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18 条记录 (耗时 0.012 秒)

    Process for the preparation of 2-aryl propionic acids
    15.
    发明申请
    Process for the preparation of 2-aryl propionic acids 审中-公开
    2-芳基丙酸的制备方法

    公开(公告)号：US20050283020A1

    公开(公告)日：2005-12-22

    申请号：US11149804

    申请日：2005-06-10

    申请人： Raghunath Chaudhari ,  Seayad A. ,  Jayasree Seayad

    发明人： Raghunath Chaudhari ,  Seayad A. ,  Jayasree Seayad

    IPC分类号： C07C51/10 ,  C07C51/12 ,  C07C51/14 ,  C07C51/16

    CPC分类号： C07C51/12 ,  C07C51/10 ,  C07C51/14 ,  C07C57/30

    摘要： The present invention provides for the preparation of 2-aryl propionic acids, which comprises the steps of: reacting an aryl compound selected from an arylalkyl halide having general formula I, aryl alcohol having general formula II or aryl substituted olefins having general formula III, as shown in the accompanying drawings, wherein, R1 is aryl, substituted aryl, naphthyl or substituted naphthyl groups, R2, R3, R4 and R5 are independently hydrogen, alkyl, aryl, arylalkyl or cycloaliphatic groups with or without substituents and X is other a halogen atom selected from chlorine, bromine, iodine with a halide promoter, an organic acid, water and a palladium catalyst in an organic solvent selected from ketones or cyclic ethers in carbon monoxide atmosphere under homogeneous conditions, at a temperature ranging between 30 to 130° C., for a period ranging between 0.3 to 4 hrs, at pressures ranging between 50 to 1500 psig, cooling the reaction mixture to ambient temperature, flushing the reaction vessel with inert gas, removing the solvent by conventional methods, and separating the catalyst and isolating 2 aryl propionic acid having formula IV as shown in the accompanying drawings, wherein, R1 is aryl, substituted aryl, naphthyl or substituted naphthyl groups, R2, R3, R4 and R5 are independently hydrogen, alkyl, aryl, arylalkyl, cycloaliphatic groups with or without substituents.

    摘要翻译： 本发明提供2-芳基丙酸的制备，其包括以下步骤：使选自具有通式I的芳基烷基卤化物，具有通式II的芳基醇或具有通式III的芳基取代烯烃的芳基化合物与 如图所示，其中R 1是芳基，取代的芳基，萘基或取代的萘基，R 2，R 3，R R 4和R 5独立地为具有或不具有取代基的氢，烷基，芳基，芳基烷基或脂环族基团，X为选自氯，溴，碘的卤素原子，其中 卤化物助催化剂，有机酸，水和钯催化剂，在一氧化碳气氛中，在均一条件下，在30至130℃的温度范围内，在选自酮或环醚的有机溶剂中，时间范围为0.3-4 小时，压力范围在50至1500psig之间，冷却r 将反应混合物与环境温度反应，用惰性气体冲洗反应容器，通过常规方法除去溶剂，并分离催化剂并分离出具有式IV的芳基丙酸，如附图所示，其中R 1， R 2是芳基，取代的芳基，萘基或取代的萘基，R 2，R 3，R 4和R 5， 独立地是氢，烷基，芳基，芳基烷基，具有或不具有取代基的脂环族基团。

    Process for preparing dioxy-functionalized propane compounds
    17.
    发明申请
    Process for preparing dioxy-functionalized propane compounds 审中-公开
    制备二官能化丙烷化合物的方法

    公开(公告)号：US20050222452A1

    公开(公告)日：2005-10-06

    申请号：US10814859

    申请日：2004-03-31

    申请人： Raghunath Chaudhari ,  Yogesh Borole ,  Shubhangi Umbarkar

    发明人： Raghunath Chaudhari ,  Yogesh Borole ,  Shubhangi Umbarkar

    IPC分类号： C07C29/14 ,  C07C29/147 ,  C07C67/29 ,  C07C69/76

    CPC分类号： C07C29/147 ,  C07C67/29 ,  C07C67/293 ,  C07C69/003 ,  C07C69/14 ,  C07C69/145 ,  C07C31/205

    摘要： The present invention relates to a process for preparing, dioxy functionalised propane compounds using cobalt and/or rhodium catalysts. More particularly, the present invention relates to a process for the preparation of the dioxy functionalised propane compounds of the formula X—CH2—CH(Y)—CH2-Z, wherein X=R—C(═O)—O— or H or —OH, Y and Z=—H or —OH or —C(═O)H, and wherein at a time, only one of X, Y and Z is —H, in high yields from vinyl carboxylates of formula R—C(═O)—O—CH═CH2 wherein, R=substituted or unsubstituted alkyl or aryl group.

    摘要翻译： 本发明涉及使用钴和/或铑催化剂制备二氧官能化丙烷化合物的方法。 更具体地说，本发明涉及一种制备式X-CH 2 -CH（Y）-CH 2 -Z -Z（CH 2）-CH 2的二氧官能化丙烷化合物的方法， 其中X = RC（-O）-O-或H或-OH，Y和Z = -H或-OH或-C（-O）H，并且其中一次只有X，Y和Z中的一个 是-H，以高得率的式RC（-O）-O-CH-CH 2乙烯基羧酸酯，其中R =取代或未取代的烷基或芳基。