公开(公告)号：US11440920B2

公开(公告)日：2022-09-13

申请号：US16671545

申请日：2019-11-01

Applicant: Showa University

Inventor： Takashi Itoh ,  Kazuhiro Nagata ,  Takuya Kanemitsu ,  Michiko Miyazaki ,  Yuichiro Tomisawa ,  Misa Mori

IPC: C07D493/04 ,  C07D311/58 ,  C07C67/30 ,  C07C67/31

Abstract: The present invention provides a compound having a dihydropyran structure, a method of producing a compound having a dihydropyran structure, a method of producing Pre-SMTP, a method of producing a group of SMTPs, and a pharmaceutical composition. The compound having a dihydropyran structure can be a useful intermediate in the chemically producing a group of Pre-SMTP and SMTP. Specifically, the compound having a dihydropyran structure is represented by the following formula (1), wherein: R3Si is a silyl group selected from TMS: trimethylsilyl, TES: triethysilyl, TBS (TBDMS): tert-butyldimethylsil, TIPS: triisopropylsilyl, TBDPS: tert-butyldiphenylsilyl, X is selected from COOH, CHO, and —CH═C(CH3)—(CH2)2—CH═C(CH3)2.

公开(公告)号：US20220218664A1

公开(公告)日：2022-07-14

申请号：US17438801

申请日：2020-03-12

Applicant: TMS Co., Ltd. ,  Showa University

Inventor： Keita Shibata ,  Ryosuke Shinouchi ,  Terumasa Hashimoto ,  Koji Nobe

IPC: A61K31/407 ,  A61P25/02 ,  A61P13/12

Abstract: A drug containing a compound represented by formula (I) as an active ingredient, used for complications from diabetes.

公开(公告)号：US11291431B2

公开(公告)日：2022-04-05

申请号：US16544924

申请日：2019-08-20

Applicant: FUJITSU LIMITED ,  RIKEN ,  SHOWA UNIVERSITY ,  NATIONAL CANCER CENTER

Inventor： Masaaki Komatsu ,  Hiroyuki Yoshida ,  Akira Sakai ,  Akihiko Sekizawa ,  Ryu Matsuoka ,  Ryuji Hamamoto

IPC: A61B8/00 ,  A61B8/08 ,  G06T7/00 ,  G06T7/11 ,  G06T7/143 ,  G06T7/174 ,  G16H50/30

Abstract: A non-transitory computer-readable recording medium stores therein an examination assisting program that causes a computer to execute a process including: performing a site detecting process that uses an object detection technique on each of a plurality of ultrasound examination images taken of an examined subject by performing a scan on the examined subject; and displaying a site detection map in which a detection result of each of a plurality of sites included in the examined subject is kept in correspondence with the scan, on a basis of detection results from the site detecting process.

公开(公告)号：US20140378947A1

公开(公告)日：2014-12-25

申请号：US14378141

申请日：2013-02-14

Applicant: TOHOKU UNIVERSITY ,  SHOWA UNIVERSITY

Inventor： Hitoshi Soyama ,  Katsunori Ami ,  Matsuo Yamamoto

IPC: A61M3/02 ,  A61B1/12

CPC classification number: A61M3/0279 ,  A61B1/126 ,  A61C17/02 ,  A61M3/0216 ,  A61M3/0233 ,  A61M3/0258 ,  A61M2210/1053

Abstract: A water jet spray nozzle has a flow path including, from the upstream side to the end of the flow path, a small-diameter portion having a small inside diameter, an expanded portion having a larger inside diameter than the small-diameter portion, and a jet orifice having a smaller inside diameter than the expanded portion. The water jet spray nozzle is configured such that water passing through the flow path with a pressure of 0.2 to 0.6 MPa is retained in the expanded portion to as to generate cavitation bubbles from the small-diameter portion to the expanded portion. The inside diameter of the small-diameter portion § is 0.5 to 0.7 mm while the inside diameter of the jet orifice is 1 to 1.3 times larger than that of the small-diameter portion.

Abstract translation: 喷水喷嘴具有包括从流路的上游侧到端部的具有小内径的小直径部分，具有比小直径部分更大的内径的扩张部分的流路，以及 具有比扩展部分更小的内径的喷射孔。 喷水喷嘴被配置为使得通过流动路径的水的压力为0.2-0.6MPa被保留在膨胀部分中以便从小直径部分到膨胀部分产生空化气泡。 小直径部分§的内径为0.5至0.7mm，而喷射孔的内径比小直径部分的内径大1至1.3倍。

公开(公告)号：US11918322B2

公开(公告)日：2024-03-05

申请号：US17196069

申请日：2021-03-09

Applicant: SEIKO GROUP CORPORATION ,  SHOWA UNIVERSITY

Inventor： Yoshifumi Yoshida ,  Ryosuke Isogai ,  Kotaro Maki ,  Rumi Shiotsu

IPC: A61B5/0205 ,  A61B5/00 ,  A61B5/021 ,  A61B5/024 ,  A61B5/026 ,  A61B5/1455 ,  A61C13/20 ,  A61K6/889 ,  A61K6/893 ,  A61K6/896

