公开(公告)号：US20070161825A1

公开(公告)日：2007-07-12

申请号：US11716828

申请日：2007-03-12

Applicant: Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Takahiro Ueda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C07C43/20

CPC classification number: C07C41/26 ,  C07C41/34 ,  C07C43/23

Abstract: The present invention provides a method for obtaining reduced coenzyme Q10 which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc. suited for a commercial scale production in high quality and efficiently. The high-quality oily reduced coenzyme Q10 which has low viscosity and thereby easily handled may be produced by separating an aqueous phase from the reaction mixture obtainable by oily reacting oxidized coenzyme Q10 with a reducing agent in water, or by distilling off an coexisting organic solvent at or above the melting temperature of reduced coenzyme Q10 in concentrating the organic phase containing reduced coenzyme Q10. Moreover, a solution or slurry of reduced coenzyme Q10 may be obtained by adding a desired solvent to the obtained oily product, or a solid of reduced coenzyme Q10 may be produced by contacting the oily product with a seed crystal.

公开(公告)号：US20050118288A1

公开(公告)日：2005-06-02

申请号：US10504256

申请日：2003-02-20

Applicant: Koki Yamashita ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Koki Yamashita ,  Tadao Ono ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: A23K1/14 ,  A23K1/16 ,  A23L1/236 ,  A23L1/30 ,  A61K9/20 ,  A61K31/352 ,  A61K31/37 ,  A61K31/56 ,  A61K36/484 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P43/00 ,  C07J63/00 ,  A61K35/78

CPC classification number: C07J63/00 ,  A23K10/30 ,  A23K20/10 ,  A23L27/30 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/352 ,  A61K31/37 ,  A61K31/56 ,  A61K36/484 ,  A23V2250/252

Abstract: It is an object of the present invention to provide a method for producing a hydrophobic licorice extract which is useful for applications, such as food, food additives, functional nutritive food, food for specified health uses, dietary supplements, drink, feedstuff, drugs, and quasi-drugs, and which has satisfactory powder characteristics. This invention relates to a method for producing a hydrophobic licorice extract comprises performing extraction from licorice with a water-soluble organic solvent, the area of the bark of the licorice occupying at least 30% of the total surface area of the licorice. This invention also relates to a method for producing a hydrophobic licorice extract comprises crystallizing an extract extracted from licorice, or an extraction residue of the licorice, with a water-soluble organic solvent in a mixed solvent comprising water and the water-soluble organic solvent, the weight ratio, water/(water-soluble organic solvent+water), being ⅓ or more.

Abstract translation: 本发明的目的是提供一种制备疏水性甘草提取物的方法，其可用于食品，食品添加剂，功能性营养食品，特定健康用途食品，膳食补充剂，饮料，饲料，药物， 和准药，具有令人满意的粉末特性。 本发明涉及一种生产疏水甘草提取物的方法，包括用水溶性有机溶剂从甘草中提取甘草的皮肤面积占甘草总表面积的至少30％。 本发明还涉及一种疏水性甘草提取物的制造方法，其特征在于，包括使水溶性有机溶剂在水和水溶性有机溶剂的混合溶剂中结晶从甘草提取的提取物或甘草的提取残渣， 重量比，水/（水溶性有机溶剂+水）为1/3以上。

公开(公告)号：US08574568B2

公开(公告)日：2013-11-05

申请号：US12092925

申请日：2006-11-07

Applicant: Takahiro Ueda ,  Shiro Kitamura

Inventor： Takahiro Ueda ,  Shiro Kitamura

IPC: A61K31/15 ,  A61K47/14

CPC classification number: A61K9/4858 ,  A61K9/4875 ,  A61K31/05

Abstract: The present invention provides a method for stabilization of reduced coenzyme Q10 characterized by concurrently containing a propylene glycol fatty acid ester in a composition containing reduced coenzyme Q10, and a composition containing reduced coenzyme Q10 and a propylene glycol fatty acid ester as essential constituting ingredients. According to the present invention, reduced coenzyme Q10, which is useful as a food, food with nutrient function claims, food for specified health use, nutritional supplement, nutritional product, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like can be stabilized especially without being made into a complicated composition.

