Stable effervescent bisphosphonate formulations with rapid solubilization characteristics
    11.
    发明授权
    Stable effervescent bisphosphonate formulations with rapid solubilization characteristics 有权
    稳定的泡腾双膦酸盐配方具有快速溶解特性

    公开(公告)号:US09592195B2

    公开(公告)日:2017-03-14

    申请号:US13991523

    申请日:2011-12-05

    CPC分类号: A61K9/0007 A61K31/663

    摘要: A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

    摘要翻译: 稳定的起泡片,颗粒或粉末组合物,其不含可能与起泡有机酸组分反应的赋形剂,其包含有效量的双膦酸盐骨吸收抑制剂,起泡有机酸组分,起泡基质组分; 其中所述组合物不含多元醇粘合剂和压片润滑剂; 干燥失重为0.25%(m / m)以下; 在5-20℃之间放置在3至8个液体盎司的水中时,其完全崩解时间不超过180秒; 并且所述二膦酸盐作为微粉化颗粒掺入或通过喷雾干燥并在2分钟内完全溶解在水中而不搅拌。

    Motor vehicle with lowerable drive unit
    12.
    发明授权
    Motor vehicle with lowerable drive unit 有权
    机动车具有可降低的驱动单元

    公开(公告)号:US07232003B2

    公开(公告)日:2007-06-19

    申请号:US10875609

    申请日:2004-06-23

    IPC分类号: B60K28/14

    CPC分类号: B60R21/34

    摘要: In a motor vehicle comprising a vehicle body having a support structure for supporting a main drive unit and at least one support block disposed on the support structure by which the main drive unit is supported in the vehicle body, each support block comprises bottom and top parts which are movable relative to each other and provided with an operating mechanism for causing such movement for lowering the drive unit when the motor vehicle is involved in a collision.

    摘要翻译: 在包括具有用于支撑主驱动单元的支撑结构的车体和设置在主驱动单元被支撑在车身中的支撑结构上的至少一个支撑块的机动车辆中,每个支撑块包括底部和顶部 它们可相对于彼此移动并且设置有用于当机动车辆参与碰撞时使该驱动单元下降的操作机构。

    STABLE EFFERVESCENT BISPHOSPHONATE FORMULATIONS WITH RAPID SOLUBILIZATION CHARACTERISTICS
    14.
    发明申请
    STABLE EFFERVESCENT BISPHOSPHONATE FORMULATIONS WITH RAPID SOLUBILIZATION CHARACTERISTICS 有权
    具有快速溶解特性的稳定的有效双膦酸盐配方

    公开(公告)号:US20130287706A1

    公开(公告)日:2013-10-31

    申请号:US13991523

    申请日:2011-12-05

    IPC分类号: A61K9/46

    CPC分类号: A61K9/0007 A61K31/663

    摘要: A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

    摘要翻译: 稳定的泡腾片,颗粒或粉末组合物,其不含有与起泡有机酸组分反应的赋形剂,其包含有效量的双膦酸盐骨吸收抑制剂,起泡有机酸组分,起泡基质组分; 其中所述组合物不含多元醇粘合剂和压片润滑剂; 干燥失重为0.25%(m / m)以下; 在5-20℃之间放置在3至8个液体盎司的水中时,其完全崩解时间不超过180秒; 并且所述二膦酸盐作为微粉化颗粒掺入或通过喷雾干燥并在2分钟内完全溶解在水中而不搅拌。

    Meter bearing comprising an integrated data detection and processing system
    15.
    发明授权
    Meter bearing comprising an integrated data detection and processing system 失效
    仪表轴承包括一个集成的数据检测和处理系统

    公开(公告)号:US07568842B2

    公开(公告)日:2009-08-04

    申请号:US10544597

    申请日:2004-02-04

    IPC分类号: F16C32/00 G01L1/00

    摘要: A meter bearing with a recess located at the periphery of at least one of the bearing rings. Expansion-measuring strips are disposed in the recess and conducting paths and electronic modules are arranged on a supporting material and evaluate and transmit the output signals of the expansion-measuring strips. The expansion-measuring strips are connected to the electrical conducting paths which extend to the electronic modules. In order to reduce the space required for such a measuring and evaluation system in a meter bearing, the expansion-measuring strips are placed below and/or above the radial plane of the supporting material and of the conductor paths and electronic modules located thereupon.

    摘要翻译: 一种具有位于至少一个轴承环的周边处的凹槽的仪表轴承。 膨胀测量条设置在凹槽中,导电路径和电子模块布置在支撑材料上,并评估和传输膨胀测量条的输出信号。 扩展测量条连接到延伸到电子模块的导电路径。 为了减少仪表轴承中这种测量和评估系统所需的空间,膨胀测量条被放置在支撑材料的径向平面和位于其上的导体路径和电子模块的径向平面之下和/或之上。

    Communications device and data transmission method
    16.
    发明申请
    Communications device and data transmission method 有权
    通信设备和数据传输方式

    公开(公告)号:US20080049829A1

    公开(公告)日:2008-02-28

    申请号:US11893756

    申请日:2007-08-17

    IPC分类号: H03K7/08 H03K9/08

    CPC分类号: H04B14/023 H04B14/026

    摘要: A communications device includes a supply terminal which is able to be connected to a two-position-controlled power supply; a pulse width recording device, which is coupled to the supply terminal and which records a pulse width of current pulses that flow through the supply terminal, and a signal processing device which assigns a first logical level to a first recorded pulse width and a second logical level to a second recorded pulse width.

    摘要翻译: 通信设备包括能够连接到两位置控制电源的供电端子; 脉冲宽度记录装置,其耦合到所述电源端子并且记录流过所述电源端子的电流脉冲的脉冲宽度;以及信号处理装置,其将第一逻辑电平分配给第一记录脉冲宽度和第二逻辑 电平到第二个记录的脉冲宽度。