公开(公告)号：US20160137994A1

公开(公告)日：2016-05-19

申请号：US14436833

申请日：2013-10-17

Applicant: TOKUSHIMA UNIVERSITY ,  MEIJI PHARMACEUTICAL UNIVERSITY

Inventor： Koji ITO ,  Hitoshi SAKURABA ,  Daisuke TSUJI

IPC: C12N9/24 ,  A61K38/47

CPC classification number: C12N9/2402 ,  A61K38/00 ,  A61K38/47 ,  C12Y302/01052

Abstract: Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.

Abstract translation: 提供了具有衍生自野生型人类 - 半胱胺糖苷酶的α-亚单位的活性的人类 - 半胱胺酶的修饰和亚基，并具有对蛋白酶的抗性。 包含具有312至318位氨基酸的氨基酸序列的氨基酸序列的氨基酸序列分别与甘氨酸，丝氨酸，谷氨酸，脯氨酸，丝氨酸，甘氨酸和苏氨酸的氨基酸序列分别在野生型 型人类和半乳糖胺酶。

公开(公告)号：US20160061704A1

公开(公告)日：2016-03-03

申请号：US14888841

申请日：2014-04-30

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Ryousuke DOHI ,  Nobukazu IKEDA ,  Kouji NISHINO ,  Michio YAMAJI ,  Tadayuki YAKUSHIJIN

IPC: G01N9/00 ,  G01N21/59 ,  G01N21/85

CPC classification number: G01N9/00 ,  G01N9/24 ,  G01N21/05 ,  G01N21/33 ,  G01N21/59 ,  G01N21/85 ,  G01N2201/08

Abstract: This invention is related to an optical-analysis-type raw material fluid density detector including a detector main body and a light oscillation unit and a light detection unit that are provided on the upper surface or the under surface of the detector main body, in which the detector main body has at least one recess formed in the upper surface and the under surface, a fluid flow path connecting a fluid inlet of the detector main body to the recess, a fluid flow path connecting the recesses to each other, and a fluid flow path connecting the recess to a fluid outlet of the detector main body; the light oscillation unit is disposed in the recess that is closest to the inlet; and light detection units are disposed in the remaining recesses.

Abstract translation: 本发明涉及一种光学分析型原料流体密度检测器，其包括设在检测器主体的上表面或下表面上的检测器主体和光振荡单元以及光检测单元，其中 检测器主体具有形成在上表面和下表面中的至少一个凹部，将检测器主体的流体入口连接到凹部的流体流动路径，将凹部彼此连接的流体流路，以及流体 将所述凹部连接到所述检测器主体的流体出口的流路; 光振动单元设置在最靠近入口的凹部中; 并且光检测单元设置在剩余的凹部中。

公开(公告)号：US20160022895A1

公开(公告)日：2016-01-28

申请号：US14761226

申请日：2014-01-14

Applicant: TOKUSHIMA UNIVERSITY ,  Takatori Corporation

Inventor： Toshiya OKAHISA ,  Yohsuke KINOUCHI ,  Tadahiko NAKAGAWA ,  Satoru YAMAJI ,  Zenji TANAKA

IPC: A61M1/34 ,  B01D69/08

CPC classification number: A61M1/3486 ,  A61M1/0281 ,  A61M1/3479 ,  A61M1/3482 ,  A61M2202/0401 ,  A61M2202/0415 ,  A61M2202/0492 ,  B01D63/02 ,  B01D65/08 ,  B01D69/08

Abstract: Provided are a stock solution concentrating device, a stock solution treatment device and a circulation-type treatment device that can prevent the deposition of cells and the like on a filtration member and that can continuously filter and concentrate a stock solution such as pleural and ascitic fluid or blood plasma. The stock solution concentrating device concentrates a stock solution such as pleural and ascitic fluid or blood plasma to form a concentrated solution, and is equipped with: a filter (10) having a filtration member that filters the stock solution; a concentrator (20) to which the filtrate which has been filtered is supplied, and which concentrates the filtrate to form a concentrated solution; and a stock solution supply unit that supplies the stock solution to the filter (10). The stock solution supply unit has a supply amount adjustment function for adjusting the amount of the stock solution supplied to the filter.

Abstract translation: 提供了能够防止细胞等沉积在过滤构件上的储液溶液浓缩装置，储备溶液处理装置和循环型处理装置，并且可以连续地过滤和浓缩诸如胸膜和腹水的储备溶液 或血浆。 储液集中装置将诸如胸膜和腹水或血浆之类的储液集中以形成浓缩溶液，并配备有：过滤器（10），其具有用于过滤储液的过滤构件; 浓缩器（20），向其中提供已经过滤的滤液，并浓缩滤液以形成浓缩溶液; 以及将储备溶液供给到过滤器（10）的储液供给单元。 储液供应单元具有用于调节供给到过滤器的储液的量的供给量调节功能。

公开(公告)号：US12234289B2

公开(公告)日：2025-02-25

申请号：US17311148

申请日：2019-12-06

Applicant: ONO PHARMACEUTICAL CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Taku Okazaki ,  Daisuke Sugiura ,  Takeo Maeda ,  Shiro Shibayama

IPC: C07K16/28 ,  A61K39/00 ,  A61P37/06

Abstract: An immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：US20240392288A1

公开(公告)日：2024-11-28

申请号：US18743834

申请日：2024-06-14

Applicant: Tokushima University

Inventor： Keishi Osakabe ,  Yuriko Osakabe

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/10

Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA encoding said guide RNA.

