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公开(公告)号：US20090075366A1
公开(公告)日：2009-03-19
申请号：US11914762
申请日：2006-05-11
申请人： Go Tazaki , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita
发明人： Go Tazaki , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita
IPC分类号： C12M3/00
摘要： It is intended to provide a cell culture chamber in a shape suitable for cell culture. It is also intended to provide a cell culture chamber which is inexpensive and facilitates observation. A cell culture chamber (100) includes a cover (10), a chamber body (20) and a plate-shaped base (30). The cover (10) covers an opening (21) of the chamber body (20). The chamber body (20) contains a culture such as cells. The plate base (30) covers a through hole (24) formed at the bottom (23) of the chamber body (20). Moreover, the plate base (30) has fine pits and projections formed thereon for culturing the culture.
摘要翻译： 旨在提供一种适于细胞培养的形状的细胞培养室。 也是为了提供廉价且便于观察的细胞培养室。 细胞培养室（100）包括盖（10），室主体（20）和板状基部（30）。 盖（10）覆盖室主体（20）的开口（21）。 腔体（20）包含诸如细胞的培养物。 板基座（30）覆盖形成在室主体（20）的底部（23）处的通孔（24）。 此外，板基（30）在其上形成有细微的凹坑和突起，用于培养培养物。
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公开(公告)号：US20090017540A1
公开(公告)日：2009-01-15
申请号：US11813720
申请日：2006-01-11
申请人： Ryosuke Nishio , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita , Seiichi Kanai , Takenori Kitani
发明人： Ryosuke Nishio , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita , Seiichi Kanai , Takenori Kitani
CPC分类号： C12M25/06 , C12M23/12 , C12N5/0657 , C12N2533/30 , C12N2535/00
摘要： [Problems]Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate.[Means for Solving Problems]A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.
摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的治疗目的，旨在提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。
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公开(公告)号：US09005970B2
公开(公告)日：2015-04-14
申请号：US11813720
申请日：2006-01-11
申请人： Ryosuke Nishio , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita , Seiichi Kanai , Takenori Kitani
发明人： Ryosuke Nishio , Taiji Nishi , Motohiro Fukuda , Yasuzo Kirita , Seiichi Kanai , Takenori Kitani
CPC分类号： C12M25/06 , C12M23/12 , C12N5/0657 , C12N2533/30 , C12N2535/00
摘要： [PROBLEMS] Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. [MEANS FOR SOLVING PROBLEMS] A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.
摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的目的是提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的多个空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。
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4.发明申请MICROCHANNEL ARRAY AND METHOD FOR PRODUCING THE SAME, AND BLOOD MEASURING METHOD EMPLOYING IT 审中-公开MICROCHANNEL ARRAY AND METHOD FOR PRODUCTION THE SAME，和BLOOD MEASURING METHODWORKING IT公开(公告)号：US20090149345A1
公开(公告)日：2009-06-11
申请号：US11908047
申请日：2006-03-01
申请人： Taiji Nishi , Motohiro Fukuda , Go Tazaki , Seiichi Kanai , Takenori Kitani , Naoto Fukuhara
发明人： Taiji Nishi , Motohiro Fukuda , Go Tazaki , Seiichi Kanai , Takenori Kitani , Naoto Fukuhara
CPC分类号： G01N33/80 , B01L3/502707 , B01L3/502746 , B01L2300/0681 , B01L2300/0816 , G01N33/56972
摘要： A microchannel array, a method of manufacturing the same, and a blood test method. The microchannel array is formed by joining first and second substrates, each including a fluid inlet and outlet on their surfaces. An internal space structure connects the fluid inlet and outlet, and includes an upstream flow channel connected with the fluid inlet, a downstream flow channel connected with the fluid outlet with a gap therebetween, and a micro flow channel connecting the upstream and downstream flow channels. A minimum distance from a center of a sectional surface of the micro flow channel to a side wall of the micro flow channel is smaller than that of the upstream and downstream flow channels. Each surface of the first and second substrates includes grooves for creating the upstream and downstream flow channels, and the surface of the second substrate has grooves for creating the micro flow channel.
