公开(公告)号：US4416772A

公开(公告)日：1983-11-22

申请号：US286625

申请日：1981-07-24

申请人： Takashi Sato ,  Makoto Mukai ,  Shiro Nagata ,  Yoshimichi Harada ,  Yasuzo Kirita

发明人： Takashi Sato ,  Makoto Mukai ,  Shiro Nagata ,  Yoshimichi Harada ,  Yasuzo Kirita

IPC分类号： A61M1/00 ,  A61M1/34 ,  A61M1/36 ,  B01D61/00 ,  B01D31/00

CPC分类号： A61M1/34 ,  A61M1/3603 ,  B01D61/145 ,  B01D61/147 ,  B01D61/18 ,  B01D63/02 ,  A61M2202/0401 ,  A61M2202/0492 ,  B01D2313/28 ,  Y10S128/03

摘要： Body cavity fluids, such as ascitic fluid and pleural fluid, are concentrated and filtered to remove bacteria and cancer cells, and the filtered concentrate is returned to the patient intravenously. The concentration and filtration are performed batch-wise, with the concentration being done before the filtration. The apparatus for concentrating and filtering includes a first container for holding the body fluid, a second container for holding the final filtered concentrate, a filter, a concentrator, a pump and two branched tubes connected to the filter and the concentrator which tubes can be selectively closed for concentrating and filtering the body fluid. The fluid outlet of the first container is designed to help prevent precipitated fibrin from passing out of the container and blocking the concentrator or filter membranes.

摘要翻译： 将体腔液体如腹水和胸膜液浓缩并过滤以除去细菌和癌细胞，并将经过滤的浓缩物静脉内返回给患者。 浓缩和过滤分批进行，浓度在过滤之前进行。 用于浓缩和过滤的装置包括用于保持体液的第一容器，用于保持最终过滤的浓缩物的第二容器，过滤器，浓缩器，泵和连接到过滤器和浓缩器的两个分支管，该管可以是选择性的 关闭用于浓缩和过滤体液。 第一容器的流体出口设计成有助于防止沉淀的纤维蛋白从容器中流出并堵塞浓缩器或过滤膜。

公开(公告)号：US20090075366A1

公开(公告)日：2009-03-19

申请号：US11914762

申请日：2006-05-11

申请人： Go Tazaki ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita

发明人： Go Tazaki ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita

IPC分类号： C12M3/00

CPC分类号： C12M25/06 ,  C12M23/10 ,  C12M23/22 ,  C12M23/38 ,  C12M25/14

摘要： It is intended to provide a cell culture chamber in a shape suitable for cell culture. It is also intended to provide a cell culture chamber which is inexpensive and facilitates observation. A cell culture chamber (100) includes a cover (10), a chamber body (20) and a plate-shaped base (30). The cover (10) covers an opening (21) of the chamber body (20). The chamber body (20) contains a culture such as cells. The plate base (30) covers a through hole (24) formed at the bottom (23) of the chamber body (20). Moreover, the plate base (30) has fine pits and projections formed thereon for culturing the culture.

摘要翻译： 旨在提供一种适于细胞培养的形状的细胞培养室。 也是为了提供廉价且便于观察的细胞培养室。 细胞培养室（100）包括盖（10），室主体（20）和板状基部（30）。 盖（10）覆盖室主体（20）的开口（21）。 腔体（20）包含诸如细胞的培养物。 板基座（30）覆盖形成在室主体（20）的底部（23）处的通孔（24）。 此外，板基（30）在其上形成有细微的凹坑和突起，用于培养培养物。

公开(公告)号：US20090017540A1

公开(公告)日：2009-01-15

申请号：US11813720

申请日：2006-01-11

申请人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

发明人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

IPC分类号： C12N5/02 ,  C12M3/00

CPC分类号： C12M25/06 ,  C12M23/12 ,  C12N5/0657 ,  C12N2533/30 ,  C12N2535/00

摘要： [Problems]Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate.[Means for Solving Problems]A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.

摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的治疗目的，旨在提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。

公开(公告)号：US4715849A

公开(公告)日：1987-12-29

申请号：US832524

申请日：1986-02-21

申请人： Hidenori Gion ,  Takumi Yoda ,  Yasuzo Kirita ,  Kazuhito Zaima ,  Noriyuki Kurata

发明人： Hidenori Gion ,  Takumi Yoda ,  Yasuzo Kirita ,  Kazuhito Zaima ,  Noriyuki Kurata

IPC分类号： A61M1/14 ,  A61B5/15 ,  A61B17/12 ,  A61M1/02

CPC分类号： A61B17/12 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/155 ,  A61M1/3496 ,  A61M1/3639

摘要： An apparatus for easily drawing blood from arm or leg, which is provided with an inflatable air bag to be wound around the arm or leg and to intermittently squeeze a part of the arm or leg in a fixed length. Control over inflation and contraction of the air bag by means of an electronic circuit permits free and precise change of a length of time for inflating or contracting the air bag as well as pressure in the air bag. An apparatus according to this invention for drawing blood from swollen vein extending within a part between the air bag and the tip of arm of leg can increase a quantity of blood to be drawn. Therefore, this apparatus is generally used together with an extracorporporeal blood circulation and treating apparatus.

