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    Tissue extraction and collection device
    13.
    发明授权
    Tissue extraction and collection device 有权
    组织提取和收集装置

    公开(公告)号：US08870788B2

    公开(公告)日：2014-10-28

    申请号：US13168160

    申请日：2011-06-24

    申请人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

    发明人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

    IPC分类号： A61B10/02 ,  G01F22/00 ,  G01F23/00 ,  A61B17/16 ,  A61B17/32 ,  A61B10/00 ,  A61B19/00

    CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B2017/320064 ,  A61B2090/0807

    摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.

    摘要翻译： 公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。 在一个实施例中，装置可以包括外管。 旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。 可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。 例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。 在一些实施例中，组织收集装置可以平移以指示收集的组织的量。 在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。 在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。 此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

    Tissue Extraction and Collection Device
    15.
    发明申请
    Tissue Extraction and Collection Device 有权
    组织提取和收集装置

    公开(公告)号：US20110257557A1

    公开(公告)日：2011-10-20

    申请号：US13168160

    申请日：2011-06-24

    申请人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

    发明人： Robert S. Pesce ,  Shelby Cook ,  Kristian DiMatteo ,  Kevin Ranucci ,  Robert Boock

    IPC分类号： A61B10/02

    CPC分类号： A61B10/025 ,  A61B10/0096 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/1635 ,  A61B17/32002 ,  A61B2017/320064 ,  A61B2090/0807

    摘要： Methods and device for extracting and collecting tissue, which can be used for example in tissue engineering and grafting applications, are disclosed. In one embodiment, a device can include an outer tube. A rotatable shaft can be disposed within the outer tube can have a tissue harvesting tip formed on its distal end, the tissue harvesting tip being effective to excise tissue upon rotation thereof. A tissue collection device can be included to receive and collected excised tissue, and the tissue collection device can indicate the amount of tissue collected therein. For example, the tissue collection device can include a straining element which collects excised tissue and an indicator by which to assess the amount of collected tissue. In some embodiments, the tissue collection device can translate to indicate the amount of collected tissue. In many cases, devices disclosed herein can include driving mechanisms that are adapted to drive a tissue harvesting tip such that the tip excises soft tissue, but stops when contacting bone (or soon after contacting bone). In some embodiments, the tissue harvesting tip can be effective to excise viable tissue samples, such that the samples can exhibit desirable proportions of viable cells. Further, in some embodiments, the tissue harvesting tips can excise a tissue sample with tissue particles falling in certain size ranges.

    摘要翻译： 公开了用于提取和收集组织的方法和装置，其可以用于组织工程和移植应用中。 在一个实施例中，装置可以包括外管。 旋转轴可以设置在外管内，可以具有形成在其远端上的组织收集尖端，组织收集尖端有效地在旋转时切除组织。 可以包括组织收集装置以接收和收集切除的组织，并且组织收集装置可以指示其中收集的组织的量。 例如，组织收集装置可以包括收集切除的组织的应变元件和用于评估收集的组织的量的指示器。 在一些实施例中，组织收集装置可以平移以指示收集的组织的量。 在许多情况下，本文公开的装置可以包括适于驱动组织收集尖端的驱动机构，使得尖端切除软组织，但是当接触骨骼时（或者在接触骨骼之后不久）停止。 在一些实施方案中，组织采集尖端可有效地切除活组织样品，使得样品可以显示出所需比例的活细胞。 此外，在一些实施例中，组织采集尖端可以用落在一定尺寸范围内的组织颗粒来切除组织样本。

    TISSUE EXTRACTION AND MACERATION DEVICE
    19.
    发明申请
    TISSUE EXTRACTION AND MACERATION DEVICE 有权
    组织提取和加工设备

    公开(公告)号：US20100022915A1

    公开(公告)日：2010-01-28

    申请号：US12569165

    申请日：2009-09-29

    申请人： Robert Boock ,  Nathan S. Cauldwell ,  Keith M. Orr

    发明人： Robert Boock ,  Nathan S. Cauldwell ,  Keith M. Orr

    IPC分类号： A61B10/00

    CPC分类号： A61B10/025 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/32002

    摘要： Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surface, and a shaft rotatably disposed within the outer tube and movable between a first, proximal position in which the shaft is fully disposed within the outer tube, and a second, distal position in which a portion of a distal end of the shaft extends through the opening in the distal end of the outer tube. The device also includes a tissue harvesting tip formed on the distal end of the shaft that is effective to excise a tissue sample when the shaft is moved to the distal position, and a cutting member that is coupled to the shaft at a position proximal to the tissue harvesting tip. The cutting member is effective to macerate a tissue sample excised by the tissue harvesting tip.

    摘要翻译： 提供了用于提取和浸泡组织以及任选地将组织沉积到组织支架上的装置和方法。 该装置通常包括具有基本上敞开的远端的外管，其适于放置在并且优选地与组织表面形成密封，以及可旋转地设置在外管内并可在第一近端位置之间移动的轴， 所述轴完全设置在所述外管内，以及第二远侧位置，所述轴的远端的一部分延伸穿过所述外管的远端中的所述开口。 所述装置还包括形成在所述轴的所述远端上的组织收获尖端，所述组织收集尖端在所述轴移动到所述远侧位置时有效地切除组织样本;以及切割构件，其在靠近所述远端的位置处联接到所述轴 组织收获尖。 切割构件有效地浸渍由组织收获尖端切除的组织样品。

    Tissue extraction and maceration device
    20.
    发明授权
    Tissue extraction and maceration device 有权
    组织提取和浸渍装置

    公开(公告)号：US07611473B2

    公开(公告)日：2009-11-03

    申请号：US10661460

    申请日：2003-09-11

    申请人： Robert Boock ,  Nathan S. Cauldwell ,  Keith M. Orr

    发明人： Robert Boock ,  Nathan S. Cauldwell ,  Keith M. Orr

    IPC分类号： A61B10/00 ,  A61B17/00 ,  A61B17/32 ,  A61B17/14 ,  A61B17/20

    CPC分类号： A61B10/025 ,  A61B10/0266 ,  A61B10/0283 ,  A61B17/32002

    摘要： Devices and methods are provided for extracting and macerating tissue, and optionally for depositing the tissue onto a tissue scaffold. The device generally includes an outer tube having a substantially open distal end that is adapted to be placed on and preferably to form a seal with a tissue surface, and a shaft rotatably disposed within the outer tube and movable between a first, proximal position in which the shaft is fully disposed within the outer tube, and a second, distal position in which a portion of a distal end of the shaft extends through the opening in the distal end of the outer tube. The device also includes a tissue harvesting tip formed on the distal end of the shaft that is effective to excise a tissue sample when the shaft is moved to the distal position, and a cutting member that is coupled to the shaft at a position proximal to the tissue harvesting tip. The cutting member is effective to macerate a tissue sample excised by the tissue harvesting tip.

    摘要翻译： 提供了用于提取和浸泡组织以及任选地将组织沉积到组织支架上的装置和方法。 该装置通常包括具有基本上敞开的远端的外管，其适于放置在并且优选地与组织表面形成密封，以及可旋转地设置在外管内并可在第一近端位置之间移动的轴， 所述轴完全设置在所述外管内，以及第二远侧位置，所述轴的远端的一部分延伸穿过所述外管的远端中的所述开口。 所述装置还包括形成在所述轴的所述远端上的组织收获尖端，所述组织收集尖端在所述轴移动到所述远侧位置时有效地切除组织样本;以及切割构件，其在靠近所述远端的位置处联接到所述轴 组织收获尖。 切割构件有效地浸渍由组织收获尖端切除的组织样品。