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    Engineered spider silk proteins and uses thereof
    11.
    发明授权
    Engineered spider silk proteins and uses thereof 有权

    公开(公告)号：US11524984B2

    公开(公告)日：2022-12-13

    申请号：US16314501

    申请日：2017-06-29

    Applicant: SPIBER TECHNOLOGIES AB

    Inventor： Anna Rising ,  Jan Johansson ,  Marlene Andersson

    IPC: C07K14/435 ,  B33Y70/00 ,  C12N5/00 ,  A61K38/00

    Abstract: A recombinant spider silk protein, consisting of no more than 800 amino acids, comprising a set of domains arranged according to the formula (NT)-REP-CT, wherein: the optional NT-domain, if present, comprises a sequence of 100 to 160 amino-acid residues derived from the N-terminal domain of a spider silk protein; the REP-domain comprises a sequence of 30 to 600 amino acid residues derived from the repetitive segment of a spider silk protein; and the CT-domain comprises a sequence of 70 to 120 amino acid residues derived from the C-terminal domain of a spider silk protein selected from: a sequence of 72 to 110 amino acid residues derived from the C-terminal domain of a spider silk protein, wherein the sequence comprises at least 7 residues independently selected from K, R, E and D; a sequence having at least 85% identity to SEQ ID NO: 15 or any one of SEQ ID NOs: 62-65 or 67-73; and a sequence having at least 70% identity to SEQ ID NOs: 64 or any one of SEQ ID NOs: 62-65 or 67-73, wherein the sequence comprises at least 7 residues independently selected from K, R, E and D.

    ENGINEERED SPIDER SILK PROTEINS AND USES THEREOF
    12.
    发明申请
    ENGINEERED SPIDER SILK PROTEINS AND USES THEREOF 有权

    公开(公告)号：US20230070786A1

    公开(公告)日：2023-03-09

    申请号：US17895320

    申请日：2022-08-25

    Applicant: SPIBER TECHNOLOGIES AB

    Inventor： Anna RISING ,  Jan JOHANSSON ,  Marlene ANDERSSON

    IPC: C07K14/435 ,  C12N5/00

    Abstract: A recombinant spider silk protein, consisting of no more than 800 amino acids, comprising a set of domains arranged according to the formula (NT)-REP-CT, wherein: the optional NT-domain, if present, comprises a sequence of 100 to 160 amino-acid residues derived from the N-terminal domain of a spider silk protein; the REP-domain comprises a sequence of 30 to 600 amino acid residues derived from the repetitive segment of a spider silk protein; and the CT-domain comprises a sequence of 70 to 120 amino acid residues derived from the C-terminal domain of a spider silk protein selected from: a sequence of 72 to 110 amino acid residues derived from the C-terminal domain of a spider silk protein, wherein the sequence comprises at least 7 residues independently selected from K, R, E and D; a sequence having at least 85% identity to SEQ ID NO: 15 or any one of SEQ ID NOs: 62-65 or 67-73; and a sequence having at least 70% identity to SEQ ID NOs: 64 or any one of SEQ ID NOs: 62-65 or 67-73, wherein the sequence comprises at least 7 residues independently selected from K, R, E and D.

    STRUCTURING OF SURFACE-ACTIVE MACROMOLECULES
    13.
    发明申请
    STRUCTURING OF SURFACE-ACTIVE MACROMOLECULES 有权

    公开(公告)号：US20210069939A1

    公开(公告)日：2021-03-11

    申请号：US16644772

    申请日：2018-09-26

    Applicant: SPIBER TECHNOLOGIES AB

    Inventor： My HEDHAMMAR ,  Linnea Gustafsson ,  Ronnie Jansson ,  Wouter van der Wijngaart

    IPC: B29C39/02 ,  C07K14/435 ,  B29C33/42 ,  B29C39/10 ,  B29C41/12 ,  C09D127/12

    Abstract: A method for manufacturing shaped polymers of surface-active macromolecules, in particular silk, is provided. The method is comprising the steps of: • a) depositing an aqueous solution of the surface-active macromolecules on a surface, wherein the aqueous solution of the surface-active macromolecules is deposited in the form of a droplet, and wherein the surface is a hydrophobic micropatterned surface adapted to prevent the aqueous solution from penetrating into the pattern and to receive the droplet of the aqueous solution of the surface-active macromolecules and retain its droplet state; and • b) forming shaped polymers of the surface-active macromolecules on the surface.

