公开(公告)号：US20050167370A1

公开(公告)日：2005-08-04

申请号：US10814177

申请日：2004-04-01

申请人： Mitsutoshi Nakajima ,  Yuji Kikuchi ,  Taiji Nishi ,  Takenori Kitani ,  Yukihiro Yanagawa ,  Motohiro Fukuda

发明人： Mitsutoshi Nakajima ,  Yuji Kikuchi ,  Taiji Nishi ,  Takenori Kitani ,  Yukihiro Yanagawa ,  Motohiro Fukuda

IPC分类号： B81B1/00 ,  B01D29/00 ,  B01D29/46 ,  B01F3/08 ,  B01F5/04 ,  B01F13/00 ,  B01J13/00 ,  B01J19/00 ,  B01D37/00 ,  H01L21/302 ,  H01L21/461

CPC分类号： B01F13/0059 ,  B01D29/00 ,  B01F3/0807 ,  B01F5/0475 ,  B01F5/0483 ,  B01F2215/0431

摘要： The resin microchannel substrate has a surface where a recess leading to a fluid supply port and a bank adjacent to the recess and having many micro grooves on a surface are formed. The grooves form microchannels connecting the inside of the recess and the outside of the recess when the surface of the substrate is firmly attached to a flat plate serving as a cover. The width and height of the microchannel are within a range of 1 to 300 μm, and the width/height ratio of the channel is within a range of 1:20 to 20:1.

摘要翻译： 树脂微通道基板具有表面，其中形成有通向流体供给口的凹部和与凹部相邻的堤，并且在表面上具有许多微槽。 当基板的表面牢固地附接到用作盖的平板时，凹槽形成连接凹部的内部和凹部的外部的微通道。 微通道的宽度和高度在1至300μm的范围内，并且通道的宽/高比在1:20至20:1的范围内。

公开(公告)号：US20160159083A1

公开(公告)日：2016-06-09

申请号：US14356066

申请日：2012-09-05

申请人： Taiji Nishi

发明人： Taiji Nishi

IPC分类号： B41J2/005

CPC分类号： B41J2/01 ,  B41J2/0057 ,  B41M5/50 ,  B41M5/506 ,  B41M5/508 ,  B41M5/52 ,  B41M5/5209 ,  B41M5/5236 ,  B41M5/5245 ,  B41M5/5254

摘要： The present invention provides a resin-based ink recorded body having high transparency, high definition, free from bleeding and having a high film strength of an ink. An ink recording member of the present invention includes a substrate containing an acrylic resin and a plant oil derived from a fatty acid having hydroxyl and carboxyl group blended to the acrylic resin, and an ink fixing film composed of a hydrophilic resin and provided on at least one main face of the substrate. An ink printed pattern is provided on the film.

摘要翻译： 本发明提供一种树脂系墨水记录体，其具有高透明度，高清晰度，无渗色性，并具有高的油墨强度。 本发明的墨水记录元件包括含有丙烯酸树脂的基材和衍生自与丙烯酸树脂共混的具有羟基和羧基的脂肪酸的植物油，以及由亲水性树脂构成并至少提供至少 衬底的一个主要面。 在薄膜上设置油墨印刷图案。

公开(公告)号：US08652833B2

公开(公告)日：2014-02-18

申请号：US12298803

申请日：2007-04-25

申请人： Yuji Morimoto ,  Taiji Nishi ,  Taisuke Kamada ,  Go Tazaki ,  Motohiro Fukuda

发明人： Yuji Morimoto ,  Taiji Nishi ,  Taisuke Kamada ,  Go Tazaki ,  Motohiro Fukuda

IPC分类号： C12M3/00 ,  B05D5/10 ,  C40B40/00 ,  C04B40/02

CPC分类号： C12M23/12 ,  C12M23/16

摘要： To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern includes cell culture portions and micro flow channels communicating with the cell culture portions. The bottom surface of each of the cell culture portions has a width 1.0 to 20 times an equivalent diameter of each of the cultured cells. A cell adhesion-inducing substance is formed only on the bottom surface and the side walls of the concave portion.

