公开(公告)号：US20100265502A1

公开(公告)日：2010-10-21

申请号：US12759082

申请日：2010-04-13

Applicant: Matthew Nelson ,  Patrick Treado ,  Ryan Priore

Inventor： Matthew Nelson ,  Patrick Treado ,  Ryan Priore

IPC: G01J3/30

CPC classification number: G01J3/36 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/027 ,  G01J3/0289 ,  G01J3/0291 ,  G01J3/2823 ,  G01N21/31 ,  G01N2201/0833 ,  G01N2201/0846

Abstract: System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack so as to effectively convert a two-dimensional array of optical fibers into a curvilinear field of view, and wherein said two-dimensional array of optical fibers is configured to receive said photons and transfer said photons out of said fiber array spectral translator device and to a spectrograph through said one-dimensional fiber stack wherein said one-dimensional fiber stack comprises at least two columns of fibers spatially offset in parallel at the entrance slit of said spectrograph. The photons are then detected at a detector to thereby obtain a spectroscopic data set representative of the sample.

Abstract translation: 用于空间和光谱平行化FAST的系统和方法。 照射样品从而产生相互作用的光子。 光子通过过滤器并在FAST装置的二维端接收，其中所述FAST装置包括被拉入一维纤维堆叠的二维光纤阵列，以有效地将二维阵列 的光纤变成曲线视场，并且其中所述二维光纤阵列被配置为接收所述光子并将所述光子从所述光纤阵列光谱转换器装置传送到通过所述一维光纤堆的光谱仪，其中 所述一维纤维堆叠包括在所述光谱仪的入口狭缝处空间上平行偏移的至少两列纤维。 然后在检测器处检测光子，从而获得代表样品的光谱数据集。

公开(公告)号：US20100179770A1

公开(公告)日：2010-07-15

申请号：US12684495

申请日：2010-01-08

Applicant: Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

Inventor： Michael Fuhrman ,  Ryan Priore ,  Oksana Olkhovyk ,  Oksana Klueva

IPC: G06F19/00 ,  G01N33/00 ,  G01J3/44

CPC classification number: G01N15/0227 ,  G01J3/02 ,  G01J3/027 ,  G01J3/44 ,  G01N21/65

Abstract: A system and method for determining at least one geometric property of a particle in a sample. A sample is irradiated to thereby generate Raman scattered photons. These photons are collected to generate a Raman chemical image. A first threshold is applied wherein the first threshold is such that all particles in the sample are detected. A particle in the sample is selected and a second threshold is applied so that at least one geometric property of the selected particle can be determined. At least one spectrum representative of the selected particle is analyzed to determine whether or not it is a particle of interest. The step of determining a second threshold may be iterative and automated via software so that candidate second thresholds are applied until a satisfactory result is achieved.

Abstract translation: 用于确定样品中颗粒的至少一个几何性质的系统和方法。 照射样品从而产生拉曼散射光子。 收集这些光子以产生拉曼化学图像。 应用第一阈值，其中第一阈值使得检测样品中的所有颗粒。 选择样品中的颗粒并施加第二阈值，使得可以确定所选择的颗粒的至少一个几何性质。 分析代表所选粒子的至少一个光谱，以确定其是否是感兴趣的粒子。 确定第二阈值的步骤可以是经由软件的迭代和自动化，使得应用候选的第二阈值直到达到令人满意的结果。

公开(公告)号：US09464934B2

公开(公告)日：2016-10-11

申请号：US13347788

申请日：2012-01-11

Applicant: Ryan Priore ,  John Maier

Inventor： Ryan Priore ,  John Maier

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/44 ,  G01N21/27 ,  G01N21/65 ,  G01J3/28 ,  G01J3/12

CPC classification number: G01J3/02 ,  G01J3/0297 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/1213 ,  G01N21/276 ,  G01N21/65 ,  G01N2201/1293

Abstract: The present disclosure provides for a correction filter that may be configured to comprise a predetermined arrangement of thin film layers. This arrangement of thin film layers may be such that it effectively enables a correction filter to generate a predetermined spectral response, wherein said predetermined spectral response is substantially the same as a determined instrument response correction associated with an instrument. The invention of the present disclosure therefore provides for effectively compensating for transmission inefficiencies associated with an instrument without the need for separate reference measurements to determine and correct for instrument response.

Abstract translation: 本公开提供了一种校正滤波器，其可被配置为包括薄膜层的预定排列。 薄膜层的这种布置可以使得其有效地使得校正滤波器能够产生预定的光谱响应，其中所述预定光谱响应与与仪器相关联的确定的仪器响应校正基本相同。 因此，本公开的发明提供了有效地补偿与仪器相关联的传输效率低下，而不需要单独的参考测量来确定和校正仪器响应。

公开(公告)号：US20150294076A1

公开(公告)日：2015-10-15

申请号：US14440987

申请日：2013-11-06

Applicant: Patrick TREADO ,  Shona STEWART ,  Heather KIRSCHNER ,  Ryan PRIORE ,  Alan WILSON ,  CHEMIMAGE CORPORATION

Inventor： Patrick Treado ,  Shona Stewart ,  Heather Kirschner ,  Ryan Priore ,  Alan Wilson

IPC: G06F19/00 ,  G06F19/24 ,  G01N21/65 ,  G01N33/49

CPC classification number: G16H50/20 ,  G01J3/1804 ,  G01J3/44 ,  G01J3/4406 ,  G01N21/65 ,  G01N33/49 ,  G01N33/57419 ,  G16B40/00