CPC classification number: A61B5/02055 ,  A61B5/0002 ,  A61B5/02108 ,  A61B5/02427 ,  A61B5/0261 ,  A61B5/14552 ,  A61B5/682 ,  A61C13/20 ,  A61K6/889 ,  A61K6/893 ,  A61K6/896 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61B2562/0261 ,  A61B2562/0271 ,  A61B2562/12

Abstract: The present intraoral sensing apparatus is configured to be installed in an oral cavity, and is provided with an electronic device equipped with electronic components mounted on a circuit board; a first dental resin material which completely covers the electronic device; a second dental resin material which completely covers the first dental resin material; and an intraoral instrument having a first recess in which the electronic device covered with the first dental resin material and the second dental resin material is accommodated.

公开(公告)号：US20240019346A1

公开(公告)日：2024-01-18

申请号：US18039446

申请日：2020-11-30

Applicant: Showa University ,  Hitachi High-Tech Corporation

Inventor： Takashi TAKAKI ,  Yoshihiro NAGASE ,  Dedong KANG ,  Kazuho HONDA ,  Mari SAKAUE ,  Megumi NAKAMURA

IPC: G01N1/31 ,  H01J37/20

CPC classification number: G01N1/31 ,  H01J37/20 ,  H01J37/28

Abstract: In order to enable use of novel immunostaining for a pathological diagnosis and research, the invention provides a sample exchange chamber including: a container 2 into which a substrate on which a sample is placed can be introduced; a specific solution inlet 3, which is a staining mechanism that stains the sample; a cleaning liquid inlet 4, which is a cleaning mechanism that cleans the sample; an evacuation port 5, which is an evacuation mechanism that evacuates the container; a drain port 6; and a sterilization mechanism 7 that sterilizes the sample and inside of the container.

公开(公告)号：US11690494B2

公开(公告)日：2023-07-04

申请号：US17046233

申请日：2019-04-12

Applicant: Showa University ,  National University Corporation Tokai National Higher Education and Research System

Inventor： Yuichi Mori ,  Shin-ei Kudo ,  Masashi Misawa ,  Kensaku Mori

IPC: A61B1/00 ,  A61B1/045

CPC classification number: A61B1/000094 ,  A61B1/00006 ,  A61B1/00045 ,  A61B1/045 ,  A61B1/00039

Abstract: An endoscope observation assistance apparatus includes an image information acquiring part to acquire and display a captured image of a luminal organ captured by the endoscope device on a display, a lesion information acquisition part to detect a predetermined lesion based on the captured image and to acquire lesion information regarding the lesion, a lesion disappearance determination part to track the lesion based on the captured image and the lesion information and to determine whether or not the lesion has disappeared from the captured image, and a notification part to notify a determination result when the lesion disappearance determination part determines that the lesion has disappeared from the captured image. Alternatively, the notification part may notify a lesion detection when a short time period passes after the lesion detection by the lesion information acquisition part.

公开(公告)号：US11365194B2

公开(公告)日：2022-06-21

申请号：US16650133

申请日：2018-09-27

Applicant: KAGOSHIMA UNIVERSITY ,  SHOWA UNIVERSITY

Inventor： Takashi Kurihara ,  Ichiro Takasaki ,  Naoki Toyooka ,  Hiroaki Gouda

IPC: C07D471/04 ,  C07D403/14

Abstract: This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

公开(公告)号：US11317864B2

公开(公告)日：2022-05-03

申请号：US16384029

申请日：2019-04-15

Applicant: SEIKO INSTRUMENTS INC. ,  SHOWA UNIVERSITY

Inventor： Shunji Watanabe ,  Yoshifumi Yoshida ,  Kotaro Maki

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/024 ,  A61B5/145

Abstract: A biometric information detection device according to one embodiment of the present disclosure is configured to be installed in a living body, and includes a sensor, a battery, a mechanical switch, a sealing member, and a holding member. The mechanical switch switches between a conduction state in which power is supplied from the battery to the sensor and a cutoff state in which supply of the power is blocked. The sealing member seals all of the sensor, the battery, and the mechanical switch. The holding member is attached to the living body and holds the sealing member.

公开(公告)号：US20220104767A1

公开(公告)日：2022-04-07

申请号：US17426504

申请日：2020-01-24

Applicant: SEIKO HOLDINGS KABUSHIKI KAISHA ,  SHOWA UNIVERSITY

Inventor： Ryosuke ISOGAI ,  Yoshifumi YOSHIDA ,  Kotaro MAKI

IPC: A61B5/00 ,  H04Q9/02 ,  A61B5/01

Abstract: An intraoral biological monitoring device includes a sensor, a communication unit that is configured to perform communication in response to an operation in which a signal is input to the sensor, and a mouthpiece that holds the sensor and the communication unit, and is attached to a crown of a subject to cover at least a part of a gum of the subject.