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    Device for treating vulnerable plaque
    14.
    发明授权
    Device for treating vulnerable plaque 有权
    治疗易损斑块的装置

    公开(公告)号：US07553292B2

    公开(公告)日：2009-06-30

    申请号：US11140240

    申请日：2005-05-26

    Applicant: Deborah L. Kilpatrick ,  Robert D. Ainsworth ,  Murthy V. Simhambhatla ,  Jeong S. Lee

    Inventor： Deborah L. Kilpatrick ,  Robert D. Ainsworth ,  Murthy V. Simhambhatla ,  Jeong S. Lee

    IPC: A61M29/00

    CPC classification number: A61F2/958 ,  A61B2017/22081

    Abstract: A method of treating vulnerable plaque comprising intentionally damaging or rupturing the vulnerable plaque using a wingless balloon which is inflated from a wingless unexpanded diameter to a limited expanded diameter. This process produces significant increase in ECM synthesis at the site of the damage or rupture. As a result, the method strengthens the vulnerable plaque while minimizing or avoiding damage to the surrounding wall of the body lumen or damaging a stable plaque mistakenly believed to be a vulnerable plaque. The method of the invention is particularly useful in treating a fibroatheroma type of vulnerable plaque. In one embodiment, the balloon is self-limiting such that it expands compliantly at initial inflation pressures, and above nominal pressure it expands noncompliantly. In an alternative embodiment, the balloon is inflated using a diameter-limiting device, such as a device which limits the inflation pressure or the volume of inflation fluid in the balloon.

    Abstract translation: 一种治疗易损斑块的方法，包括使用从无翅未膨胀直径膨胀至有限扩张直径的无翼气球故意破坏或破裂易损斑块。 该过程在损伤或破裂部位产生ECM合成的显着增加。 因此，该方法可加强易损斑块，同时最大限度地减少或避免对体腔周围壁的损害或损坏被认为是易损斑块的稳定斑块。 本发明的方法特别可用于治疗纤维腺瘤型易损斑块。 在一个实施例中，气囊是自限制性的，使得其在初始充气压力下顺应地膨胀，并且在额定压力之上，其膨胀不顺利。 在替代实施例中，使用直径限制装​​置（例如限制气囊中的充气压力或膨胀流体的体积的装置）使球囊膨胀。

    Medical device formed of ultrahigh molecular weight polyolefin
    16.
    发明授权
    Medical device formed of ultrahigh molecular weight polyolefin 失效
    由超高分子量聚烯烃形成的医疗器械

    公开(公告)号：US06890395B2

    公开(公告)日：2005-05-10

    申请号：US10438525

    申请日：2003-05-15

    Applicant: Murthy V. Simhambhatla

    Inventor： Murthy V. Simhambhatla

    IPC: A61F2/82 ,  A61L27/00 ,  A61L27/16 ,  A61L29/00 ,  A61L29/04 ,  A61M25/00 ,  B29C47/88 ,  B29C53/40 ,  B29C53/42

    CPC classification number: A61L27/16 ,  A61L29/041 ,  C08L23/06 ,  C08L2207/068 ,  Y10T156/1038 ,  Y10T428/1352 ,  Y10T428/139

    Abstract: Medical devices having at least a component, such as a catheter balloon, stent cover and vascular graft, formed of ultrahigh molecular weight polyolefin, such as ultrahigh molecular weight polyethylene. The device component is formed from ultrahigh molecular weight polyethylene that has been processed so that it is microporous and has an oriented node and fibril structure. The device component expands compliantly at low strains and are substantially less compliant at higher strains. The invention also comprises methods for making such medical devices, including the steps of compacting a polyethylene powder and deforming it to impart the oriented structure.

    Abstract translation: 至少具有由超高分子量聚烯烃（例如超高分子量聚乙烯）形成的至少一种成分的医疗装置，例如导管球囊，支架盖和血管移植物。 该器件组件由超高分子量聚乙烯形成，该聚乙烯已被加工成微孔并具有取向的节点和原纤维结构。 器件部件在低应变下易于扩展，并且在较高应变下基本不太顺应。 本发明还包括制造这种医疗装置的方法，包括压制聚乙烯粉末并变形以赋予定向结构的步骤。

    Process of making a balloon for an intraluminal catheter
    17.
    发明授权
    Process of making a balloon for an intraluminal catheter 有权
    制作腔内导管球囊的工艺

    公开(公告)号：US06761786B2

    公开(公告)日：2004-07-13

    申请号：US10165916

    申请日：2002-06-10

    Applicant: Murthy V. Simhambhatla ,  Robert D. Ainsworth ,  Robert P. Saltman

    Inventor： Murthy V. Simhambhatla ,  Robert D. Ainsworth ,  Robert P. Saltman

    IPC: B29C4788

    CPC classification number: A61L27/16 ,  A61L29/041 ,  C08L23/06 ,  C08L2207/068 ,  Y10T156/1038 ,  Y10T428/139

    Abstract: Medical devices such as catheter balloons, stent covers and vascular grafts formed of ultrahigh molecular weight polyethylene. The devices are formed from polyethylene that has been processed so that it is microporous and has an oriented node and fibril structure. The balloons expand compliantly at low strains and are substantially less compliant at higher strains. The invention also comprises methods for making such balloons, including the steps of compacting a polyethylene powder and deforming it to impart the oriented structure.