摘要翻译： 微通道阵列，其制造方法和血液检查方法。 微通道阵列通过接合第一和第二基底而形成，每个基底在其表面上包括流体入口和出口。 内部空间结构连接流体入口和出口，并且包括与流体入口连接的上游流动通道，与流体出口连接的下游流动通道，其间具有间隙，以及连接上游和下游流动通道的微流动通道。 从微流动通道的截面的中心到微流动通道的侧壁的最小距离小于上游和下游流动通道的最小距离。 第一和第二基板的每个表面包括用于产生上游和下游流动通道的槽，并且第二基板的表面具有用于产生微流动通道的凹槽。
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公开(公告)号：US08435782B2
公开(公告)日：2013-05-07
申请号：US12280607
申请日：2007-02-19
申请人： Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
发明人： Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
IPC分类号： C12M1/14
CPC分类号： C12M23/12 , B01L3/5085 , B01L3/5088 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/0893 , C12M25/00
摘要： An object of the present invention is to provide a cell culture chamber with which the survival rate of cells to be cultured can be increased, and a method of producing the same. A cell culture chamber according to the present invention includes a mass of projections formed of a plurality of microprojections 1 formed on a surface on which cells are cultured. The width or diameter of each of the microprojections 1 is in a range of 20 nm to 3 μm, and the aspect ratio of each of the microprojections is in a range of 0.2 to 3.0. Thus, there can be provided a cell culture chamber most suitable for the adhesion and differentiation/proliferation of cells to be cultured.
摘要翻译： 本发明的目的是提供一种能够提高培养细胞存活率的细胞培养室及其制造方法。 根据本发明的细胞培养室包括由在其上培养细胞的表面上形成的多个微突出物1形成的突起体。 每个微喷射体1的宽度或直径在20nm至3μm的范围内，并且每个微喷射体的纵横比在0.2至3.0的范围内。 因此，可以提供最适合于待培养细胞的粘附和分化/增殖的细胞培养室。
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公开(公告)号：US20090170190A1
公开(公告)日：2009-07-02
申请号：US12280607
申请日：2007-02-19
申请人： Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
发明人： Taiji Nishi , Go Tazaki , Motohiro Fukuda , Michio Yazawa , Masayuki Takahashi
CPC分类号： C12M23/12 , B01L3/5085 , B01L3/5088 , B01L2300/0829 , B01L2300/0851 , B01L2300/0858 , B01L2300/0893 , C12M25/00
摘要： An object of the present invention is to provide a cell culture chamber with which the survival rate of cells to be cultured can be increased, and a method of producing the same. A cell culture chamber according to the present invention includes a mass of projections formed of a plurality of microprojections 1 formed on a surface on which cells are cultured. The width or diameter of each of the microprojections 1 is in a range of 20 nm to 3 μm, and the aspect ratio of each of the microprojections is in a range of 0.2 to 3.0. Thus, there can be provided a cell culture chamber most suitable for the adhesion and differentiation/proliferation of cells to be cultured.
摘要翻译： 本发明的目的是提供一种能够提高培养细胞存活率的细胞培养室及其制造方法。 根据本发明的细胞培养室包括由在其上培养细胞的表面上形成的多个微突出物1形成的突起体。 每个微喷射体1的宽度或直径在20nm至3μm的范围内，并且每个微喷射体的纵横比在0.2至3.0的范围内。 因此，可以提供最适合于待培养细胞的粘附和分化/增殖的细胞培养室。
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公开(公告)号：US20090075363A1
公开(公告)日：2009-03-19
申请号：US12298803
申请日：2007-04-25
申请人： Yuji Morimoto , Taiji Nishi , Taisuke Kamada , Go Tazaki , Motohiro Fukuda
发明人： Yuji Morimoto , Taiji Nishi , Taisuke Kamada , Go Tazaki , Motohiro Fukuda
摘要： To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern includes cell culture portions and micro flow channels communicating with the cell culture portions. The bottom surface of each of the cell culture portions has a width 1.0 to 20 times an equivalent diameter of each of the cultured cells. A cell adhesion-inducing substance is formed only on the bottom surface and the side walls of the concave portion.
