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20 条记录 (耗时 0.025 秒)

    Compositions and methods for stimulating bone growth
    13.
    发明授权
    Compositions and methods for stimulating bone growth 失效
    用于刺激骨骼生长的组合物和方法

    公开(公告)号：US6080779A

    公开(公告)日：2000-06-27

    申请号：US96957

    申请日：1998-06-12

    申请人： Shirley R. Gasper ,  Robert R. West ,  Theresa Martinez ,  Kirk G. Robbins ,  Patricia A. McKernan ,  Nand Baindur ,  Virender M. Labroo ,  Gregory R. Mundy

    发明人： Shirley R. Gasper ,  Robert R. West ,  Theresa Martinez ,  Kirk G. Robbins ,  Patricia A. McKernan ,  Nand Baindur ,  Virender M. Labroo ,  Gregory R. Mundy

    IPC分类号： A61K31/22 ,  A61K31/366 ,  A61K31/404 ,  A61K31/335 ,  A61K31/33 ,  A61K31/66

    CPC分类号： A61K31/404 ,  A61K31/22 ,  A61K31/366

    摘要： Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6 C;Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6 C; andthe dotted lines represent optional .pi.-bonds,promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. These compounds can be used in combination with other bone growth-promoting compounds and/or estrogens and/or bisphosphonates for this purpose.

    摘要翻译： 式（1）和（2）各自表示X为2-6的取代或未取代的亚烷基，亚烯基或亚炔基连接基的式 Y表示一个或多个碳环或杂环; 当Y中存在两个或更多个环时，它们可以任选地稠合; R'表示1-6个C的阳离子，H或取代或未取代的烷基; 虚线表示可选的pi-键，促进骨形成，因此可用于治疗骨质疏松症，骨折或缺陷，原发性或继发性甲状旁腺功能亢进，牙周病或缺陷，转移性骨病，溶骨性骨病，整形外手术 假体关节手术和牙植入后。 为了此目的，这些化合物可以与其它骨生长促进化合物和/或雌激素和/或二膦酸盐组合使用。

    Glucagon antagonists and methods relating thereto
    14.
    发明授权
    Glucagon antagonists and methods relating thereto 失效
    胰高血糖素拮抗剂及其相关方法

    公开(公告)号：US5508304A

    公开(公告)日：1996-04-16

    申请号：US288875

    申请日：1994-08-10

    申请人： Robert R. West ,  Virender Labroo ,  James R. Piggott ,  Robert A. Smith ,  Patricia A. McKernan

    发明人： Robert R. West ,  Virender Labroo ,  James R. Piggott ,  Robert A. Smith ,  Patricia A. McKernan

    IPC分类号： A61K31/12 ,  A61K31/122 ,  A61K31/22 ,  A61K31/27 ,  C12P15/00 ,  A61K31/21

    CPC分类号： A61K31/122 ,  A61K31/12 ,  A61K31/22 ,  A61K31/27 ,  C12P15/00

    摘要： Glucagon antagonists and methods relating thereto are disclosed. The glucagon antagonists include skyrin and skyrin analogs, and serve to inhibit the stimulation of a glucagon-induced response pathway, such as the adenylate cyclase response pathway or the inositol phosphate response pathway. The glucagon antagonists may be used within therapeutic compositions to treat disease states associate with elevated glucose levels, including diabetes and hyperglycemia. The present invention also discloses a biologically pure culture of ATCC accession number 74200, as well as methods relating to the production of glucagon antagonists by cultivating the same in a nutrient medium and recovering the glucagon antagonist therefrom.

    摘要翻译： 公开了胰高血糖素拮抗剂及其相关方法。 胰高血糖素拮抗剂包括天冬氨酸和天冬氨酸类似物，并且用于抑制胰高血糖素诱导的应答途径的刺激，例如腺苷酸环化酶应答途径或肌醇磷酸应答途径。 胰高血糖素拮抗剂可用于治疗组合物内以治疗与升高的葡萄糖水平相关的疾病状态，包括糖尿病和高血糖。 本发明还公开了ATCC保藏号74200的生物纯纯培养物，以及通过在营养培养基中培养并从其中回收胰高血糖素拮抗剂来产生胰高血糖素拮抗剂的方法。