摘要:
Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.
摘要:
Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.
摘要:
A level detector for storage tanks for fluids comprises a microprocessor, a network of resistive elements connected in series or parallel, and a plurality of conductive elements between them, connected across a power source. The resistive elements have a high temperature coefficient, and are heated by passing a high electric current through them, after which a low electric current is passed through them and the voltage between them is sampled by the microprocessor. The resistive elements lose heat through conduction, so that a pair of resistive elements can be detected having differential cooling between them as a consequence of being adjacent to the void within the tank or the fluid within the tank. Thus, an approximation of the fluid level within the storage tank can be determined and signalled remotely.
摘要:
Improved methods for forming fine particles of a material have been developed, wherein the method steps include dissolving the material in a solvent to form a dilute solution, immobilizing the dilution solution, and then removing the solvent to yield particles of the material. Methods of immobilizing the dilute solution include freezing, gelation, and chelation. In a preferred embodiment, the immobilized solvent is removed by lyophilization, i.e. reducing the ambient pressure while avoiding application of sufficient heat to power a phase transition. Essentially any material and solvent for the material can be used in the methods described herein. Proteins and peptides in an aqueous solvent are the preferred systems.
摘要:
A formulation composed of a sugar such as glucose and a surfactant such as myristoyl lysophosphocholine (LMPC) has been designed to stabilize both hydrophilic and hydrophobic portions of the glucagon molecule, under prolonged physiological conditions, in a formulation that is sufficiently similar to the pH and osmolarity of plasma so as not to induce or to minimize site irritation. The combination of a simple sugar and an surfactant stabilizes the glucagon molecule in an aqueous solution for seven days at 37° C.
摘要:
A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing having an air intake, an air flow-control/check-valve, a mixing section and a mouthpiece. A cartridge loaded with a single dose of medicament can be installed in the mixing section.
摘要:
An electronic control system especially for non-linear loads, such as high pressure sodium (HPS) lamps, includes an active power factor correction circuit (APFC). The system provides a power factor correction of above 0.95; total harmonic distortion (THD) below 5%; lamp crest factor (LCF) close to unity; efficient power consumption and reliable open circuit voltage (OCV) under all power line conditions. A ballast would include integrated circuits (ICs) and a four-arm transistor bridge which is directly driven by integrated circuits. The bridge generates reversal of polarity to the load. An approximate average current feedback is derived from a load current. A resistor divider in parallel with the load provides voltage feedback. The average current feedback and voltage feedback are added together to provide an approximation of power consumed by the load, without the complex circuitry required for a true power feedback of current multiplied by voltage. That composite feedback signal is transmitted to the integrated circuit (IC) which compares it with an internal reference voltage and which adjusts the IC output to minimize the error.
摘要:
A system using audio and visual information to count coughs or evaluate other discrete information, including respiration and heart rate, relating to a patient in a fixed location such as a bed is disclosed. The system provides movement- and sound-based information derived from the patient's activities to a storage device and subsequently to a signal processing apparatus. One embodiment of the invention includes a pressure transducer, a video camera, a directional microphone, and a videocassette recorder (VCR) having two audio channels. Signals obtained from the transducer and microphone are transmitted to the two audio channel inputs of the VCR, while movement of the patient is recorded using the video camera connected to the video channel input of the VCR. Part or all of the information stored using the VCR may be transmitted to signal processing equipment and frequency filtered to determine the presence and number of coughs, and any remaining information (e.g. the video data) may be used to confirm the count. Because various conditions manifest themselves in movements having different frequency characteristics, the present system, as appropriately modified, also can be used to determine the presence of symptoms such as restlessness and thereby evaluate the effectiveness of medicines such as sedatives and hypnotics.