公开(公告)号：US20060063931A1

公开(公告)日：2006-03-23

申请号：US11262427

申请日：2005-10-28

Applicant: Christine Dykstra ,  Maurice Givens ,  David Stringfellow ,  Kenny Brock ,  David Boykin ,  Arvind Kumar ,  W. David Wilson ,  Richard Tidwell ,  Chad Stephens

Inventor： Christine Dykstra ,  Maurice Givens ,  David Stringfellow ,  Kenny Brock ,  David Boykin ,  Arvind Kumar ,  W. David Wilson ,  Richard Tidwell ,  Chad Stephens

IPC: C07D405/14

CPC classification number: C07D405/14 ,  A61K31/341 ,  A61K31/381 ,  A61K31/401 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/426 ,  A61K31/428 ,  A61K31/506 ,  C07D207/08 ,  C07D207/09 ,  C07D277/28 ,  C07D307/14 ,  C07D333/20 ,  C07D405/04 ,  C07D405/10

Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.

公开(公告)号：US20050158785A1

公开(公告)日：2005-07-21

申请号：US11035627

申请日：2005-01-14

Applicant: W. Wilson ,  David Boykin ,  Richard Tidwell

Inventor： W. Wilson ,  David Boykin ,  Richard Tidwell

IPC: C12N15/09 ,  A61K31/4184 ,  A61K48/00 ,  A61P31/04 ,  A61P35/00 ,  A61P43/00 ,  C07D207/40 ,  C07D207/416 ,  C07D307/54 ,  C07D405/04 ,  C07D405/14 ,  C12Q1/68 ,  C07D413/14 ,  C07D417/14 ,  C07D43/14

CPC classification number: C07D207/416 ,  C07D307/54 ,  C07D405/04 ,  C07D405/14 ,  C12Q1/6816 ,  C12Q2563/173

Abstract: Asymmetric derivatives of furamidines with one of the phenyl rings of furamidine replaced with a benzimidazole have been found by quantitative footprinting analyses to bind GC containing sites on DNA more strongly than to pure AT sequences. These compounds have been shown to bind in the minor groove at specific GC containing sequences of DNA in a highly cooperative manner as a stacked dimer. Compounds of the present invention find use in selectively binding mixed sequence DNA, and may also be used in methods of regulating gene expression, methods of treating opportunistic infections and cancer, as well as in methods of detecting certain sequences of DNA.

Abstract translation: 已经通过定量印迹分析发现了呋喃脒苯基环之一与呋喃脒苯基环之一取代的不对称衍生物，以比纯AT序列更强地结合含DNA位点的DNA。 已经显示这些化合物以高度协同的方式作为堆叠的二聚体以特定的GC含有DNA序列在小沟中结合。 本发明化合物可用于选择性结合混合序列DNA，也可用于调节基因表达的方法，治疗机会性感染和癌症的方法，以及检测某些DNA序列的方法。

公开(公告)号：US20070232621A1

公开(公告)日：2007-10-04

申请号：US11698257

申请日：2007-01-25

Applicant: Richard Tidwell ,  David Boykin ,  W. Wilson ,  Reto Brun ,  Karl Werbovetz ,  Mohamed Ismail ,  Reem Arafa ,  Laixing Hu

Inventor： Richard Tidwell ,  David Boykin ,  W. Wilson ,  Reto Brun ,  Karl Werbovetz ,  Mohamed Ismail ,  Reem Arafa ,  Laixing Hu

IPC: A61K31/34 ,  A61K31/16 ,  A61K31/4164 ,  A61K31/435 ,  C07D213/00 ,  C07D239/00 ,  C07D307/00

CPC classification number: C07C257/18 ,  C07C259/18 ,  C07C279/18 ,  C07C279/24 ,  C07D213/58 ,  C07D239/26 ,  C07D307/68 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14

Abstract: Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.

Abstract translation: 新型的二联三联苯化合物及其杂环类似物。 用新型双极化三联苯化合物及其氮杂类似物对抗微生物感染的方法。 合成新型双线性三联苯化合物及其氮杂类似物的方法。

公开(公告)号：US20050197378A1

公开(公告)日：2005-09-08

申请号：US11005524

申请日：2004-12-06

Applicant: Richard Tidwell ,  Karl Werbovetz ,  Scott Franzblau ,  Svetlana Bakunova ,  Stanislav Bakunov

Inventor： Richard Tidwell ,  Karl Werbovetz ,  Scott Franzblau ,  Svetlana Bakunova ,  Stanislav Bakunov

IPC: A61K20060101 ,  A61K31/343 ,  A61K31/4178 ,  C07D307/87

CPC classification number: C07D307/80

Abstract: A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense, a Trypanosoma cruzi, and Plasmodium falciparum, and fungal pathogens, such as Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.

Abstract translation: 一种通过向受试者施用有效量的阳离子取代的苯并呋喃化合物来治疗有需要的受试者的结核分枝杆菌感染的方法。 治疗微生物感染的方法，包括原生动物病原体的感染，例如杜氏利什曼原虫，罗非鱼锥虫，克氏锥虫和恶性疟原虫，以及真菌病原体，例如白色念珠菌，烟曲霉和新型隐球酵母，需要的受试者 其通过向受试者施用有效量的阳离子取代的苯并呋喃化合物。 合成新型阳离子取代苯并呋喃化合物和新化合物本身的方法。

公开(公告)号：US20050165044A1

公开(公告)日：2005-07-28

申请号：US10992607

申请日：2004-11-18

Applicant: David Boykin ,  Richard Tidwell ,  W. Wilson ,  Reto Brun ,  Reem Arafa ,  Chad Stephens

Inventor： David Boykin ,  Richard Tidwell ,  W. Wilson ,  Reto Brun ,  Reem Arafa ,  Chad Stephens

IPC: A01N37/52 ,  A01N43/42 ,  A61K20060101 ,  A61K31/155 ,  A61K31/44 ,  A61K31/444 ,  A61K31/473 ,  C07C279/18 ,  C07C279/24 ,  C07D219/00 ,  C07D219/08 ,  C07D41/02

CPC classification number: C07D219/08 ,  C07C257/18 ,  C07C279/18 ,  C07C279/24 ,  C07C291/04 ,  C07C2603/18 ,  C07C2603/24

Abstract: Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r.) and Plasmodium falciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.

Abstract translation: 新型稠环双阳离子抗原生动物化合物。 代表性的原生动物物种包括但不限于罗非鱼锥虫（T.b.r.）和恶性疟原虫。 这些化合物的前药可用作疟疾和人类非洲锥虫病的口服治疗。