Abstract translation: 本发明提供还原型辅酶Q10的稳定化方法，其特征在于含有还原型辅酶Q10的组合物中含有丙二醇脂肪酸酯，还含有还原型辅酶Q10和丙二醇脂肪酸酯作为必要构成成分的组合物。 根据本发明，可用作食品的具有营养功能的食品的还原型辅酶Q10，用于特定健康用途的食物，营养补充剂，营养产品，动物药物，饮料，饲料，化妆品，药​​物产品，治疗药物， 预防药物等可以稳定化，而不会形成复杂的组合物。

公开(公告)号：US08562975B2

公开(公告)日：2013-10-22

申请号：US10501698

申请日：2003-01-20

Applicant: Yasuyoshi Ueda ,  Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Kenji Fujii ,  Kazunori Hosoe

Inventor： Yasuyoshi Ueda ,  Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura ,  Kenji Fujii ,  Kazunori Hosoe

IPC: A61K38/43

CPC classification number: A61K8/347 ,  A23D9/007 ,  A23K20/105 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/345 ,  A61K8/355 ,  A61K8/375 ,  A61K8/39 ,  A61K8/92 ,  A61K8/922 ,  A61K8/925 ,  A61K31/122 ,  A61K47/10 ,  A61K47/14 ,  A61K2800/52 ,  A61Q19/00 ,  C07C41/46 ,  C07C43/23 ,  A23V2250/314 ,  A23V2250/1842 ,  A23V2250/18 ,  A23V2250/192 ,  A23V2250/1944

Abstract: The present invention relates to a method for stabilizing reduced coenzyme Q10, which is useful as an ingredient in good foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc., and to a composition therefor. The composition comprises reduced coenzyme Q10, a fat and oil (excluding olive oil) and/or a polyol, and doesn't substantially inhibit the stabilization of reduced coenzyme Q10. Additionally, the composition is a reduced coenzyme Q10-containing composition which comprises reduced coenzyme Q10, a polyglycerol fatty acid ester, and a fat and oil and/or a polyol.

Abstract translation: 本发明涉及一种用于稳定还原型辅酶Q10的方法，其可用作良好食品中的成分，功能营养食品，特定保健食品，营养补充剂，营养物质，动物药物，饮料，饲料，化妆品，药​​物，补救剂，预防剂 药物等，以及其组合物。 组合物包含还原型辅酶Q10，脂肪和油（不包括橄榄油）和/或多元醇，并且基本上不抑制还原型辅酶Q10的稳定化。 此外，该组合物是还原型辅酶Q 10组合物，其包含还原型辅酶Q10，聚甘油脂肪酸酯和脂肪和油和/或多元醇。

公开(公告)号：US20120201802A1

公开(公告)日：2012-08-09

申请号：US13502181

申请日：2010-10-14

Applicant: Takao Yamaguchi ,  Takaaki Jikihara ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Takao Yamaguchi ,  Takaaki Jikihara ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: A61K38/43 ,  A61K31/122 ,  A23L1/30 ,  C07C50/28

CPC classification number: A61K36/53 ,  A23L33/10 ,  A23L33/105 ,  A23L33/15 ,  A23P10/30 ,  A23V2002/00 ,  A61K9/4875 ,  A61K31/09 ,  A61K31/122 ,  A61K36/15 ,  A61K36/736 ,  A61K36/82 ,  C07C41/26 ,  C07C41/46 ,  C07C43/23 ,  A23V2250/21 ,  A23V2250/314

Abstract: The present invention aims to provide a component having not only an ability to reduce oxidized coenzyme Q10 and an ability to stabilize reduced coenzyme Q10, but also nutrient, flavor, broad utility and the like, and a utilization method thereof. The present invention relates to a safe and convenient method of producing reduced coenzyme Q10, including reducing oxidized coenzyme Q10 by using, as a component derived from a naturally-occurring substance, which is safe for the body, any one or more components selected from the group consisting of an acerola extract, a tea extract, a rosemary extract, a pine bark extract and a Vaccinium vitis-idaea extract. In addition, the present invention also relates to a method of stabilizing reduced coenzyme Q10 in the co-presence of a component derived from a naturally-occurring substance, and a stabilized composition. Since the above-mentioned components derived from a naturally-occurring substance can also be expected to function as nutrients, the composition of the present invention is particularly useful as a pharmaceutical product, a supplement, a food with nutrient function claims, a food for specified health use, a nutritional supplement, a nutritional product, an animal drug, a cosmetic, a therapeutic drug and the like, which are required to show various effects.

Abstract translation: 本发明的目的在于提供一种不仅具有减少氧化型辅酶Q10的能力和稳定还原型辅酶Q10的能力，而且还具有养分，风味，广泛用途等的成分及其利用方法。 本发明涉及一种生产还原型辅酶Q10的安全且方便的方法，其包括使用作为对身体安全的天然存在物质的成分的还原氧化型辅酶Q10，任何一种或多种选自 一组由槭树提取物，茶提取物，迷迭香提取物，松树皮提取物和痘苗提取物组成。 此外，本发明还涉及在衍生自天然存在物质的成分的共存下稳定还原型辅酶Q10的稳定化组合物的方法。 由于上述衍生自天然物质的组分也可以预期作为营养物质使用，所以本发明的组合物特别可用作药物产品，补充剂，具有营养功能要求的食品，特定食品 健康用品，营养补充剂，营养产品，动物药物，化妆品，治疗药物等，需要显示各种效果。