摘要翻译： 一种用于容易地从臂或腿抽取血液的装置，其具有围绕臂或腿缠绕的可充气气囊，并且以固定长度间歇地挤压臂或腿的一部分。 通过电子线路控制气囊的膨胀和收缩，可以自由和精确地改变气囊膨胀或收缩的时间长度以及气囊中的压力。 根据本发明的用于从腿部的气囊和尖端之间的部分内延伸的肿胀静脉抽取血液的装置可以增加待汲取的血液量。 因此，该装置通常与体外血液循环和治疗装置一起使用。

公开(公告)号：US4747952A

公开(公告)日：1988-05-31

申请号：US902127

申请日：1986-09-02

申请人： Akiyoshi Nakano ,  Yoshimichi Harada ,  Yasuzo Kirita ,  Tadashi Miyahara ,  Yoshio Yagiri ,  Michiko Ueda ,  Yasunori Ueda

发明人： Akiyoshi Nakano ,  Yoshimichi Harada ,  Yasuzo Kirita ,  Tadashi Miyahara ,  Yoshio Yagiri ,  Michiko Ueda ,  Yasunori Ueda

IPC分类号： A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  B01D13/00 ,  B01D17/038

CPC分类号： A61M1/30 ,  A61M1/303 ,  A61M1/304 ,  A61M1/308 ,  A61M1/3693 ,  A61M1/3496 ,  A61M2205/3389 ,  A61M2205/707

摘要： Separation apparatus capable of separating plasma into high molecular weight substances and low molecular weight substances containing albumin, regardless of whether plasma is obtained by separation of corpuscular components in a continuous centrifugal separator or in a batch-type centrifugal separator. The apparatus comprises a filtration membrane module, a plasma feeding circuit connecting the centrifugal separator with the filtration membrane module, a plasma return circuit for returning to a patient purified plasma freed of high molecular weight substances, a supplemental fluid circuit for supplying additional fluid to the plasma return circuit, and a condensed plasma discharge circuit for disposal of high molecular weight substances. The apparatus is controlled independently of the centrifugal separator.

摘要翻译： 能够将等离子体分离成高分子量物质的分离装置和含有白蛋白的低分子量物质，而不管等离子体是通过在连续离心分离器或间歇式离心分离器中分离出红细胞成分得到的。 该装置包括过滤膜组件，将离心分离器与过滤膜组件连接的等离子体供给回路，用于使患者免除高分子量物质的纯化血浆的等离子体返回回路，补充流体回路， 等离子体返回电路和用于处置高分子量物质的冷凝等离子体放电电路。 该设备独立于离心分离器进行控制。

公开(公告)号：US4559034A

公开(公告)日：1985-12-17

申请号：US559855

申请日：1983-12-12

申请人： Yasuzo Kirita ,  Masaru Kawahashi ,  Keiki Kariu ,  Kimihisa Sunahara ,  Hidemune Naito

发明人： Yasuzo Kirita ,  Masaru Kawahashi ,  Keiki Kariu ,  Kimihisa Sunahara ,  Hidemune Naito

IPC分类号： A61M1/36 ,  G11C9/06

CPC分类号： A61M1/3639 ,  A61M1/3627 ,  A61M2202/0401

摘要： A method for treating blood uses a tubular body fluid passageway member at least part of which is made of a flexible material, an outer tubular member which is made of a nonflexible material and contains said tubular body fluid passageway member hermetically enclosed therein, a pressure detecting member for monitoring the pressure of the flowing body fluid by means of a fluid filled in the hermetically closed space between the outside surface of said tubular body fluid passageway member and said outer tubular member without substantial contact of the body fluid with air, and a body fluid filtering member comprising a filter. The method is especially useful for non-anticoagulant hemodialysis.

摘要翻译： 用于治疗血液的方法使用管状体液通道构件，其至少一部分由柔性材料制成，外管状构件由非弹性材料制成，并且包含密封地封闭在其中的管状体液通道构件，压力检测 构件，用于通过填充在所述管状体液通道构件的外表面和所述外管状构件的外表面之间的密封空间中的流体而不流体体积与空气接触来监测流体体液的压力， 流体过滤构件包括过滤器。 该方法对非抗凝血液透析特别有用。

公开(公告)号：US4936980A

公开(公告)日：1990-06-26

申请号：US224899

申请日：1988-07-27

申请人： Harada: Yoshimichi ,  Kenji Kubota ,  Yasuzo Kirita ,  Tadayuki Yamane

发明人： Harada: Yoshimichi ,  Kenji Kubota ,  Yasuzo Kirita ,  Tadayuki Yamane

IPC分类号： A61K35/14 ,  A61M1/02 ,  A61M1/34 ,  B01D61/22

CPC分类号： B01D61/22 ,  A61M1/3496 ,  A61M2205/707

摘要： The invention provides an apparatus and method for plasma separation which is designed so that during the process of separating blood into plasma and corpuscular components by means of plasma separation membranes, if the rate of plasma permeation through the membranes is decreased so that the trans-membrane pressure differential exceeds a predetermined value, the number of revolutions of a plasma pump is adjusted downward to permit restoration of a trans-membrane pressure differential lower than the predetermined value. The rate of plasma discharge is gradually decreased according to the varying permeability of the membranes to plasma, whereby a most effective performance of the membranes can be assured. The apparatus and method can be employed in practicing various blood treatment methods wherein blood is separated into plasma and corpuscular fractions to remove the plasma containing pathogenic factors or to remove the pathogenic factors from the plasma.

