利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.018 秒)

    Information processing system for counting coughs or evaluating other activities of a patient
    1.
    发明授权
    Information processing system for counting coughs or evaluating other activities of a patient 失效
    信息处理系统用于计数或评估患者的其他活动

    公开(公告)号：US5197490A

    公开(公告)日：1993-03-30

    申请号：US510936

    申请日：1990-04-19

    申请人： Solomon S. Steiner ,  Bruce J. Albala ,  Robert Feldstein

    发明人： Solomon S. Steiner ,  Bruce J. Albala ,  Robert Feldstein

    IPC分类号： A61B5/00 ,  A61B5/11

    CPC分类号： A61B5/0017 ,  A61B5/11 ,  A61B5/1123 ,  A61B5/1128 ,  A61B5/6892

    摘要： A system using audio and visual information to count coughs or evaluate other discrete information, including respiration and heart rate, relating to a patient in a fixed location such as a bed is disclosed. The system provides movement- and sound-based information derived from the patient's activities to a storage device and subsequently to a signal processing apparatus. One embodiment of the invention includes a pressure transducer, a video camera, a directional microphone, and a videocassette recorder (VCR) having two audio channels. Signals obtained from the transducer and microphone are transmitted to the two audio channel inputs of the VCR, while movement of the patient is recorded using the video camera connected to the video channel input of the VCR. Part or all of the information stored using the VCR may be transmitted to signal processing equipment and frequency filtered to determine the presence and number of coughs, and any remaining information (e.g. the video data) may be used to confirm the count. Because various conditions manifest themselves in movements having different frequency characteristics, the present system, as appropriately modified, also can be used to determine the presence of symptoms such as restlessness and thereby evaluate the effectiveness of medicines such as sedatives and hypnotics.

    摘要翻译： 公开了一种使用音频和视觉信息计算咳嗽或评估与固定位置（例如床）中的患者有关的其它离散信息（包括呼吸和心率）的系统。 该系统将从患者活动得到的基于运动和声音的信息提供给存储装置，随后提供给信号处理装置。 本发明的一个实施例包括压力换能器，摄像机，定向麦克风和具有两个音频通道的录像机（VCR）。 从传感器和麦克风获得的信号被传送到VCR的两个音频通道输入端，同时使用连接到VCR的视频通道输入的摄像机记录病人的移动。 使用VCR存储的信息的部分或全部可以被发送到信号处理设备并经频率滤波以确定咳嗽的存在和数量，并且可以使用任何剩余信息（例如，视频数据）来确认计数。 由于各种条件表现为具有不同频率特征的运动，所以适当修改的本系统也可用于确定诸如不安的症状的存在，从而评估诸如镇静剂和催眠药之类的药物的有效性。

    Method for drug delivery to the pulmonary system
    5.
    发明授权
    Method for drug delivery to the pulmonary system 失效

    公开(公告)号：US08394414B2

    公开(公告)日：2013-03-12

    申请号：US10706243

    申请日：2003-11-12

    申请人： Solomon S. Steiner ,  Robert Feldstein ,  Huiling Lian ,  Christopher A. Rhodes ,  Gregory S. Shen

    发明人： Solomon S. Steiner ,  Robert Feldstein ,  Huiling Lian ,  Christopher A. Rhodes ,  Gregory S. Shen

    IPC分类号： A61K9/16

    CPC分类号： A61K9/5146 ,  A61K9/0073 ,  A61K9/0075 ,  A61K9/1617

    摘要： Drug delivery to the pulmonary system has been achieved by encapsulation of the drug to be delivered in microparticles having a size range between 0.5 and ten microns, preferably in the range of two to five microns, formed of a material releasing drug at a pH of greater than 6.4. In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are stable at a pH of 6.4 or less and unstable at pH of greater than 6.4, or which are stable at both acidic and basic pH, but which are unstable at pH between about 6.4 and 8. Other types of materials can also be used, including biodegradable natural and synthetic polymers, such as proteins, polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have been modified to effect targeting to specific cell types and to effect release only after reaching the targeted cells.

