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    VENTING OR DEGASSING OF FILTER DEVICES AND FILTRATION SYSTEMS
    11.
    发明申请
    VENTING OR DEGASSING OF FILTER DEVICES AND FILTRATION SYSTEMS 有权

    公开(公告)号：US20220193614A1

    公开(公告)日：2022-06-23

    申请号：US17559792

    申请日：2021-12-22

    Applicant: Repligen Corporation

    Inventor： Bao Le ,  Philip Yuen

    IPC: B01D63/02 ,  B01D19/00

    Abstract: Devices, systems, and methods for continually degassing/venting a feedstream within a filtration system. The filtration system may include a filter device utilizing hollow fiber filters to filter the feedstream. Additional venting hollow fiber filters vent gas from the filtration system to outside the filtration system. The venting hollow fiber filters may have ends which expose the interior lumens thereof to outside the filter unit to vent gases which pass through the walls of the hollow fiber filters. Degassed permeate thus flows through the filtering hollow fiber filters.

    Micro alternating tangential flow perfusion filter, micro bioreactor, and methods of use thereof
    12.
    发明授权
    Micro alternating tangential flow perfusion filter, micro bioreactor, and methods of use thereof 有权

    公开(公告)号：US11339364B2

    公开(公告)日：2022-05-24

    申请号：US16171867

    申请日：2018-10-26

    Applicant: Repligen Corporation

    Inventor： Michael Bransby ,  Philip Yuen

    IPC: B01D61/14 ,  B01D61/18 ,  C12M1/00 ,  C12M1/26

    Abstract: A micro alternating tangential flow (microATF) perfusion filter includes a hollow cylinder having a proximal end and a distal end. The proximal end is connected in series to a permeate chamber, followed by a retentate chamber. The proximal end either (i) terminates in or at the permeate chamber, or (ii) terminates in or at the retentate chamber. The portion of the proximal end within the permeate chamber, in a case of (ii), possesses at least one opening allowing fluid communication between an inside of the hollow cylinder and the permeate chamber. The microATF perfusion filter further includes an inlet, positioned over the retentate chamber, for communication with a source of positive or negative pressure, and an outlet, positioned in a wall of the permeate chamber, which can be connected to a check valve, which, in turn, can be connected to a hydrophobic fluid vent filter.

    Fluid monitoring assembly with replaceable sensor functionality
    15.
    发明授权
    Fluid monitoring assembly with replaceable sensor functionality 有权

    公开(公告)号：US11015962B2

    公开(公告)日：2021-05-25

    申请号：US16570656

    申请日：2019-09-13

    Applicant: REPLIGEN CORPORATION

    Inventor： Michael C. Gagne ,  Steven V. Cates ,  Dean Richards ,  Scott Bendon

    IPC: G01D11/24 ,  G01L19/14 ,  G01D11/30 ,  G01F15/14 ,  G01N27/07 ,  G01D18/00

    Abstract: A fluid monitoring assembly includes a conduit having a wall defining a lumen for carrying fluid. A sensor mount is integrally formed with the wall of the conduit and extends generally transverse with respect to a longitudinal axis of the conduit, the sensor mount including an aperture defining an inner surface extending to the lumen. The assembly includes a sensor configured to be removably secured within the sensor mount, the sensor having an elongate body terminating at one end thereof in a sensing portion, the elongate body having a male projection on a portion thereof and configured to rest within the inner surface of the sensor mount. The assembly further includes a housing having first and second portions connected to one another, the housing defining an interior portion configured to encapsulate the conduit, at least a portion of the elongate body of the sensor, and the sensor mount.

    Device, System and Process for Modification or Concentration of Cell-Depleted Fluid
    20.
    发明申请
    Device, System and Process for Modification or Concentration of Cell-Depleted Fluid 审中-公开
    用于改变或浓缩细胞消耗液体的装置，系统和方法

    公开(公告)号：US20170002305A1

    公开(公告)日：2017-01-05

    申请号：US15269409

    申请日：2016-09-19

    Applicant: Repligen Corporation

    Inventor： Jerry Shevitz

    IPC: C12M1/00 ,  B01D61/14 ,  C12M1/26 ,  B01D63/02

    CPC classification number: C12M29/18 ,  B01D61/14 ,  B01D61/58 ,  B01D63/02 ,  B01D2313/13 ,  B01D2313/243 ,  B01D2313/50 ,  C12M29/04 ,  C12M29/16 ,  C12M33/10

    Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.

    Abstract translation: 一种产品浓度装置，其利用连接到中空纤维过滤元件的储存器，其中储存器可以用作从另一个过滤装置发出的滤液的容器，使得储存器中的产品可以根据需要进行储存，浓缩和/或进一步处理 。 封闭的反应器系统，每个至少三个室，在由选择性渗透屏障控制的室之间的流体流动，由交流流动隔膜泵控制。

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