    Abstract translation: 诸如导管球囊，支架盖和由超高分子量聚乙烯形成的血管移植物的医疗装置。 这些装置由聚乙烯形成，其已经被处理以使其是微孔的并且具有定向的节点和原纤维结构。 气球在低应变下柔顺扩张，并且在较高应变下基本上较不顺应。 本发明还包括制造这种气球的方法，包括压制聚乙烯粉末并变形以赋予定向结构的步骤。

    Foamed inner member cover stent retention and method of use
    18.
    发明授权
    Foamed inner member cover stent retention and method of use 失效
    发泡内部构件覆盖支架保留和使用方法

    公开(公告)号：US06447521B1

    公开(公告)日：2002-09-10

    申请号：US09662551

    申请日：2000-09-15

    Applicant: Steven L. Mouw ,  Murthy V. Simhambhatla ,  Chicheng Wang

    Inventor： Steven L. Mouw ,  Murthy V. Simhambhatla ,  Chicheng Wang

    IPC: A61F1100

    CPC classification number: A61F2/958 ,  A61F2002/9583

    Abstract: A catheter system for removably securing a stent which generally includes an inner tubular member and an outer tubular member with an expandable member disposed about the inner tubular member. A foamed cover is disposed between the expandable member and the inner tubular member. An expandable stent is crimped onto the expandable member and is retained in place by compressing the foamed cover. Used with a stent delivery system, the catheter system is inserted into a body lumen such as an artery. The stent is secured in place while advancing the system through tortuous body lumen passages. The stent is advanced to the desired location in the body lumen and implanted by inflating the expandable member and thereby expanding the stent into the body lumen. The stent is released from the system by deflating the expandable member and withdrawing the catheter system from the body.

    Abstract translation: 一种用于可拆卸地固定支架的导管系统，其通常包括内部管状构件和具有围绕内部管状构件设置的可扩张构件的外部管状构件。 泡沫盖布置在可膨胀构件和内管状构件之间。 可扩张支架被卷曲到可膨胀构件上并通过压缩发泡盖保持在适当的位置。 与支架输送系统一起使用时，将导管系统插入诸如动脉的体腔内。 支架固定在适当的位置，同时使系统通过曲折的体腔通道。 支架前进到体腔内的所需位置，并且通过使可膨胀构件膨胀并从而将支架扩张到体腔中而植入。 支架通过使可膨胀构件放气并将导管系统从身体上取出而从系统释放。

    High pressure catheter balloon
    20.
    发明授权
    High pressure catheter balloon 有权
    高压导管气囊

    公开(公告)号：US06270522B1

    公开(公告)日：2001-08-07

    申请号：US09469728

    申请日：1999-12-21

    Applicant: Murthy V. Simhambhatla ,  Venu Ghanta ,  Timoteo Tomas

    Inventor： Murthy V. Simhambhatla ,  Venu Ghanta ,  Timoteo Tomas

    IPC: A61F206

    CPC classification number: B29C49/18 ,  A61L29/06 ,  A61L29/14 ,  A61M25/1029 ,  B29C49/6481 ,  B29C2049/0089 ,  B29K2105/258 ,  B29L2022/022 ,  B29L2031/7542 ,  C08L67/02

    Abstract: A balloon formed of a single layer of polybutylene terephthalate and polytetramethylene ether glycol terephthalate copolymer in a substantially unblended form. The copolymer has a flexural modulus of greater than about 150,000 psi. The presently preferred copolymer is Hytrel® 8238 by DuPont. The balloon would be substantially unblended, defined as greater than about 60% by weight to about 100% by weight of the copolymer. The balloon is formed in a series of molds. The balloon exhibits high rupture pressure and low compliance coupled with good lesion cross and recross ability.

    Abstract translation: 由单层聚对苯二甲酸丁二醇酯和聚四亚甲基醚二醇对苯二甲酸乙二醇酯共聚物形成的气囊，基本上是非混合形式。 共聚物的挠曲模量大于约150,000psi。 目前优选的共聚物是DuPont的Hytrel 8238。 气囊将基本上未共混，定义为大于约60重量％至约100重量％的共聚物。 气球形成一系列模具。 气球表现出高的破裂压力和低顺应性，并具有良好的病变交叉和交叉能力。

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