公开(公告)号：US07910340B2

公开(公告)日：2011-03-22

申请号：US11981181

申请日：2007-10-31

Applicant: Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

Inventor： Kazuyoshi Yajima ,  Takahisa Kato ,  Akihisa Kanda ,  Shiro Kitamura ,  Yasuyoshi Ueda

IPC: C12P1/00 ,  C12P7/66

CPC classification number: C12P7/66 ,  C12P7/22

Abstract: The present invention relates to a process for producing reduced coenzyme Q10 which comprises obtaining microbial cells containing reduced coenzyme Q10 at a ratio of not less than 70 mole % among the entire coenzymes Q10, optionally disrupting the cells and recovering thus-produced reduced coenzyme Q10. The present invention also relates to a process for producing oxidized coenzyme Q10 which comprises either recovering oxidized coenzyme Q10 after oxidizing the above-mentioned microbial cells or disrupted product thereof, or recovering reduced coenzyme Q10 from the above-mentioned microbial cells or disrupted product thereof to oxidize thus-obtained reduced coenzyme Q10 thereafter. According to the processes of the present invention, reduced coenzyme Q10 and oxidized coenzyme Q10 can be produced simply on the industrial scale.

Abstract translation: 本发明涉及还原型辅酶Q10的制备方法，其包括在整个辅酶Q10中获得含有不少于70摩尔％的还原型辅酶Q10的微生物细胞，任选地破坏细胞并回收如此生产的还原型辅酶Q10。 本发明还涉及氧化型辅酶Q10的制造方法，该方法包括在氧化上述微生物细胞或其破坏的产物后回收氧化型辅酶Q10，或将还原型辅酶Q10从上述微生物细胞或其破坏性产物回收至 此后氧化由此得到的还原型辅酶Q10。 根据本发明的方法，可以简单地在工业规模上制备还原型辅酶Q10和氧化型辅酶Q10。

公开(公告)号：US07829080B2

公开(公告)日：2010-11-09

申请号：US11741290

申请日：2007-04-27

Applicant: Takahiro Ueda ,  Shiro Kitamura ,  Hiroshi Kubo ,  Kazunori Hosoe

Inventor： Takahiro Ueda ,  Shiro Kitamura ,  Hiroshi Kubo ,  Kazunori Hosoe

IPC: A61K9/64 ,  A61K38/43 ,  A61K38/54

CPC classification number: A61K31/047 ,  A61K9/4858

Abstract: The present invention provides a method for stabilizing reduced coenzyme Q10, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like. The present invention also provides a method of producing a reduced coenzyme Q10-containing composition which includes the co-presence of reduced coenzyme Q10 and reduced coenzyme Q9 and/or reduced coenzyme Q11.

Abstract translation: 本发明提供一种用于稳定还原型辅酶Q10的方法，其可用作食品，营养产品，营养补充剂，动物药物，饮料，饲料，化妆品，药​​物，治疗药物，预防药物等。 本发明还提供了还原型辅酶Q 10组合物的制造方法，该组合物包括还原型辅酶Q 10和还原型辅酶Q 9和/或还原型辅酶Q 11的共存。

公开(公告)号：US20090186009A1

公开(公告)日：2009-07-23

申请号：US12298449

申请日：2007-04-24

Applicant: Masao Sato ,  Takashi Ueda ,  Yoshiyuki Shinagawa ,  Shinsuke Akao ,  Naohiro Imai ,  Shiro Kitamura

Inventor： Masao Sato ,  Takashi Ueda ,  Yoshiyuki Shinagawa ,  Shinsuke Akao ,  Naohiro Imai ,  Shiro Kitamura

IPC: A61K31/122

CPC classification number: A61K31/05 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/1075 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K31/122 ,  A23V2200/326 ,  A23V2250/314 ,  A23V2200/254

Abstract: The present invention provides a coenzyme Q-containing solid wherein coenzyme Q fine particles are dispersed in particles made of a physically crosslinked polymer. In addition, the present invention provides a method of producing a coenzyme Q-containing solid, which includes a step of bringing an atomized water-soluble polymer solution capable of forming a physical gel, wherein coenzyme Q is dispersed, into contact with an atomized gelling solution.In the solid of the present invention, the disintegratability is suppressed in the stomach, and rapidly disintegrated in the intestine. Accordingly, coenzyme Q is more quickly absorbed from the intestine, which in turn enhances the absorbability of coenzyme Q from the intestine. In addition, the production method of the present invention is industrially advantageous.