摘要翻译： 本发明提供了一种血浆分离装置和方法，其设计使得在通过等离子体分离膜将血液分离成血浆和红细胞成分的过程中，如果通过膜的血浆渗透速率降低，使得跨膜 压力差超过预定值时，等离子泵的转数向下调整以允许恢复低于预定值的跨膜压力差。 根据膜对等离子体的渗透性变化，等离子体放电速率逐渐降低，从而可以确保膜的最有效的性能。 该装置和方法可用于实践各种血液处理方法，其中将血液分离成血浆和红细胞级分以除去含有致病因子的血浆或从血浆中除去致病因子。

公开(公告)号：US09005970B2

公开(公告)日：2015-04-14

申请号：US11813720

申请日：2006-01-11

申请人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

发明人： Ryosuke Nishio ,  Taiji Nishi ,  Motohiro Fukuda ,  Yasuzo Kirita ,  Seiichi Kanai ,  Takenori Kitani

IPC分类号： C12M1/12 ,  C12M1/32 ,  C12N5/02 ,  C12M1/22

CPC分类号： C12M25/06 ,  C12M23/12 ,  C12N5/0657 ,  C12N2533/30 ,  C12N2535/00

摘要： [PROBLEMS] Relating to a bioassay method with the use of cultured cells and cell culture for a therapeutic purpose in the case of determining the efficacy of a drug or the like or examining the toxicity thereof, it is intended to provide a method of culturing cells under regulation in the extension direction and a cell culture plate. [MEANS FOR SOLVING PROBLEMS] A cell culture plate having a plural number of side walls (1) and a plural number of space structures (3) for providing cultured cells which are formed by the side walls (1), wherein the side walls (1) are provided with openings (2) so that the space structures (3) are linked together. By using this cell culture plate, a method of culturing cells under regulation in the extension direction can be provided.

摘要翻译： [问题]关于在确定药物等的功效或检查其毒性的情况下使用培养细胞和细胞培养物进行生物测定方法的目的是提供培养细胞的方法 在延伸方向调节和细胞培养板。 解决问题的手段具有多个侧壁（1）和多个用于提供由侧壁（1）形成的培养细胞的多个空间结构（3）的细胞培养板，其中侧壁 1）设置有开口（2），使得空间结构（3）连接在一起。 通过使用该细胞培养板，可以提供在延伸方向的调节下培养细胞的方法。

公开(公告)号：US06732734B2

公开(公告)日：2004-05-11

申请号：US09842794

申请日：2001-04-27

申请人： Masayasu Ogushi ,  Kyoichiro Shibatani ,  Toshihide Nakashima ,  Motohiro Fukuda ,  Toshiyuki Zento ,  Yasuzo Kirita ,  Yukihiro Fujieda ,  Chuck Bates

发明人： Masayasu Ogushi ,  Kyoichiro Shibatani ,  Toshihide Nakashima ,  Motohiro Fukuda ,  Toshiyuki Zento ,  Yasuzo Kirita ,  Yukihiro Fujieda ,  Chuck Bates

IPC分类号： A61M2510

CPC分类号： A61M25/10184 ,  A61L29/049 ,  A61M16/04 ,  A61M16/0434 ,  A61M16/044 ,  A61M16/0443 ,  A61M25/10187 ,  A61M2205/0216 ,  Y10T428/1352 ,  Y10T428/139

摘要： A balloon catheter and its pilot balloon system visually indicate the state of the inflation of a balloon placed in a human body. The small pilot balloon is conveniently manufactured by blow molding utilizing substantially the same material and has substantially the same structure as the main balloon. The pilot balloon is useful for a catheter with balloon or a tube with cuff where the balloon or the cuff is made of a very resilient material. The preferred material is a blend of composition having certain properties comprising styrenic thermoplastic elastomer and polyolefin.

摘要翻译： 球囊导管及其导航气球系统可视地指示放置在人体内的气球的充气状态。 通过使用基本上相同的材料的吹塑方便地制造小型先导气球，并且具有与主气囊基本相同的结构。 引导气球对于具有球囊的导管或具有袖带的管是有用的，其中气囊或袖带由非常有弹性的材料制成。 优选的材料是具有包括苯乙烯类热塑性弹性体和聚烯烃的某些性质的组合物的共混物。