    Engineered Spider Silk Proteins And Uses Thereof
    15.
    发明申请
    Engineered Spider Silk Proteins And Uses Thereof 审中-公开

    公开(公告)号：US20190248847A1

    公开(公告)日：2019-08-15

    申请号：US16314501

    申请日：2017-06-29

    Applicant: SPIBER TECHNOLOGIES AB

    Inventor： Anna Rising ,  Jan Johansson ,  Marlene Andersson

    IPC: C07K14/435 ,  C12N5/00 ,  B33Y70/00

    CPC classification number: C07K14/43518 ,  B33Y70/00 ,  C12N5/0018 ,  C12N5/0062 ,  C12N2513/00 ,  C12N2533/50

    Abstract: A recombinant spider silk protein, consisting of no more than 800 amino acids, comprising a set of domains arranged according to the formula (NT)-REP-CT, wherein: the optional NT-domain, if present, comprises a sequence of 100 to 160 amino-acid residues derived from the N-terminal domain of a spider silk protein; the REP-domain comprises a sequence of 30 to 600 amino acid residues derived from the repetitive segment of a spider silk protein; and the CT-domain comprises a sequence of 70 to 120 amino acid residues derived from the C-terminal domain of a spider silk protein selected from: a sequence of 72 to 110 amino acid residues derived from the C-terminal domain of a spider silk protein, wherein the sequence comprises at least 7 residues independently selected from K, R, E and D; a sequence having at least 85% identity to SEQ ID NO: 15 or any one of SEQ ID NO:s 62-65 or 67-73; and a sequence having at least 70% identity to SEQ. ID NO: 64 or any one of SEQ ID NO:s 62-65 or 67-73, wherein the sequence comprises at least 7 residues independently selected from K, R, E and D. Solutions, polymers, uses and methods of manufacture thereof.

    SPIDER SILK FUSION PROTEIN STRUCTURES FOR BINDING TO AN ORGANIC TARGET
    17.
    发明申请
    SPIDER SILK FUSION PROTEIN STRUCTURES FOR BINDING TO AN ORGANIC TARGET 审中-公开
    用于绑定到有机目标的SPIDER SILK融合蛋白质结构

    公开(公告)号：US20150291674A1

    公开(公告)日：2015-10-15

    申请号：US14753101

    申请日：2015-06-29

    Applicant: SPIBER TECHNOLOGIES AB

    Inventor： My HEDHAMMAR ,  Jan JOHANSSON ,  Anna RISING ,  Per Åke NYGREN

    IPC: C07K14/435 ,  C07K14/76 ,  B01D15/20 ,  C07K14/31 ,  C12N5/00 ,  C07K16/06 ,  C07D495/04

    CPC classification number: C07K14/43518 ,  B01D15/20 ,  B01D15/3804 ,  B01D15/3809 ,  B01D15/3823 ,  B01J20/281 ,  C07D495/04 ,  C07K14/31 ,  C07K14/76 ,  C07K16/065 ,  C07K2319/01 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/70 ,  C07K2319/705 ,  C12N5/0068 ,  C12N2533/50 ,  Y10S210/905

    Abstract: A protein structure capable of selective interaction with an organic target is provided. The protein structure is a polymer comprising as a repeating structural unit a recombinant fusion protein that is capable of selective interaction with the organic target. The fusion protein is comprising the moieties B, REP and CT, and optionally NT. B is a non-spidroin moiety of more than 30 amino acid residues, which provides the capacity of selective interaction with the organic target. REP is a moiety of from 70 to 300 amino acid residues and is derived from the repetitive fragment of a spider silk protein. CT is a moiety of from 70 to 120 amino acid residues and is derived from the C-terminal fragment of a spider silk protein. NT is an optional moiety of from 100 to 160 amino acid residues and is derived from the N-terminal fragment of a spider silk protein. The fusion protein and protein structure thereof is useful as an affinity medium and a cell scaffold material.

    Abstract translation: 提供能够与有机靶相互选择性的蛋白质结构。 蛋白质结构是包含能够与有机靶选择性相互作用的重组融合蛋白作为重复结构单元的聚合物。 融合蛋白包含部分B，REP和CT，以及任选的NT。 B是超过30个氨基酸残基的非宿主部分，其提供与有机靶的选择性相互作用的能力。 REP是70至300个氨基酸残基的部分，并衍生自蜘蛛丝蛋白的重复片段。 CT是70至120个氨基酸残基的部分，衍生自蜘蛛丝蛋白的C末端片段。 NT是100至160个氨基酸残基的任选部分，并衍生自蜘蛛丝蛋白的N-末端片段。 其融合蛋白质和蛋白质结构可用作亲和介质和细胞支架材料。

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