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公开(公告)号：US08013156B2
公开(公告)日：2011-09-06
申请号：US10549300
申请日：2004-03-19
Applicant: Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
Inventor： Lynne Canne Bannen , S. David Brown , Wei Cheng , Vasu Jammalamadaka , John M. Nuss , Morrison B. Mac , Jason Jevious Parks , Matthew A. Williams , Wei Xu , Atwood Kim Cheung , Lisa Esther Dalrymple , Sergey Epshteyn , Mohamed Abdulkader Ibrahim , James William Leahy , Gary Lee Lewis , Robin Tammie Noguchi , Larry Wayne Mann , Brian Hugh Ridgway , Joan C. Sangalang , Kevin Luke Schnepp , Xian Shi , Richard George Khoury
IPC: C07D401/14 , C07D403/14 , A61K31/4425 , A61K31/495 , A61K31/506 , A61P19/02 , A61P35/00
CPC classification number: A61K31/496 , C07D213/75 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12 , C07D417/14
Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Abstract translation: 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
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公开(公告)号：US20100249071A1
公开(公告)日：2010-09-30
申请号：US12731997
申请日：2010-03-25
Applicant: Lynne Canne Bannen , Diva Sze-Ming Chan , Morrison B. Mac , Stephanie Ng , John M. Nuss , Yong Wang , Wei Xu
Inventor： Lynne Canne Bannen , Diva Sze-Ming Chan , Morrison B. Mac , Stephanie Ng , John M. Nuss , Yong Wang , Wei Xu
IPC: A61K31/4439 , C07D417/04 , C07D513/04 , A61K31/433 , C07D285/12 , C07D417/12 , C07F9/09 , A61K31/675 , C07D417/14 , A61K31/506 , A61P37/06 , A61P17/06 , A61P19/02 , A61P29/00 , A61P19/10
CPC classification number: C07D285/12 , C07D417/04 , C07D417/12 , C07D513/04
Abstract: The invention is directed to Compounds of Formula I: as well as methods of making and using the compounds.
Abstract translation: 本发明涉及式I化合物：以及制备和使用该化合物的方法。
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公开(公告)号：US20090143386A1
公开(公告)日：2009-06-04
申请号：US12322422
申请日：2009-02-02
Applicant: S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
Inventor： S. David Brown , Lynne Canne-Bannen , Erick Wang Co , Vasu Jammalamadaka , Rickard George Khoury , Moon Hwan Kim , Donna T. Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , John M. Nuss , Michael P. Prisbylla , Wei Xu
IPC: A61K31/5375 , C07C311/00 , A61K31/215 , A61K31/445 , A61K31/4965 , C07D241/04 , C07D211/30 , C07D295/00
CPC classification number: C07D409/04 , C07C311/29 , C07C2601/14 , C07D207/09 , C07D211/34 , C07D213/56 , C07D213/65 , C07D213/70 , C07D233/48 , C07D233/64 , C07D295/13 , C07D295/15 , C07D295/185 , C07D295/215 , C07D311/70
Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role. The invention also provides methods for making bis-aryl ether sulfonyl chlorides and ADAM-10 modulators therefrom.
Abstract translation: 本发明提供了可用于抑制ADAM-10蛋白质的化合物。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。 本发明还提供从其制备双芳基醚磺酰氯和ADAM-10调节剂的方法。
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公开(公告)号：US20090105211A1
公开(公告)日：2009-04-23
申请号：US12049225
申请日：2008-03-14
Applicant: Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
Inventor： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC: C07D239/84 , C07D413/12 , A61K31/517 , A61K31/5377 , A61K31/496 , A61K31/553 , A61K31/55 , C07D401/12 , C07D403/12 , A61P35/00 , C07D401/14
CPC classification number: C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
Abstract translation: 本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。
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公开(公告)号：US20130144056A1
公开(公告)日：2013-06-06
申请号：US13541503
申请日：2012-07-03
Applicant: Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
Inventor： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew Tsuhako , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
IPC: C07D241/04 , C07D403/06 , C07D401/06 , C07D413/06
CPC classification number: C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
Abstract translation: 本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
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Patent Agency Ranking
公开(公告)号：US08367667B2
公开(公告)日：2013-02-05
申请号：US13214665
申请日：2011-08-22
Applicant: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
Inventor： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC: A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC classification number: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
Abstract translation: 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US20120070368A1
公开(公告)日：2012-03-22
申请号：US13087094
申请日：2011-04-14
Applicant: Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrison B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wei Xu , Diane Simeone
Inventor： Lynne Canne Bannen , Diva Sze-Ming Chan , Timothy Patrick Forsyth , Richard George Khoury , James William Leahy , Morrison B. Mac , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Yong Wang , Wei Xu , Diane Simeone
CPC classification number: A61K31/47 , A61K31/517 , A61K31/7068 , A61K45/06 , A61N5/10 , A61K2300/00
Abstract: Disclosed are methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt thereof, in combination with gemcitabine (GEM), or a pharmaceutically acceptable salt thereof, and optionally one or more additional treatments, wherein:R1 is halo;R2 is halo;R3 is (C1-C6)alkyl;R4 is (C1-C6)alkyl; andQ is CH or N.