摘要翻译： 提供能够在体内再现细胞功能的细胞培养室及其制造方法。 根据本发明的细胞培养室具有形成在其上培养细胞的表面上的凹凸图案。 凹凸图案的凹部包括与细胞培养部连通的细胞培养部和微流路。 每个细胞培养部分的底表面具有每个培养细胞的当量直径的1.0至20倍的宽度。 细胞粘附诱导物质仅形成在凹部的底面和侧壁上。

公开(公告)号：US07972543B2

公开(公告)日：2011-07-05

申请号：US11577474

申请日：2005-10-11

申请人： Mitsutoshi Nakajima ,  Taiji Nishi ,  Seiichi Kanai ,  Takenori Kitani ,  Motohiro Fukuda

发明人： Mitsutoshi Nakajima ,  Taiji Nishi ,  Seiichi Kanai ,  Takenori Kitani ,  Motohiro Fukuda

IPC分类号： B29B9/00

CPC分类号： B01J13/04 ,  A23P10/25 ,  A61K9/1682 ,  B01F3/0807 ,  B01F5/0475 ,  B01F13/0059 ,  B01F2215/0014 ,  B01F2215/0016 ,  B01F2215/0019 ,  B01F2215/0031 ,  B01F2215/0034 ,  B01J13/02 ,  C25D1/08 ,  Y10T428/24273

摘要： An object of the present invention is to provide a process for producing microspheres that are solid microparticles or liquid microparticles for use as an emulsion employed in the food industry, production of medicine and cosmetic etc. or an emulsion for DDS (drug delivery system). The object is attained by a process for producing a microsphere including: separating a disperse phase from a continuous phase by a substrate 1 having a through-hole 7; and extruding the disperse phase into the continuous phase through the through-hole 7, in which the substrate having the through-hole 7 with a width of 0.5 to 500 μm, a depth of 10 μm to 6000 μm and a ratio of the width to the depth of the through-hole 7 of 1 to 1/30 is a metal substrate.

摘要翻译： 本发明的目的是提供一种制备用作食品工业中使用的乳液的固体微粒或液体微粒的微球的制造方法，药物和化妆品的制造等，或用于DDS（药物输送系统）的乳液。 该目的通过一种制备微球体的方法来实现，包括：通过具有通孔7的基底1将分散相与连续相分离; 并且通过通孔7将分散相挤出到连续相中，其中具有宽度为0.5至500μm的通孔7的基底，深度为10μm至6000μm，宽度与 通孔7的深度为1〜1/30是金属基板。

公开(公告)号：US20090075366A1

公开(公告)日：2009-03-19

申请号：US11914762

申请日：2006-05-11

申请人： Go Tazaki ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita

发明人： Go Tazaki ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita

IPC分类号： C12M3/00

CPC分类号： C12M25/06 ,  C12M23/10 ,  C12M23/22 ,  C12M23/38 ,  C12M25/14

摘要： It is intended to provide a cell culture chamber in a shape suitable for cell culture. It is also intended to provide a cell culture chamber which is inexpensive and facilitates observation. A cell culture chamber (100) includes a cover (10), a chamber body (20) and a plate-shaped base (30). The cover (10) covers an opening (21) of the chamber body (20). The chamber body (20) contains a culture such as cells. The plate base (30) covers a through hole (24) formed at the bottom (23) of the chamber body (20). Moreover, the plate base (30) has fine pits and projections formed thereon for culturing the culture.

