hydroxyl-functionality and unsaturation-functionality to an unsaturation-containing polyester matrix. Adhesion between the polyester matrix and the polyurethane matrix in the inventive composites is promoted by the polyether containing both hydroxyl-functionality and unsaturation-functionality.

摘要翻译： 本发明提供了通过将包含至少一种含有羟基官能团和不饱和官能团的聚醚的聚氨酯基质涂覆到含不饱和聚酯基体而制备的聚酯 - 聚氨酯复合材料。 本发明复合材料中聚酯基质和聚氨酯基质之间的粘合力由含有羟基官能团和不饱和官能团的聚醚促进。

公开(公告)号：US20140220617A1

公开(公告)日：2014-08-07

申请号：US14007738

申请日：2012-04-02

申请人： Chong Wing Yung ,  Karel Domansky ,  Richard Terry ,  David Kalish ,  Alexa Schulte ,  Joo Hun Kang ,  Donald E. Ingber ,  Michael Super ,  Ryan M. Cooper

发明人： Chong Wing Yung ,  Karel Domansky ,  Richard Terry ,  David Kalish ,  Alexa Schulte ,  Joo Hun Kang ,  Donald E. Ingber ,  Michael Super ,  Ryan M. Cooper

IPC分类号： C12Q1/04 ,  B03C1/00 ,  B01L3/00

CPC分类号： C12Q1/04 ,  A61M1/36 ,  A61M1/3618 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/56 ,  B01L2200/0652 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/043 ,  B01L2400/0487 ,  B03C1/002 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/26

摘要： A dialysis like therapeutic (DLT) device is provided. The DLT device includes at least one source channel connected at least one collection channels by one or more transfer channels. Fluid contacting surface of the channels can be an anti-fouling surface such as slippery liquid-infused porous surface (SLIPS). Fluids can be flown at high flow rates through the channels. The target components of the source fluid can be magnetic or bound to magnetic particles using an affinity molecule. A source fluid containing magnetically bound target components can be pumped through the source channel of the microfluidic device. A magnetic field gradient can be applied to the source fluid in the source channel causing the magnetically bound target components to migrate through the transfer channel into the collection channel. The collection channel can include a collection fluid to flush the target components out of the collection channel. The target components can be subsequently analyzed for detection and diagnosis. The source channel and the collection channels of the microfluidic device are analogous to the splenic arterioles and venules, respectively; the transfer channels mimic the vascular sinusoids of the spleen where opsonized particles are retained. Thus, the device acts as a dialysis like therapeutic device by combining fluidics and magnetics.

摘要翻译： 提供透析治疗（DLT）装置。 DLT设备包括通过一个或多个传输信道连接至少一个收集信道的至少一个源信道。 通道的流体接触表面可以是防污表面，例如滑动的液体注入的多孔表面（SLIPS）。 流体可以通过通道以高流速流动。 源流体的目标组分可以是磁性的或使用亲和分子结合到磁性颗粒。 含有磁结合的靶组分的源流体可以泵送通过微流体装置的源通道。 磁场梯度可以施加到源通道中的源流体，使得磁结合的目标分量通过传输通道迁移到收集通道中。 收集通道可以包括收集流体以将目标组分冲洗出收集通道。 随后分析目标成分进行检测和诊断。 微流体装置的源通道和收集通道分别类似于脾小动脉和小静脉; 转移通道模拟脾脏的血管窦状，其中保留调理颗粒。 因此，通过组合流体学和磁性，该装置作为透析像治疗装置。

公开(公告)号：US20140187666A1

公开(公告)日：2014-07-03

申请号：US13980858

申请日：2012-01-19

申请人： Joanna Aizenberg ,  Benjamin Hatton ,  Donald Ingber ,  Michael Super ,  Tak Sing Wong

发明人： Joanna Aizenberg ,  Benjamin Hatton ,  Donald Ingber ,  Michael Super ,  Tak Sing Wong

IPC分类号： C09D5/16

CPC分类号： C09D5/1693 ,  A61L15/24 ,  A61L15/34 ,  A61L15/42 ,  A61L15/46 ,  A61L27/28 ,  A61L27/34 ,  A61L27/50 ,  A61L33/0094 ,  A61L33/064 ,  A61L2400/12 ,  B05D5/083 ,  C09D5/1656 ,  C09D5/1681 ,  F15D1/02 ,  F15D1/10 ,  C08L27/12

摘要： A self-healing, scratch resistant slippery surface that is manufactured by wicking a chemically-inert, high-density liquid coating over a roughened solid surface featuring micro and nanoscale topographies is described. Such a slippery surface shows anti-wetting properties, as well as exhibits significant reduction of adhesion of a broad range of biological materials, including particles in suspension or solution. Specifically, the slippery surfaces can be applied to medical devices and equipment to effectively repel biological materials such as blood, and prevent, reduce, or delay coagulation and surface-mediated clot formation. Moreover, the slippery surfaces can be used to prevent fouling by microorganisms such as bacteria.

摘要翻译： 描述了通过在具有微观和纳米尺度形貌的粗糙化固体表面上吸收化学惰性，高密度液体涂层制造的自愈合，耐刮擦的光滑表面。 这种光滑表面显示出抗湿润性，并且显示出广泛范围的生物材料（包括悬浮液或溶液中的颗粒）的粘附性的显着降低。 具体地说，滑动表面可以应用于医疗装置和设备以有效地排斥诸如血液的生物材料，并且防止，减少或延迟凝血和表面介导的凝块形成。 此外，光滑表面可用于防止微生物如细菌的结垢。

公开(公告)号：US20070154473A1

公开(公告)日：2007-07-05

申请号：US11648505

申请日：2006-12-29

申请人： Michael Super ,  Jonathan Davis ,  Pascal Stein

发明人： Michael Super ,  Jonathan Davis ,  Pascal Stein

IPC分类号： A61K39/395 ,  C07K16/44

CPC分类号： C07K16/30 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2866 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/732 ,  A61K2300/00

摘要： Anti-CD19 B4 antibodies with modified variable regions are disclosed. The modified anti-CD19 variable region polypeptides have alterations to one or more framework regions or complementarity determining regions of the heavy chain variable region or light chain variable region, thereby to reduce a T-cell response.

摘要翻译： 公开了具有改变的可变区的抗CD19 B4抗体。 修饰的抗CD19可变区多肽具有对重链可变区或轻链可变区的一个或多个构架区或互补决定区的改变，从而降低T细胞应答。