Abstract translation: 本发明提供了一种辅酶Q固体，其中辅酶Q细颗粒分散在由物理交联的聚合物制成的颗粒中。 另外，本发明提供了含有辅酶Q的固体的制造方法，该方法包括使能够形成物理凝胶的雾化的水溶性聚合物溶液（其中辅酶Q分散）与雾化胶凝剂接触的步骤 解。 在本发明的实施方案中，胃中的崩解性被抑制，并且在肠中迅速分解。 因此，辅酶Q更快地从肠中吸收，这又增强了辅酶Q从肠中的吸收性。 另外，本发明的制造方法在工业上是有利的。

公开(公告)号：US20090036519A1

公开(公告)日：2009-02-05

申请号：US12233069

申请日：2008-09-18

Applicant: Tatsumasa MAE ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

Inventor： Tatsumasa MAE ,  Misuzu Tsukagawa ,  Mikio Kitahara ,  Kaku Nakagawa ,  Shiro Kitamura ,  Yasuyoshi Ueda ,  Minpei Kuroda ,  Yoshihiro Mimaki ,  Yutaka Sashida

IPC: A61K31/352 ,  A61P29/00 ,  A61P35/00

CPC classification number: C07D311/06 ,  A23K20/111 ,  A23K20/121 ,  A23K50/00 ,  A23K50/40 ,  A23L33/10 ,  A23L33/105 ,  A61K31/12 ,  A61K31/353 ,  A61K31/37 ,  A61K36/484 ,  A61K2300/00

Abstract: The present invention easily and efficiently provides a peroxisome proliferator-activated receptor ligand, and a composition for amelioration of insulin resistance or for prevention and/or amelioration of the insulin resistance syndrome containing the same, as an active ingredient.The present invention relates to a peroxisome proliferator-activated receptor ligand which comprises a prenylflavonoid, a chalcone derivative exclusive of prenylflavonoids, a flavonol derivative exclusive of prenylflavonoids, and a salt, a glycoside and/or an esterified substance thereof acceptable as a pharmaceutical preparation or a food or a beverage; a composition containing the above ligand; a plant-derived extract containing the above ligand; and a process for producing the above extract.

Abstract translation: 本发明容易且有效地提供过氧化物酶体增殖物激活受体配体，以及用于改善胰岛素抵抗或用于预防和/或改善含有它们的胰岛素抵抗综合征作为活性成分的组合物。 本发明涉及一种过氧化物酶体增殖物激活受体配体，其包含异戊烯基类黄酮，不含异戊烯基黄酮的查耳酮衍生物，不含异戊烯基黄酮的黄酮醇衍生物，以及作为药物制剂可接受的盐，糖苷和/或其酯化物质， 食物或饮料; 含有上述配体的组合物; 含有上述配体的植物来源的提取物; 以及生产上述提取物的方法。

公开(公告)号：US20070258967A1

公开(公告)日：2007-11-08

申请号：US11741522

申请日：2007-04-27

Applicant: Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura

Inventor： Takahiro Ueda ,  Tadao Ono ,  Shiro Kitamura

IPC: A61K38/43 ,  C07C39/10

CPC classification number: C07C43/23 ,  A61K8/355 ,  A61Q19/00

Abstract: The present invention provides reduced coenzyme Q10 with a low reduced coenzyme Q10 analog content, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, and a production method of the reduced coenzyme Q10. The present invention also provides a method of producing a reduced coenzyme Q10 crystal or reduced coenzyme Q10-containing composition, which includes subjecting reduced coenzyme Q10 to chromatography under oxidation preventive conditions, or purifying oxidized coenzyme Q10 by chromatography and converting the oxidized coenzyme Q10 to reduced coenzyme Q10. According to this method, high quality reduced coenzyme Q10 containing not more than 1 wt %, relative to reduced coenzyme Q10, of at least one reduced coenzyme Q10 analog selected from the group consisting of cis-reduced coenzyme Q10, reduced coenzyme Q11 and ubichromenol, can be obtained.

Abstract translation: 本发明提供具有低还原型辅酶Q 10 O 3类似物含量的还原型辅酶Q 10，其可用作食品，营养产品，营养补充剂，动物药物，饮料， 饲料，化妆品，药​​物，治疗药物，预防药物等，以及还原型辅酶Q 10的制造方法。 本发明还提供了还原型辅酶Q 10结晶或还原型辅酶Q 10系组合物的制备方法，该组合物包括将还原型辅酶Q 10 在氧化防止条件下进行色谱法，或通过色谱法纯化氧化型辅酶Q 10，并将氧化型辅酶Q 10转化为还原型辅酶Q 10 。 根据该方法，相对于还原型辅酶Q 10含有不超过1重量％的至少一种还原型辅酶Q 1的高质量还原型辅酶Q 10 N， 可以得到选自顺式还原型辅酶Q 10，还原型辅酶Q 11和二倍氯酚的10种类似物。