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11.发明申请公开(公告)号：US20200009227A1
公开(公告)日：2020-01-09
申请号：US16502509
申请日：2019-07-03
发明人： Raul Bastarrachea
摘要： Described herein are pharmaceutical compositions containing genes encoding a positive regulatory domain zinc finger protein 16, a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, and a bone morphogenetic protein 7. Also disclosed are methods of treating or managing obesity and diabetes by delivering these pharmaceutical compositions using ultrasound-targeted microbubble destruction.
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公开(公告)号：US20180369251A1
公开(公告)日：2018-12-27
申请号：US16118144
申请日：2018-08-30
IPC分类号： A61K31/5377 , A61P31/12 , C07D413/12 , A61K31/4155 , C07D409/14
摘要： Described herein are pharmaceutical compositions capable of inhibiting vesicle formation and methods of treatment or prophylactic administration of these pharmaceutical compositions to treat pathogenic infections.
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公开(公告)号：US20240180929A1
公开(公告)日：2024-06-06
申请号：US18042648
申请日：2021-08-23
发明人： Larry Schlesinger , Eusondia Arnett
IPC分类号： A61K31/635 , A61K31/4162 , A61K31/426 , A61K31/519 , A61K31/5377 , A61K31/553 , A61K45/06 , A61P31/06
CPC分类号： A61K31/635 , A61K31/4162 , A61K31/426 , A61K31/519 , A61K31/5377 , A61K31/553 , A61K45/06 , A61P31/06
摘要： Provided are methods of treating infectious diseases by administering a BCL-2 inhibitor and a MCL-1 inhibitor to a subject in need thereof. One such infectious disease is an infection of Mycobacterium tuberculosis. Also provided are methods of inhibiting the growth of Mycobacterium tuberculosis in a granuloma by contacting the granuloma with a BCL-2 inhibitor and a MCL-1 inhibitor.
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公开(公告)号：US20190298820A1
公开(公告)日：2019-10-03
申请号：US16348097
申请日：2017-11-07
发明人： Ruth M. Ruprecht , Hemant K. Vyas
摘要： Provided herein are recombinant nucleic acid sequences derived from the C-terminal domain of the HIV-1 gp41 protein, and more specifically compositions and methods for using these epitopes to develop vaccine protection against HIV. Also provided here are monoclonal antibodies that specifically bind to these recombinant nucleic acid sequences derived from the C-terminal domain of the HIV-1 gp41 protein.
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公开(公告)号：US20150037364A1
公开(公告)日：2015-02-05
申请号：US14233710
申请日：2014-01-15
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , TEXAS BIOMEDICAL RESEARCH INSTITUTE , THE GOVERNMENT OF THE UNITED STATES OF AMERICA
IPC分类号： C12Q1/70 , G01N33/569 , C12N7/00 , C12N15/86 , C07K14/005 , C07K16/08
CPC分类号： C12Q1/701 , A61K2039/55566 , C07K14/005 , C07K14/075 , C07K16/081 , C07K2317/76 , C12N7/00 , C12N15/86 , C12N15/861 , C12N2710/10321 , C12N2710/10343 , C12Q1/68 , C12Q1/702 , C12Q2563/131 , C12Q2600/156 , G01N33/56983
摘要： Baboon Adenovirus (BaAdV)-2/4 and BaAdV-3 are disclosed herein. BaAdV-2/4 and BaAdV-3 polynucleotide, polypeptides and antibodies that specifically bind BaAdV-2/4 and/or BaAdV-3 are disclosed. Methods are disclosed for detecting BaAdV-2/4 and BaAdV-3. Methods are also disclosed for treating, preventing, and inducing an immune response to BaAdV-2/4 and/or BaAdV-3. Kits are also provided.