Abstract translation: 公开了通过给予式I化合物或其药学上可接受的盐与吉西他滨（GEM）或其药学上可接受的盐以及任选的一种或多种另外的治疗组合治疗癌症的方法，其中：R1是卤素; R2是卤素; R3是（C1-C6）烷基; R4是（C1-C6）烷基; Q为CH或N.
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公开(公告)号：US08076338B2
公开(公告)日：2011-12-13
申请号：US11568173
申请日：2005-04-22
Applicant: Neel K. Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Lynne Canne Bannen , Diva Sze-Ming Chan , Baili Chen , Erick Wang Co , Simona Costanzo , Steven Charles Defina , Larisa Dubenko , Maurizio Franzini , Ping Huang , Vasu Jammalamadaka , Richard George Khoury , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Morrison B. Mac , John M. Nuss , Jason Jevious Parks , Kenneth D. Rice , Tsze H. Tsang , Amy Lew Tsuhako , Yong Wang , Wei Xu
Inventor： Neel K. Anand , Charles M. Blazey , Owen Joseph Bowles , Joerg Bussenius , Lynne Canne Bannen , Diva Sze-Ming Chan , Baili Chen , Erick Wang Co , Simona Costanzo , Steven Charles Defina , Larisa Dubenko , Maurizio Franzini , Ping Huang , Vasu Jammalamadaka , Richard George Khoury , Moon Hwan Kim , Rhett Ronald Klein , Donna Tra Le , Morrison B. Mac , John M. Nuss , Jason Jevious Parks , Kenneth D. Rice , Tsze H. Tsang , Amy Lew Tsuhako , Yong Wang , Wei Xu
IPC: A61K31/501 , A61K31/497 , C07D473/16 , C07D401/04
CPC classification number: C07D487/04
Abstract: The present invention relates to compounds of the Formula (I) and (II) wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Abstract translation: 本发明涉及式（I）和（II）的化合物，其中R，R 21，R 25 -R 33，m，n，X 21-X 23和Q 1在本文中定义。 该化合物调节蛋白激酶酶活性以调节细胞活性，如增殖，分化，程序性细胞死亡，迁移和化学侵袭。 本发明的化合物抑制，调节和/或调节激酶，特别是p70S6和/或Akt激酶。 使用和制备化合物的方法及其药物组合物治疗激酶依赖性疾病和病症也是本发明的一个方面。
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公开(公告)号：US20100160369A1
公开(公告)日：2010-06-24
申请号：US12630663
申请日：2009-12-03
Applicant: Lynne Canne Bannen , Diva Sze-Ming Chan , Xiao-Hui Gu , Morrison B. Mac , Stephanie Ng , Tie-Lin Wang , Yong Wang , Wei Xu
Inventor： Lynne Canne Bannen , Diva Sze-Ming Chan , Xiao-Hui Gu , Morrison B. Mac , Stephanie Ng , Tie-Lin Wang , Yong Wang , Wei Xu
IPC: A61K31/437 , C07D471/04 , A61P17/06 , A61P37/00
CPC classification number: C07D471/04
Abstract: The invention is directed to Compounds of Formula I: as well as methods of making and using the compounds.
Abstract translation: 本发明涉及式I化合物：以及制备和使用该化合物的方法。
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公开(公告)号：US20090170896A1
公开(公告)日：2009-07-02
申请号：US12393806
申请日：2009-02-26
Applicant: Lynn Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
Inventor： Lynn Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takeuchi , Yong Wang , Wie Xu
IPC: A61K31/47 , C07D215/20 , A61P35/00
CPC classification number: C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
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