摘要翻译： 旨在提供一种适于细胞培养的形状的细胞培养室。 也是为了提供廉价且便于观察的细胞培养室。 细胞培养室（100）包括盖（10），室主体（20）和板状基部（30）。 盖（10）覆盖室主体（20）的开口（21）。 腔体（20）包含诸如细胞的培养物。 板基座（30）覆盖形成在室主体（20）的底部（23）处的通孔（24）。 此外，板基（30）在其上形成有细微的凹坑和突起，用于培养培养物。

公开(公告)号：US20090017540A1

公开(公告)日：2009-01-15

申请号：US11813720

申请日：2006-01-11

申请人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

发明人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

IPC分类号： C12N5/02 ,  C12M3/00

CPC分类号： C12M25/06 ,  C12M23/12 ,  C12N5/0657 ,  C12N2533/30 ,  C12N2535/00

摘要： [Problems]Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate.[Means for Solving Problems]A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.

摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的治疗目的，旨在提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。

公开(公告)号：US20070276972A1

公开(公告)日：2007-11-29

申请号：US11659952

申请日：2005-08-04

申请人： Yuji Kikuchi ,  Mitsutoshi Nakajima ,  Taiji Nishi ,  Motohiro Fukuda

发明人： Yuji Kikuchi ,  Mitsutoshi Nakajima ,  Taiji Nishi ,  Motohiro Fukuda

IPC分类号： G06F13/00

CPC分类号： B01L3/502761 ,  B01F3/0807 ,  B01F5/0453 ,  B01F5/0456 ,  B01F13/0059 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2300/0816 ,  C12M23/16 ,  Y10T436/25375

摘要： A microchannel array according to the present invention includes a first substrate 1, and a second substrate 11 bonded to the first substrate 1. Two sets, that is, a set of a first through-hole 9, a first recess 7, and a first groove 8 and a set of a second through-hole 4, a second recess 2, and a second groove 3 are formed on the first substrate 1. The different sets are separated by a partition 5. A cell differentation/proliferation speed after micro-injection can be increased by using such microchannel array.

摘要翻译： 根据本发明的微通道阵列包括第一基板1和接合到第一基板1的第二基板11.两组，即一组第一通孔9，第一凹槽7和第一基板11。 凹槽8和一组第二通孔4，第二凹槽2和第二凹槽3形成在第一基底1上。不同的组由分隔体5分隔开。微孔之后的细胞分化/ 可以通过使用这种微通道阵列来增加注射。

公开(公告)号：US20070202560A1

公开(公告)日：2007-08-30

申请号：US11360672

申请日：2006-02-24

申请人： Yuji Kikuchi ,  Taiji Nishi ,  Motohiro Fukuda

发明人： Yuji Kikuchi ,  Taiji Nishi ,  Motohiro Fukuda

IPC分类号： C12Q1/54 ,  C12M3/00

CPC分类号： B01L3/502707 ,  B01L3/502746 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/086 ,  B81B2201/0214 ,  B81B2201/058 ,  B81C1/00071 ,  B81C99/009 ,  B81C2201/034

摘要： A resin microchannel array includes a first substrate having a plurality of depressions, each depression having an inlet port at one end and an outlet port at another end, and walls sectioning the depressions, each wall having a micro groove connecting the depressions, and a second substrate having a flat surface bonded or pressure-contacted to a surface of the first substrate. Spaces created by the depressions and the grooves in a bonded or pressure contacted part between the first substrate and the second substrate serve as flow channels. Each of a width and a depth of the flow channel is within a range of 1 to 50 μm, and a ratio of the width and the depth of the flow channel is within a range of 1:10 to 10:1.

摘要翻译： 树脂微通道阵列包括具有多个凹陷的第一基底，每个凹陷部分在一端具有入口端口和另一端部的出口端口，以及分隔凹陷部分的壁，每个壁具有连接凹部的微凹槽， 衬底，其具有与第一衬底的表面结合或压力接触的平坦表面。 由第一基板和第二基板之间的结合或压力接触部分中的凹陷和凹槽产生的空间用作流动通道。 流路的宽度和深度各自在1〜50μm的范围内，流路的宽度和深度的比例在1:10〜10:1的范围内。