公开(公告)号：US12018282B2

公开(公告)日：2024-06-25

申请号：US16870388

申请日：2020-05-08

Applicant: FUJIFILM Corporation ,  Tokushima University

Inventor： Kentaro Nakamura ,  Mitsuo Shimada ,  Tetsuya Ikemoto

IPC: C12N5/00 ,  C12N5/071

CPC classification number: C12N5/0676 ,  C12N2500/38 ,  C12N2501/12 ,  C12N2501/16 ,  C12N2501/335 ,  C12N2506/1384

Abstract: An object of the present invention is to provide a method for producing insulin-producing cells having sufficient glucose responsiveness from mesenchymal stem cells, an insulin-producing cell having sufficient glucose responsiveness, a cell structure containing the insulin-producing cell, and a pharmaceutical composition. According to the present invention, there is provided a method for producing an insulin-producing cell from a mesenchymal stem cell, including (a) a step of producing a cell structure by incubating a plurality of biocompatible macromolecular blocks and a plurality of mesenchymal stem cells, and (b) a step of culturing one or more of the mesenchymal stem cells before the incubation in the step (a), the mesenchymal stem cell in the incubation in the step (a), or the cell structure produced in the step (a) in a medium containing the GLP-1 receptor agonist, and (c) a step of culturing the cell structure obtained in the step (a) or the step (b) in a medium containing the water-soluble vitamin and the hepatocyte growth factor.

公开(公告)号：US11685902B2

公开(公告)日：2023-06-27

申请号：US16341175

申请日：2017-10-06

Applicant: Tokushima University

Inventor： Hideharu Abe

IPC: C12N5/071 ,  G01N33/50

CPC classification number: C12N5/0686 ,  G01N33/5044 ,  C12N2502/02 ,  C12N2502/1352 ,  C12N2502/28 ,  C12N2503/04

Abstract: A novel tissue usable for a kidney tissue model is provided. A method for producing a kidney-like tissue includes co-culturing a cell group containing mesenchymal stem cells, vascular endothelial cells, and clonal embryonic kidney cells.

公开(公告)号：US20230183671A1

公开(公告)日：2023-06-15

申请号：US17926032

申请日：2021-06-04

Applicant: TOHOKU UNIVERSITY ,  Tokushima University

Inventor： Masaki OKUMURA ,  Motonori MATSUSAKI ,  Kenji INABA ,  Tomohide SAIO ,  Shingo KANEMURA

IPC: C12N9/90 ,  C07K1/10

CPC classification number: C12N9/90 ,  C07K1/10 ,  C12Y503/04001

Abstract: An object to be achieved by the present in is to prepare a droplet using a protein that has not been known heretofore to form a droplet. The present invention provides a droplet including an assembly of a protein, wherein the protein is a PDI family protein and/or an artificial protein, and contains a thioredoxin-like domain.

公开(公告)号：US20230113633A1

公开(公告)日：2023-04-13

申请号：US18081322

申请日：2022-12-14

Applicant: TANAKA KIKINZOKU KOGYO K.K. ,  TOKUSHIMA UNIVERSITY

Inventor： Michimasa OKUBO ,  Kenji GOTO ,  Kunihiro TANAKA ,  Kojiro SHIRAISHI ,  Kunihiro SHIMA ,  Yuya KATO ,  Kenichi HAMADA ,  Eiichi HONDA ,  Emi TAKEGAWA

IPC: C22C5/02 ,  A61L29/02 ,  A61L31/02 ,  C22F1/14

Abstract: The present invention relates to a medical Au-Pt-Pd alloy including Au, Pt,Pd, and inevitable impurities. The Au-Pt-Pd alloy has an alloy compositioninside a polygon (A1-A2-A3-A4) surrounded by straight lines connected at pointA1 (Au: 53 atom%, Pt: 4 atom%, and Pd: 43 atom%), point A2 (Au: 70 atom%,Pt: 4 atom%, and Pd: 26 atom%), point A3 (Au: 69.9 atom%, Pt: 30 atom%, and Pd: 0.1 atom%), and point A4 (Au: 49.9 atom%, Pt: 50 atom%, and Pd: 0.1 atom%) in a Au-Pt-Pd ternary state diagram. In a metal structure of the alloy, at least one of a Au-rich phase and a Pt-rich phase is distributed, and the total of the area ratio of the Au-rich phase and the area ratio of the Pt-rich phase is 1.5% or more and 25.4% or less.

公开(公告)号：US20230040395A1

公开(公告)日：2023-02-09

申请号：US17757610

申请日：2020-12-18

Applicant: DAICEL CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  TOKUSHIMA UNIVERSITY

Inventor： Takanori NAKAJIMA ,  Yoko YAMASHITA ,  Hitoshi ASHIDA ,  Rie MUKAI

IPC: A61K31/352 ,  A61P3/04 ,  A23L33/10 ,  A23L2/52

Abstract: The present disclosure addresses the problem of providing at least a composition for suppressing obesity and the problem is solved by a composition for suppressing obesity comprising a prenylflavonoid represented by general formula (1), as an active ingredient, below.