摘要翻译： 本文公开了狒狒腺病毒（BaAdV）-2/4和BaAdV-3。 公开了BaAdV-2/4和BaAdV-3多核苷酸，特异性结合BaAdV-2/4和/或BaAdV-3的多肽和抗体。 公开了用于检测BaAdV-2/4和BaAdV-3的方法。 还公开了治疗，预防和诱导对BaAdV-2/4和/或BaAdV-3的免疫应答的方法。 还提供套件。
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公开(公告)号：US20240307525A1
公开(公告)日：2024-09-19
申请号：US18612258
申请日：2024-03-21
发明人： Luis Martinez-Sobrido , Chengjin Ye
IPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00 , C12N15/85 , G01N33/68
CPC分类号： A61K39/215 , A61P31/14 , C07K14/005 , C12N7/00 , C12N15/85 , G01N33/6854 , C12N2770/20034 , G01N2333/165
摘要： Provided here are compositions for a bacterial artificial chromosome-based construct containing a replication-competent recombinant severe acute respiratory syndrome coronavirus-2 (rSARS-CoV-2) genome and methods of making such compositions and uses thereof. The rSARS-Cov-2 provided herein can be attenuated and safely worked with under BLS-2+ conditions.
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公开(公告)号：US20240270828A1
公开(公告)日：2024-08-15
申请号：US18688935
申请日：2022-09-06
发明人： James KOBIE , Michael PIEPENBRINK , Paul GOEPFERT , Mark R. WALTER , Nathan ERDMANN , Ashlesha DESHPANDE , Luis MARTINEZ-SOBRIDO , Jun-Gyu PARK
CPC分类号： C07K16/1003 , A61P31/14 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The disclosure is based, at least in part, on certain human monoclonal antibodies, or antigen binding fragments thereof, having unexpected broad neutralizing activities against SARS-CoV-2. The disclosed antibodies and/or antigen-binding fragments thereof are therapeutic agents for the treatment of SARS-CoV-2 infections and are suitable for use in therapeutic methods to protect individuals from SARS-CoV-2 infections.
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公开(公告)号：US20240100150A1
公开(公告)日：2024-03-28
申请号：US18255612
申请日：2021-12-02
申请人： TEXAS BIOMEDICAL RESEARCH INSTITUTE , Spanish National Centre for Biotechnology , Scripps Research
IPC分类号： A61K39/215 , A61P31/14 , C12N15/70
CPC分类号： A61K39/215 , A61P31/14 , C12N15/70 , A61K2039/53 , C12N2770/20022 , C12N2770/20034 , C12N2770/20062 , C12N2770/20071 , C12N2800/204
摘要： Provided here are compositions for a bacterial artificial chromosome-based construct containing a replication-competent recombinant severe acute respiratory syndrome coronavirus-2 genome and methods of making such compositions and uses thereof.
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19.发明申请公开(公告)号：US20180177858A1
公开(公告)日：2018-06-28
申请号：US15672108
申请日：2017-08-08
摘要： The present invention provides for novel compositions and methods for delivering genes of interest to stem cells using vectors that contain differentiation-specific transcriptional regulatory elements. For example, stem cells in the internal epithelia could be transfected with a vaccine construct, which has an epithelial cell differentiation-specific promoter driving the expression of viral envelope proteins. When the promoter used is specific for terminally differentiated epithelial cells, then the viral envelope proteins will be expressed only in the upper part of the epithelia and therefore, stimulate the immune response. The infected epithelial stem cells in the basal layer will continue to produce new antigen-expressing cells, without being eliminated by the immune response. This invention will be useful in the development of vaccines against viral agents that target the internal mucosa like HIV.
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公开(公告)号：US09730996B2
公开(公告)日：2017-08-15
申请号：US14062125
申请日：2013-10-24
CPC分类号： A61K39/12 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/55566 , C12N15/00 , C12N15/86 , C12N2740/15034 , C12N2740/15041
摘要： The present invention provides for novel compositions and methods for delivering genes of interest to stem cells using vectors that contain differentiation-specific transcriptional regulatory elements. For example, stem cells in the internal epithelia could be transfected with a vaccine construct, which has an epithelial cell differentiation-specific promoter driving the expression of viral envelope proteins. When the promoter used is specific for terminally differentiated epithelial cells, then the viral envelope proteins will be expressed only in the upper part of the epithelia and therefore, stimulate the immune response. The infected epithelial stem cells in the basal layer will continue to produce new antigen-expressing cells, without being eliminated by the immune response. This invention will be useful in the development of vaccines against viral agents that target the internal mucosa like HIV.
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