摘要翻译： 提供能够在体内再现细胞功能的细胞培养室及其制造方法。 根据本发明的细胞培养室具有形成在其上培养细胞的表面上的凹凸图案。 凹凸图案的凹部包括与细胞培养部连通的细胞培养部和微流路。 每个细胞培养部分的底表面具有每个培养细胞的当量直径的1.0至20倍的宽度。 细胞粘附诱导物质仅形成在凹部的底面和侧壁上。
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公开(公告)号：US08652833B2
公开(公告)日：2014-02-18
申请号：US12298803
申请日：2007-04-25
申请人： Yuji Morimoto , Taiji Nishi , Taisuke Kamada , Go Tazaki , Motohiro Fukuda
发明人： Yuji Morimoto , Taiji Nishi , Taisuke Kamada , Go Tazaki , Motohiro Fukuda
摘要： To provide a cell culture chamber capable of reproducing a cell function in vivo, and a method of producing the same. The cell culture chamber according to the present invention has a concave-convex pattern formed on the surface on which cells are cultured. A concave portion of the concave-convex pattern includes cell culture portions and micro flow channels communicating with the cell culture portions. The bottom surface of each of the cell culture portions has a width 1.0 to 20 times an equivalent diameter of each of the cultured cells. A cell adhesion-inducing substance is formed only on the bottom surface and the side walls of the concave portion.
摘要翻译： 提供能够在体内再现细胞功能的细胞培养室及其制造方法。 根据本发明的细胞培养室具有形成在其上培养细胞的表面上的凹凸图案。 凹凸图案的凹部包括与细胞培养部连通的细胞培养部和微流路。 每个细胞培养部分的底表面具有每个培养细胞的当量直径的1.0至20倍的宽度。 细胞粘附诱导物质仅形成在凹部的底面和侧壁上。
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公开(公告)号：US06732734B2
公开(公告)日：2004-05-11
申请号：US09842794
申请日：2001-04-27
申请人： Masayasu Ogushi , Kyoichiro Shibatani , Toshihide Nakashima , Motohiro Fukuda , Toshiyuki Zento , Yasuzo Kirita , Yukihiro Fujieda , Chuck Bates
发明人： Masayasu Ogushi , Kyoichiro Shibatani , Toshihide Nakashima , Motohiro Fukuda , Toshiyuki Zento , Yasuzo Kirita , Yukihiro Fujieda , Chuck Bates
IPC分类号： A61M2510
CPC分类号： A61M25/10184 , A61L29/049 , A61M16/04 , A61M16/0434 , A61M16/044 , A61M16/0443 , A61M25/10187 , A61M2205/0216 , Y10T428/1352 , Y10T428/139
摘要： A balloon catheter and its pilot balloon system visually indicate the state of the inflation of a balloon placed in a human body. The small pilot balloon is conveniently manufactured by blow molding utilizing substantially the same material and has substantially the same structure as the main balloon. The pilot balloon is useful for a catheter with balloon or a tube with cuff where the balloon or the cuff is made of a very resilient material. The preferred material is a blend of composition having certain properties comprising styrenic thermoplastic elastomer and polyolefin.
摘要翻译： 球囊导管及其导航气球系统可视地指示放置在人体内的气球的充气状态。 通过使用基本上相同的材料的吹塑方便地制造小型先导气球，并且具有与主气囊基本相同的结构。 引导气球对于具有球囊的导管或具有袖带的管是有用的，其中气囊或袖带由非常有弹性的材料制成。 优选的材料是具有包括苯乙烯类热塑性弹性体和聚烯烃的某些性质的组合物的共混物。
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公开(公告)号：US20110318829A1
公开(公告)日：2011-12-29
申请号：US13229087
申请日：2011-09-09
申请人： Go TAZAKI , Tomoko Kosaka , Motohiro Fukuda
发明人： Go TAZAKI , Tomoko Kosaka , Motohiro Fukuda
摘要： To provide a cell culture chamber and a cell culture method that are capable of effectively constructing an intercellular network in a culture space. A cell culture chamber (10) according to the present invention is a cell culture chamber (10) including a plurality of microchambers (11) formed on a surface thereof, characterized in that convex portions (side walls 12) that partition the microchambers (11) adjacent to each other are formed to prevent cells from being adhered to upper surfaces of the convex portions. Consequently, cells can be cultured exclusively within the microchambers (11), and an intercellular network can be constructed effectively.
摘要翻译： 提供能够有效地构建培养空间中的细胞间网络的细胞培养室和细胞培养方法。 根据本发明的细胞培养室（10）是包括形成在其表面上的多个微室（11）的细胞培养室（10），其特征在于，将微型室（11）分隔开的凸部（侧壁12） ）形成为防止细胞粘附到凸部的上表面。 因此，可以在微室（11）内专门培养细胞，并且可以有效地构建细胞间网络。
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