Abstract: A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

Abstract translation: 用于分析诸如干人血清的生物样品以确定诸如结肠直肠癌（CRC）的疾病状态的系统和方法。 使用干燥的样品可能具有增强样品组分的局部浓度和/或分割的潜力。 该方法可以包括照射生物样品的至少一个位置以产生多个相互作用的光子，收集相互作用的光子并产生代表生物样品的至少一个拉曼数据集。 系统可以包括照明源以照亮生物样品的至少一个位置并且生成至少一个多个相互作用的光子，至少一个反射镜，用于将相互作用的光子引导到检测器。 检测器可以被配置为产生代表生物样品的至少一个拉曼数据集。 该系统和方法可以利用FAST设备进行多点分析，或者可以配置为使用线扫描配置分析样本。

公开(公告)号：US08184295B2

公开(公告)日：2012-05-22

申请号：US12530267

申请日：2008-03-27

Applicant: Michael L. Myrick ,  Robert P. Freese ,  John Blackburn ,  David L. Perkins ,  Leonard Zheleznyak ,  Ryan Priore

Inventor： Michael L. Myrick ,  Robert P. Freese ,  John Blackburn ,  David L. Perkins ,  Leonard Zheleznyak ,  Ryan Priore

IPC: G01N21/00

CPC classification number: G01N21/25 ,  G01N21/31 ,  G01N21/9508 ,  G01N2201/1293

Abstract: The present subject matter relates to multivariate optical analysis systems employ multivariate optical elements and utilize multivariate optical computing methods to determine information about a product carried by light reflected from or transmitted through the product. An exemplary method of processing and monitoring the product includes introducing the product at an inspection point; illuminating the product with a spectral-specific light though an optic lens; directing the light that has passed through at least a section of the product through at least one multivariate optical element to produce a first signal, the directed light carrying information about the product; detecting the signal at a detector; and determining at least one property of the product based upon the detector output.

Abstract translation: 本主题涉及采用多变量光学元件的多变量光学分析系统，并且利用多变量光学计算方法来确定关于从产品反射或透过产品运送的光携带的产品的信息。 处理和监测产品的示例性方法包括在检查点引入产品; 通过光学透镜照射具有光谱特定光的产品; 将穿过至少一部分产品的光引导通过至少一个多变量光学元件以产生第一信号，所述导光携带关于产品的信息; 在检测器处检测信号; 以及基于所述检测器输出来确定所述产品的至少一个属性。

公开(公告)号：US20110261351A1

公开(公告)日：2011-10-27

申请号：US13020944

申请日：2011-02-04

Applicant: Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

Inventor： Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

IPC: G01N21/27 ,  G01N21/75

CPC classification number: G01J3/32 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0264 ,  G01J3/0289 ,  G01J3/36 ,  G01J3/4338 ,  G01J3/44 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N33/0057

Abstract: A system and method for detection of explosive agents using hyperspectral imaging. A system comprising an illumination source, a spectral encoding device, and at least one imaging detector configured for at least one of SWIR and MWIR hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material, assessing interacted photons using a spectral encoding device, and detecting interacted photons using at least one of SWIR hyperspectral imaging and MWIR hyperspectral imaging. Algorithms and chemometric techniques may be applied to assess the MWIR hyperspectral image to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using SWIR and MWIR hyperspectral imaging.

Abstract translation: 使用高光谱成像检测爆炸物的系统和方法。 一种包括照明源，光谱编码装置和至少一个成像检测器的系统，该至少一个成像检测器被配置用于包括未知材料的靶的SWIR和MWIR高光谱成像中的至少一个。 一种方法，包括照射包括未知材料的靶，使用光谱编码装置评估相互作用的光子，以及使用SWIR高光谱成像和MWIR高光谱成像中的至少一种来检测相互作用的光子。 可以应用算法和化学计量技术来评估MWIR高光谱图像，以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像设备还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用SWIR和MWIR高光谱成像识别用于询问的目标。

公开(公告)号：US20110242533A1

公开(公告)日：2011-10-06

申请号：US13020935

申请日：2011-02-04

Applicant: Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

Inventor： Patrick Treado ,  Charles W. Gardner, JR. ,  Matthew Nelson ,  Ryan Priore

IPC: G01J3/28

CPC classification number: G01J3/32 ,  G01J3/44 ,  G01N21/359 ,  G01N33/0057

Abstract: A system and method for MWIR hyperspectral imaging to detect hazardous agents including explosive agents. A system comprising an illumination source, a tunable filter, and an imaging detector configured for MWIR hyperspectral imaging of a target comprising an unknown material. A method comprising illuminating a target comprising an unknown material, passing interacted photons through a tunable filter, and generating a MWIR hyperspectral image of the target. Algorithms and chemometric techniques may be applied to assess the MWIR hyperspectral image to identify the unknown material as comprising an explosive agent or a non-explosive agent. A video imaging device may also be configured to provide a video image of an area of interest, which may be assessed to identify a target for interrogation using MWIR hyperspectral imaging.

Abstract translation: 用于MWIR高光谱成像检测危险物质（包括爆炸物质）的系统和方法。 一种包括照明源，可调谐滤光器和被配置用于包含未知材料的靶的MWIR高光谱成像的成像检测器的系统。 一种方法，包括照射包括未知材料的靶，通过可调滤波器传递相互作用的光子，以及生成目标的MWIR高光谱图像。 可以应用算法和化学计量技术来评估MWIR高光谱图像，以将未知材料识别为包括爆炸剂或非爆炸剂。 视频成像设备还可以被配置为提供感兴趣区域的视频图像，其可以被评估以使用MWIR高光谱成像识别用于询问的目标。