    Unit Dose Capsules and Dry Powder Inhaler
    6.
    发明申请
    Unit Dose Capsules and Dry Powder Inhaler 有权
    单位剂量胶囊和干粉吸入器

    公开(公告)号：US20080127970A1

    公开(公告)日：2008-06-05

    申请号：US11949707

    申请日：2007-12-03

    申请人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    发明人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    IPC分类号： A61M15/00

    CPC分类号： A61M15/003 ,  A61M13/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M16/0495 ,  A61M16/0825 ,  A61M2202/064 ,  A61M2205/43 ,  F16L37/252

    摘要： Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece. The mouthpiece is connected by a swivel joint to the mixing section, and may swivel back onto the intake section and be enclosed by a cover. The intake chamber comprises a special piston with a tapered piston rod and spring, and one or more bleed-through orifices to modulate the flow of air through the device. The intake chamber further optionally comprises a feedback module to generate a tone indicating to the user when the proper rate of airflow has been achieved. The mixing section holds a capsule with holes containing a dry powder medicament, and the cover only can open when the mouthpiece is at a certain angle to the intake section. The mixing section further opens and closes the capsule when the intake section is at a certain angle to the mouthpiece. The mixing section is a Venturi chamber configured by protrusions or spirals to impart a cyclonic flow to air passing through the mixing chamber. The mouthpiece includes a tongue depressor, and a protrusion to contact the lips of the user to tell the user that the DPI is in the correct position. An optional storage section, with a cover, holds additional capsules. The cover for the mouthpiece, and the cover for the storage section may both be transparent, magnifying lenses. The capsules may be two-part capsules where each portion has apertures which correspond to apertures in the other half when each half is partially fitted to the other half, and fully fitted to the other half. All the apertures may be closed when the two halves are rotated around their longitudinal axes with respect to each other. Each capsule may have a unique key on each half that only fits with a particular inhaler.

    摘要翻译： 描述了一种干粉吸入器，其包括进气段; 混合部分和喉舌。 接口通过旋转接头连接到混合部分，并且可以旋转回到进气部分并被盖封闭。 进气室包括具有锥形活塞杆和弹簧的特殊活塞，以及一个或多个渗流孔口，用于调节通过该装置的空气流。 进气室还可选地包括反馈模块，以产生当达到适当的气流速率时向用户指示的音调。 混合部分容纳具有含有干粉药物的孔的胶囊，并且仅当吸嘴与进气部分成一定角度时，盖子才能打开。 当进气部分与嘴件成一定角度时，混合部分进一步打开和关闭胶囊。 混合部分是由突起或螺旋构成的文丘里室，以使气流通过混合室。 接口管包括舌形按压器和用于接触用户嘴唇的突起，以告诉用户DPI处于正确的位置。 带有盖子的可选存储部分可容纳另外的胶囊。 用于接口管的盖和用于存储部的盖可以都是透明的放大镜。 胶囊可以是两部分胶囊，其中每个部分具有对应于另一半中的孔的孔，当每个半部分部分地配合到另一半时，并且完全配合到另一半。 当两个半部相对于彼此的纵向轴线旋转时，所有的孔可以被关闭。 每个胶囊可以在每一半上具有仅与特定吸入器配合的唯一键。

    Unit dose capsules for use in a dry powder inhaler
    7.
    发明授权
    Unit dose capsules for use in a dry powder inhaler 有权
    用于干粉吸入器的单位剂量胶囊

    公开(公告)号：US07305986B1

    公开(公告)日：2007-12-11

    申请号：US09621092

    申请日：2000-07-21

    申请人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    发明人： Solomon S. Steiner ,  Robert Feldstein ,  Per B. Fog ,  Trent Poole

    IPC分类号： A61M15/00

    CPC分类号： A61M15/003 ,  A61M13/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0025 ,  A61M15/0028 ,  A61M15/0043 ,  A61M16/0495 ,  A61M16/0825 ,  A61M2202/064 ,  A61M2205/43 ,  F16L37/252

    摘要： Described are capsules to contain a drug for use in an inhaler. The capsules may be two-part capsules where each half has apertures which may correspond to apertures in the other half. The first half fits snugly within the second half and the two halves may be rotated around their longitudinal axes with respect to each other to produce unlocked and locked positions. In the unlocked position, at least one aperture in the first half aligns with at least one aperture in the second half, which permits introduction of a medicament. In the locked position, at least two apertures in the first half align with at least two apertures in the second half, allowing air to pass through the capsule, releasing the medicament contained therein. Each capsule may have a unique key on each half that only fits with a particular inhaler or identifies the medicament contained therein.

    摘要翻译： 描述了容纳用于吸入器的药物的胶囊。 胶囊可以是两部分胶囊，其中每一半具有可对应于另一半中的孔的孔。 前半部分紧密地配合在第二半部分内，并且两个半部可以相对于彼此绕其纵向轴线旋转以产生解锁和锁定位置。 在解锁位置，前半部中的至少一个孔与第二半中的至少一个孔对准，这允许引入药物。 在锁定位置，第一半部中的至少两个孔与第二半部中的至少两个孔对准，允许空气通过胶囊，释放其中所含的药物。 每个胶囊可以在每一半上具有仅与特定吸入器匹配的识别钥匙，或识别其中包含的药物。